49 results about "Breast nodules" patented technology

A breast tumor marker based on a serum protein, used for carrying out serum measurement on suspected breast tumor patients, and effectively distinguishing healthy people, breast nodule patients, and breast cancer patients. A serum protein spectrum classifier has, in an independent verification queue, an accuracy of 0.87, a precision of 0.93, a recall of 0.82, and an F1-score of 0.86. The area under the ROC curve for benign nodule patients is 0.96, the area under the ROC curve for breast cancer patients is 0.96, and the area under the ROC curve for healthy people is 0.96. The marker has high accuracy and good specificity, and has a good application prospect in clinical diagnosis of breast lesions.

Disclosed in the present invention is a physician-interpretable ultrasound-based breast cancer pathological subtype detection system, comprising: a segmentation module, which uses a U-Net network and incorporates a foreground optimization network to segment a breast and a nodule; a texture channel, which extracts a texture channel feature; an edge channel, which extracts boundary information; a position channel, which extracts position information, so as to quantize the overall relationship between the nodule and the boundary information of the breast to extract a breast nodule growth position feature; a shape channel, which calculates an edge aspect ratio on the basis of a segmented nodule region, so as to obtain a predicted interval value as a shape channel feature; an echo channel, which calculates the echo difference between the interior and exterior of the nodule to serve as an echo channel feature value; and a joint prediction module, which uses a multinomial logistic regression model to classify and predict breast cancer pathological subtypes on the basis of output features of the texture channel, the edge channel, the echo channel, the shape channel and the position channel. An artificial intelligence diagnosis tool that is interpretable to physicians is built, thereby providing an automated theoretical basis for clinical diagnosis and decision-making.

The invention provides a mammary nodule malignant transformation risk prediction system and method, a terminal, a medium and a product. The system comprises a multi-source data acquisition module used for acquiring multi-source mammary gland related medical data of a target mammary nodule patient and preprocessing the multi-source mammary gland related medical data; the key prediction feature screening module is used for carrying out key feature screening on the preprocessed data to obtain mammary gland key prediction feature data; and the prediction module is used for inputting the breast key feature data into a pre-constructed breast nodule risk prediction model to obtain a corresponding breast nodule malignant transformation risk prediction result. According to the method, the related medical data of the multi-source mammary gland is integrated, and key feature screening and the mammary nodule risk prediction model are combined, so that the limitation of traditional single-dimensional evaluation is broken through, and early warning of malignant transformation of the mammary nodule is realized.

The invention provides a method, a system, equipment and a program product for predicting benign and malignant breast nodules, and the method comprises the steps: collecting an ultrasonic image of a to-be-detected breast nodule; based on the ultrasonic image, a gaze graph generator of the attention guiding module generates a virtual gaze graph corresponding to the ultrasonic image; based on the ultrasonic image and the virtual staring image, a staring image classifier of the attention guiding module outputs the malignant probability of the breast nodule to be detected corresponding to the virtual staring image; wherein the staring image generator and the staring image classifier are obtained based on training of the training ultrasonic image and the real staring image; the real staring map comprises attention information of the expert during ultrasonic diagnosis; and based on the ultrasonic image, the uncertainty calculation module generates an evidence vector corresponding to the ultrasonic image, and generates credibility corresponding to the malignancy probability based on the evidence vector. The interpretability of benign and malignant prediction of breast nodules can be improved, and automation bias is reduced.

The invention discloses a medicinal and edible traditional Chinese medicine composition for treating breast nodules and a preparation method thereof, and belongs to the technical field of biology and new medicine. The traditional Chinese medicine composition for treating breast nodules comprises dandelion, kelp, ginseng, mulberry, astragalus membranaceus, lucid ganoderma, brassica juncea, oyster, perilla seeds, platycodon grandiflorum, fingered citron, pericarpium citri reticulatae and the like. In addition, the invention also provides a preparation method of the traditional Chinese medicine composition, which comprises the following steps: pouring the lucid ganoderma, the dried orange peel, the peach kernel, the Chinese angelica and the like together with soaking water into a pot, decocting, adding the soaked dandelion, kelp and the like into the pot, continuously decocting, filtering and collecting a first decoction and decoction dregs, adding a proper amount of water into the decoction dregs again, and filtering to obtain the traditional Chinese medicine composition. Continuing to boil and decoct, collecting a second decoction, and combining the first decoction and the second decoction to obtain the traditional Chinese medicine composition. The traditional Chinese medicine composition for treating breast nodules, provided by the invention, has a remarkable effect of treating breast nodules under the synergistic effect of all the components.

