Traditional Chinese medicine patch for treating breast nodules and preparation process thereof

Abstract

The invention relates to the technical field of mastopathy medicines, and discloses a traditional Chinese medicine patch for treating breast nodules and a preparation process thereof. The traditional Chinese medicine patch comprises the following raw materials: safflower, pollen typhae, caulis spatholobi, angelica sinensis, trogopterus dung, lumbricus, gastrodia elata, pseudo-ginseng, cassia twig, thunberg fritillary bulb, frankincense, endothelium corneum gigeriae galli, rhizoma atractylodis, platycodon grandiflorum, curcuma zedoary, radix semiaquilegiae, radix bupleuri and salvia miltiorrhiza. Through reasonable compatibility of the raw materials and effective extraction of the active ingredients of the traditional Chinese medicines, the effects of the raw materials can be maximized, all the components have a synergistic effect, the permeability is high, the efficacy is lasting, and the traditional Chinese medicine preparation has the effects of soothing liver and regulating qi, promoting blood circulation to remove meridian obstruction, eliminating stasis and dissipating binds, clearing heat and dispelling wind, and nourishing yin and relieving pain; the traditional Chinese medicine composition has obvious curative effects on various breast diseases such as breast nodules, hyperplasia of mammary glands, pains, lumps and the like, the nodules disappear, and the mammary glands basically have no pains and uncomfortable symptoms.

Description

Technical Field

[0001] The invention relates to the technical field of breast disease drugs, and more specifically to a traditional Chinese medicine patch for treating breast nodules and a preparation process thereof. Background Art

[0002] The breast is one of the target organs of estrogen. Due to the decrease of progesterone and the excessive secretion of estrogen, the imbalance of the ratio of estrogen and progesterone acts on the sensitive breast tissue for a long time, thus causing breast diseases. Among breast diseases, the incidence of breast nodules and breast hyperplasia is very high, which brings a lot of physical and mental pain and a huge economic burden to patients. Among them, breast nodules are more common in young and middle-aged women. The incidence has gradually increased in recent years, and there is a possibility of canceration. It has become one of the main diseases that endanger women's health, often accompanied by pain and discomfort, causing serious troubles to women's work and life. Breast nodules belong to "breast disease syndrome" in traditional Chinese medicine. The occurrence of this disease is related to kidney deficiency, Chongren disorder, liver qi stagnation, qi stagnation and blood stasis, and spleen deficiency and dysfunction. Kidney deficiency is the root of the disease, and liver depression is the symptom of the disease. Modern medicine believes that the onset of breast nodules is related to endocrine disorders, low levels of corpus luteum in the body and relatively increased estrogen secretion, which cause hyperplasia of mammary duct epithelial cells and fibrous tissue. At the same time, the body is affected by certain stress factors, such as high pressure in life and emotional tension, which leads to the inability of the proliferated tissue to recover or incomplete recovery, forming nodules or fibroids, accompanied by breast pain.

[0003] Western medicine often uses hormones, iodine preparations or other symptomatic medications or surgical treatments for breast nodules, but there are many side effects such as hirsutism and hoarseness of voice. In addition, the surgery mainly removes the nodules and dilated glands, and the endocrine system in the body is not corrected, so there are problems such as easy recurrence. The current topical drugs of traditional Chinese medicine can only relieve discomfort to a certain extent, but cannot regulate the patient's own endocrine level, so they cannot cure the disease and are slow to take effect. Oral drugs have great side effects and are prone to endocrine disorders, gastrointestinal irritation and other problems.

[0004] Therefore, how to obtain a traditional Chinese medicine patch for treating breast nodules and its preparation process is a problem that those skilled in the art need to solve urgently. Summary of the invention

[0005] In view of this, the present invention provides a traditional Chinese medicine patch for treating breast nodules and a preparation process thereof.

[0006] In order to achieve the above object, the present invention adopts the following technical solution:

[0007] A traditional Chinese medicine patch for treating breast nodules comprises the following raw materials: safflower, pollen, millettia reticulata, angelica, aconiti lobata, earthworm, gastrodia, notoginseng, cassia twig, fritillaria thunbergii, frankincense, chicken gizzard lining, atractylodes, platycodon, zedoaria, tiankui seeds, bupleurum and salvia miltiorrhiza.

