84 results about "Pandemic" patented technology

The invention provides arrays and probes for resequencing a SARS virus using an array of probes that are complementary to a SARS reference sequence and to each possible single nucleotide substitution of the reference sequence. Methods of identifying mutations in viral sequences and methods of characterizing viral isolates are also provided. The invention also provides high throughput methods to monitor epidemics and pandemics caused by pathogens such as viruses.

Polypeptides, polynucleotides, methods, compositions, and vaccines comprising (avian pandemic) influenza hemagglutinin and neuraminidase variants are provided.

Polypeptides, polynucleotides, methods, compositions, and vaccines comprising (avian pandemic) influenza hemagglutinin and neuraminidase variants are provided.

A device, system, and method for facilitating a sleep cycle in a subject during a pandemic or peri COVID vaccination period, comprising determining a current awake or sleep stage of a person; automatically defining a desired sleep cycle pattern, dependent on the current awake or sleep stage of the person; generating an audio or optical stimulation pattern by an automated processor; and entraining brainwaves of the brain of the person with the stimulation pattern corresponding to the desired sleep cycle pattern, to thereby induce a sleep cycle in the person according to the sleep cycle pattern. When sleep patterns are normalized, a SARS-Cov-2 vaccination may be administered to the person.

The invention discloses a bovine A-type foot-and-mouth disease broad-spectrum multi-epitope recombinant vaccine, and a preparation method and an application thereof, and belongs to the field of veterinary vaccine research. The preparation method comprises the following steps: carrying out reasonable serial connection on the major antigen epitopes of pandemic in China and bovine A-type foot-and-mouth disease virus representative strains recently pandemic in countries bordering China by adopting a brand new reverse vaccinology idea and strategy, coupling with a bovine IgG heavy chain constant region, cloning into a prokaryotic expression vector to construct a recombinant expression vector, transforming Escherichia coli cells to express a recombinant antigen, purifying by adopting Ni-NAT column chromatography, quantifying by a Bio-Rad protein quantification kit, and preparing the vaccine individually or combining with a recombinant foot-and-mouth disease virus 3D protein. A result of animal immune experiments shows that the multi-epitope antigen or 3D protein combined vaccine can stimulate the body to produce a protective antibody with high titer and also can protect immune animals against a virus attack, so the bovine A-type foot-and-mouth disease broad-spectrum multi-epitope recombinant vaccine has a good application prospect.

In one example embodiment, a system and method is illustrated that includes receiving user count information that includes a user count value and an address identifier. Further, an operation is executed that includes using the user count information to determine whether a limit variable has been exceeded. An operation is executed that removes a member, identified by the address identifier, from a load balancing pool, where the limit variable has been exceed by the user count information. A further operation is shown that includes introducing a device into the load balancing pool, where the user count information is less than or equal to the difference between the limit variable value and a buffer variable.

Unlike the existing powered air-purifying respirators (PAPR) that are bulky, heavy, and expensive the invention offers a light-weighted inexpensive portable PAPR consisted of a single piece secured on user's head. The respirator is for use in contaminated environment including one with highly contagious viruses such as SARS-CoV-2 that causes COVID-19. A clear visor of the respirator protects eyes, nose, and mouth. The rest of the user's head protected with a soft airtight cover. A small fan or fans pump air through the filters. Because the fan capacity exceeds airflow required for breathing, air pressure under the cover is slightly higher than ambient pressure. It protects the visor and user glasses from fogging and prevents leaks through any looseness. A special port allows use of equipment and devices as a stethoscope for medics or oxygen supply for patients. Despite the respirator primarily targeted for medical personnel and patients, its convenience, l lightness and affordability allow usage by general population especially at the time of an epidemic or a pandemic.

The invention discloses a primer composition for detecting different influenza viruses and an application thereof. The primer composition disclosed by the invention comprises any one of primer pairs represented by the following (1)-(4): (1) a DNA molecule shown in SEQ ID No.1 and a DNA molecule shown in SEQ ID No.2; (2) a DNA molecule shown in SEQ ID No.3 and a DNA molecule shown in SEQ ID No.4; (3) a DNA molecule shown in SEQ ID No.5 and a DNA molecule shown in SEQ ID No.6; and (4) a DNA molecule shown in SEQ ID No.7 and a DNA molecule shown in SEQ ID No.8. The primer composition has positive meanings on timely diagnosing and timely treating pathogenetic canine, timely forecasting epidemic trends, preventing influenza large pandemic, and implementing large-scale canine influenza virus epidemiology monitoring.

The disclosure relates to a process which determines a cross-training plan in order to ensure a company or business unit will be better prepared for a pandemic event by cross-training additional employees in the most critical services or functions. The pandemic cross-training plan is determined by utilizing such criteria such as geography, experience-level, and employee preference to strategically and systematically cross-train an employee in a critical function. This can be completed either manually through a criteria matrix approach or automatically by a computing device and utilizing mathematical formulas.

The invention discloses a general nest-PCR primer set for amplifying the gp90 gene of the main classical strain of equine infectious anemia virus, and also relates to the method of using the primer set to perform nest-PCR amplification on a sample to be tested and detecting equine infectious anemia virus The method and the use of the primer set in preparing biological reagents for detecting or diagnosing equine infectious anemia virus. The invention is based on the whole gene sequence alignment of EIAV main classical strains EIAVwyo, EIAVArgen, EIAVLN40, and designs amplification primers based on the conserved regions. Experimental results show that the nest-PCR primers designed by the present invention can be generally used for the amplification of the gp90 gene of the main representative strain of EIAV, and also have amplification specificity for the field isolates. The nest-PCR primers established in this study can be used in clinical molecular epidemiological studies of EIAV epidemic strains, and are effective general primers for amplifying the gp90 gene.

