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46 results about "Viral resistance" patented technology
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Fusion proteins for HIV therapy
InactiveUS20120121597A1Improved potency and breadth against HIVImprove barrier propertiesHybrid immunoglobulinsAntibody mimetics/scaffoldsHiv envelopeBinding site
Disclosed herein are fusion antibodies created to provide both an antigen-binding site that targets the CD4 receptor and an antigen-binding site that targets the HIV envelope. The fusion antibodies disclosed herein provide improved potency and breadth against HIV as compared to monospecific antibodies, and additionally provide high barrier against viral resistance. Also disclosed are pharmaceutical formulations and therapeutic methods utilizing such fusion proteins.
Owner:THE ROCKEFELLER UNIV
Recessive plant viral resistance results from mutations in translation initiation factor eIF4E
Owner:CORNELL RES FOUNDATION INC
Recessive plant viral resistance results from mutations in translation initiation factor eIf4e
InactiveUS20060294618A1Good antiviral effectBacteriaOther foreign material introduction processesHeterologousInitiation factor
The present invention relates to methods of imparting virus resistance to plants. In one aspect, this method involves silencing a gene encoding a translation initiation factor eIF4E in the plant. In another aspect, this method involves overexpressing a heterologous translation initation factor eIF4E in a plant. The present invention further relates to a genetic construct containing a nucleic acid molecule encoding a heterologous translation initiation factor eIF4E, as well as to an expression system containing the genetic construct and a host cell transformed with the genetic construct. The present invention also relates to transgenic plants, seeds, and plant parts transformed with the genetic construct. The present invention also relates to an isolated nucleic acid molecule encoding a mutant translation initiation factor eIF4E that is effective in imparting virus resistance in plants. The present invention also relates to a mutant translation initiation factor eIF4E and a method for making the mutant.
Owner:CORNELL RES FOUNDATION INC
Health-maintenance consolidated composite flooring and manufacturing technique thereof
ActiveCN103334571AAuxiliary effect on health careSuppresses free formaldehyde odorWood working apparatusWood layered productsHuman bodyFiber
The invention provides health maintenance consolidated composite flooring. The health maintenance consolidated composite flooring comprises a surface layer, a core layer and a bottom layer from top to bottom in sequence, and is formed by the upper layer, the core layer and the bottom layer in a composite mode. Wood fibers, wormwood fibers and sandalwood fibers are combined through glue to form the core layer. The invention further provides a manufacturing technique of the health maintenance consolidated composite flooring. According to the health maintenance consolidated composite flooring, wormwood and sandalwood are added in the raw materials of a core plate, and besides the effects of attractive and practical of a general flooring product, the effect that free formaldehyde odor in original flooring is restrained and eliminated is achieved. In addition, the wormwood and the sandalwood in the health maintenance consolidated composite flooring can further achieving the effects of bacterial resistance, insect killing, viral resistance, skin moisten, mind tranquilization, cough relief, allergy resistance and the like, and an auxiliary effect of health maintenance and health care of human bodies can be achieved by using the flooring in a long period of time.
Owner:HUBEI JIUKESONG WOODEN PROD
Fusion antibodies for HIV therapy
InactiveUS8637024B2Improved potency and breadth against HIVImprove barrier propertiesHybrid immunoglobulinsPeptide/protein ingredientsHiv envelopeBinding site
Owner:THE ROCKEFELLER UNIV
Nasal irrigation care solution
InactiveCN106581148AEffectively treats rhinitis symptomsStrong irritantAntibacterial agentsHydroxy compound active ingredientsNasal cavityPolyethylene glycol
Owner:四川艾医生医疗科技有限公司
Air purification spray for removing indoor fitment pollution and preparation method thereof
ActiveCN105251341ARemove persistentEfficient removalBiocideDispersed particle separationAntioxidantSurface-active agents
The invention provides an air purification spray for removing indoor fitment pollution and a preparation method thereof. The air purification spray comprises a photocatalyst, aloe gel juice, water and auxiliary additives. The photocatalyst and the aloe gel juice are mixed to obtain gel, then the gel is dispersed in the water, and finally the auxiliary additives are added. The aloe gel juice is prepared from raw materials comprising aloe juice, citric acid, antioxidant, a bacterial inhibitor and a surface active agent. The photocatalyst is coated with the aloe gel juice, after the spray is sprayed to the surface of a plate to form a film, the photocatalyst can be firmly combined in the film and will not lose, hazardous gas released in the plate can be continuously removed, and the good effect of removing formaldehyde and benzene is achieved. Meanwhile, the aloe gel juice can effectively remove volatile organic compound in air. The air purification spray can effectively remove volatile organic compound in air, and achieve the effects of air purification, sterilization, viral resistance and the like.
