19 results about "Breast nodules" patented technology

The invention provides a mammary nodule malignant transformation risk prediction system and method, a terminal, a medium and a product. The system comprises a multi-source data acquisition module used for acquiring multi-source mammary gland related medical data of a target mammary nodule patient and preprocessing the multi-source mammary gland related medical data; the key prediction feature screening module is used for carrying out key feature screening on the preprocessed data to obtain mammary gland key prediction feature data; and the prediction module is used for inputting the breast key feature data into a pre-constructed breast nodule risk prediction model to obtain a corresponding breast nodule malignant transformation risk prediction result. According to the method, the related medical data of the multi-source mammary gland is integrated, and key feature screening and the mammary nodule risk prediction model are combined, so that the limitation of traditional single-dimensional evaluation is broken through, and early warning of malignant transformation of the mammary nodule is realized.

The invention discloses nucleus eliminating granules which are prepared by the following steps: adding water into 12 medicinal materials, namely selfheal, oyster, kelp, beautiful sweetgum fruit, fructus aurantii, cowherb seed, salvia miltiorrhiza, curcuma zedoary, ligusticum wallichii, white paeony root, corydalis tuber and radix bupleuri, heating, extracting, filtering, concentrating and drying to obtain medicinal powder; and sieving, adding auxiliary materials, adding a wetting agent, preparing a soft material, granulating, and drying to obtain the kernel eliminating granules. The invention further discloses a preparation method of the nucleus eliminating particles, a thin-layer chromatography identification and content determination method and application of the nucleus eliminating particles. According to the invention, the nucleus-eliminating mixture is developed into the nucleus-eliminating particles, the forming rate, the dissolution rate, the moisture absorption rate, the fluidity and the like of the nucleus-eliminating particles all meet the requirements of Chinese Pharmacopoeia, and the stability experiment result shows that the product stability is good; the curative effect of the nucleus eliminating granules on breast pain, breast nodules, hyperplasia of mammary glands and breast diseases can be achieved; doctors realize accurate medication under treatment based on syndrome differentiation, and the flexibility of adjusting prescriptions along with symptoms is guaranteed; on the other hand, more convenient carrying and taking experience can be provided for the patient.

The application discloses a traditional Chinese medicine composition and a preparation method and application thereof; active ingredients of the traditional Chinese medicine composition include rose, bergamot, cydonia, poria cocos, Chinese yam, gordon euryale seed, coix seed, sea buckthorn, malt, chicken gizzard, angelica, longan, medlar, donkey-hide gelatin, mulberry, kelp, oyster, dandelion, dried tangerine or orange peel, platycladus, yellow mustard seed, peach kernel, saffron, radix astragali, American ginseng, raw sun-dried ginseng, dendrobium officinale, lily, ganoderma lucidum, jujube and mint; the traditional Chinese medicine composition is formed by the principle of monarch, minister, assistant and guide, forms a traditional Chinese medicine prescription of specific active ingredients, forms a herbal ointment that treats in all directions, has a remarkable curative effect on breast nodules, and has a good taste, is portable, and meets the long-term treatment requirements.

The present disclosure provides a breast nodule three-dimensional reconstruction method and system, the method comprising acquiring multiple frames of breast ultrasound images and preprocessing, the preprocessing comprising filtering denoising processing and image enhancement processing; a lightweight convolutional neural network structure is used to extract features from the images to obtain feature maps; a segmentation module is used to segment the feature maps; SGBM stereo matching operation is performed on the segmented images to obtain disparity information between the images, and the disparity information is adaptively corrected to realize three-dimensional reconstruction of the breast nodule; a dynamic calibration mechanism is established and an adaptive adjustment algorithm is designed to continuously optimize and calibrate the three-dimensional reconstruction operation. Through image preprocessing, optimization algorithm, dynamic calibration and adaptive adjustment, the present disclosure overcomes the problems of high image quality requirement, susceptibility to influence, large calculation resource consumption and low three-dimensional reconstruction precision in the prior art.

