10results about How to "Reduce synthesis" patented technology

This invention discloses the application of a branched-chain amino acid (BCAA) restricted diet in the preparation of drugs for treating liver metastases of tumors. Through mouse model experiments, this invention found that restricting the intake of BCAAs (valine, isoleucine, and leucine) in the diet, or using the SCD1 inhibitor A939572, can significantly inhibit liver metastases of tumors, especially pancreatic cancer liver metastases. Experimental results show that a BCAA restricted diet or SCD1 inhibitor can reduce the number and volume of liver metastases and inhibit their growth. This invention also reveals its mechanism of action: BCAA restriction reduces the propionylation modification of SREBP1, downregulates the transcriptional expression of its target gene SCD1, and thus reduces lipid synthesis, thereby exerting an anti-tumor liver metastasis effect. This invention provides a novel dietary intervention strategy and drug target for the treatment of liver metastases of tumors.

This invention relates to a lipid-lowering synbiotic, its preparation method, and its application, belonging to the field of egg-laying hen farming technology. The lipid-lowering synbiotic of this invention comprises the following components in parts by weight: 3-85 parts of traditional Chinese medicine extract, 1-25 parts of probiotics, 3-30 parts of prebiotics, 1-16 parts of enzyme preparation, and 4-55 parts of dietary therapy components. This synbiotic not only significantly improves the lipid metabolism of laying hens but also significantly prolongs the peak egg-laying period, increases the egg production rate, reduces cholesterol content in egg yolks, promotes calcium and phosphorus absorption, and reduces the paralysis rate in laying hens. It comprehensively improves the economic benefits of egg-laying hen farming.

The invention discloses compact anti-wrinkle elastin peptide freeze-dried powder and a preparation method thereof, and belongs to the technical field of bioactive peptides. The freeze-dried powder is prepared by taking core tubes and / or throat tubes of bred animals as raw materials through cleaning and impurity removal, crushing and homogenizing, degreasing and impurity removal, composite enzymolysis, enzymolysis inactivation, centrifugal separation, gradient filtration, concentration, sterilization and vacuum freeze drying, and has remarkable elastinase inhibitory activity and tightening and anti-wrinkle effects. The livestock and poultry slaughtering byproducts which are wide in source and low in cost are selected as raw materials, high-value utilization of the livestock and poultry slaughtering byproducts is achieved, the optimized preparation technology solves the problems that in the prior art, enzymolysis efficiency is low, product purity is low, activity is insufficient, and stability is poor, the technology is simple, large-scale production is easy, and the method can be widely applied to the fields of cosmetics, food and health care products.

A novel non-Saccharomyces cerevisiae strain and its application in plum wine fermentation belongs to the field of microbial fermentation technology. The strain is *Pichia kudrica*. Pichia kudriavzevii SWU-PL21, deposited at the Guangdong Provincial Microbial Culture Collection Center (GDMCC No: 68253) on May 12, 2026, exhibits the following pectinase activity: 201.98 ± 7.38 U / mL; PME: 0.8 ± 0.0 U / mL; and tanninase activity: 27.53 ± 0.57 U / mL. In the fermentation of plums with skin, SWU-PL21 improved the alcohol yield and clarity. Sequential inoculation of SWU-PL21 with *Saccharomyces cerevisiae* promoted the formation and accumulation of fruit, floral, and sweet aroma compounds during plum fermentation, and increased the content of total phenols and total flavonoids.

The invention belongs to the field of tumors, and relates to an application of NRF2 in regulation and control of arsenic-induced cell malignant proliferation, and the NRF2 gene of malignant proliferative cells is instantaneously knocked down. After the NRF2 is instantaneously knocked down, the G6PD / NADK mediated NADP synthesis increase is inhibited, so that the cell malignant proliferation phenotype caused by the cell redox steady state imbalance is reversed.

The application discloses chalcone synthase mutants and application thereof, and belongs to the technical field of biology.The application obtains multiple CHS mutants, which are 1.1-2.96 times of the yield of wild-type synthesized naringenin, wherein the best mutant is CHS-3-15, and the yield of naringenin is 1.85 mM.Through in-vitro characterization and pure-enzyme activity comparison, the specific activity of CHS-2-7, CHS-2-12, CHS-3-15 and CHS-3-27 is 1.11-2.30 times of that of the wild type.To improve the synthesis of naringenin and reduce the synthesis of by-product CTAL, a specific chassis is constructed, and the CHIL protein capable of reducing by-products is co-expressed, the CHIL expression amount is optimized by optimizing the ribosome binding site sequence, and finally the yield of naringenin reaches 3.98 mM in a shake flask.