Owner:NANJING RUNZHONG BIOTECH
Method of enhancing virus-resistance in plants and producing virus-immune plants
InactiveUS20040068764A1Lower Level RequirementsDelayed and reduced spreadSsRNA viruses positive-senseMicrobiological testing/measurementBiotechnologyNucleotide
The present invention provides a method of enhancing resistance of plants to one or multiple viruses, comprising introducing to a plant cell, and preferably expressing therein, a nucleotide sequence encoding a virus-encoded polypeptide. The present invention provides a method of enhancing the proportion of virus-resistant or virus-immune lines obtained from a single transformation experiment comprising introducing to a plant cell, a nucleotide sequence encoding a virus-encoded polypeptide operably in connection with a strong promoter sequence. The present invention provides novel gene sequences encoding the coat proteins of a virus and novel dysfunctional replicase sequences as well as gene constructs comprising same, in particular binary vector constructs suitable for introducing into plants and expressing the genes therein. The present invention provides and methods using same to enhance viral resistance in plants. The present invention provides novel methods of testing transgenic plants for the presence of a transgene.
Owner:DAIRY AUSTRALIA +2
Method for inducing viral resistance into a plant
InactiveUS6297428B1High degree of toleranceRapid and total blocking of multiplication and diffusion mechanismSsRNA viruses positive-senseVirus peptidesPlant cellNucleic acid sequencing
The present invention concerns a method for inducing resistance to a virus comprising a TGB3 sequence with the proviso that it is not the potato virus X, into a plant cell or plant, comprising the following steps: preparing a nucleic acid construct comprising a nucleic acid sequence corresponding to at least 70% of the nucleic acid sequence of TGB3 of said virus or its corresponding cDNA, being operably linked to one or more regulatory sequence(s) active in a plant, transforming a plant cell with the nucleic acid construct, and possibly regenerating a transgenic plant from the transformed plant cell. The present invention is also related to the plant obtained.
Owner:SES EURO N V
Disease Resistant Pepper Plants
ActiveUS20110035832A1Solve the low germination rateMicrobiological testing/measurementGenetic engineeringDiseaseAllele
The present invention relates to pepper plants resistant to powdery mildew disease as well as to infection by potyviruses, particularly potato virus Y (PVY). Specifically, the present invention relates to pepper plants comprising a viral resistance allele and a powdery mildew resistant allele in cis configuration on the same chromosome, such that the two resistance alleles are in coupling phase.
Owner:HAZERA SEEDS LTD +1
Gene transfer vector comprising papaya ringspot virus auxiliary component protease gene and application thereof for providing broad-spectrum virus resistance in crops
ActiveCN102277376ASolving the problem of non-dependent homologous resistanceBacteriaMicroorganism based processesMicroorganismGene transfer
The invention discloses a recombinant vector comprising a control sequence and a coded sequence fragment of papaya ringspot virus (PRSV) helper component protease gene (HC-Pro gene) in manipulatable connection with the control sequence. The invention also provides a recombinant microorganism, a method for endowing a plant with resistance to viruses, and application of a full-length gene or a genefragment thereof of the PRSV HC-Pro gene to culture of plants with resistance to the viruses. In the invention, by adopting the strategy of attacking the virus by taking the PRSV HC-Pro gene as a target, the capability of the PRSV to resist plant host defense responses is collapsed, the problem that the resistance of genetically modified genes subjected to gene silencing is lost is solved, the wide-spectrum resistance of a genetically modified plant to different PRSV strain viruses is provided, and the cultured genetically modified plant is endowed with an application value of crossing geographical regions.
Owner:薛富盛
Novel preparation method for sulfated chitosan
The invention discloses a novel preparation method for sulfated chitosan. The method comprises the following specific steps: dissolving chitosan in 100ml of distilled water, stirring for 30-60min, and regulating the pH value; carrying out freeze drying on the chitosan-bisulfate solution; heating the freeze-dried sulfated chitosan for 1-5 days under the dry condition, and carrying out sulfation reaction; and carrying out dialyzing and freeze drying to obtain the sulfated chitosan. The invention has the advantages that the organic solvent is not utilized during the preparation process; sulfating products are safe and can avoid environment pollution; the process flow is simple, the conditions are controllable, the production cost is low and the industrialized production can be easily realized; the sulfated chitosan in the invention has good activities of anticoagulation, viral resistance, HIV resistance and the like; and in addition, the sulfated chitosan has the immunoregulation function and good antioxidant activity, and has profound significances on developing antiviral medicines and bionic materials and the like.