The invention discloses a breast nodule detection method and system based on ultrasonic medicine, and the method comprises the steps: firstly obtaining breast ultrasonic video data, and carrying out the preprocessing of interception, zooming, sampling, screening, enhancement and the like; 18 layers of ResNet18 are adopted for feature extraction, a linear classification network and an attention selection network are combined, and a detection model is constructed through optimization of a cross entropy and a center loss function. The system is correspondingly provided with a feature extraction module, a linear classification module and the like. And finally, to-be-tested video data are input into the model, so that whether breast nodules exist or not and the result of benign and malignant nodules can be quickly obtained, and efficient and accurate assistance is provided for breast disease diagnosis.

The invention discloses an ABUS-based nodule elastography detection method, device and equipment and a medium, and the method comprises the following steps: controlling a probe in an ABUS to carry out flat scanning along the surface of a mammary gland, obtaining a cross section two-dimensional ultrasonic image, and generating a coronal plane image; detecting and identifying the position of a focus in the coronal plane image, and tracing a cross section image sequence containing the focus; detecting and segmenting the focus, and determining the specific position of the focus in the sequence; a probe in the ABUS is controlled to move to the section position corresponding to the maximum section of the focus, the probe in the ABUS is controlled to apply pressure to the surface of the tissue, so that the tissue deforms, the displacement change of the tissue under the pressure effect is recorded, and a strain elasticity image is generated; and evaluating the relative hardness of the lesion area according to the strain elasticity image. The method has the advantages that the ABUS is used for achieving elastography of breast nodules, the relative hardness of a focus area is evaluated, the method can be used for breast lesion screening, positioning and tracking return visit, and the performance and application of ABUS equipment are expanded.

The application provides a traditional Chinese medicine external application composition for treating benign breast disease and preparation and application thereof, and belongs to the technical field of traditional Chinese medicine compositions, and is used for solving the problems of slow effect, large side effect and poor compliance of existing drugs for treating benign breast disease. The composition is composed of Tribulus terrestris 8-12 parts, Taraxacum officinale 8-12 parts, Pheretima 2-4 parts, Cornu Cervi 8-12 parts, mirabilite 16-24 parts, Pericarpium Citri Reticulatae Viride 10-14 parts, Swertia 8-12 parts, Ophiocordyceps sinensis 2-4 parts and borneol 1-3 parts. The medicinal materials are prepared into an external application powder, and the breast part is externally applied before sleep, and the application time is more than 6 hours each time. The application adopts external use and transdermal administration, has fast effect, no digestive tract stimulation and liver and kidney burden, is convenient to use, has high compliance, and is clinically verified to have exact curative effect on mastalgia, breast hyperplasia and benign breast nodules (including BI-RADS 3 and 4a nodules), has high safety, and is suitable for long-term conditioning of benign breast disease.

The invention provides a breast ultrasound image segmentation method based on state propagation and edge prior and application thereof, and belongs to the field of medical image processing. In order to solve the problems of large noise interference, blurred focus boundary and insufficient long-range dependence modeling of a breast ultrasound image, the invention provides an SP-EdgeNet network, and a mixed feature enhancement module is constructed to replace traditional jump connection. The module captures a global context by using a state propagation path, explicitly enhances a geometric edge by using an edge prior path, and dynamically fuses through an adaptive mechanism. And meanwhile, a structure-semantic decoupling module and a cross-resolution collaborative mechanism are supplemented, so that deep purification and multi-scale alignment of the features are realized. According to the method, the problems of edge degradation and semantic gaps in feature transmission are effectively solved, and the breast nodule segmentation precision and boundary integrity are remarkably improved.

The invention provides a diagnostic reagent and method for early discovery of breast nodules based on serum GRP detection. The reagent comprises a GRP standard substance, a GRP primary antibody, a buffer solution, a developing solution and a stop solution, the GRP level in serum is detected through enzyme-linked immunosorbent assay (ELISA), and the reagent is used for screening breast benign nodules and early breast cancer. By collecting a serum sample, detecting the GRP concentration and comparing the GRP concentration with a healthy control group, existence of breast nodules is judged, and the kit has high sensitivity and specificity, is particularly suitable for early-stage cases without obvious anomalies in imaging, and provides an efficient tool for non-invasive diagnosis of breast diseases. The diagnostic reagent is easy and convenient to operate, short in detection time and suitable for clinical large-scale screening, the method is combined with correlation analysis of the GRP level and the nodule volume, benign nodules, early breast cancer and advanced breast cancer can be effectively distinguished, a basis is provided for disease prognosis evaluation, the accuracy of early discovery of breast nodules is remarkably improved, and the clinical application prospect is wide. And an important reference is provided for formulating a treatment scheme.