[0008] Preferably, the ingredients, by weight, include: 60-80 parts of safflower, 60-80 parts of pollen, 50-60 parts of millettia reticulata, 48-55 parts of angelica sinensis, 48-55 parts of aconiti lobata, 40-45 parts of earthworms, 40-45 parts of gastrodia elata, 30-40 parts of notoginseng, 30-40 parts of cassia twig, 25-28 parts of fritillaria thunbergii, 20-23 parts of frankincense, 20-23 parts of chicken's gizzard lining, 10-15 parts of atractylodes, 10-18 parts of platycodon, 6-12 parts of zedoaria, 6-12 parts of tiankui seeds, 3-8 parts of bupleurum, and 3-8 parts of salvia miltiorrhiza.

[0009] Preferably, the ingredients, by weight, include: 70 parts of safflower, 70 parts of pollen, 55 parts of millettia reticulata, 50 parts of angelica sinensis, 50 parts of aconiti lobata, 42 parts of earthworms, 42 parts of gastrodia elata, 35 parts of notoginseng, 35 parts of cassia twig, 26 parts of fritillaria thunbergii, 22 parts of frankincense, 22 parts of chicken's gizzard lining, 12 parts of atractylodes, 15 parts of platycodon, 8 parts of curcuma, 8 parts of amaranth, 6 parts of bupleurum, and 6 parts of salvia miltiorrhiza.

[0010] As the same inventive concept as the above technical solution, the present invention also claims protection for a method for preparing the above Chinese medicine patch, comprising the following steps:

[0011] (1) Weighing each raw material according to the above weight parts;

[0012] (2) Grinding safflower, pollen, millettia, angelica, aconiti lobata, earthworm, gastrodia, notoginseng, cassia twig, and thunbergia thunbergii into powder with an average particle size of 30 to 40 mesh using a pulverizer, extracting the obtained powder by heating and refluxing with deionized water for 3 to 5 times, filtering, combining the extracts, and concentrating them into an extract with a relative density of 1.15 to 1.25 to obtain extract I;

[0013] (3) Grinding frankincense, chicken gizzard lining, atractylodes, platycodon, zedoaria, kelp seed, bupleurum, and salvia miltiorrhiza into powder with an average particle size of 40 to 60 mesh using a pulverizer, adding the obtained powder into an ethanol solution, performing ultrasound-assisted extraction, filtering, recovering ethanol in the filtrate, and concentrating the filtrate into an extract with a relative density of 1.15 to 1.25 to obtain extract II;

[0014] (4) Mixing extract I and extract II, and drying under reduced pressure to obtain a Chinese medicine patch.

[0015] Preferably, the mass ratio of the powder to deionized water in step (2) is 1:5-8.

[0016] Preferably, the extraction temperature in step (2) is 80-95° C., and the extraction time is 40-90 min.

[0017] Preferably, the volume fraction of the ethanol solution in step (3) is 60-85%.

[0018] Preferably, the power of the ultrasound in step (3) is 800-1000W and the frequency is 20-30kHz.

[0019] Preferably, the extraction temperature in step (3) is 60-70°C and the extraction time is 30-60 minutes.

[0020] Preferably, the temperature of the reduced pressure drying in step (4) is 40-55° C. and the time is 12-20 h.

[0021] The effects of the raw materials in the Chinese medicine patch of the present invention are as follows:

[0022] Safflower: pungent, dispersing, warming and unblocking, enters the heart and liver meridians. Good at promoting blood circulation and removing blood stasis, relieving swelling and pain, strong medicinal effect. Can dredge breast ducts and dissipate breast nodules.

[0023] Typhae pollen: sweet and neutral in nature. It enters the liver and pericardium meridians. It has the effects of promoting blood circulation and removing blood stasis, softening and dispersing nodules. It mainly contains naringenin, isorhamnetin-3-O-neohesperidin, cattail glycosides, quercetin, etc. It also contains steroids, volatile oils, polysaccharides, etc.