Owner:YUNNAN UNIV
Multifunctional health burdock tea paste and preparation method thereof
The invention discloses multifunctional health burdock tea paste. The multifunctional health burdock tea paste is prepared from burdock root, fructus arctii, green tea, mushroom and cordyceps militaris as raw materials through enzymolysis and extraction. The multifunctional health burdock tea paste has functions of burdock root, fructus arctii, green tea, mushroom and cordyceps militaris producing synergism and has abundant nutrition values and health care functions. The health care functions comprise human humoral immunity improvement, viral resistance and cancer resistance. The burdock, cordyceps militaris and mushroom extract can effectively prevent ethanol from entering blood, protect liver and accelerate an ethanol metabolism rate in vivo so that the multifunctional health burdock tea paste has effects of relieving the effect of alcohol and sobering up and is an ideal health drink.
Owner:王国泰 +2
Compositions and methods for viral resistance genes
The present invention further provides a method of evaluating yellow fever virus susceptibility in a subject, which comprises obtaining a nucleic acid containing at least a portion of OAS gene from the subject, and determining whether the nucleic acid comprises SNPs relating to the susceptibility of the subject to yellow fever virus-associated condition. Also provided is a method of evaluating tick-borne encephalitis virus susceptibility in a subject, which comprises obtaining a nucleic acid containing at least a portion of OAS gene from the subject, and whether the nucleic acid comprises SNPs relating to the susceptibility of the subject to tick-borne encephalitis virus-associated condition.
Owner:GEORGIA STATE UNIV RES FOUND INC
Compounds for preventing or treating viral infections and methods of use thereof
Described herein are compounds and methods that prevent the viral infection of cells. The compounds and methods described herein minimize viral resistance and maximize the number of targeted viruses.Additionally, the compounds and methods minimize the toxicity toward uninfected cells.
Owner:艾伯塔大学校董
Composition of broad-spectrum antiviral food material extract and nutrients and preparation method thereof
InactiveCN105902668AImprove actual functionsImprove immunityHeavy metal active ingredientsSenses disorderDiseaseSide effect
The invention relates to a composition of broad-spectrum antiviral food material extract and nutrients. The composition is prepared from, by weight, 40-55 parts of potassium citrate, 4-6 parts of sodium citrate, 4-6 parts of calcium citrate, 40-55 parts of magnesium sulfate, 9-11 parts of zinc sulfate, 10-15 parts of microelements, 3-5 parts of food extract, 9-11 parts of lysine and the balance purified water. Compared with the prior art, the composition has the advantages that the microelements, the food extract and the nutrients achieve the effect of improving the human body functions, then, the purposes of improving the immunity of a human body immune system is achieved, other medicines have the effects of sterilization, antiphlogosis, viral resistance and expelling of toxin at different degrees, the effects of the medicines are not reduced or weakened, otherwise, on the contrary, the medicines achieve mutual complementarity and supplement one another, meanwhile, the composition has the effects of diuresis and urine alkalizing, can treat potassium deficiency diseases and has few side effects, and bacteria, fungi and viruses are not likely to produce drug resistance and tolerance.
Owner:SHENYANG AIYIGE BIOLOGICAL TECH CO LTD
Compositions and methods for viral resistance genes
InactiveUS20050244815A1Reduce expressionMicrobiological testing/measurementTransferasesVaccinationGenotype
The present invention is directed to methods and compositions for identifying viral resistance genes and for identifying individuals having resistant or susceptible genotypes. Once identified as either resistant or susceptible, appropriate actions, such as vaccination, can be undertaken by the individuals. In particular, methods and compositions for identifying genes associated with resistance or susceptibility for flaviviruses are disclosed.
Owner:GEORGIA STATE UNIV RES FOUND INC
Microfluidic chip imaging system for monitoring cell pharmacokinetics
InactiveCN107779399ALow costImprove throughputBioreactor/fermenter combinationsBiological substance pretreatmentsChemical synthesisChemical reaction
The invention relates to a microfluidic imaging system, specifically a high-precision sensitive detector and a microfluidic chip layer, which are applied in the fields of drug screening and precision medicine. It integrates functional modules such as multifunctional microvalve, positron detection, and image reconstruction analysis on the basis of existing microfluidic chips, and uses computers for unmanned automatic control, and develops a set that can be used in the development and research of modern biomedicine. It is a digital valve-controlled biomedical development microfluidic platform that integrates precise sample injection, chemical reaction synthesis, biological drug screening, cell culture and online drug effect analysis. Realize low-cost, high-throughput biopharmaceutical development, synthesis and screening, virus resistance screening, individualized drug tracking and other functions.