The invention discloses nucleus eliminating granules which are prepared by the following steps: adding water into 12 medicinal materials, namely selfheal, oyster, kelp, beautiful sweetgum fruit, fructus aurantii, cowherb seed, salvia miltiorrhiza, curcuma zedoary, ligusticum wallichii, white paeony root, corydalis tuber and radix bupleuri, heating, extracting, filtering, concentrating and drying to obtain medicinal powder; and sieving, adding auxiliary materials, adding a wetting agent, preparing a soft material, granulating, and drying to obtain the kernel eliminating granules. The invention further discloses a preparation method of the nucleus eliminating particles, a thin-layer chromatography identification and content determination method and application of the nucleus eliminating particles. According to the invention, the nucleus-eliminating mixture is developed into the nucleus-eliminating particles, the forming rate, the dissolution rate, the moisture absorption rate, the fluidity and the like of the nucleus-eliminating particles all meet the requirements of Chinese Pharmacopoeia, and the stability experiment result shows that the product stability is good; the curative effect of the nucleus eliminating granules on breast pain, breast nodules, hyperplasia of mammary glands and breast diseases can be achieved; doctors realize accurate medication under treatment based on syndrome differentiation, and the flexibility of adjusting prescriptions along with symptoms is guaranteed; on the other hand, more convenient carrying and taking experience can be provided for the patient.

The application discloses a traditional Chinese medicine composition and a preparation method and application thereof; active ingredients of the traditional Chinese medicine composition include rose, bergamot, cydonia, poria cocos, Chinese yam, gordon euryale seed, coix seed, sea buckthorn, malt, chicken gizzard, angelica, longan, medlar, donkey-hide gelatin, mulberry, kelp, oyster, dandelion, dried tangerine or orange peel, platycladus, yellow mustard seed, peach kernel, saffron, radix astragali, American ginseng, raw sun-dried ginseng, dendrobium officinale, lily, ganoderma lucidum, jujube and mint; the traditional Chinese medicine composition is formed by the principle of monarch, minister, assistant and guide, forms a traditional Chinese medicine prescription of specific active ingredients, forms a herbal ointment that treats in all directions, has a remarkable curative effect on breast nodules, and has a good taste, is portable, and meets the long-term treatment requirements.

The invention discloses a breast-dredging and stasis-removing health-care cream and a preparation method thereof. The breast-dredging and stasis-removing health-care cream is composed of active components such as a ranunculus ternatus alcohol extract, panax notoginseng saponins, radix bupleuri volatile oil and the like, and an emulsion matrix. Through targeted liposome modification and a temperature-sensitive slow release technology, efficient delivery of anti-hyperplasia components is realized, the cream has dual effects of reducing the volume and relieving pain on breast nodules, and the transdermal efficiency is improved by 210% compared with that of traditional cream.

The invention discloses a method for analyzing an action mechanism of a breast nodule removing tablet. The method comprises the following steps: identifying chemical components of the breast nodule removing tablets; predicting effective target spots of the chemical components based on network pharmacology, and predicting target spots of hyperplasia of mammary glands; and performing clustering analysis and other operations on the relative content of differential proteins in the mammary gland hyperplasia model before and after the breast nodule removing tablets are taken based on proteomics. According to the application, a method for integrating multi-dimensional data through a'chemical component-target network-omics technology 'is used for discussing the action mechanism of the breast nodule removing tablets, important proteins, metabolites or pathways are screened out, research targets are more easily locked, and the action mechanism of the traditional Chinese medicine compound breast nodule removing tablets is disclosed.

The invention relates to the field of medical image analysis and artificial intelligence, and discloses a mammary gland benign nodule follow-up visit data processing and nodule risk early warning method, which comprises the following steps of: obtaining gray-scale ultrasonic images and color Doppler blood flow images of a baseline and a plurality of follow-up visit time points; an improved U-Net model is adopted to automatically segment the nodule area, and morphological features and blood flow features are extracted; constructing a feature change rate matrix based on the percentage change rate of each time point feature relative to the baseline, quantifying a dynamic evolution trend in combination with a time decay weight matrix, and generating a dynamic malignant risk score by coupling patient age and breast cancer high risk factors; and further dynamically optimizing a risk judgment threshold value through a deep reinforcement learning model, dividing low, medium and high risk levels according to a comparison result of the score and the threshold value, and outputting differentiated clinical intervention suggestions. According to the invention, accurate and personalized early warning of the malignant risk of the breast benign nodule is realized, and intelligent support is provided for clinical follow-up decision.