The invention relates to a method for obtaining pathological diagnosis according to color ultrasound images of breast nodules by applying an artificial intelligence technology. The breast nodule color ultrasound image-pathological diagnosis system has the functions of image acquisition, image preprocessing, feature extraction, image recognition and the like, and can be used for recognizing, extracting and memorizing color ultrasound image features of breast nodules and internal features of abnormal cells in pathological tissue staining pictures of the breast nodules. Color Doppler ultrasound image data of breast nodules directly correspond to pathological picture data, and the data can be interpreted. A color Doppler ultrasound image database and a pathological picture database of breast nodules are established, deep learning is carried out with sufficient data, and functions are improved. The system is verified and clinically tested to ensure the accuracy of the system. Pathological diagnosis can be displayed after color Doppler ultrasound image data of breast nodules are input into the system. The device has the advantages that pathological diagnosis can be judged when nodules are seen on breast color ultrasound, so that the aim of accurate treatment is fulfilled. Clinical final diagnosis is based on pathological results under a microscope.

The invention relates to application of an FABP4 inhibitor in preparation of a medicament for preventing and treating alopecia and a medicament for growing hair. Research finds that the FABP4 inhibitor can promote hair growth and induce hair follicle increase in the growth period and can be used in drugs for preventing and treating alopecia and / or hair growth drugs, and the FABP4 inhibitor does not need to regulate the effects of hormones and related pathways and does not have the risk of induced dysfunction or breast nodules and the like; the FABP4 inhibitor can be orally taken, so that the irritation to the skin is avoided, and the administration is convenient.

The application relates to a breast cancer risk assessment method and related equipment. The method comprises the following steps: obtaining germline genome sequencing data of a target object; the target object is a patient to be evaluated who is positive for breast nodules according to an ultrasonic examination result; inputting the germline genome sequencing data into a breast cancer germline genome evaluation model to obtain a breast cancer germline etiology score result of the target object; determining an immune exhaustion state evaluation result according to immune cell detection data of the target object and immune exhaustion reference information; the immune exhaustion reference information is obtained based on immune exhaustion analysis data of a non-breast cancer population; combining the breast cancer germline etiology score result and the immune exhaustion state evaluation result to obtain a breast cancer risk assessment result of the target object; the immune exhaustion state evaluation result is used for verifying the breast cancer germline etiology score result from the function level of immune cells. The method can effectively improve the accuracy of breast cancer risk assessment.

This invention discloses a medicinal and edible herbal composition with expectorant and nodule-dispersing effects and its preparation method, belonging to the technical field of medicinal and edible herbal compositions. The composition comprises 10-30 parts oyster shell, 10-20 parts tangerine peel, 10-20 parts Poria cocos, 10-20 parts bergamot, 8-18 parts honeysuckle, and 10-30 parts houttuynia cordata. A preferred ratio is 30 parts oyster shell, 15 parts tangerine peel, 15 parts Poria cocos, 15 parts bergamot, 9 parts honeysuckle, and 30 parts houttuynia cordata. Honey and other medicinal and edible excipients can be added. The preparation involves raw material pretreatment, volatile oil extraction, decoction, concentration, molding, and sterilization steps, and can be made into various dosage forms such as powder and granules. The raw materials used in this invention are all food and medicine homologous ingredients, which are safe for long-term use. The formula follows the theory of "softening and dispersing nodules, regulating qi and resolving phlegm, clearing heat and detoxifying". It improves the pathological microenvironment of nodules through related signaling pathways, and can effectively promote the shrinkage or dissipation of benign lung nodules, thyroid nodules and breast nodules. The preparation process is simple and has broad application prospects.

