697results about How to "Reduce synthesis" patented technology

A powder which is capable of being used in a layer-by-layer process in which regions of the respective pulverulent layer are selectively melted and, after cooling, are fixed, contains a mixture of diacid-regulated polyamide and diamine-regulated polyamide and / or diacid-regulated copolyamide and diamine-regulated copolyamide.

The invention relates a method wherein a molecule is used for inducing and / or promoting skipping of at least one of exon 43, exon 46, exons 50-53 of the DMD pre-mRNA in a patient, preferably in an isolated cell of a patient, the method comprising providing said cell and / or said patient with a molecule. The invention also relates to said molecule as such.

The present methods and compositions are of use for treatment of conditions involving fibrosis, such as Peyronie's disease plaque, penile corporal fibrosis, penile veno-occlusive dysfunction, Dupuytren's disease nodules, vaginal fibrosis, clitoral fibrosis, female sexual arousal disorder, abnormal wound healing, keloid formation, general fibrosis of the kidney, bladder, prostate, skin, liver, lung, heart, intestines or any other localized or generalized fibrotic condition, vascular fibrosis, arterial intima hyperplasia, atherosclerosis, arteriosclerosis, restenosis, cardiac hypertrophy, hypertension or any condition characterized by excessive fibroblast or smooth muscle cell proliferation or deposition of collagen and extracellular matrix in the blood vessels and / or heart. In certain embodiments, the compositions may comprise a PDE-4 inhibitor, a PDE-5 inhibitor, a compound that elevates cGMP and / or PKG, a stimulator of guanylyl cyclase and / or PKG, a combination of a compound that elevates cGMP, PKG or NO with an antioxidant that decreases ROS, or a compound that increases MMP activity.

The invention relates to a method for inducing or promoting skipping of exon 45 of DMD pre-mRNA in a Duchenne Muscular Dystrophy patient, preferably in an isolated (muscle) cell, the method comprising providing said cell with a molecule that binds to a continuous stretch of at least 21 nucleotides within said exon. The invention further relates to such molecule used in said method.

The invention provides compositions comprising an effective amount of an agent that inhibits a BET protein (e.g., Brd2, Brd3, Brd4), and methods of using such compositions for treating or preventing metabolic syndrome, obesity, type II diabetes, insulin resistance, and related disorders characterized by undesirable alterations in metabolism or fat accumulation.

Topical use of teprenone in a cosmetic or dermopharmaceutical composition as an active preventing and / or limiting the skin cells sénescence and / or protecting the general state of the skin.

The present invention provides methods of treating TNF-α-mediated disorders, the methods generally involving administering to an individual in need thereof effective amounts of pirfenidone or a pirfenidone analog and a second therapeutic agent that reduces TNF-α synthesis or that reduces TNF-α binding to a TNF receptor. The present invention further provides methods for treating non-alcoholic steatohepatitis, the method generally involving administering to an individual in need thereof an effective amount of pirfenidone. The present invention further provides methods of treating end-stage or advanced Type II diabetes, the methods generally involving administering to an individual in need thereof effective amounts of pirfenidone and insulin.

The present invention relates to a method that is useful for improving the appearance, texture and / or moisture of skin. In particular, the methods of the present invention comprise administering a composition comprising Chia Seed oil, Opuntia Ficus Indica extract, or both to stimulate collagen or hyaluronic acid synthesis, or decrease Interleukin-1b synthesis, in the skin.

The present invention features a unique, natural formulation and method of administering the same to treat and prevent diabetes, or rather advances treatment of diabetes, by providing a naturaceutical composition or treatment formulated with one or more processed Morinda citrifolia products as derived from the Indian Mulberry plant. The Morinda citrifolia is particularly adapted to treat Type II diabetes. The Morinda citrifolia product is preferably a leaf extract, but may also be in the form of a juice, a puree juice, a dietary fiber, or other similar forms and is incorporated into various carriers or naturaceutical compositions suitable for in vivo treatment of a patient. The naturaceutical may also combine other food products into the naturaceutical, such as fruit juices, dietary supplements, vitamins and minerals, and others.

The sulfated oxysterol 5-cholesten-3β, 25-diol 3-sulphate, a nuclear cholesterol metabolite that decreases lipid biosynthesis and increases cholesterol secretion and degradation, is provided as an agent to lower intracellular and serum cholesterol and / or triglycerides, and to prevent or treat lipid accumulation-associated inflammation and conditions associated with such inflammation. Methods which involve the use of this sulfated oxysterol to treat conditions associated with high cholesterol and / or high triglycerides and / or inflammation (e.g. hypercholesterolemia, hypertriglyceridemia, non-alcoholic fatty liver diseases, atherosclerosis, etc.) are also provided.