Owner:HENAN TIANSHENG TAIFENG PHARM TECH CO LTD
Astragaloside for preventing and treating pulmonary hypertension and use thereof
InactiveCN108685932ARegulatory immunityRegulates ischemic protectionOrganic active ingredientsAntipyreticEccentric hypertrophyAstragaloside
The invention relates to astragaloside for preventing and treating pulmonary hypertension and a use thereof. The astragaloside (I) is an astragaloside substance extracted from plant radix astragali. The modern pharmacological research result shows that the astragaloside mainly has effects of immune regulation, ischemia protection, cardioprotection, inflammation diminishing, viral resistance and tumor resistance, is used for treating viral myocarditis, cardiac insufficiency and hepatitis caused by dampness stagnancy due to spleen deficiency in clinic, can be used for preventing and / or treatingpulmonary arterial hypertension, can be used for preparation of drugs for reducing pulmonary arterial hypertension-caused rat ventriculus dexter hypertrophy index and mean pulmonary artery pressure, can be used for preparation of drugs for improving plasma NO content and reducing plasma ET-1 content and can be used for preparation of drugs for affecting rat pulmonary arterial hypertension tissue pathological structures.
Owner:SUN YAT SEN UNIV +2
Compositions and methods for treating hepatitis b virus infection
The invention generally relates to compositions and methods for treating hepatitis B virus infection. More particularly, the invention relates to treating hepatitis B virus infection and related conditions in humans using unique and synergistic combinations of lamivudine and adefovir that maximize favorable therapeutic outcomes while minimizing or preventing viral resistance, which commonly occurs from using lamivudine or adefovir alone, and reducing the side effects of adefovir.
Owner:周晓剑
Application of ZmPAO gene in maize dwarf mosaic virus resistance
InactiveCN107177624AImprove copyIncreased proliferationPlant peptidesFermentationSugarcane mosaic virusMaize dwarf mosaic virus
The invention relates to application of ZmPAO gene in maize dwarf mosaic virus resistance. The ZmPAO gene is overexpressed in maize by means of gene engineering, so that maize dwarf mosaic virus resistance in crops is improved. It is discovered for the first time that SCMV (sugarcane mosaic virus) replication and proliferation levels can be significantly increased by silencing the ZmPAO gene, it is indicated that the maize protein ZmPAO and its encoding gene play an important role in resisting SCMV infections in maize and in proliferation, and the encoding gene is a maize-encoded anti-SCMV antiviral gene applicable to molecular breeding of anti-SCMV maize and other works. Basis is provided for the study on the role of vegetable proteins in viral infections, antiviral breeding of maize and other fields, viral resistance research level for maize is increased for China, and the production safety of Chinese maize is promoted and guaranteed.
Owner:CHINA AGRI UNIV
ANTIBACTERIAL AND ANTIVIRUS COMPOSITION COMPRISING Extract of CANNABIS SATIVA L.
PendingUS20220016193A1Easy to adjustEfficient removalAntibacterial agentsCosmetic preparationsBiotechnologyCannabis
The present disclosure relates to an antibacterial and antiviral composition containing an extract of Cannabis sativa L. as an active ingredient. More specifically, the present disclosure provides an antibacterial and antiviral composition which contains an extract of the natural product Cannabis sativa L., and thus may exhibit antibacterial and antiviral activities, and when taken or administered, has no side effects and does not cause bacterial or viral resistance.
Owner:FAMENITY
Tri-specific antibodies for HIV therapy
ActiveUS20180179299A1High potencyImprove barrier propertiesHybrid immunoglobulinsAntibody mimetics/scaffoldsEpitopeImmunodeficiency virus
Provided are tri-specific fusion antibodies created to target multiple epitopes of the Human Immunodeficiency Virus (HIV). The fusion antibodies provide improved potency and breadth against HIV as compared to monospecific and bispecific antibodies, and additionally provide a high barrier against viral resistance. Also disclosed are pharmaceutical formulations and therapeutic methods utilizing such fusion proteins.