[0024] Millettia reticulata: bitter, sweet, warm in nature. Enters the liver and kidney meridians. Slightly smelly, astringent in taste. Bitter, warming, slightly sweet, nourishing, enters the liver and kidney meridians. It not only activates blood circulation and relieves pain, but also nourishes blood and relaxes tendons and relieves pain.

[0025] Angelica: Sweet, pungent, warm, enters the liver, heart, and spleen meridians. Sweet can moisten, pungent and warm can disperse, which can effectively promote the evacuation of breast nodules.

[0026] Wulingzhi: bitter, salty, sweet, warm; enters the liver meridian. Bitter, purgative, warming, different effects when raw or stir-fried. Raw is better at dispersing, good at promoting blood circulation, unblocking meridians and relieving pain, and treats various pains caused by blood stasis.

[0027] Earthworm: salty in taste and cold in nature, it enters the liver, spleen, and bladder meridians. This product is salty and cold, clearing away heat and purging, and it can move freely and unblock the meridians. It enters the liver meridian, can clear away heat and calm the wind, and stop spasms; it moves along the meridians, can dredge the meridians and treat arthritis. It has the effects of clearing heat and calming the nerves, and dredge the meridians.

[0028] Gastrodia elata: sweet, neutral in nature, and enters the liver meridian. Gastrodia elata is sweet, slow, heavy, soft and moist without being dry, neutral in nature, and enters the liver. It is good at calming wind and stopping spasms, calming liver yang, and treating liver yang and liver wind symptoms, regardless of cold, heat, deficiency or excess. It can dispel wind and dredge meridians, and treat arthralgia, limb numbness, and paralysis of hands and feet.

[0029] Panax notoginseng: sweet, slightly bitter, warm in nature, enters the liver and stomach meridians. Panax notoginseng is slightly bitter and dispersing, sweet and warming, and has both moving and guarding properties, and can both dissipate and replenish. It has strong hemostatic and stasis-dissolving properties, and can replenish deficiency, with the advantages of stopping bleeding without leaving stasis, and activating blood circulation without consuming qi. It has the effects of dispersing stasis, stopping bleeding, and relieving swelling and pain.

[0030] Cinnamon twig: pungent, sweet, warm. It enters the heart, lung, and bladder meridians. Cinnamon twig is pungent, dispersing, warming, and tonifying. It is sweet, warm, and yang-boosting. It warms and tonifies, moistens and tonifies the yang qi of the whole body, and tonifies the blood vessels of the whole body. It enters the lung and bladder meridians, and is good at dispersing wind and cold and relieving wind and cold or wind evil on the surface. It enters the heart meridian and blood, and is good at warming and tonifying the yang, dispersing cold evil, tonifying the blood vessels, unblocking the chest yang, warming and transforming water and dampness, and relieving pain. It is not as good as ephedra in sweating, but is good at boosting yang and tonifying the blood vessels. It moves both on the surface and inside, and is suitable for all wind-cold symptoms, whether they are deficiency or excess, and for all cold symptoms, whether they are deficiency or excess, or external cold directly in the body, or yang deficiency and internal generation. It enters both the qi and blood, and it is advisable to stop using it if there is blood stasis, cold, and yang deficiency and water. It has the effects of sweating and relieving muscles, warming and unblocking the meridians, assisting yang and transforming qi, and balancing and descending qi.

[0031] Fritillaria thunbergii: bitter and cold in nature. Enters the lung and heart meridians. Has the effects of clearing away heat and detoxifying, dispersing nodules and eliminating carbuncle.

[0032] Frankincense: pungent, bitter, warm. Enters the heart, liver, and spleen meridians. This product is pungent and fragrant, dispersing, bitter, warming, and enters the heart, liver, and spleen meridians. It is good at promoting blood circulation, and blood circulation can relieve pain, stretch tendons, reduce swelling, and promote muscle growth. Therefore, it can promote blood circulation, relieve pain, reduce swelling, promote muscle growth, and stretch tendons.

[0033] Chicken gizzard lining: sweet, flat, enters spleen, stomach, small intestine, bladder meridian. It has the effect of relieving stranguria and dispelling stones, and can promote the disappearance of nodules.

