The invention relates to a monepantel emulsion. Every 100g of the emulsion is prepared from the following components by weight: 0.01 to 3.0 g of monepantel, 1.0 to 8.0 g of peach kernel oil, 0.1 to 6.0 g of ethyl caprylate, 2.0 to 4.0 g of oleyl alcohol, 2.0 to 10.0 g of polyoxyethylene (10) castor oil, 2.0 to 12.0 g of tetrabutyl phenolic aldehyde, 5.0 to 15.0 g of tween-85, .1 to 3.0 g of benzyl alcohol and the balance of deionized water. The monepantel drug particles provided by the invention are distributed in a multi-particle-size range, and can achieve quick-acting, slow-release and long-acting effects after being injected, so that the administration frequency is remarkably reduced. Meanwhile, the problem of poor water solubility of the monepantel is solved, mass-occurring nematode infection of livestock and poultry can be treated in a water drinking mode, the stability is good, medication is uniform, the time and labor are saved, and the monepantel emulsion is mainly used for preventing and treating nematode diseases of livestock and poultry. The invention further discloses a preparation method, the process and technology are easy to transform, and the market prospect is wide.