Owner:THE ROCKEFELLER UNIV
Antibacterial peptide type pet feed and preparation method thereof
InactiveCN110235988AEase of market accessImprove conversion rateAnimal feeding stuffAccessory food factorsLife qualityGrowth promotion
The invention discloses an antibacterial peptide type pet feed and a preparation method thereof. The method comprises the following steps of performing fermentation culture on screened high-yield antibacterial peptide strains; preparing a semi-finished basic pet feed, and performing puffing and granulating; uniformly spraying grease onto the surfaces of puffed particles of the basic pet feed; spraying a fermentation liquor onto the surfaces of the puffed particles of the basic pet feed which is subjected to grease spraying treatment to prepare the antibacterial peptide type pet feed. After the pet feed is puffed and granulated, the temperature is lowered, then an antibacterial peptide component is added, the structure and property of an antibacterial peptide are thus prevented from being damaged by high temperature, and the concentration of effective components in the feed is increased. According to the method, the antibacterial peptide is used as a pet feed raw material; since the antibacterial peptide has the advantages of great broad-spectrum bacterial and viral resistance, good immune regulation function and excellent growth promotion function, the life quality of pets is improved, and the probability of illness and death of the pets is lowered at the same time.
Owner:SHAANXI UNIV OF SCI & TECH
Disease resistant pepper plants
ActiveUS8642845B2Solve the low germination rateVarious stressBryophytesMicrobiological testing/measurementBiotechnologyCapsicum annuum
Owner:HAZERA SEEDS LTD +1
Medicine for treating viral herpes
InactiveCN101947269AHigh cure rateSignificant effectAntiviralsDermatological disorderChlorhexidine AcetatePropanoic acid
The invention relates to a medicine for treating viral herpes, comprising the following components: chlorhexidine acetate, golden cypress, acyclovir, chloramphenicol injection, ketoconazole, propionic acid clobetasol and hexadecadrol injection. The medicine in the invention has effects of viral resistance, heat clearing, blood cooling, detumescence and relieveing pain. The clinical observation proves that the cure rate of the medicine is up to 96.69%; and the medicine of the invention has the advantages of remarkable efficacy and quick effect taking, can control and remit state of an illness after being taken, has certain pharmacological property and applicability, and has wide popularization and clinical practice value.
Owner:刘安庆
Method of preventing and controlling tobacco viral diseases via photosynthetic high-fat membrane agent
InactiveCN110140564AImprove the immunityInhibited DiffusionTobacco cultivationPlant protectionNicotiana tabacumViral disease
A method of preventing and controlling tobacco viral diseases via a photosynthetic high-fat membrane agent is provided. The photosynthetic high-fat membrane agent included herein comprises, by weight,180 parts of 1-dodecanol, 120 parts of 1-hexadecanol, 8 parts of an emulsifying agent, 5 parts of a co-emulsifier, 40 parts of a thickener, and 800 parts of water. After being diluted with water, thephotosynthetic high-fat membrane agent is sprayed to tobacco in its seedling stage, seedling resuscitation stage, root extending stage, prosperous growth stage and topping and sucker-smearing stage.Compared with the prior art of cultivation, the method has the advantages that the method herein helps enhance photosynthetic effect of a plant to promote vigorous growth of the plant and to improve viral resistance in the plant, and the method also helps inhibit further spread of viruses.
Owner:ZHUHAI RUNNONG SCI & TECH CO LTD
Exogenous ketone supplementation compositions, systems and methods
PendingUS20210322350A1Significant comprehensive benefitsEasily be indexedOrganic active ingredientsFood scienceBeta-Hydroxybutyric acidHydroxybutyric acid
The claimed invention addresses the benefits of exogenous ketone supplementation in a subject in need thereof. In particular, the exogenous ketone supplementation includes the natural D-Beta HydroxyButyric acid, also described as natural D-BHB. As detailed in representative FIG. 1, natural D-BHB is preferentially consumed in the brain to glucose and additionally has a wide range of positive regulatory effects on the body and mind. Consumer applications for supplementation with natural D-BHB include improved sleep, anti-hunger, anti-anxiety, improved cognitive enhancement and athletic duration and post workout recovery through consumption of 10 grams or more of natural D-BHB. Therapeutic applications for exogenous natural D-BHB supplementation include anti-cancer, anti-kidney disease, anti-cognitive disorders and improved viral resistance through consumption of 10-20 grams or more of D-Beta HydroxyButyric acid.
Owner:KETONE CLARITY LLC
P0 gene silencing constructs and use
ActiveUS9932603B2Vector-based foreign material introductionAngiosperms/flowering plantsBeet mild yellowing virusBeet necrotic yellow vein virus
The present invention is related to a method for conveying viral resistance or tolerance to one or more virus(es), in particular to beet mild yellowing virus (BMYV) and to beet necrotic yellow vein virus (BNYVV) or to BMYV alone in a plant, in particular in a sugar beet plant. Furthermore, the present invention relates to the virus resistant or -tolerant plant obtained according to this method, as well as to seeds and progeny derived therefrom.
Owner:SESVANDERHAVE
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