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A number of techniques are disclosed to facilitate process data collection and monitoring. The techniques may involve and support the selection of process parameters to be monitored, including scanning techniques for automated identification of such parameters. The techniques may also involve the management of data storage and archiving operations to facilitate continued process data collection arising from an on-line process. In these and other ways, the disclosed techniques are well-suited for process data collection and monitoring in connection with diagnostic elements of a process control system and other contexts involving process status indicators and the underlying process variables.

The invention provides compositions comprising an effective amount of an agent that inhibits a BET protein (e.g., Brd2, Brd3, Brd4), and methods of using such compositions for treating or preventing metabolic syndrome, obesity, type II diabetes, insulin resistance, and related disorders characterized by undesirable alterations in metabolism or fat accumulation.

Disclosed herein are compositions and methods for eliciting immune responses against antigens. In particular embodiments, the compounds and methods elicit immune responses against antigens that are otherwise recognized by the host as “self” antigens. The immune response is enhanced by presenting the host immune system with a chimeric antigen comprising an immune response domain and a target binding domain, wherein the target binding domain comprises a xenotypic antibody fragment. By virtue of the target binding domain, antigen presenting cells take up, process, and present the chimeric antigen, eliciting both a humoral and cellular immune response.

Disclosed is a vaccine that includes a dendritic cell loaded with a yeast vehicle and antigen. Also disclosed are methods of making the vaccine and using the vaccine to elicit cellular and humoral immune responses in a mammal. Additionally, a method to elicit an immune response by administration of a yeast vehicle and an antigen that is not complexed to the yeast vehicle is disclosed.

The invention features compositions and methods for the prevention or treatment of one or more strains of Chikungunya virus, as well as other alphavirus-mediated diseases.

A method to prepare recombinant influenza viruses comprising a mutant M2 protein which has a deletion of two or more residues in the cytoplasmic tail and is attenuated in vivo, is provided, as well the resulting virus and vaccines with the virus.

The present invention provides a library of membrane protein-embedded liposomes suitable for proteome analysis, a method for preparing same and a proteome analysis method using same.

The present invention features compositions and methods for characterizing thyroid lesions (e.g., benign follicular adenomas (FAs), papillary thyroid carcinomas (PTC) and follicular variant papillary thyroid carcinomas (FVPTCs)).

A system for analyzing malicious botnet activity in real time is disclosed. This system may include: a control server configured to generate botnet activity information relating to a type of malicious botnet activity, and transmit the botnet activity information to the outside, after receiving bot occurrence information from the outside;and a bot executing server configured to execute a malicious bot corresponding to the bot occurrence information received from the outside in a virtual environment operating system and transmit a real-time botnet detection result to the control server for generating the botnet activity information, according to a control of the control server, wherein the real-time botnet detection result includes information on whether or not the malicious bot performs malicious activity based on a command from a remote command / control server existing independently outside.

An electroconductive rubber roller (10) whose outermost layer consists of a rubber layer (1) made of a rubber composition containing an ionic-conductive rubber as a main component thereof. The surface of the rubber layer consists of an oxide film; and the rubber composition contains a dielectric loss tangent-adjusting filler to set a dielectric loss tangent of the electroconductive rubber roller to 0.1 to 1.5. Weak electroconductive carbon black and / or calcium carbonate treated with fatty acid can be used as the dielectric loss tangent-adjusting filler.

The invention provides compositions and methods for characterizing breast cancer stem In particular, the invention provides for the identification of cells expressing Twist and CD44 that express little or virtually undetectable levels of CD24 (i.e. a Twist+ / CD44+ / CD24− / low cell sub-population). The presence of such cells in a breast cancer specimen identifies the breast cancer as having increased metastic potential. Such cancers are identified as requiring aggressive therapies. Accordingly, the invention provides biomarkers suitable for identifying, diagnosing, and monitoring treatment of a subject with breast cancer.

Compositions and methods for identifying new treatments for Facioscapulohumeral muscular dystrophy (FSHD), and uses thereof.

The present invention features compositions and methods for identifying a subject having a B cell neoplasia or related condition responsive to treatment with lenalidomide and lenalidoinide-related compounds.

A system is configured to provide an IoT device with access to cloud resources. The system includes a backend system configured to provide at least one service selected from a group consisting of: data management, file management, user management, and device management. The system also includes an IoT client device including an IoT device and a backend services module in communication with the IoT device, the IoT client device is configured to communicate with the backend system over a wide area network. The backend services module includes an IoT protocol engine configured to identify an API call for the backend system from a message communicated from the IoT device and a backend services API engine in communication with the IoT protocol engine, the backend services module configured to generate the identified API call. The backend services module also includes an Internet stack for communication of the API call to the backend system;

The invention relates to a preparation method of a fiber-shaped nanometer magnesium hydroxide. The bitter brine of the discharge liquid after extraction of potassium, lithium, boron and other elements from the salt lake water is used as the raw material; the ammonia liquor or the sodium hydroxide solution is taken as the precipitant; the mixed solution of absolute ethanol, gelatin and lauryl sodium sulfate is used as the compound dispersing agent; the technological proposal is that the precipitation reaction is carried out at room temperature; through a serial procedures of heating and aging, washing in the dilute ammonia liquor, filtering, drying in the vacuum and grinding, the pure-white fiber-shaped nanometer magnesia powder is prepared with an average size of 30 to 80nm in diameter and 200 to 500nm in length. When the fiber-shaped nanometer magnesia powder is used as an inorganic flame retardant, the filling amount needed decreases significantly and the fiber-shaped nanometer magnesia powder can reinforce and toughen the polymer materials; the reaction temperature is the normal temperature, which reduces the energy consumption significantly; the fiber-shaped nanometer magnesia powder also develops a new method for comprehensive utilization of the salt lake resources.