The invention discloses a weight-loss health-care food which is prepared from the main raw materials of, by weight, 1-60% of a white kidney bean extract, 1-50% of L-malic acid, 1-65% of L-carnitine tartrate, and 1-40% of konjac powder. The invention also discloses a preparation method of the weight-loss health-care food. The method comprises the step that: the main materials of the white kidney bean extract, L-malic acid, L-carnitine tartrate, and konjac powder are well mixed, such that the health-care food with weight-loss function is obtained. With the health-care food, starchy substance absorption is inhibited, body metabolism is promoted, and energy conversion is promoted, such that fat consumption is increased, fat formation is prevented, and a weight-loss function is achieved. With the preparation method, absorption of nutrients such as proteins and vitamins is not influenced, diet control is not needed, and weight can be naturally controlled and reduced. The preparation method provided by the invention has the advantages of simple process, no high-temperature operation, convenient operation, and energy saving.

The invention provides a genetically engineered bacterium for high-yielding L-valine. A construction method of the genetically engineered bacterium comprises the steps that starting from an escherichia coli W3110, an acetolactate synthase gene alsS of a bacillus subtilis is integrated on a genome of the escherichia coli W3110 and subjected to high expression; an escherichia coli ppGpp 3'-pyrophosphoric acid hydrolytic enzyme mutant R290E / K292D gene spoT is integrated on the genome of the escherichia coli W3110 and subjected to high expression; genes of frdA, frdB, frdC and frdD of four subunits of a lactic dehydrogenase gene ldhA, a pyruvate formate lyase I gene pflB and fumaric reductase on the genome of the escherichia coli W3110 are knocked out; a branched chain amino acid transaminasegene ilvE of the escherichia coli is replaced with leucine dehydrogenase gene bcd of the bacillus subtilis; and an acetyl-hydroxyl acid isomerized reductase gene ilvC of the escherichia coli is replaced with an encoding gene of a mutant L67E / R68F / K75E. According to the genetically engineered bacterium for the high-yielding L-valine, an L-valine fermentation method is further modified. Double-phasedissolved oxygen control is adopted, and the L-valine yield and the saccharic acid conversion rate are improved.

Cosmetic compositions comprising a metal-complexed peptide fraction of stressed yeast extracts and / or a calcium influx inhibitor are disclosed, as well as methods of using such compositions to impart exfoliating, anti-aging, anti-lipid, anti-inflammatory, and / or lightening benefits to the skin; and / or lightening benefits to the hair. These compositions are believed to have modulatory activity against at least one biochemical pathway implicated in skin aging, inflammation, lipid synthesis, and melanin production.

The present invention features a unique, natural formulation and method of administering the same to treat and prevent diabetes, or rather advances treatment of diabetes, by providing a nutraceutical composition or treatment formulated with one or more processed Morinda citrifolia products, including TAHITIAN NONI® juice and juice concentrate, as derived from the Indian Mulberry plant.

A shape deformation encoding device includes: a calculation unit for calculating a difference data between a pre-deformation shape data which represents a shape of an object before shape change and a post-deformation shape data which represents a shape of the object after shape change; and a determination unit for determining an action area on which the shape change of the object is arisen and an external force which is acted to the action area for the shape change, based on the pre-deformation shape data and the difference data. The action area includes a plurality of small areas, each of the plurality of small areas includes a plurality of control points, and the external force is calculated as an external force required to deform the plurality of small areas from before to after the shape change independently based on the physical model structure of each of the plurality of small areas. The physical model structure in which the plurality of control points are connected together with springs and dampers are used as a physical model structure.

The present invention relates to skin care compositions, including cosmeceuticals, for topical application, and more particularly, a skin cream, comprising exosomes and cell culture medium conditioned by cells grown in two-dimensional culture. Also included are methods of making and using such compositions and kits comprising the skin cream therein.

The present invention relates to the treatment of conditions characterized by loss of appetite (anorexia) and / or pathological weight loss by administering a therapeutically effective amount of an agent that modulates androgen activity. The present invention further relates to the treatment and prevention of anorexia nervosa with such agents.