The invention discloses a mammary gland stasis removing patch and a preparation method, and relates to the technical field of mammary gland nodule nursing, in particular to the mammary gland stasis removing patch which comprises an adhesive patch body, a center patch body is attached to the middle of one side of the adhesive patch body, stasis removing ointment connected with the adhesive patch body is arranged on the periphery of a patch film, and a combined patch body is attached to the periphery of the adhesive patch body; the traditional Chinese medicine composition further comprises a ginger root extract, angelica sinensis, liquorice, safflower carthamus, pseudo-ginseng root, ligusticum wallichii, laurel, salvia miltiorrhiza, elecampane, radix curcumae, poncirus trifoliate, cowherb seed, leonurus, selfheal, turtle shell powder, corydalis tuber, menthol, cape jasmine, azelaone, rhizoma cyperi, borneol and seaweed. The mammary gland stasis removing patch can achieve the qi and blood conditioning effect on the mammary gland, has the effects of promoting blood circulation to remove blood stasis, dredging meridians and collaterals, improving smooth blood flow of the mammary gland, stimulating blood capillaries, increasing local blood circulation and promoting nutrient absorption, can promote blood circulation in the mammary gland to a certain extent, can indirectly improve the hematopoietic function, and can effectively treat the mammary gland. The effect of eliminating mammary glands can be realized after long-term use.

The present disclosure provides a breast nodule three-dimensional reconstruction method and system, the method comprising acquiring multiple frames of breast ultrasound images and preprocessing, the preprocessing comprising filtering denoising processing and image enhancement processing; a lightweight convolutional neural network structure is used to extract features from the images to obtain feature maps; a segmentation module is used to segment the feature maps; SGBM stereo matching operation is performed on the segmented images to obtain disparity information between the images, and the disparity information is adaptively corrected to realize three-dimensional reconstruction of the breast nodule; a dynamic calibration mechanism is established and an adaptive adjustment algorithm is designed to continuously optimize and calibrate the three-dimensional reconstruction operation. Through image preprocessing, optimization algorithm, dynamic calibration and adaptive adjustment, the present disclosure overcomes the problems of high image quality requirement, susceptibility to influence, large calculation resource consumption and low three-dimensional reconstruction precision in the prior art.

The invention discloses an ointment composition for conditioning mammary glands and a preparation method of the ointment composition. The composition is prepared from the following raw materials in parts by mass: 5 to 50 parts of spica prunellae, 5 to 50 parts of herba hedyotidis diffusae, 50 to 200 parts of rhizoma coptidis, 50 to 200 parts of radix scutellariae, 50 to 200 parts of cortex phellodendri, 50 to 200 parts of radix astragali seu hedysari, 10 to 200 parts of radix notoginseng, 10 to 200 parts of radix angelicae sinensis, 50 to 200 parts of silkworm larva, 50 to 200 parts of semen pharbitidis, 10 to 50 parts of white lime, 10 to 50 parts of talcum powder and the like. The solid raw materials are respectively ground and sieved into powder of more than 100 meshes, the powder is mixed according to the proportion of the formula, rosa roxburghii tratt, tribulus terrestris or agilawood seed oil is added into sesame oil, and the mixture is blended with glycerin or sesame oil to prepare the ointment. The traditional Chinese medicine composition is used for conditioning mammary glands, has the effects of softening hardness to dissipate stagnation, removing blood stasis and activating collaterals, is mild in medicine property, good in permeability and free of toxic and side effects, reaches 5 mm or above of mammary glands and interstices, and is used for daily mammary gland conditioning and maintenance and mammary gland disease prevention; the composition is suitable for mammary gland syndromes such as breast pain, breast lumps, milk discharge, hyperplasia of mammary glands, mammary gland fibroma, mammary cyst, mammary nodule, plasma cell mastitis and the like.

