The invention discloses a high-strength refractory six-element high-entropy alloy CoCrFeNiVAlx and a preparation method thereof. The high-strength refractory six-element high-entropy alloy is composedof cobalt, chromium, iron, nickel, vanadium and aluminum which all have the purity of at least 99.9%; and all the elements are calculated according to the atomic percent, specifically, Co is 14-20 at%, Cr is 14-20 at%, Fe is 14-20 at%, Ni is 14-20 at%, V is 14-20 at%, and Al is 0-30 at%. The alloy is prepared through an intermediate alloying method, and the preparation steps include that Co, Ni,Fe and Al which are low in melting point are mixed and molten, Cr and V which are high in melting point are mixed and molten, smelting is performed repeatedly for several times, then two intermediatealloys are smelted, and smelting is performed repeatedly for several times so as to guarantee the uniformity. By means of the high-entropy alloy CoCrFeNiVAlx obtained through the method, the problemsthat Al is prone to being damaged by burning and multi-element alloy smelting is non-uniform can be solved excellently, the strength, hardness and plasticity are high, and the high-strength refractorysix-element high-entropy alloy CoCrFeNiVAlx and the preparation method thereof can be applied to the fields of aerospace, mechanical heavy industries and the like.