The invention is suitable for the technical field of ultrasonic image target detection, and relates to an ABUS image breast nodule automatic detection method, which comprises the following steps: S10, extracting ABUS three-view original video data frame by frame into three-view two-dimensional ultrasonic tomographic images, and constructing an ABUS breast nodule cross section data set; s20, constructing a cross-section breast nodule detection network, wherein the cross-section breast nodule detection network comprises BUS-Mama breast ultrasound special image encoder construction and detection head construction; s30, constructing a secondary identification model of the Mama block nodules of the three views; s40, cross section breast nodule detection network training and three-view Mama nodule secondary identification model training are carried out; and S50, carrying out BUS-Mama cross section nodule coarse detection and three-view Mama block nodule secondary identification. The method is simple in process and convenient to operate, and the breast nodule detection accuracy and efficiency are effectively improved.

The application discloses a traditional Chinese medicine composition suitable for preventing female breast hyperplasia and dissipating breast nodules and a traditional Chinese medicine breast patch, and belongs to the technical field of external preparations of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from Chinese herbal medicines of the blood-activating and stasis-dissolving type, the liver-soothing and qi-regulating type, the heat-clearing and swelling-dissolving type and the deficiency-tonifying and regulating type, such as Bupleurum, Radix Curcumae, etc., and is prepared into small-molecule extracts below 3kDa after composite fermentation of Lactobacillus plantarum and Bacillus subtilis and composite enzymolysis of cellulase, etc.; the traditional Chinese medicine breast patch is prepared into a paste from the composition, transdermal adjuvants, humectants and the like, and is coated on a base of a composite breathable non-woven fabric of bamboo fiber, wormwood fiber and viscose fiber. The application has scientific formula, treats both symptoms and root causes, has good transdermal absorption effect of small-molecule extracts, is comfortable and non-irritating in patching, can quickly relieve breast distending pain and dissipate breast nodules, can also strengthen body resistance and reduce the recurrence rate, is safe and reliable, is suitable for female patients with various benign breast diseases, is especially suitable for patients intolerable to oral administration, and is easy to be industrially produced.

This application proposes a breast ultrasound image segmentation method based on state propagation and edge priors, and its application, belonging to the field of medical image processing. Addressing the problems of high noise interference, blurred lesion boundaries, and insufficient long-range dependency modeling in breast ultrasound images, this invention proposes the SP-EdgeNet network, constructing a hybrid feature enhancement module to replace traditional skip connections. This module uses the state propagation path to capture the global context, explicitly enhances geometric edges using the edge prior path, and dynamically fuses them through an adaptive mechanism. Simultaneously, a structure-semantic decoupling module and a cross-resolution collaborative mechanism are employed to achieve deep feature cleansing and multi-scale alignment. This invention effectively solves the problems of edge degradation and semantic gap in feature propagation, significantly improving the accuracy and boundary integrity of breast nodule segmentation.

The invention provides a medical fever-reducing traditional Chinese medicine liquid capable of treating pain. The medical fever-reducing traditional Chinese medicine liquid is prepared from, by weight, 21 g of gastrodia elata, 3 g of mint, 21 g of ligusticum wallichii, 10 g of caulis spatholobi, 10 g of radix angelicae pubescentis, 10 g of lycopodium clavatum, 10 g of notopterygium root, 10 g of garden balsam stem, 6 g of angelica sinensis, 2 g of radix angelicae, 6 g of ginger, 6 g of lemon, 6 g of wormwood, 6 g of codonopsis pilosula, 6 g of ginseng, 1 g of liquorice, 0.3 g of folium eucalypti, 3.5 g of lavender and 4 g of rosemary. The fever-reducing traditional Chinese medicine liquid prepared by the invention has all-around effects of assisting fever reduction and aiming at various discomforts caused by cervical vertebra, such as migraine, lumbar vertebra soreness, numbness, redness, swelling and pain, gout, rheumatic arthritis, breast nodules, dysmenorrhea, refreshing and restoring consciousness, sprain, shoulder pain, joint pain, tendons and temple pain, headache and the like, and the purposes of reducing fever and relieving pain can be effectively achieved.