[0034] Atractylodes: pungent, bitter, warm in nature. Enters the spleen, stomach, and liver meridians. Expels wind and dampness, relieves pain and reduces swelling.

[0035] Platycodon grandiflorum: It is bitter, pungent, and neutral in nature. It belongs to the lung meridian. Platycodon grandiflorum can lead the medicine upward, carry the medicine directly to the affected area, and improve the efficacy of the whole prescription. Platycodon grandiflorum's main component, platycodon saponin, can increase the leaching amount of insoluble components in other drugs through solubilization, thereby increasing the absorption of other drugs.

[0036] Curcuma: Medicinal properties are pungent, bitter, and warm. It enters the liver and spleen meridians. It enters the blood and moves the qi, and has a strong medicinal effect. It is a product that breaks blood and moves the qi to relieve pain and eliminate symptoms, and it also moves the qi to eliminate accumulation and eliminate swelling and relieve pain.

[0037] Tiankuizi: cold in nature, bitter and pungent in taste, has the effects of clearing away heat and detoxifying, reducing swelling and dispersing nodules. It is suitable for internal blood heat or breast pain caused by nipple obstruction, external evil fire poison, or milk obstruction.

[0038] Bupleurum: Medicinal properties are pungent, bitter, and slightly cold. It enters the liver, gallbladder, and lung meridians. Bitterness dissipates and pungentness disperses, aromaticity ascends, and slightly coldness can clear. It can disperse the evil qi in the gallbladder meridian and relieve fever, and it can also disperse the stagnant qi in the liver and gallbladder meridians and relieve liver depression.

[0039] Danshen: bitter in nature, slightly cold, enters the heart and liver meridians. Bitterness can dissipate, and slightly cold can clear. It can not only activate blood circulation, remove blood stasis, relieve pain, but also refresh and cool blood, relieve restlessness and eliminate carbuncle. It is mainly used to treat blood stasis, blood heat, heat disturbing the mind, and heat-toxic sores, carbuncle, swelling and pain.

[0040] When the Chinese medicine patch of the present invention is used, a pharmaceutically acceptable carrier is added and the patch is applied to the affected part. Each patch can be applied for 2-3 days, 5 patches constitute a course of treatment, and the patch will take effect within 7 days. The affected part can be cured within 3-5 courses of treatment without recurrence of the disease.

[0041] It can be seen from the above technical solution that, compared with the prior art, the present invention discloses a Chinese medicine patch for treating breast nodules and a preparation process thereof, which has the following beneficial effects:

[0042] (1) The present invention can maximize the effects of the raw materials through the reasonable combination of various raw materials and the effective extraction of the active ingredients of traditional Chinese medicine. The components are synergistic, the permeability is strong, the medicinal effect is long-lasting, and the efficacy is soothing the liver and regulating qi, promoting blood circulation and unblocking collaterals, eliminating stasis and dispersing nodules, clearing away heat and dispelling wind, nourishing yin and relieving pain. It has obvious therapeutic effects on various breast diseases such as breast nodules, breast hyperplasia, pain, lumps, etc., which are manifested as the disappearance of nodules and the basic absence of pain and discomfort symptoms in the breast.

[0043] (2) Compared with oral preparations, the Chinese medicine patch of the present invention can act directly on the lesion site, has a mild effect, is conducive to absorption, does not stimulate the digestive system, has the advantages of short effective time and high safety. At the same time, the raw material source is wide, the preparation method is simple, and it is suitable for large-scale application. DETAILED DESCRIPTION

[0044] The technical solutions in the embodiments of the present invention are described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0045] Example 1

[0046] A traditional Chinese medicine patch for treating breast nodules comprises the following raw materials, measured by weight: 60 parts of safflower, 60 parts of pollen, 50 parts of millettia reticulata, 48 parts of angelica, 48 parts of aconiti lobata, 40 parts of earthworms, 40 parts of gastrodia, 30 parts of notoginseng, 30 parts of cassia twig, 25 parts of fritillaria thunbergii, 20 parts of frankincense, 20 parts of chicken gizzard lining, 10 parts of atractylodes, 10 parts of platycodon, 6 parts of zedoaria, 6 parts of tiankui seeds, 3 parts of bupleurum, and 3 parts of salvia miltiorrhiza.

