8 results about "Interfering virus" patented technology

The invention discloses a broad-spectrum novel coronavirus-resistant double-target polypeptide and application thereof, and relates to the field of biological medicines. The polypeptide drug provided by the invention can more effectively and synergistically inhibit the infection process of the virus by simultaneously acting on two key targets of RBD and HR1 of the virus. On one hand, through targeting RBD, combination of viruses and host cells can be blocked, so that the phenomenon that the viruses are adsorbed on the surfaces of the host cells is blocked, and the adsorption process of the viruses is restrained; on the other hand, by targeting HR1, formation of virus 6-HB can be interfered, and the fusion process of a virus envelope and a host envelope is further inhibited. The polypeptide capable of simultaneously targeting the double targets RBD and HR1 of the novel coronavirus, particularly R1L25HR2, provided by the invention, can effectively inhibit SARS-CoV-2 and a mutant strain thereof, and has broad-spectrum activity for resisting the novel coronavirus.

The utility model relates to the technical field of preparation device, specifically disclose a kind of preparation device of canine feline interference virus compound peptide, including base, motor is fixedly installed in base middle part, motor output shaft end portion is fixedly installed with disc, disc side edge is equipped with the evenly distributed limit mouth, disc is located in the limit mouth side edge and is all equipped with through -going hole, disc side edge, limit mouth and through -going hole are all set to be inclined, through -going hole is equipped with centrifugal tube, centrifugal tube is set to be through -going, the plug of centrifugal tube top is fixedly connected, the size of plug is compatible with the size of limit mouth, the preparation device of canine feline interference virus compound peptide, can quickly directly canine feline cell liquid solid-liquid separation, using centrifugal force quickly makes cell debris, solid impurities such as organelle sedimentation and isolation, efficiently obtain the clear solution containing target interference virus compound peptide, strong practicality.

The invention provides a composition which comprises the following components in parts by mass: a biological fermentation base material and a functional auxiliary material, the biological fermentation base material comprises 30-50 parts of corn flour, 15-20 parts of soybean meal, 3-8 parts of fish meal, 3-10 parts of whey powder, 10-20 parts of wheat flour, 4-12 parts of brown sugar, 1-5 parts of a complex microbial inoculant and 18-25 parts of water; the functional auxiliary materials comprise 5-10 parts of citric acid, 2-5 parts of a vitamin mineral premix and 1-3 parts of a plant extract. According to the technical scheme, through a multi-way synergistic mechanism of synergistic fermentation of the complex microbial inoculants, multi-acid staged dissociation, interference of virus replication by the active peptide and infection blocking by the adsorbent, the ASFV is efficiently inactivated, meanwhile, complete nutritional ingredients of the feed are kept, the immunity of live pigs and the utilization rate of the feed are remarkably improved, and double breakthrough of prevention and control effects and breeding benefits is achieved.

The present invention discloses a broad-spectrum dual-target polypeptide against the new coronavirus and its application, relating to the field of biomedicine. The polypeptide drug provided by the present invention can more effectively and synergistically inhibit the infection process of the virus by acting on the two key targets of the virus, RBD and HR1, at the same time. On the one hand, by targeting RBD, the binding of the virus to the host cell can be blocked, thereby hindering the adsorption of the virus on the surface of the host cell and curbing its adsorption process; on the other hand, by targeting HR1, the formation of the virus 6-HB can be interfered with, further inhibiting the fusion process of the viral envelope and the host envelope. The polypeptide that can simultaneously target the dual targets of the new coronavirus RBD and HR1, especially R1L25HR2, provided by the present invention, can effectively inhibit SARS-CoV-2 and its mutants, and has a broad-spectrum activity against the new coronavirus.

The invention provides application of fructus arctii essential oil in preparation of an external medicine for resisting human papilloma virus. The invention further provides application of the ganoderma lucidum spore oil in preparation of the external medicine for resisting the human papilloma virus. The invention provides a pharmaceutical composition for treating human papilloma virus infection. The pharmaceutical composition is prepared from the following raw materials in parts by weight: 3.2-4.8 parts of fructus arctii essential oil and 0.8-1.2 parts of ganoderma lucidum spore oil. The invention also provides a preparation method and application of the pharmaceutical composition. According to the invention, a compounding process is adopted, the formula of main medicines and auxiliary materials is determined, the compound ganoderma lucidum essential oil with good stability is successfully prepared, and a thin-layer chromatography method and a gas chromatography quality evaluation method for the main medicines in the compound are preliminarily established. The compound coriolus versicolor essential oil is administrated in a local smearing mode, in-vitro experiments show that the compound coriolus versicolor essential oil can interfere with virus replication and is high in antiviral effect, especially for HPV16, the effect is mild, no stimulation to skin is found through clinical observation, and adverse reactions are few.

Provided herein are antiviral compounds having the structure of Formula (I) and compositions thereof for use in the treatment of viral infection. In particular, the compounds of Formula (I) are capable of interfering with the export of viral mRNA processing as reflected in the altered accumulation of viral RNA isoforms as well as transport from the nucleus to the cytoplasm. Such compounds show a reduction of HIV, adenovirus and coronavirus infection of cells. The invention provides compounds that may be suitable for the treatment of HIV / AIDS.

The invention discloses a cat omega interferon RNA vaccine and application thereof, and relates to the technical field of veterinary biological products. After the optimized cat omega interferon is used for immunizing an experimental animal, virus replication can be inhibited, so that the effect of protecting the body is achieved. Therefore, the nucleic acid molecule provided by the invention can be used for developing recombinant protein vaccines or preparing nucleic acid vaccines. Compared with the recombinant interferon protein on the market, the vaccine provided by the invention has the capability of enhancing the neutralizing antibody level of various vaccines, and can efficiently reduce the virus titer, interfere the combination of the virus and a host cell receptor and inhibit the replication of the virus, thereby playing a role in protecting the body and promoting the antiviral capability of the body.

The present invention discloses a method for effectively inhibiting the assembly of HIV-1 virus based on synthetic oligonucleotides. This method first designs a series of synthetic RNA oligonucleotides to self-assemble into an RNA self-assembled nanomaterial with a more complex spatial structure and multiple stem-loop structures. Then, the RNA oligonucleotides and their self-assembled nanomaterials are used to effectively bind to the HIV-1 structural protein Gag molecule, thereby interfering with virus assembly and effectively inhibiting the release of HIV-1 virus. The present invention realizes for the first time the inhibition of the assembly of HIV-1 virus using synthetic RNA oligonucleotides and self-assembled nanomaterials, expands the application of RNA oligonucleotides in the biomedical field, and provides new ideas for disease treatment.