The invention relates to an artemisia apiacea-containing penetration enhancing composition with skin cell repairing and relieving effects, and a preparation method and application thereof, and belongs to the technical field of cosmetics. The research finds that the anti-inflammatory effect generated by only inhibiting an upstream anti-inflammatory path of an NF-kappa B channel is limited, and the anti-inflammatory effect can be remarkably enhanced by blocking a downstream conduction chain while inhibiting the NF-kappa B channel. On the basis, through the artemisia apiacea extract and the flos magnoliae extract, an upstream anti-inflammatory path is inhibited, recruitment and infiltration of inflammatory cells are reduced, a downstream conduction chain is blocked, and the anti-inflammatory effect is synergistically improved. Besides, through cooperation of the oat kernel oil, the jasmine flower oil and the squalane, on one hand, the solubility of fat-soluble active matter is improved, on the other hand, the composition can participate in repairing, stabilizing and optimizing the lipid structure of the skin cuticle, synchronously open the skin fat-soluble channel and convey the active matter more efficiently, and therefore the excellent relieving, repairing and stabilizing effects are achieved.

The invention belongs to the technical field of natural product extraction and medicine, and particularly relates to application of a sea-buckthorn extract in resisting melanin. The invention provides an application of a sea-buckthorn extract in preparation of a product for inhibiting melanogenesis. The sea-buckthorn extract is a sea-buckthorn water-phase extract. The sea-buckthorn water-phase extract has a remarkable inhibition effect on tyrosinase, and meanwhile shows good DPPH and ABTS free radical scavenging capacity, so that the sea-buckthorn water-phase extract has the dual effects of resisting oxidation and inhibiting melanin generation key enzyme activity. The sea-buckthorn aqueous phase extract can be used for remarkably reducing the expression of melanin synthesis key genes (Tyr, Trp1, Mitf, Msh and Mc1r) and partial genes (Erk2 and Rsk) of an MAPK pathway. The sea-buckthorn water-phase extract provided by the invention is derived from natural plants, is high in safety and clear in effect, and provides new active ingredients and experimental basis for developing natural medicines, functional cosmetics or health care products with the melanin generation resisting effect.

The present application relates to a skin cell soothing and repairing composition containing artemisia and its preparation method and application, and belongs to the technical field of cosmetics. The present application finds that only by inhibiting the upstream anti-inflammatory pathway of the NF-kappa B pathway, the anti-inflammatory effect is limited, while inhibiting the NF-kappa B pathway, the downstream transmission chain is blocked, and the anti-inflammatory effect is significantly enhanced. Based on this, the present application inhibits the upstream anti-inflammatory pathway by artemisia extract and jasminum officinale extract, reduces the recruitment and infiltration of inflammatory cells, blocks the downstream transmission chain, and synergistically improves the anti-inflammatory effect. In addition, the present application cooperates oat kernel oil, jasmine flower oil and squalane, on the one hand, improves the solubility of fat-soluble active substances, on the other hand, participates in the repair, stabilization and optimization of the lipid structure of the skin cuticle, synchronously opens the skin fat-soluble channel, and more efficiently transports active substances, thereby realizing excellent soothing, repairing and stabilizing effects.

The present application provides a kind of whitening, improve skin barrier composition and its preparation method and application, it is related to skin care product technical field.The composition raw material includes: plant extract 30-42 parts, Lotus nut extract 13-17 parts, Beauveria extract 12-14 parts, malt oligosaccharide glucoside 1.2-1.6 parts, raspberry ketone glucoside 2-3 parts, oligopeptide 4-6 parts, sucrose laurate 1-2 parts, humectant 2-4 parts, thickening agent 1-1.8 parts, water 280-340 parts.The present application can inhibit tyrosinase activity by the synergistic effect of specific plant extract, Lotus nut extract, Beauveria extract, malt oligosaccharide glucoside, raspberry ketone glucoside, oligopeptide and other raw materials, achieve good whitening effect, and make each active ingredient transdermal absorption, protect skin keratin layer lipid bilayer structure from being destroyed, maintain the water-retention capacity of skin, avoid water loss, thereby play the role of improving skin barrier.