[0047] The preparation method of the above-mentioned Chinese medicine patch comprises the following steps:

[0048] (1) Weighing each raw material according to the above weight parts;

[0049] (2) Grinding safflower, pollen, millettia, angelica, aconiti lobata, earthworm, gastrodia, notoginseng, cassia twig, and thunbergia thunbergii into powder with an average particle size of 30 mesh using a pulverizer, extracting the obtained powder by heating and refluxing with deionized water for 3 times, filtering, combining the extracts, and concentrating them into an extract with a relative density of 1.2 to obtain extract I;

[0050] (3) using a pulverizer to grind frankincense, chicken gizzard lining, atractylodes, platycodon, zedoaria, kelp seed, bupleurum, and salvia miltiorrhiza into powder with an average particle size of 40 mesh, adding the obtained powder to an ethanol solution, performing ultrasound-assisted extraction, filtering, recovering ethanol in the filtrate, and concentrating it into an extract with a relative density of 1.2 to obtain extract II;

[0051] (4) mixing extract I and extract II, and drying under reduced pressure to obtain a Chinese medicine patch;

[0052] The mass ratio of the powder to deionized water in step (2) is 1:5;

[0053] The extraction temperature in step (2) is 80° C. and the extraction time is 40 min.

[0054] The volume fraction of the ethanol solution in step (3) is 60%;

[0055] The power of the ultrasound in step (3) is 800W and the frequency is 20kHz;

[0056] The extraction temperature in step (3) is 60° C. and the extraction time is 30 min;

[0057] The temperature of the reduced pressure drying in step (4) is 40° C. and the time is 12 h.

[0058] Example 2

[0059] A traditional Chinese medicine patch for treating breast nodules comprises the following raw materials, measured by weight: 80 parts of safflower, 80 parts of pollen, 60 parts of millettia reticulata, 55 parts of angelica, 55 parts of aconiti lobata, 45 parts of earthworms, 45 parts of gastrodia, 40 parts of notoginseng, 40 parts of cassia twig, 28 parts of thunbergia thunbergii, 23 parts of frankincense, 23 parts of chicken's gizzard lining, 15 parts of atractylodes, 18 parts of platycodon, 12 parts of zedoaria, 12 parts of tiankui seeds, 8 parts of bupleurum, and 8 parts of salvia miltiorrhiza.

[0060] The preparation method of the above-mentioned Chinese medicine patch comprises the following steps:

[0061] (1) Weighing each raw material according to the above weight parts;

[0062] (2) Grinding safflower, pollen, millettia, angelica, aconiti lobata, earthworm, gastrodia, notoginseng, cassia twig, and thunbergia thunbergii into powder with an average particle size of 40 mesh using a pulverizer, extracting the obtained powder by heating and refluxing with deionized water for 5 times, filtering, combining the extracts, and concentrating them into an extract with a relative density of 1.25 to obtain extract I;

[0063] (3) using a pulverizer to grind frankincense, chicken's gizzard lining, atractylodes, platycodon, zedoaria, kelp seed, bupleurum, and salvia miltiorrhiza into powder with an average particle size of 60 mesh, adding the obtained powder to an ethanol solution, performing ultrasound-assisted extraction, filtering, recovering ethanol in the filtrate, and concentrating it into an extract with a relative density of 1.25 to obtain extract II;

[0064] (4) mixing extract I and extract II, and drying under reduced pressure to obtain a Chinese medicine patch;

[0065] The mass ratio of the powder to deionized water in step (2) is 1:7;

[0066] The extraction temperature in step (2) is 95° C. and the extraction time is 90 min each time;

[0067] The volume fraction of the ethanol solution in step (3) is 80%;

[0068] The power of the ultrasound in step (3) is 1000W and the frequency is 30kHz;

[0069] The extraction temperature in step (3) is 70° C. and the extraction time is 60 min;

[0070] The temperature of the reduced pressure drying in step (4) is 55° C. and the time is 20 h.

