14 results about "Vaginal Suppository" patented technology

Aspects of disclosure relate to a composition and methodology for treating menopause symptoms utilizing a cannabinoid-based nanoplatform composition. The composition includes phytocannabinoids like CBD, CBG, and CBN, alongside isoflavones and polyphenols, all integrated into nanoplatform designed for enhanced bioavailability and controlled release. The formulation is designed to alleviate key menopause-related issues, including vasomotor symptoms (VMS), genitourinary syndrome of menopause (GSM), bone loss, mood disturbances, and sleep disorders, while addressing cardiovascular disease (CVD) risks. The composition combines cannabinoids, such as CBD, with isoflavones and polyphenols, and is incorporated into nanoplatforms for enhanced delivery and efficacy. Additionally, the disclosure includes a kit comprising oral capsules, intravaginal ovules, and instructions for use. The capsules contain a blend of cannabinoids, flavonoids, and polyphenols, while the ovules are composed of CBD and cocoa butter. The kit provides a comprehensive solution for managing menopause symptoms and mitigating cardiovascular risks.

The present application relates to the field of animal reproduction, and discloses a method for improving the efficiency of in vivo oocyte collection of dairy goats by using aminophylline, which comprises the following steps: step one, superovulation treatment of dairy goats, (1) placing a vaginal suppository; (2) orally administering aminophylline; (3) injecting follicle stimulating hormone (FSH); step two, an in vivo oocyte collection operation method (LOPU) of dairy goats; step three, in vitro culture of oocytes, in vitro maturation (IVM) of oocytes; in vitro fertilization (IVF); and in vitro culture (IVC) of oocytes.The present application has the advantage that, compared with the prior art, the number of oocytes collected from dairy goats is significantly increased by aminophylline treatment, and the problem of low oocyte collection rate is solved.

The invention relates to the technical field of breeding regulation and control of black goats, in particular to a hormone treatment method for inducing estrus synchronization of black goats, which comprises the following steps: placing a CIDR vaginal suppository containing 1.38-1.56 g of progesterone into the vagina of an ewe, and keeping for 12-14 days; 48 hours before the thrombus is removed, intramuscularly injecting a sustained release preparation of 330 IU follicle-stimulating hormone and 30% polyvinylpyrrolidone; when the thrombus is removed, intramuscularly injecting a mixed solution containing 330IU pregnant mare serum gonadotropin and 0.1 mg of cloprostenol; 24 hours after the thrombus is removed, 25 micrograms of luteinizing hormone is intravenously injected to release hormone A3; single-time artificial insemination is performed within 48-56 hours after injection, 0.5 ml of semen is left for each injection, and the number of effective sperms is not less than 1.5 * 10 < 8 >. By precisely regulating and controlling CIDR progesterone and multi-hormone stepped injection, the estrus synchronization rate of a group is larger than or equal to 95%, and the traditional synchronization bottleneck is broken through; insemination parameters are controlled and optimized management is carried out, each fetal live lamb is 2.5-3.0, and the breeding efficiency is improved; treatment is started 45-50 days after delivery, the lambing interval is 210 + / -10 days, and large-scale efficient breeding is assisted.

Disclosed herein are compositions and methods of manufacturing, testing, and using a biocompatible and disposable vaginal suppository, comprising chitosan, collagen, carboxymethyl cellulose, and an enzyme, capable of breaking down vaginal mucous and releasing the active ingredients consistently over extended periods of time. Methods disclosed herein may also include the use of these compositions, methods, and devices for treating vaginal diseases, such as vaginitis, genitourinary syndrome, and other conditions, such as vulvar and vaginal cancer, or cervical cancer.

The present invention relates generally to nitric oxide-releasing suppositories and methods for their use. According to some embodiments of the present invention, a nitric oxide (NO)-releasing suppository (e.g., vaginal suppositories) is described. Some embodiments relate to compositions, kits, and / or methods for treating and / or preventing an infection (e.g., a viral infection). In some embodiments, a method is provided for treating and / or preventing a viral infection in a subject in need.

The utility model provides a vaginal suppository administration pen which comprises a pen container and a pushing mechanism, a containing groove, a first sliding groove and a second sliding groove are formed in the pen container, the containing groove is used for containing a suppository, and the pushing mechanism is connected in the containing groove, the first sliding groove and the second sliding groove in a sliding mode. The pushing mechanism is used for pushing the suppository out of the placing groove; the pushing mechanism comprises a piston rod and a spring, one end of the piston rod is located in the containing groove and abuts against the suppository, and the spring is located in the first sliding groove and used for driving the piston rod to push and reset; compared with a traditional mode that a suppository is stuffed with fingers, by arranging the pen container and the pushing mechanism, the stability of the vagina of a patient is kept in the dosing process, the probability of cross infection is reduced, and the dosing efficiency and the comfort of the patient are improved; meanwhile, the dosing depth and part can be effectively controlled, and the convenience degree of dosing into the vagina by an operator is improved.

A pessary (50) having a generally rounded main body formed as a completely reticulated outer shell (52, 56, 58) surrounding a void (54) forming a hollow interior. The pessary is suitably spherical, ovoid or spheroidal and manufactured from an elastomeric material. This enables the pessary to be comfortably inserted into the vaginal cavity (22), where it can act (34) upon the cervix (32), and / or anterior / posterior walls of the vagina (22) to provide structural support to the cervix. The reticulated outer shell enables the pessary to compress radially inwardly so as to facilitate its insertion and extraction into or from the vaginal cavity.

