32 results about "Pandemic" patented technology

Waning immunity induced by first-generation Spike-alone-based COVID-19 has failed to prevent immune escape by many variants of concern (VOCs) that emerged from 2020 to 2024, resulting in a prolonged COVID-19 pandemic. Thus, a next-generation Coronavirus (CoV) vaccine incorporating highly conserved non-Spike SARS-CoV-2 antigens is described herein. Conserved non-Spike T cell antigens in combination with a Spike antigen encapsulated in lipid nanoparticles: (i) Induced high frequencies of lung-resident antigen-specific CXCR5+CD4+ T follicular helper cells, GzmB+CD4+ and GzmB+CD8+ cytotoxic T cells, and CD69+IFN-γ+TNFα+CD4+ and CD69+IFN-γ+TNFα+CD8+ effector T cells; and (ii) Reduced viral load and COVID-19-like symptoms caused by various VOCs. The combined antigen / LNP-based pan-CoV vaccine could be rapidly adapted for clinical use to confer broader cross-protective immunity against emerging highly mutated and pathogenic VOCs.

RFID-based operations management systems and methods are provided herein, particularly RFID based Kanban systems. Such system can realize increased efficiencies, improved visibility of inventory throughout the workflow and improved response to variations in demand. RFID based solutions can automatically transact consumption of Kanban inventory in real-time and trigger replenishment signals to warehouses automatically, resulting in increased Kanban inventory accuracy and lower manual efforts for replenishment and consumption posting. This approach can interface with existing operational management software (e.g. ERP systems, such as SAP) seamlessly integrating with product manufacturing workflows. Such systems are uniquely applicable to manufacture of biological testing kits, where demands fluctuate considerably in response to crises, disasters, epidemics and pandemics.

The nose mask is intended to be used during an airborne pandemic. The nose mask is a single triangle / cone shaped that covers only the nose, that comes with two ear elastic bands or a single head elastic band for support. The nose mask is designed to be disposable with a filter for better protection and to minimize the passage of aerosols, fluids and airborne pathogen agents or to be made with washable material allowing users to re-use it.

Organizations are struggling to ensure business continuity without compromising on delivery excellence in the face of pandemic related uncertainties which exists along multiple dimensions effected by authorities. This uncertainty plays out in a non-uniform manner thus leading to highly heterogeneous evolution of pandemic. Present disclosure provides digital twin based systems and methods for business continuity plan and safe return to workplace wherein a simulation-based data-driven evidence-backed approach is implemented that captures details pertaining to virus, individualistic characteristics of employees and their dependents, offices, locations of the employees and offices, and various pandemic control measures that are in effect and need to be explored using a hybrid modelling and simulation approach that combines fine-grained actor / agent model and coarse-grained stock-and-flow model. The present disclosure further leverages past macro-level data pertaining to pandemic evolution of relevant cities, states, and countries to make available information amenable for collective analysis and infection prediction.

A system for the rapid development of vaccines or anti-bacterial drugs is required when working with pandemics. The easiest way to formulate these new vaccines is through computational reduction of existing organisms via statistical models. Once vaccine candidates are arrived at through this method, “Super Organisms” containing all of the computationally reducible fragments can then be taken through a Crispr reduction process wherein those computationally reducible fragments are removed. The result is a vaccine candidate which has possible problematic function partially or fully removed. The “neutered” version of the virus, as well as the DNA fragments and their mRNA transcriptions, can then be tested in a lab and in clinical trials for efficacy. This patent covers a vaccine candidate production methodology using computationally reducible fragments removed from Super Organisms either collectively or individually; as well as the DNA fragments themselves and the mRNA transcripts of those fragments.

The coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to be a threat to global public health. While some individuals exhibit mild symptoms, others develop severe disease leading to severe lymphopenia and death. Provided herein are methods for determining whether a subject suffering from a SARS-Cov-2 infection is more likely to suffer from severe or mild disease. Also provided are methods for predicting whether a subject suffering from a SARS-Cov-2 infection with mild disease will progress to more severe disease and methods for treating patients having an infection via SARS-Cov-2 and related family members.