The invention provides a method for detecting circulating tumor cells through combination of Reigi staining and density gradient centrifugation. Comprising the following steps: (1) separating mononuclear cells from a blood sample; (2) performing Wright-Giemsa staining on the mononuclear cells obtained in the step (1); and (3) detecting the circulating tumor cells based on cell morphological characteristics. According to the method, the characteristics of the CTC cells can be observed more visually, and the method can be used for distinguishing benign breast nodules and malignant breast nodules, distinguishing stages of breast cancer and judging whether lymph node metastasis occurs or not.

The invention discloses a breast nodule detection method and system based on ultrasonic medicine, and the method comprises the steps: firstly obtaining breast ultrasonic video data, and carrying out the preprocessing of interception, zooming, sampling, screening, enhancement and the like; 18 layers of ResNet18 are adopted for feature extraction, a linear classification network and an attention selection network are combined, and a detection model is constructed through optimization of a cross entropy and a center loss function. The system is correspondingly provided with a feature extraction module, a linear classification module and the like. And finally, to-be-tested video data are input into the model, so that whether breast nodules exist or not and the result of benign and malignant nodules can be quickly obtained, and efficient and accurate assistance is provided for breast disease diagnosis.

The invention discloses a lactation dredging and stasis removing health-care liquid and a preparation method thereof. According to the preparation, through triple anti-hyperplasia core compatibility of selfheal, paris polyphylla and stigma croci and in combination with supercritical extraction and liposome encapsulation technologies, the concentration of crocin mammary tissue reaches 35.6 mu g / g. A vinegar-fried frankincense / myrrh nanocrystallization dispersion process is innovatively adopted, the problem of crystallization of resin components is solved, and no precipitate is generated in a 12-month accelerated test. Animal experiments prove that the volume of breast nodules can be reduced by 68.3%, and the traditional Chinese medicine composition is suitable for conditioning the sub-health state of female mammary glands.

The invention discloses an ABUS-based nodule elastography detection method, device and equipment and a medium, and the method comprises the following steps: controlling a probe in an ABUS to carry out flat scanning along the surface of a mammary gland, obtaining a cross section two-dimensional ultrasonic image, and generating a coronal plane image; detecting and identifying the position of a focus in the coronal plane image, and tracing a cross section image sequence containing the focus; detecting and segmenting the focus, and determining the specific position of the focus in the sequence; a probe in the ABUS is controlled to move to the section position corresponding to the maximum section of the focus, the probe in the ABUS is controlled to apply pressure to the surface of the tissue, so that the tissue deforms, the displacement change of the tissue under the pressure effect is recorded, and a strain elasticity image is generated; and evaluating the relative hardness of the lesion area according to the strain elasticity image. The method has the advantages that the ABUS is used for achieving elastography of breast nodules, the relative hardness of a focus area is evaluated, the method can be used for breast lesion screening, positioning and tracking return visit, and the performance and application of ABUS equipment are expanded.

1. The name of this design product: Ultrasonic medical bed. 2. Purpose of this design product: used to treat breast nodules or tumors. 3. The key point of the design of this product lies in its shape. 4. The picture or photo that best illustrates the key points of the design: Design 2 Stereoscopic Figure 2. 5. Designate Design 2 as the base design.

The application provides a traditional Chinese medicine external application composition for treating benign breast disease and preparation and application thereof, and belongs to the technical field of traditional Chinese medicine compositions, and is used for solving the problems of slow effect, large side effect and poor compliance of existing drugs for treating benign breast disease. The composition is composed of Tribulus terrestris 8-12 parts, Taraxacum officinale 8-12 parts, Pheretima 2-4 parts, Cornu Cervi 8-12 parts, mirabilite 16-24 parts, Pericarpium Citri Reticulatae Viride 10-14 parts, Swertia 8-12 parts, Ophiocordyceps sinensis 2-4 parts and borneol 1-3 parts. The medicinal materials are prepared into an external application powder, and the breast part is externally applied before sleep, and the application time is more than 6 hours each time. The application adopts external use and transdermal administration, has fast effect, no digestive tract stimulation and liver and kidney burden, is convenient to use, has high compliance, and is clinically verified to have exact curative effect on mastalgia, breast hyperplasia and benign breast nodules (including BI-RADS 3 and 4a nodules), has high safety, and is suitable for long-term conditioning of benign breast disease.

1. The name of the design product: ultrasonic medical trolley. 2. The use of the design product: for treating breast nodules or tumors. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view 2.

