4results about How to "Avoid cytotoxicity" patented technology

The invention relates to the technical field of biological material manufacturing, in particular to vanadium-doped mesoporous bioactive glass powder for treating diabetic wounds and a preparation method of the vanadium-doped mesoporous bioactive glass powder. Adding an ammonia solution into the template agent solution to obtain a mixed solution; adding a silicon source, a phosphorus source, a calcium source and a vanadium source into the mixed solution in batches according to a preset interval time under a continuous stirring condition, continuously stirring and reacting for 5.5-24 hours, and centrifuging and collecting a precipitation product; and washing, roasting and grinding the obtained precipitation product to obtain the vanadium-doped mesoporous bioactive glass powder for treating diabetic wounds.

The invention relates to the technical field of medical instruments, in particular to an ERCP novel bile duct stent and a preparation method thereof.The bile duct stent prepared through the preparation method has certain antibacterial ability by using an AMP-Chol12 peptide chain with the antibacterial ability, the bacterial membrane structure is destroyed through the electric charge effect, bacterial death is caused, and the bile duct stent has a certain antibacterial ability. Therefore, the bacterial infection risk is reduced. The physical antibacterial mechanism does not depend on chemical release, so that the antibacterial property is lasting, silver ions and antibiotics are not contained, bacterial drug resistance is not caused, meanwhile, good biocompatibility is achieved, the lubricating property can be improved, friction and damage are reduced, and bile sludge deposition is reduced.

This invention relates to the field of biomedical materials, specifically to an antibacterial hydrogel, its preparation method, and its applications. The method involves first preparing thiolated tannic acid and copper-doped Prussian blue nanozyme (CuPB). Methacrylated gelatin is mixed with the thiolated tannic acid, followed by the sequential addition of CuPB, ε-polylysine, trehalose, horseradish peroxidase, and a photoinitiator. The mixture is stirred until homogeneous to obtain a photosensitive prepolymer solution, which is then photocured under visible light to obtain the antibacterial hydrogel. The antibacterial hydrogel prepared by this invention responds to changes in H2O2 concentration at the wound site: during infection, CuPB and HRP cascade catalyze the generation of reactive oxygen species, synergistically with ε-polylysine and copper ions to achieve multi-mechanism, highly efficient antibacterial action; simultaneously, it triggers oxidative crosslinking of the thiolated tannic acid, enhancing its mechanical properties and accompanied by color changes, thus aiding in monitoring the infection status; possessing excellent biocompatibility, antibacterial properties, and mechanical properties, it can be used in wound dressings, biosensors, and other fields.

This invention relates to the field of biomedical technology, providing a microsphere composition and its preparation method, as well as its application in the preparation of contrast agents and drugs. The microsphere composition includes a microsphere dispersant and microsphere particles; the microsphere particles include a shell and a core; the shell comprises a lipid mixture consisting of charged lipids and auxiliary lipids; the core comprises an optional therapeutic gas, and one or both of an inert gas or inert liquid; the molar amount of charged lipids is ≤60% based on the total molar amount of the lipid mixture; the pH value of the microsphere dispersant is 5-6.9. The microsphere particles of this invention can efficiently load therapeutic gases and conventional drugs, precisely target their application, exhibit excellent stability, and have high biocompatibility.