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3 results about "Immunoglobulin region" patented technology
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The variable region is the region of the immunoglobulin (Ig) which varies greatly in amino acid sequence among different immunoglobulins of the same class. Each immunoglobulin molecules is a tetramer of two identical light chains and two identical heavy chains linked by disulfide bonds.
Long-acting insulin gene constructs and uses thereof
Owner:POSTECH ACADEMY INDUSTRY FOUNDATION
Fc region-based heterodimeric molecules and uses thereof
Owner:PHRONTLINE BIOPHARMA (SUZHOU) CO LTD +1
VirusTAC platform for targeted degradation of tumor cell membrane proteins and psoriasis extracellular pathogenic factors and applications thereof
The application discloses a VirusTAC platform for targeted degradation of tumor cell membrane protein EGFR and psoriasis extracellular pathogenic factor IL17A and application thereof, and belongs to the technical field of biological medicine. The platform comprises a heterodimer with R1-R2-R3 structure formed by a first polypeptide chain and a second polypeptide chain, wherein R1 is MeV H or a variant thereof; R2 is a linker composed of R4 and R5, R4 is an immunoglobulin Fc region, the Fc regions corresponding to the first polypeptide chain and the second polypeptide chain are associated by heterodimerization mutation; R5 is a linker that can be cut by a protease; and R3 is a target protein binding domain EGFR antibody or IL17A antibody. The platform realizes precise degradation of tumor-related membrane proteins and extracellular proteins by constructing a chimera of a natural ligand and a targeting antibody, and by means of tumor-specific expression and efficient endocytosis characteristics of Nectin-4.
Owner:WUHAN TEKKANDE LIFE SCIENCES RESEARCH CO LTD