The application discloses an energy supply planning method and device under an emergency, a storage medium and a system. By considering the influence of an emergency such as a disease pandemic, combining the different influences of different regions under external events, and building an energy supply cost optimization model considering the impact of events such as pandemics, the energy supply cost is reasonably optimized. The energy supply planning management method, device, storage medium and system under the emergency improve the energy supply planning efficiency and accuracy under the emergency.

The present invention relates to an ESP decision optimization system for epidemiological modeling. ESP based modeling approach is used to predict how non-pharmaceutical interventions (NPIs) affect a given pandemic, and then automatically discover effective NPI strategies as control measures. The ESP decision optimization system comprises of a data-driven predictor, a supervised machine learning model, trained with historical data on how given actions in given contexts led to specific outcomes. The Predictor is then used as a surrogate in order to evolve prescriptor, i.e. neural networks that implement decision policies (i.e. NPIs) resulting in best possible outcomes. Using the data-driven LSTM model as the Predictor, a Prescriptor is evolved in a multi-objective setting to minimize the pandemic impact.

The present disclosure relates to a novel coronavirus SARS-CoV-2 mutant vaccine and its application, the vaccine comprising a fusion protein comprising: (1) interferon or a functional fragment thereof; (2) novel coronavirus SARS-CoV-2 or a functional fragment thereof; and (3) an immunoglobulin Fc region. The mutant vaccine disclosed herein has long-lasting efficacy, is amenable to industrial production, has activity comparable to that of conventional IFN, has higher immunogenicity and neutralizing antibody titers, and can increase defense against mutant strains. It can be used as a new generation of mutant vaccine drugs to combat the spread of the COVID-19 pandemic.

Infectious diseases have been sources of large-scale epidemics and pandemics resulting in millions of casualties worldwide. Detection of these biological agents normally involves several lab processes including sample preparation, nucleic acid separation and amplification, and diagnostic analysis. These steps, either performed manually or automated by high-throughput machinery, are tedious, expensive, and highly susceptible to cross-contamination. The present system is an integrated lab-on-a-device designed, developed, and tested in compatibility with a mechanical fixture for sample-to-answer biological analysis of infectious diseases.

An object of the system according to the embodiment is to perform quick and effective prediction and measures for preventing occurrence of a new pandemic.SOLUTION: A system includes a variant prediction unit, a vaccine design unit, a data collection unit, and a preventive measure proposal unit. The variant prediction unit predicts a variant of a virus. The vaccine design unit designs a vaccine based on the structure information of the variant predicted by the variant prediction unit. The data collection unit collects and analyzes disease data collected from around the world in real time. A preventive measure proposal part proposes preventive measures in cooperation with an international health organization on the basis of the data collected and analyzed by the data collection part.SELECTED DRAWING: Figure 1

The present invention discloses a neutralizing monoclonal antibody against the HA protein of the Eurasian avian and Pdm / 09 evolutionary lineage H1 subtype swine influenza virus and its application. The monoclonal antibody is named 5F3 and the deposit number is CCTCC NO: C2022145. The monoclonal antibody targets the HA protein and can not only specifically recognize Eurasian avian H1N1 subtype swine influenza viruses of various genotypes including G4, but also has good reactivity to the 2009 pandemic (Pdm / 09) H1N1 subtype swine influenza virus, and can bind to human and avian H1N1 subtype influenza viruses, showing broad-spectrum action characteristics against H1 subtype influenza viruses. The monoclonal antibody of the present invention has been shown to have strong neutralizing activity through chicken embryo neutralization tests and mouse preventive protection tests, and is expected to be used in the diagnosis and prevention of diseases of pigs caused by H1N1 subtype swine influenza viruses and possible human infections.