A distributed type traffic line tracing apparatus of the present disclosure is personally installed in a residence of a tracing target person, to automatically verify whether a traffic line of the tracing target person coincides with a traffic line of a confirmed person and automatically report a result to a disease management authority only when the traffic lines coincide with each other in an emergency situation such as an infectious disease pandemic, so that a quarantining target person is discovered and found early while protecting a privacy of an individual much more when compared to a centralized type, thereby rapidly establishing an infectious disease management system for patients with suspected diseases and efficiently managing the patients from the spread of infectious diseases.

Universal flu vaccines are disclosed. The vaccines induce broad and sustained protection against a wide range of influenza A viruses, reduce the need for annual vaccination campaigns with vaccines based upon viral strains predicted to be the predominant circulating strains, and ameliorate the threat of future pandemics that can potentially kill millions.

This disclosure provides universal influenza vaccines which can provide extended protection for several years, provide improved protection to circulating influenza strains that were not predicted accurately for annual vaccine manufacturing, and provide protection against newly emerging strains of influenza virus which carry the potential for establishing global pandemics.

A method and system estimating the gross output change in one or more industrial sectors is provided. Users are enabled to assess the impact of a pandemic on the demand market of a firm and to take proactive actions, for instance, shifting demand among industrial sectors, or among geographic regions. Economic impact is measured by gross output change in each industrial sector, as affected by workforce availability, infrastructure availability in each sector, and consumption change in each sector during the pandemic occurrence.

The disclosure is generally directed to systems and methods for obtaining and evaluating a test result report in real-time so as to determine an entry status of an individual into the establishment. In an example embodiment, a method involves an entry verification apparatus executing actions such as: receiving digital data associated with the individual; obtaining a test result report that provides an indication whether the individual is currently infected, previously infected, or not infected, by a viral pathogen; evaluating digital data and/or a machine-readable element of the test result report to verify an identity of the individual and an authenticity of the test result report; converting non-standardized information contained in the test result report into standardized information; obtaining entry requirements for enabling entry into the establishment; analyzing the standardized information to determine whether entry requirements are met; and determining an entry status based on the entry requirements being met.

The present invention provides for a device and method for the rapid detection (within seconds) of viruses and virions (proteins and nucleic acids) found in novel coronavirus (SARS-CoV-2), Human Immunodeficiency Virus (HIV), and other pandemic viruses. The device can be used at front line, hospitals, clinical laboratories, airports, groceries, homes, and the like. The device can be used as a single probe for single use or home use, or the device integrated into a carrousel or multiple probe magazine for fast detection of multiple samples simultaneously. This carrousel would facilitate multiple testing at times of pandemics when a large number of samples have to be tested in short periods of time.

The invention discloses a novel affinity peptide M1 of corona virus main protease and application thereof. The affinity peptide M1 of the corona virus is screened out through a phage display technology, the affinity peptide has high affinity with the main protease Mpro of the corona virus SARS-CoV-2 and can be used as a lead compound of an anti-corona virus drug, further experimental verification shows that affinity peptide M1 modified gold nano particles can be used in auxiliary detection of corona virus, and the affinity peptide M1 provided by the invention provides reference for further research and development of related novel vaccines and anti-corona virus drugs for resisting the corona virus, and has important significance for preventing and controlling pandemic of the corona virus.

The invention belongs to the field of cold chain transportation. Aiming at solving the problems that existing suction cup equipment can only adsorb and carry a small number of cartons of cold-chain containers, most of carton cargoes still need to be manually loaded and unloaded, and the risk of personnel contact infection under the coronavirus pandemic situation is large, the invention provides a clamp for loading and unloading carton cargoes of cold-chain containers, and a method. The clamp adopts a suction cup mechanism as auxiliary, and a supporting plate mechanism and a pressing mechanism are matched, so that the cargoes are disassembled under the condition that the cargoes are not damaged; and most of the carton cargoes can be grabbed, so that personnel contact is reduced, and the loading and unloading automation degree of the cold chain carton cargoes is improved.

A board game which creates an entertaining playing and learning environment pertaining to the Covid-19 pandemic, comprises a game board with spaces thereon corresponding to geographical locations or places which have significance to the novel coronavirus pandemic, game pieces for each player to move around the board, dice to be rolled to advance game pieces along the board, currency, various learning elements including information cards and said locations or places, all working together to create a fun and learning environment.

Specific monoclonal antibodies and fragments including bispecific antibodies thereof that are crossreactive with multiple clades of influenza virus including both Group 1 and Group 2 representatives are disclosed. These antibodies are useful in controlling influenza epidemics and pandemics as well as in providing prophylactic or therapeutic protection against seasonal influenza.

Disclosed herein are personal protection equipment systems which provide improved protection from infectious agents, and can be constructed and distributed in high volume during public health crises, such as global pandemics where supplies become limited and bioterrorism events where public panic and uncertainty can provide additional obstacles to conventional protective measures. Methods of implementing protective equipment are also disclosed herein. The protective biohazard equipment disclosed herein can be made in a short amount of time at a low cost using readily available materials.