Liquid preparation for inhibiting male animal oestrus and preparation method thereof

Abstract

The invention discloses a liquid preparation for inhibiting male animal oestrus and a preparation method of the liquid preparation. Every 100g of the liquid preparation comprises the following components by weight: 0.1 to 3.0 g of genistein, 0.5 to 5.5 g of soybean oil, 0.1 to 2.0 g of ethyl oleate, 1.0 to 5.0 g of poloxamer 188, 20.0 to 30.0 g of Tween 40, 5.0 to 15.0 g of benzylazine 30, 0.1 to 6.0 g of polyethylene glycol 600 and the balance of deionized water. The liquid preparation for inhibiting male animal oestrus is an oil-water-in-water emulsion, can be diluted with water for drinking administration, can also be directly administered by subcutaneous injection, and can be flexibly used clinically according to physiological characteristics and medication habits of different animals. The invention further discloses a preparation method, the process operability is high, large-scale production is easy to realize, and the market prospect is wide.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicine, and in particular relates to a liquid preparation for suppressing estrus in male animals and a preparation method thereof. Background technique [0002] With the acceleration of my country's large-scale breeding process and the continuous introduction of foreign advanced breeding technologies, the scale of livestock and poultry breeding has become larger and larger, providing sufficient protein foods such as meat, eggs, and milk for the market. However, large-scale breeding has also brought some problems. Many livestock and poultry are close to or have entered sexual maturity before they are slaughtered, and they are prone to estrus. Once male animals are in estrus, they behave differently from females. They will fight with each other, climb over, and keep agitating. Fighting can cause animal injuries. If the wounds are not treated in time, they are prone to infection, and even death ...

AI Technical Summary

Problems solved by technology

However, this method is cruel and does not conform to the development trend of animal welfare. Strictly speaking, the castration process is also an operation, and it is difficult to avoid animal death or late infection.

For small animals, due to the large number, it is time-consuming and labor-intensive to castrate one by one, which increases labor costs

The second is the hormone method. The hormone method is to inhibit the effect of male hormones by injecting estradiol and other estrogen substances. However, this method is prohibited from being used on food animals because it involves food safety issues.

The third method is the isolation method. Male animals with severe estrus are raised separately to avoid contact with other individuals, which can reduce certain losses. However, after isolation, the animals need to be cared for individually, which increases labor costs and management costs. Fundamentally solve the problem of estrus disturbance

The fourth method is the blinding method, which is widely used in the field of poultry breeding. The roosters wear a kind of plastic glasses before they reach sexual maturity. The glasses can block the front sight and reduce the fighting behavior between roosters There are also great disadvantages. Part of the eyes are blocked, which will also have a certain impact on food intake. In addition, the process of wearing glasses requires the fixing rod to pass through the nasal septum. The stress is greater, and the wound is easy to be infected. It is not in line with animal welfare, and the operation is not good. Skilled can also cause the death of chickens

However, genistein itself is insoluble in water, and it cannot be administered through drinking water when it is used in the breeding industry. When using the mix, it is very difficult to mix it evenly because of the very small amount of this category, which leads to poisoning of some animals after use. , some medicines are insufficient and basically ineffective. In addition, many farms currently use full-price compound feed, and the feed particles need to be destroyed twice when mixing the feed, which hinders the promotion of genistein in the aquaculture industry.

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