The present invention relates to a folding, forming and flattening device and a mask production machine. The folding, forming and flattening device comprises a feeding component (100) for feeding a continuous sheet, a pre-folding, forming component (200) for forming an initial sinusoidal sheet from the continuous sheet, a primary folding, forming component (300) for forming a primary sinusoidal sheet from the initial sinusoidal sheet, a folding, forming and flattening component (400) for forming a mask sheet with folds from the primary sinusoidal sheet, and a receiving component (600) for receiving the mask sheet with folds. The present invention provides a better method for producing masks that are more cost-effective, less contaminated by particles, and better in cleanliness for use by the public during the current COVID-19 pandemic faced by the global population.

One problem to be addressed by the present invention is to provide a drug which is capable of suppressing the proliferation of SARS-CoV-2 with high efficiency. Another problem to be addressed by the present invention is to provide a drug which exhibits an inhibitory effect on a wide range of coronaviruses and thereby can immediately respond to the pandemic of unknown SARS-CoV-2 mutants and new types of coronaviruses which could happen in the future.　Provided is an oligonucleotide or a pharmaceutically acceptable salt thereof, wherein: the oligonucleotide comprises an oligonucleotide that is composed of 17-30 nucleotides and comprises a nucleotide sequence and is complementary to a region lying between a nucleotide located at position-13520 to a nucleotide located at position-13550 in SARS-CoV-2 RNA genome comprising the nucleotide sequence represented by SEQ ID NO: 1; and the oligonucleotide is a mixmer and is capable of inhibiting the viral proliferation of coronaviruses, wherein the 5'-end and / or the 3'-end of the oligonucleotide may be chemically modified. Also provided is a drug comprising the oligonucleotide or a pharmaceutically acceptable salt thereof.

This invention discloses the preparation and application of a universal mRNA vaccine for H5N1 influenza. The mRNA vaccine contains mRNA molecule 1 and mRNA molecule 2; mRNA molecule 1 encodes the H5m protein; mRNA molecule 2 encodes the N1m protein; the H5m protein is the protein shown in SEQ ID NO:1; the N1m protein is the protein shown in SEQ ID NO:2. The universal mRNA vaccine for H5N1 influenza prepared by this invention possesses broad-spectrum protection, rapid iteration, and low-cost mass production characteristics. It can efficiently express native conformational proteins in host cells, not only covering the main variation spectrum of the H5N1 virus, but also overcoming the broad-spectrum limitations of traditional vaccines by activating cross-neutralizing antibodies and polyclonal T-cell immunity. This invention provides key technical support for addressing the continuous evolution and potential pandemic of H5N1.

Waning immunity induced by first-generation Spike-alone-based COVID-19 has failed to prevent immune escape by many variants of concern (VOCs) that emerged from 2020 to 2024, resulting in a prolonged COVID-19 pandemic. Thus, a next-generation Coronavirus (CoV) vaccine incorporating highly conserved non-Spike SARS-COV-2 antigens is described herein. Conserved non-Spike T cell antigens in combination with a Spike antigen encapsulated in lipid nanoparticles: (i) Induced high frequencies of lung-resident antigen-specific CXCR5+CD4+ T follicular helper cells, GzmB+CD4+ and GzmB+CD8+ cytotoxic T cells, and CD69+IFN-γ+TNFα+CD4+ and CD69+IFN-γ+TNFα+CD8+ effector T cells; and (ii) Reduced viral load and COVID-19-like symptoms caused by various VOCs. The combined antigen / LNP-based pan-CoV vaccine could be rapidly adapted for clinical use to confer broader cross-protective immunity against emerging highly mutated and pathogenic VOCs.

The method describes an invention whose novelty also rests on activating the high existing capacity of individual citizens who are willing or legally obligated to perform a high level of effort in preventing their own infection over a short period of time. This is because asking citizens for help, supported by long-term measures, is not particularly effective because citizens primarily have a self-interest, not necessarily a public interest, and because testing measures in private settings is largely impossible. The inventive achievement is characterized, among other things, by the fact that, taking into account one- and two-stage testing procedures, an automatic mechanism is created to synchronize joint infection prevention during a pandemic. This allows for the longest possible phases in which infection prevention can be carried out with less stress, thus allowing normality to return to everyday life, and subsequently providing the motivation for a short phase of performance. Thus, the method is socially applicable for various infectious diseases, for pandemics, but also for other situations in which infection must be prevented, such as the consequences of the use of biological weapons.