The invention provides a breast ultrasound image segmentation method based on state propagation and edge prior and application thereof, and belongs to the field of medical image processing. In order to solve the problems of large noise interference, blurred focus boundary and insufficient long-range dependence modeling of a breast ultrasound image, the invention provides an SP-EdgeNet network, and a mixed feature enhancement module is constructed to replace traditional jump connection. The module captures a global context by using a state propagation path, explicitly enhances a geometric edge by using an edge prior path, and dynamically fuses through an adaptive mechanism. And meanwhile, a structure-semantic decoupling module and a cross-resolution collaborative mechanism are supplemented, so that deep purification and multi-scale alignment of the features are realized. According to the method, the problems of edge degradation and semantic gaps in feature transmission are effectively solved, and the breast nodule segmentation precision and boundary integrity are remarkably improved.

The invention provides a diagnostic reagent and method for early discovery of breast nodules based on serum GRP detection. The reagent comprises a GRP standard substance, a GRP primary antibody, a buffer solution, a developing solution and a stop solution, the GRP level in serum is detected through enzyme-linked immunosorbent assay (ELISA), and the reagent is used for screening breast benign nodules and early breast cancer. By collecting a serum sample, detecting the GRP concentration and comparing the GRP concentration with a healthy control group, existence of breast nodules is judged, and the kit has high sensitivity and specificity, is particularly suitable for early-stage cases without obvious anomalies in imaging, and provides an efficient tool for non-invasive diagnosis of breast diseases. The diagnostic reagent is easy and convenient to operate, short in detection time and suitable for clinical large-scale screening, the method is combined with correlation analysis of the GRP level and the nodule volume, benign nodules, early breast cancer and advanced breast cancer can be effectively distinguished, a basis is provided for disease prognosis evaluation, the accuracy of early discovery of breast nodules is remarkably improved, and the clinical application prospect is wide. And an important reference is provided for formulating a treatment scheme.

The invention discloses a traditional Chinese medicine composition for treating thyroid nodules and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine compositions. The Uygur medicine honey ointment aims at solving the problem that safe and effective Uygur medicine honey ointment for treating thyroid nodules is lacked in the prior art. The traditional Chinese medicine composition comprises the following components in parts by weight: 5-15 parts of bungarus parvus, 5-15 parts of peganum harmala, 5-15 parts of capparis spinosa root bark, 10-20 parts of galangal, 10-20 parts of dried ginger, 5-15 parts of fructus piperis longi and 5-15 parts of cinnamon. The traditional Chinese medicine composition is prepared into the Uygur medicine honey ointment, and natural medicinal materials with homology of medicine and food are selected and are safe and free of toxic and side effects; through reasonable compatibility and synergistic interaction of a plurality of medicinal materials, the traditional Chinese medicine composition has remarkable effects of removing abnormal spleen fluid and qi, eliminating stagnation, expelling wind and removing cold, and resisting tumors; the traditional Chinese medicine composition not only can be used for treating thyroid nodules, but also can be used for treating gland nodular diseases caused by dry cold such as breast nodules and benign prostatic hyperplasia, and can effectively relieve clinical symptoms of patients; the preparation method is simple and convenient to operate, easy to popularize, suitable for industrial production and worthy of popularization and application.

The invention relates to a method for obtaining pathological diagnosis according to color ultrasound images of breast nodules by applying an artificial intelligence technology. The breast nodule color ultrasound image-pathological diagnosis system has the functions of image acquisition, image preprocessing, feature extraction, image recognition and the like, and can be used for recognizing, extracting and memorizing color ultrasound image features of breast nodules and internal features of abnormal cells in pathological tissue staining pictures of the breast nodules. Color Doppler ultrasound image data of breast nodules directly correspond to pathological picture data, and the data can be interpreted. A color Doppler ultrasound image database and a pathological picture database of breast nodules are established, deep learning is carried out with sufficient data, and functions are improved. The system is verified and clinically tested to ensure the accuracy of the system. Pathological diagnosis can be displayed after color Doppler ultrasound image data of breast nodules are input into the system. The device has the advantages that pathological diagnosis can be judged when nodules are seen on breast color ultrasound, so that the aim of accurate treatment is fulfilled. Clinical final diagnosis is based on pathological results under a microscope.

The invention relates to application of an FABP4 inhibitor in preparation of a medicament for preventing and treating alopecia and a medicament for growing hair. Research finds that the FABP4 inhibitor can promote hair growth and induce hair follicle increase in the growth period and can be used in drugs for preventing and treating alopecia and / or hair growth drugs, and the FABP4 inhibitor does not need to regulate the effects of hormones and related pathways and does not have the risk of induced dysfunction or breast nodules and the like; the FABP4 inhibitor can be orally taken, so that the irritation to the skin is avoided, and the administration is convenient.