[0071] Example 3

[0072] A traditional Chinese medicine patch for treating breast nodules comprises the following raw materials, measured by weight: 70 parts of safflower, 70 parts of pollen, 55 parts of millettia reticulata, 50 parts of angelica, 50 parts of aconiti lobata, 42 parts of earthworms, 42 parts of gastrodia, 35 parts of notoginseng, 35 parts of cassia twig, 26 parts of thunbergii, 22 parts of frankincense, 22 parts of chicken's gizzard lining, 12 parts of atractylodes, 15 parts of platycodon, 8 parts of zedoaria, 8 parts of tiankui seeds, 6 parts of bupleurum, and 6 parts of salvia miltiorrhiza.

[0073] The preparation method of the above-mentioned Chinese medicine patch comprises the following steps:

[0074] (1) Weighing each raw material according to the above weight parts;

[0075] (2) Grinding safflower, pollen, millettia, angelica, aconiti lobata, earthworm, gastrodia, notoginseng, cassia twig, and thunbergia thunbergii into powder with an average particle size of 40 mesh using a pulverizer, extracting the obtained powder with deionized water by heating and refluxing for 4 times, filtering, combining the extracts, and concentrating them into an extract with a relative density of 1.2 to obtain extract I;

[0076] (3) using a pulverizer to grind frankincense, chicken gizzard lining, atractylodes, platycodon, zedoaria, kelp seed, bupleurum, and salvia miltiorrhiza into powder with an average particle size of 60 mesh, adding the obtained powder to an ethanol solution, performing ultrasound-assisted extraction, filtering, recovering ethanol in the filtrate, and concentrating it into an extract with a relative density of 1.2 to obtain extract II;

[0077] (4) mixing extract I and extract II, and drying under reduced pressure to obtain a Chinese medicine patch;

[0078] The mass ratio of the powder to deionized water in step (2) is 1:7;

[0079] The extraction temperature in step (2) is 85° C. and the extraction time is 60 min each time;

[0080] The volume fraction of the ethanol solution in step (3) is 75%;

[0081] The power of the ultrasound in step (3) is 900 W and the frequency is 25 kHz;

[0082] The extraction temperature in step (3) is 65° C. and the extraction time is 40 min;

[0083] The temperature of the reduced pressure drying in step (4) is 45° C. and the time is 14 h.

[0084] Comparative Example 1

[0085] A Chinese medicine patch for treating breast nodules is prepared by removing safflower and pollen cattail from the raw materials of Example 3, while the rest of the raw materials are the same.

[0086] Comparative Example 2

[0087] A Chinese medicine patch for treating breast nodules is prepared by removing angelica sinensis, aconite root and earthworm from the raw materials of Example 3, while the rest of the raw materials are the same.

[0088] Comparative Example 3

[0089] A Chinese medicine patch for treating breast nodules is prepared by removing frankincense, chicken gizzard lining, atractylodes lancea and platycodon grandiflorum from the raw materials of Example 3, while the rest of the raw materials are the same.

[0090] Comparative Example 4

[0091] A traditional Chinese medicine patch for treating breast nodules is prepared by replacing 70 parts of safflower and 70 parts of pollen cattail with 140 parts of safflower based on the raw materials of Example 3.

[0092] Effects of Chinese medicine patch on mammary nodules in rats in animal experiments

[0093] 100 female non-pregnant Wi star rats, weighing 190-240g, were selected and randomly divided into multiple groups: blank group, model group, Example 1-3 groups, and Comparative Example 1-4 groups, with 10 rats in each group. Except for the blank group, each group was intraperitoneally injected with 0.5 mg / kg of estradiol benzoate, once a day, for 20 consecutive days, and then intramuscularly injected with progesterone, 5 mg / kg, once a day on the 21st-25th day. The blank group was gavaged with the same volume of normal saline. Starting from the 26th day, the corresponding Chinese medicine patches were applied to the breasts of the rats in the Example and Comparative Example groups, once a day, for 30 consecutive days.