The invention discloses a traditional Chinese medicine vaginal suppository for treating cervicitis diseases and a preparation method and application thereof, and relates to the field of traditional Chinese medicine preparations, the preparation method comprises the following steps: S1, mixing polygonum aviculare, radix rehmanniae, curcuma zedoary, pepper and croton, crushing and sieving to obtain traditional Chinese medicine powder; s2, dividing the traditional Chinese medicine powder into two parts, and blending to form quick-release layer medicine slurry and slow-release layer medicine slurry; s3, injecting the slow-release layer medicine slurry into a mold cavity, cooling and curing, injecting the quick-release layer medicine slurry into the outer layer of the mold cavity, and performing pressure treatment and cooling to obtain a molded suppository; and S4, wrapping the formed suppository with a disinfection material, and mooring a thread which can be taken out to obtain the traditional Chinese medicine vaginal suppository. The suppository disclosed by the invention can quickly exert anti-inflammatory and antibacterial effects, improve symptoms such as cervical erosion and abnormal leukorrheal and is beneficial to breaking the persistent circulation of cervicitis, so that both symptoms and root causes are treated, and disease relapse is reduced.

The application discloses a preparation method of a nystatin fatty acid ester vaginal suppository responding to inflammation, a product and application thereof, and belongs to the field of medicine. The preparation method comprises the following steps: dissolving fatty acid in a solvent, adding a catalyst, uniformly mixing, and activating a carboxyl group of the fatty acid, adding nystatin, and stirring to obtain nystatin fatty acid ester. The fatty acid is saturated or unsaturated fatty acid with a carbon chain length of 4-17 carbons. The application effectively solves the problems that nystatin is unevenly distributed in the suppository matrix and is prone to suppository sedimentation and stratification. Meanwhile, the nystatin fatty acid ester disclosed by the application can be hydrolyzed under the action of leukocyte esterase at an inflammation site of a vagina, release nystatin raw medicine, and play a bactericidal role responding to inflammation. In the non-inflammation area, the nystatin fatty acid ester is hardly hydrolyzed into nystatin, and thus the local adverse reaction of the vagina caused by nystatin can be effectively reduced.

The invention relates to the field of activated carbon, and particularly discloses a preparation method and application of Chinese herbal medicine-based trace element-containing activated carbon. The preparation method of the Chinese herbal medicine-based trace element-containing activated carbon comprises the following steps: cleaning astragalus membranaceus, leonurus, tea leaves, sanguisorba officinalis and bamboos, crushing, removing impurities, and airing to obtain a mixture; putting the mixture into a carbonization furnace for carbonization treatment to obtain activated carbon; and cooling the activated carbon to room temperature, and grinding to obtain the Chinese herbal medicine-based trace element-containing activated carbon. The Chinese herbal medicine-based trace element-containing activated carbon can be used in vaginal suppositories, and has the effect of improving gynecological inflammation and gynecological dysbacteriosis.

A system, method, and apparatus to insert and remove a thermally activated vaginal pessary, by employing a nitinol core material that is integrated into the construction of the thermally activated vaginal pessary and configured to increase in radial size upon contact with body temperature by undergoing a configurational phase change in the underlying nitinol core material.

The invention provides an antibody combined with HPV66 L1 protein or an antigen binding fragment thereof and a pharmaceutical composition containing the antibody, and further provides a polynucleotide molecule for coding the antibody or the antigen binding fragment thereof, and an expression vector for expressing the antibody or the antigen binding fragment thereof. The antibody or the antigen binding fragment thereof can be widely applied to infection detection of the HPV66 virus in a clinical sample, can be prepared into vaginal gel, vaginal cleaning liquid, external washing liquid, vaginal suppository, freeze-dried powder, vaginal effervescent tablets and the like, is used for prevention and / or treatment of HPV66 infected patients, and can effectively improve the clinical negative conversion rate of the HPV66 patients. The invention has important significance on female reproductive health and public health prevention and control.

The utility model relates to the technical field of medicine plugging devices, in particular to a medicine plugging device for vaginitis, which comprises a sleeve, one end of the sleeve is provided with a medicine storage tube, one end of the medicine storage tube is fixedly connected with a clamping block, one end of the sleeve is fixedly connected with a clamping seat, the clamping block is inserted into the clamping seat and is connected with the clamping seat in a clamping manner, and the clamping seat is fixedly connected with the sleeve. A piston is slidably connected to the interior of the medicine storage tube, a pushing rod is fixedly connected to the surface of the piston, a pushing rod is fixedly connected to the other end of the pushing rod, a pressing plate is fixedly connected to one end of the pushing rod, and an auxiliary pushing plate is fixedly connected to one end of the sleeve. The medicine storage tube and the sleeve are fixedly connected, the connection mode is simple and rapid, compared with a threaded connection mode, the convenience of connection and the working efficiency of disassembly are greatly improved, and the medicine storage tube and the sleeve are more efficiently and rapidly disassembled and assembled.

The invention discloses a traditional Chinese medicine vaginal suppository for treating female pelvic inflammation and a preparation method and application thereof, and relates to the field of traditional Chinese medicine preparations, the preparation method comprises the following steps: S1, mixing polygonum aviculare, radix rehmanniae, pepper and croton, crushing and sieving to obtain traditional Chinese medicine powder; s2, dividing the traditional Chinese medicine powder into two parts, and blending to form quick-release layer medicine slurry and slow-release layer medicine slurry; s3, injecting the slow-release layer medicine slurry into a mold cavity, cooling and curing, injecting the quick-release layer medicine slurry into the outer layer of the mold cavity, and performing pressure treatment and cooling to obtain a molded suppository; and S4, wrapping the formed suppository with a disinfection material, and mooring a thread which can be taken out to obtain the traditional Chinese medicine vaginal suppository. The suppository compatibility system not only eliminates pathogens, but also improves local microcirculation and immune states, so that the suppository is helpful for breaking the persistent circulation of chronic pelvic inflammation, thereby achieving the purposes of treating both symptoms and root causes and reducing disease relapse.