The invention relates to the technical field of traditional Chinese medicines, and provides a traditional Chinese medicine effective part composition for treating hyperplasia of mammary glands, a traditional Chinese medicine preparation and application. Comprising the following components in parts by weight: 10-25 parts of a centipede rhizome total saponin extract, 10-25 parts of a cucurbit rhizome total terpene extract, 10-25 parts of a star-flower root total terpene extract, 5-10 parts of a radix paeoniae alba total terpene extract, 5-15 parts of a platycodon grandiflorum total flavone extract, 5-10 parts of a paederia scandens total terpene extract, 5-10 parts of a gentiana apiata total flavone extract, 5-10 parts of a bighead atractylodes rhizome total terpene extract and 5-10 parts of a fructus aurantii total flavone extract. 5-10 parts of a common cnidium fruit total coumarin extract; the traditional Chinese medicine preparation comprises the composition and auxiliary materials. The invention also discloses application of the composition in preparation of medicines for treating hyperplasia of mammary glands and breast nodules. The traditional Chinese medicine composition directly acts on a focus part according to a treatment principle of activating blood, soothing the liver, removing stasis and regulating endocrine, and is used for treating hyperplasia of mammary glands and breast nodules in a multi-way synergistic manner.

The present invention provides an end-to-end segmentation method for ultrasonic breast nodules based on multi-scale and cross-space fusion, including: using the encoding-decoding structure of the traditional U-Net as the main framework. Among them, the encoder replaces the convolution operation of the traditional Unet through a multi-scale feature extraction and fusion module to obtain context information with different receptive fields; at the bottleneck layer, a receptive field adaptive aggregation module is used to fuse the information under different receptive fields obtained through the multi-scale feature extraction and fusion module to generate a weight matrix, and the deep semantic channels are feature-screened through the weights to highlight the semantic features related to the segmentation result; on the skip connection between the encoder and the decoder, a cross-space residual fusion module is added to alleviate the semantic differences between the equivalent layers of the encoder and decoder; through ablation experiments, the segmentation effect is verified.

The application relates to a breast cancer risk assessment method and related equipment. The method comprises the following steps: obtaining germline genome sequencing data of a target object; the target object is a patient to be evaluated who is positive for breast nodules according to an ultrasonic examination result; inputting the germline genome sequencing data into a breast cancer germline genome evaluation model to obtain a breast cancer germline etiology score result of the target object; determining an immune exhaustion state evaluation result according to immune cell detection data of the target object and immune exhaustion reference information; the immune exhaustion reference information is obtained based on immune exhaustion analysis data of a non-breast cancer population; combining the breast cancer germline etiology score result and the immune exhaustion state evaluation result to obtain a breast cancer risk assessment result of the target object; the immune exhaustion state evaluation result is used for verifying the breast cancer germline etiology score result from the function level of immune cells. The method can effectively improve the accuracy of breast cancer risk assessment.

The invention provides a liver-soothing and depression-relieving pill as well as a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine compositions. The pill is prepared from the following traditional Chinese medicinal materials: pericarpium citri reticulatae viride, szechwan chinaberry fruit, corydalis tuber, pericarpium citri reticulatae, rhizoma sparganii, motherwort, radix curcumae, seaweed, radix paeoniae alba, vinegar-processed rhizoma cyperi, poria cocos, curcuma zedoary, radix bupleuri and the like according to a specific proportion through the processes of superfine grinding, uniform mixing, pelleting and the like. Based on the traditional Chinese medicine theory of liver depression, spleen deficiency, qi stagnation and blood stasis, the composition has the effects of soothing liver and regulating qi, tonifying spleen and nourishing heart, soothing nerves and stabilizing mind and the like, and is suitable for adjuvant therapy of symptoms such as anxiety, depression, sleep disorder, breast nodule and irregular menstruation caused by emotional disorder and uncomfortable liver qi. The traditional Chinese medicine composition is especially suitable for common emotion and sleep problems such as anxiety, anxiety and insomnia after rehabilitation of new coronavirus infection. The liver-soothing and depression-relieving pill is simple in process, scientific in formula and convenient for industrial production and clinical popularization.