Aspects of the present disclosure are directed to a Biological and Chemical Threat Prediction and Reasoning System (BiCEPS). BiCEPS can leverage Artificial Intelligence (AI) and Machine Learning (ML) approaches on uniquely pre-processed data derived from wearable devices to enable early detection, monitoring, and possibly prevention (or containment) of communicable diseases that can result in pandemics. Such communicable diseases may hereinafter be referred to as biological and / or chemical threats or simply threats.

The invention addresses the problem of air filtration and decontamination as required immediately for the COVID-19 pandemic but also will be useful in a variety of applications. Air (1) to the apparatus (100) enters and passes through an optional pre-filter (2) and through a one- way air "check" valve (3). The incoming air (1) then enters the counter-flow heat exchange path (4) and proceeds towards the heating chamber (6). As air enters the heating chamber (6), it immediately encounters heating elements (7). Upon encountering the heating chamber (6), the incoming air, which has been pre-heated by the exiting air, is heated to the desired temperature and exits via the return path (5). Upon completing the path through the exit path for the air, the air is now cooled to the desired exit temperature, for example within a few degrees of the incoming air, and is at a temperature suitable to exit (11) and be delivered to a user. This air may not have the virus removed from it, but the virus will be rendered harmless at this point. The invention is applicable in other contexts. For example, the operation of these systems can generally be reversed to decontaminate air including air exhaled by a user. This may be used in conjunction with a mask worn by a patient or an isolation chamber at least partially enclosing a patient, e.g., a patient room(s) or a tent erected over a patient gurney or bed.

A composition includes a first primer set consisting of the nucleotide sequences of SEQ ID Nos.1 to 6, and a second primer set consisting of the nucleotide sequences of SEQ ID Nos. 7 to 11. A multi-diagnostic kit for mosquito-borne diseases includes the composition. The multi-diagnostic kit enables rapid and accurate detection of dengue virus and malaria parasites by using specific primer sets. The multi-diagnostic kit is applicable in regions with high incidences of mosquito-borne disease pandemics including Africa and Latin America since it exhibits excellent thermal stability even in harsh environments.

Angiotensin-converting enzyme 2(ACE2) has been confirmed as a specific receptor for several β group coronaviruses include severe respiratory syndrome (SARS) coronavirus (SARS-CoV-1) and recently the causative agent for the World pandemic CoVID-19, SARS-CoV-2, and low pathogenic coronavirus of HCoV-NL63, a member in α-coronavirus group. Viral spike protein (S) of viral envelope is confirmed to bind to ACE2 as viral receptor to start a virus replication cycle. The present invention provides ACE2 and its mutants or variants, the viral or non-viral vectors thereof. Methods of treatment of viral infection of a human subject by using such mutants or variants are also provided.

Doubly reentrant topology (DRT) is a unique structure. The present invention first validated the outstanding performance of an anti-biofouling artificial surface comprising a superhydrophobic surface; thereon a plurality of microstructures and having a doubly re-entrant topology (DRT) situated atop respective base structures which demonstrates a striking anti-biofouling effect that can prevent viral contamination. Furthermore, the present invention per se features excellent anti-biofouling ability, which may shed light on the applications of pathogen elimination in alleviating the COVID-19 pandemic.

Gateways for patient-responsibility portions of medical bills (PRPMB) transactions, regardless of healthcare provider or merchant services (Credit card processing) provider are disclosed, which also provide big data analytics and interoperability across systems and networks. These principles provide uniform, consistent and secure devices, methods and systems that allow a patient to make PRPMB payments on one website or by one phone call or physical address regardless of the entity that is due payment, or when multiple entities are due payment and allow or the use of cryptocurrencies as well as prescription escrows, as well as data gathering and analytical techniques for combatting the COVID-19 pandemic.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the strain of coronavirus that causes coronavirus disease 2019 (COVID-19), the respiratory illness responsible for the COVID-19 pandemic. Antibodies produced from an immune response against SARS-CoV-2 infection are used to analyze prior exposure to the virus. The present invention provides methods for detecting antibodies in response to SARS-CoV-2 infection in a single multiplex immunoassay.