The invention relates to a BaTiO3 group positive temperature coefficient thermistance and a preparation method thereof, wherein, the BaTiO3 group positive temperature coefficient thermistance has high Curie temperature. The invention belongs to the electronic ceramics technique. The recombination positive temperature coefficient thermistance is composed of main materials and assistant materials. The mol ratio of TiO2 and (BaCO3+SrCO3+Bi2O3+Na2CO3) of the main materials is 1:1. The mol components of the assistant materials are that Nb2O5 is 0.0011; TiO2 is 0.01; Sb2O3 is 0.0006; MnO2 is 0.0004; SiO2is 0.005; Al2O3 is 0.0017. The preparation process comprises that materials are weighed and mixed according to the mol prescription; the mixed materials are processed with ball milling after being added with water, and preparative complex materials are made through drying and heat preservation. The preparative complex materials are again added with raw materials, and then the preparative complex materials are processed with ball milling after being added with the water, thus the positive temperature coefficient thermistance is made through drying, granulation, foliation and baking. The invention has the advantages that the process of the composite (Na0.5Bi0.5)TiO3 is simple; the made positive temperature coefficient thermistance is unleaded and environment-friendly.

The invention belongs to the technical field of cosmetics and particularly a biological skin brightening facial mask liquid and a preparation method thereof. The biological skin brightening facial mask liquid is prepared from the following components in percentage by mass: 0.1-2 percent of glabridin, 0.5-3 percent of microalgae skin brightening agent, 0.5-2.5 percent of citrus peel extract, 0.05-2percent of alpha-arbutin, 0.1-3 percent of radix paeoniae extract, 0.5-5 percent of yeast extract and the balance of matrix. The prepared facial mask liquid is capable of reducing melanin from multiple aspects and in multiple ways aiming to various parts in the process from generation to discharge of the melanin, has the remarkable effects of skin whitening and brightening, is capable of replenishing water, preserving moisture, resisting ageing and keeping skin healthy at the same time and does not have irritation.

The invention discloses a multifunctional compound fertilizer additive and a preparation method thereof. The preparation method comprises the following steps: uniformly spraying a compound amino acid complex solution of trace elements containing Fe, B, Mn, Cu, Zn and Mo, rare earth elements containing Ce and La and beneficial mineral elements containing Ni, Co and Ti on grass carbon, brown coal or weathered coal powder, airing or drying, and then crushing to obtain a material A; preparing dicyandiamide used as a nitrification inhibitor into an ammonia solution to be adsorbed on carboxymethyl cellulose used as a water retention agent, airing or drying, and then crushing to obtain a material B; mixing cobalt sulfide and molybdenum sulfide which are used as nitrogen fixation catalysts with bean cakes or corn starch to obtain a material C; and uniformly mixing the material A, the material B and the material C to obtain the additive. The multifunctional compound fertilizer added with the additive of the invention has the advantages of fixing nitrogen, dissolving phosphorus, enriching soil, reducing nutrient loss, improving nutrient utilization ratio, improving crop enzyme activity, promoting metabolism, improving crop quality, increasing crop yield, retaining water, saving water, resisting drought, regulating buffering acidity or saline-alkali soil, and improving soil structure.

The present invention discloses pharmaceutical preparations for treatment of eye disorders containing an alpha 2 adrenergic agonist, to processes for producing the pharmaceutical preparations and methods for treatment of various eye disorders including dry eye and Meibomian gland dysfunction and a medicinal applicator for topical application of an alpha 2 adrenergic agonist to a subject, a package assembly for the medicinal applicator and methods of using the medicinal applicator to treat eye disorders.

The invention discloses a flue-cured tobacco cultivation method fitting in with the light environment of the Yunnan tobacco-growing area and belongs to the technical field of tobacco plant cultivation. The flue-cured tobacco cultivation method comprises the following steps of float breeding, soil preparation and ridging, transplanting under film, management in film covering period and field management. The seeding time is from mid December to mid February, the float disc floating seedling method is adopted, and seeding hardening lasts for 8-14 days before transplanting; ridging is conducted after the soil is pulverized and moisture is stored, and inorganic fertilizer and cake fertilizer which is thoroughly decomposed are mixed to be applied to the field; the transplanting period is from mid March to mid April, the density of tobacco plants is 1000-12000 plant / mu, each tobacco plant is irrigated with 1.5-2.5kg root water after transplanting, and colored mulching film is covered; top dressing is conducted twice after transplanting, and seeding leading is conducted 15-25 days after the top of each tobacco seeding ejects the film; the mulching film is removed when the tobacco plants enter the mid of the vigorous growth period, earthing up, weeding and watering are conducted in time, and topping, leaf reserving and bifurcation removing are conducted. The flue-cured tobacco cultivation method can fitting in with the light environment of the Yunnan tobacco-growing area, the local light source can be utilized fully and reasonably, the quality of tobacco leaves can be improved, and the aroma style of the fen-flavor tobacco leaves is enhanced.

