46 results about "Viral resistance" patented technology

Disclosed herein are fusion antibodies created to provide both an antigen-binding site that targets the CD4 receptor and an antigen-binding site that targets the HIV envelope. The fusion antibodies disclosed herein provide improved potency and breadth against HIV as compared to monospecific antibodies, and additionally provide high barrier against viral resistance. Also disclosed are pharmaceutical formulations and therapeutic methods utilizing such fusion proteins.

The present invention relates to methods of imparting virus resistance to plants. In one aspect, this method involves silencing a gene encoding a translation initiation factor eIF4E in the plant. In another aspect, this method involves overexpressing a heterologous translation initiation factor eIF4E in a plant. The present invention further relates to a genetic construct containing a nucleic acid molecule encoding a heterologous translation initiation factor eIF4E, as well as to an expression system containing the genetic construct and a host cell transformed with the genetic construct. The present invention also relates to transgenic plants, seeds, and plant parts transformed with the genetic construct. The present invention also relates to an isolated nucleic acid molecule encoding a mutant translation initiation factor eIF4E that is effective in imparting virus resistance in plants. The present invention also relates to a mutant translation initiation factor eIF4E and a method for making the mutant.

Disclosed herein are fusion antibodies created to provide both an antigen-binding site that targets the CD4 receptor and an antigen-binding site that targets the HIV envelope. The fusion antibodies disclosed herein provide improved potency and breadth against HIV as compared to monospecific antibodies, and additionally provide high barrier against viral resistance. Also disclosed are pharmaceutical formulations and therapeutic methods utilizing such fusion proteins.

The present invention relates to pepper plants resistant to powdery mildew disease as well as to infection by potyviruses, particularly potato virus Y (PVY). Specifically, the present invention relates to pepper plants comprising a viral resistance allele and a powdery mildew resistant allele in cis configuration on the same chromosome, such that the two resistance alleles are in coupling phase.

Described herein are compounds and methods that prevent the viral infection of cells. The compounds and methods described herein minimize viral resistance and maximize the number of targeted viruses.Additionally, the compounds and methods minimize the toxicity toward uninfected cells.

The invention relates to astragaloside for preventing and treating pulmonary hypertension and a use thereof. The astragaloside (I) is an astragaloside substance extracted from plant radix astragali. The modern pharmacological research result shows that the astragaloside mainly has effects of immune regulation, ischemia protection, cardioprotection, inflammation diminishing, viral resistance and tumor resistance, is used for treating viral myocarditis, cardiac insufficiency and hepatitis caused by dampness stagnancy due to spleen deficiency in clinic, can be used for preventing and / or treatingpulmonary arterial hypertension, can be used for preparation of drugs for reducing pulmonary arterial hypertension-caused rat ventriculus dexter hypertrophy index and mean pulmonary artery pressure, can be used for preparation of drugs for improving plasma NO content and reducing plasma ET-1 content and can be used for preparation of drugs for affecting rat pulmonary arterial hypertension tissue pathological structures.

The present invention relates to pepper plants resistant to powdery mildew disease as well as to infection by potyviruses, particularly potato virus Y (PVY). Specifically, the present invention relates to pepper plants comprising a viral resistance allele and a powdery mildew resistant allele in cis configuration on the same chromosome, such that the two resistance alleles are in coupling phase.

The present invention is related to a method for conveying viral resistance or tolerance to one or more virus(es), in particular to beet mild yellowing virus (BMYV) and to beet necrotic yellow vein virus (BNYVV) or to BMYV alone in a plant, in particular in a sugar beet plant. Furthermore, the present invention relates to the virus resistant or -tolerant plant obtained according to this method, as well as to seeds and progeny derived therefrom.

The invention discloses a method for enabling a scion variety to acquire virus resistance as well as an RNA (Ribonucleic Acid) interference vector pCAMBIA2300-3A and a transgenic method, belonging to a transgenic technology of plants and application thereof. The method comprises the following steps of firstly, preparing a transgenic stock for resisting virus; secondly, enabling scions to be grafted onto the transgenic stock for growing and developing. The method is characterized in that the virus-resisting transgenic stock is obtained by transferring the RNA interference vector; a target sequence of the RNA interference vector is a gene segment in a target virus genome. The method disclosed by the invention is used for a test that a tomato scion variety acquires the virus resistance, and a good effect is obtained; aiming at a specific embodiment of the tomato, the constructed RNA interference vector is pCAMBIA2300-1A, pCAMBIA2300-2A, pCAMBIA2300-2B, pCAMBIA2300-3A, pCAMBIA2300-CP or pCAMBIA2300-CMV5. The invention also provides the improved transgenic method. According to virus-resisting plants obtained by using the method, potential safety hazards of transgenic foods can be effectively avoided; in addition, the acquiring efficiency of virus-resisting transgenic varieties can be greatly increased.