The COVID-19 pandemic has led to a surge in patients, a collapse of the healthcare system, economic deterioration, increased subsidy spending, worsening national finances, and even jeopardizing the holding of the Olympics. This paper proposes an invention of a theory utilizing natural laws to solve these problems, along with a method for applying this theory. [Solution] Conventional thinking methods based on the third principle of science have failed to solve the difficult problems described above. Therefore, this invention involves inventing a completely new theory that utilizes the natural laws of the first principle of science, and further, inventing a method for using that theory.

The invention relates to a multifunctional heating device 1, “ALL in ONE” for bathing forms Infrared cabin...infrared sauna...sauna fin. Art...Bio-soft-Danarium... Danarium...inhalations etc. with state-of-the-art equipment. The advantageous technology can be optionally equipped for wall and floor-standing models, as well as for "stone column towers, etc.", and also for taller and larger but also smallest cabins, with pipe or ceramic radiators and their corresponding fillings. mainly with infrared wavelength “C” for air heating 16 and infrared “A - B - C” wavelength radiation 17 for generating convection heat vertically 20 , and infrared ABC ,21 , heat radiation horizontally and can be equipped and mounted according to corresponding specifications. With the special reflectors 13...14...15...and an energy-saving infusion "Master-Löyly" and other bathing forms, the multi-way air supply 24 and the pandemic virus corona mutation blocking system 7, also perfectly suited against infectious aerosols and mutants, especially through splashing water on the floor area according to the latest state of the art. According to current technology, the multifunctional heating device can also be operated via an "app" from a smartphone or tablet, even via touchscreen. The experience gained over 60 years and numerous innovations and awards in the wellness, sauna, and danarium sector also form the basis for the successful development of the latest technology and other global bathing methods.

An improved technology for inactivation of viruses, for example the SARS-COV-2 virus that is causing the Covid-19 pandemic, is described. The technology can include a device that includes a substrate coated in a polymer that is infused with a pathogen inactivating material. In various embodiments, at a given time, a portion of the pathogen inactivating material is exposed to the environment, and the device is configured to periodically or intermittently expose additional pathogen inactivating material to the environment. For example, the polymer can be ablative or sacrificial.

The present invention relates to a system for monitoring the physiological variables of a patient who is supplied with oxygen through an oxygen concentrator. It contains a central control device which makes the concentrator's operating process controlled by the oxygen extraction device. This device also controls the monitoring of three fundamental variables of a patient: the first measurement is the electrical activity of the heart through an electrocardiogram, another measurement is body temperature, and finally the oxygen saturation level and pulse rate for real-time display.All of this is aimed at streamlining essential patient measurements to reduce costs for additional medical devices, and to ensure the patient is adequately monitored for their medical condition. Furthermore, these measurements were the most requested during the SARS-CoV-2 virus pandemic, and having them under control could save lives.

One problem to be addressed by the present invention is to provide a drug which is capable of suppressing the proliferation of SARS-CoV-2 with high efficiency. Another problem to be addressed by the present invention is to provide a drug which exhibits an inhibitory effect on a wide range of coronaviruses and thereby can immediately respond to the pandemic of unknown SARS-CoV-2 mutants and new types of coronaviruses which could happen in the future.　Provided is an oligonucleotide or a pharmaceutically acceptable salt thereof, wherein: the oligonucleotide comprises an oligonucleotide that is composed of 17-30 nucleotides and comprises a nucleotide sequence and is complementary to a region lying between a nucleotide located at position-13520 to a nucleotide located at position-13550 in SARS-CoV-2 RNA genome comprising the nucleotide sequence represented by SEQ ID NO: 1; and the oligonucleotide is a mixmer and is capable of inhibiting the viral proliferation of coronaviruses, wherein the 5'-end and / or the 3'-end of the oligonucleotide may be chemically modified. Also provided is a drug comprising the oligonucleotide or a pharmaceutically acceptable salt thereof.