Provided herein are a hybridoma cell line producing monoclonal antibody against foot-and-mouth disease virus (FMDV), the monoclonal antibody therefrom, reagent and kit for ELISA, and immunoassay method. The hybridoma cell line is produced by cell fusion of a parental cell and a myeloma cell line and has the same characteristics as the cell line whose strain designation is CmA40 and deposition number is ATCC (To be Provided). The parental cell is a splenocyte isolated from the spleen of a mouse immunized by an antigen derived from a 3ABC non-structural protein (NSP) of FMDV. The antigen used here is expressed by a prokaryotic cell. The monoclonal antibody produced by the hybridoma cell line can specifically recognize a 3ABC polypeptide and does not cross-react with an antiserum of swine vesicular disease virus.

This invention relates to a composition and its use for formulating nucleic acid-based drugs / vaccines with sugar alcohol compositions into complexes for both in-vitro and in-vivo delivery. Particularly, the present invention includes the ingredients and processes necessary for formulating therapeutic and pharmaceutical nucleic acid compositions, such as miRNA, microRNA precursors, shRNAs, siRNAs, ribozymes, antisense RNAs / DNAs, RNA-DNA hybrids and DNA vectors / vaccines, with glycylated sugar alcohols / sugars into delivery complexes, which can then be absorbed by cells in vivo and in vitro via active endocytosis. Also, the present invention discloses that chemical compounds containing sugar alcohol- and / or sugar-like structures can protect nucleic acids, in particular miRNAs, shRNAs, siRNAs and ribozymes, from degradation in vivo as well as in vitro. Therefore, the present invention is also a formula and method for preserving the structural integrity and functional efficacy of these nucleic acid-based drugs and / or vaccines in vivo and in vitro.

The core structure of pentaerythritol has been used as a replacement for one or both sugars in lipid A, leading to the generation of a series of lipid A analogs. These lipid A analogs may further differ from lipid A with respect to, e.g., the number, nature and location of negatively charged groups, and the number, nature and location of the lipid chains. The lipid A analogs may be lipid A agonists useful as immunostimulatory agents, or lipid A antagonists useful in the treatment of septic shock. In a like manner, a residue of pentaerythritylamine may be used as a replacement for an amino sugar residue in a carbohydrate ligand having a biological activity of interest, generating a series of ligand analogs. These are useful, e.g., as haptens, inhibitors of bacterial-host cell adhesion, etc.

A small and inexpensive signal detector is provided, which can be simply used for noise detection as a development tool for development engineers of systems and devices. A signal suppression filter (22) of inhibiting high-frequency signals contained in power voltage and a signal separation filter (23) of inhibiting transmission of the high-frequency signals are provided in series in power lines (21A), (21B) connected to a power input terminal (T1), and high-frequency signals contained in power voltage between a power output terminal (T2) and the signal separation filter (23) are outputted from signal output terminals (T3) to (T5). High-frequency signals from a power source can be blocked by the signal suppression filter (22) and the signal separation filter (23), so that influence of power noise on a measurement system can be eliminated. Since the signal separation filter (23) situated between the signal suppression filter (22) and the power output terminal (T2) inhibits high-frequency signals generated in a device to be measured (3) from being absorbed by the signal suppression filter (22), a signal detection level can be prevented from being reduced at the signal output terminals (T3) to (T5).

A screening method is described for selecting patient-specific anti-cancer agents reflecting individual genetic properties, in a precise and rapid manner, using an extremely small amount of cancer cells. Such screening method is useful for development of novel anti-cancer agents and the personalized medical field.

An extensible project system for software development is provided by allowing a flavor, with a specific purpose, to be applied to a base project system. More than one flavor may be applied. Where components are distributed objects, such as where COM (component object model) is used, the project system is assembled by aggregation of a base project object, which contains some data for creating a project system with a flavor object, which modifies the project system. The base project object is the participating object in the aggregation and the flavor object is the controlling object. Multiple flavors may be applied to create a project system intended for multiple purposes, corresponding to the applied flavors.

The invention provides compositions featuring chitosan and methods for using such compositions for the local delivery of biologically active agents to an open fracture, complex wound or other site of infection. Advantageously, the degradation and drug elution profiles of the chitosan compositions can be tailored to the needs of particular patients at the point of care (e.g., in a surgical suite, clinic, physician's office, or other clinical setting).

The present invention features a non-human animal model of malaria, e.g., Plasmodium, particularly Plasmodium falciparum. The model is based on a non-human, immunocompromised transgenic animal having a human-mouse chimeric liver, where the transgene provides for expression of a urokinase-type plasminogen activator in the liver. The invention also features methods for identifying candidate therapeutic agents, e.g., agents having anti-pathogenic activity against malaria.