The present invention relates to a special clinical nutritional formula for anemia. The nutritional formula comprises proteins, fats, carbohydrates, dietary fibers, macro elements, trace elements, vitamins, dietary essences, medicinal and edible ingredients, natural plant compounds and new resource food. The dietary essences comprise beef powder, pork liver powder, red date powder and cherry powder. The medicinal and edible ingredients comprise Chinese yams, Chinese wolfberry fruits, chicken's gizzard-membrane, haws, cloves, orange peels and honeysuckles. A preparation method comprises the following steps: each component is prepared into powder in advance, then the corresponding dosage forms are prepared, wherein the medicinal and edible ingredients are subjected to water extracting, concentrating is performed, the concentrated ingredients are spray-dried to prepare powder, and the vitamins and fats are subjected to microencapsulation treatment to prepare powder; or a wet method technology is used to conduct emulsifying and homogenizing on the ingredients, and the homogenized ingredients are spray-dried to prepare powder. Compared with the prior art, the nutritional formula can provide energy, key nutrients and essential trace elements for patients with anemia, and improves and treats anemia syndromes caused by insufficient nutrient intake and iron deficiency.

The present invention provides a herpes simplex virus strain having a functional ICP27 gene and lacking at lease a functional ICP4 gene and a functional ICP34.5 gene. It also provides the use of a herpes simplex virus strain which lacks at least a functional ICP4 gene and a functional ICP34.5 gene in the treatment of disorders of, or injuries to, the nervous system of a mammal.

The sulfated oxysterol 5-cholesten-3β, 25-diol 3-sulphate, a nuclear steroid metabolite that increases cholesterol secretion and degradation, is provided as an agent to lower intracellular and serum cholesterol and / or triglycerides. Methods which involve the use of this sulfated oxysterol to treat conditions associated with high cholesterol and / or high triglycerides (e.g. hypercholesterolemia, hyperlipidemia, and atherosclerosis) are also provided.

The invention relates to a preparation method of zirconium carbide ceramics powder; the method for rapidly preparing zirconium carbide ceramics powder is characterized in that: the method comprises the following steps: 1) raw material selection: the raw materials are selected according to 12:4-12:5 of mass ratio of zirconium propoxide solution and sugar and 8:32:1:1-8:64:2:4 of volume ratio of zirconium propoxide solution, normal propyl alcohol, chelant-acetic acid and water; the solvent acetic acid is selected according to (7-8)g:50ml of proportion of the sugar and the solvent acetic acid; 2) the preparation of dried gel power; 3) preparation of precursor powder; 4) heat treatment of the precursor powder; carbothermal reduction reaction is carried out under the conditions of high heating rate and short temperature preservation time, the synthesizing process of the zirconium carbide powder is shortened into dozens of minutes even several minutes, so as to obtain high-purity and refined zirconium carbide ceramics powder with good sintering character; single zirconium carbide phase can be analyzed by X-ray diffraction, the oxygen content in the product is 0.5-3 percent, and the free carbon content is from 0.2 to 2 percent; the crystal particles are uniform and tiny, and the mean grain size is less than 500nm.

The invention belongs to the field of health beverages, and in particular relates to a gynura procumbens compound preparation as well as a preparation method and application thereof. The gynura procumbens compound preparation is characterized by being prepared from the following raw materials in percentage by weight: 75-85% of gynura procumbens, 5-10% of barley seedlings, 3-6% of common lophatherum herb, 2-5% of frostbitten mulberry leaves, 2-4% of kudzuvine root and 1-3% of poria cocos. The preparation method of the gynura procumbens compound preparation comprises the following steps: performing weighing, drying and small fire baking on gynura procumbens, then mixing with other weighed raw materials, and crushing. The preparation disclosed by the invention is safe, healthy and natural, has various effects of treating gout in multiple ways comprehensively, can play roles in adjusting uric acid metabolism, promoting excretion of uric acid, preventing uric acid crystallization, diminishing inflammation and relieving pain, and controlling arthralgia, swelling and inflammations in an attack stage of gout, also can be used for reducing the blood lipid and blood sugar and strengthening kidney metabolism, can be used for treating both symptoms and root causes and achieving the effects of preventing and treating gout, and has the characteristics of natural compounds and natural health maintenance; and the preparation method disclosed by the invention is simple and convenient, and can be used for keeping original components of the raw materials to the greatest extent.