[0094] After the application, the nipples of the blank group showed no obvious changes. The nipples of the model group rats were red and swollen, and enlarged significantly. The nipples of the example rats were slightly red and swollen, and slightly enlarged. The redness and swelling of the control rats were lighter than those of the model group, but more serious than those of the example. Therefore, the present invention has a significant inhibitory effect on breast nodules.

[0095] (1) The nipple diameter and nipple height of the second pair of breasts of each mouse were measured with a vernier caliper, and the average was taken. As shown in Table 1. Analysis shows that after the rats were affected by estrogen, endocrine abnormalities occurred, and the nipples were red, swollen and enlarged, as shown in the model group. The Chinese medicine patch of the present invention can significantly improve the breast nodule situation, promote breast health, and reduce abnormal nipple diameter and nipple height. The comparative example lacks the key components of the present invention, and the therapeutic effect is relatively poor.

[0096] Table 1: Test results

[0097]

[0098]

[0099] (2) Blood was collected by decapitation, serum was separated, and serum estradiol (E2) and progesterone (P) were determined by ELISA. The average values ​​were taken, and the results are shown in Table 2. It can be seen that the present invention can reduce the estradiol content in serum, increase the progesterone content, regulate endocrine conditions, reduce the stimulation of estrogen on breast tissue, and improve breast nodules.

[0100] Therefore, the components of the present invention synergize and enhance the effect, have strong permeability, have the effects of soothing the liver and regulating qi, promoting blood circulation and unblocking collaterals, eliminating stasis and dispersing nodules, clearing away heat and expelling wind, nourishing yin and relieving pain, and have obvious therapeutic effects on breast nodules.

[0101] Table 2: Test results

[0102]

[0103]

[0104] The various embodiments in this specification are described in a progressive manner, and each embodiment focuses on the differences from other embodiments. The same or similar parts between the various embodiments can be referenced to each other.

[0105] Finally, it should be noted that the above content is only used to illustrate the technical solution of the present invention, rather than to limit the scope of protection of the present invention. Simple modifications or equivalent substitutions of the technical solution of the present invention by ordinary technicians in this field do not deviate from the essence and scope of the technical solution of the present invention.

Claims

1. A Chinese medicine patch for treating breast nodules, characterized in that: The following raw materials are included: safflower, pollen, Millettia reticulata, angelica, aconiti lobata, earthworm, gastrodia elata, Panax notoginseng, cassia twig, Fritillaria thunbergii, frankincense, chicken gizzard lining, atractylodes, platycodon, zedoaria, atractylodes seed, bupleurum, and salvia miltiorrhiza.

2. A Chinese medicine patch for treating breast nodules according to claim 1, characterized in that, The invention comprises, by weight, 60-80 parts of safflower, 60-80 parts of pollen cattail, 50-60 parts of millettia reticulata, 48-55 parts of angelica sinensis, 48-55 parts of aconiti lobata, 40-45 parts of earthworm, 40-45 parts of gastrodia elata, 30-40 parts of panax notoginseng, 30-40 parts of cassia twig, 25-28 parts of fritillaria thunbergii, 20-23 parts of frankincense, 20-23 parts of chicken gizzard lining, 10-15 parts of atractylodes, 10-18 parts of platycodon, 6-12 parts of zedoaria, 6-12 parts of tiankui seeds, 3-8 parts of bupleurum, and 3-8 parts of salvia miltiorrhiza.

3. A Chinese medicine patch for treating breast nodules according to claim 2, characterized in that, The ingredients, in parts by weight, include: 70 parts of safflower, 70 parts of pollen, 55 parts of millettia reticulata, 50 parts of angelica, 50 parts of aconite, 42 parts of earthworm, 42 parts of gastrodia, 35 parts of notoginseng, 35 parts of cassia twig, 26 parts of fritillaria, 22 parts of frankincense, 22 parts of chicken's gizzard lining, 12 parts of atractylodes, 15 parts of platycodon, 8 parts of curcuma, 8 parts of amaranth, 6 parts of bupleurum, and 6 parts of salvia miltiorrhiza.

4. A method for preparing a Chinese medicine patch for treating breast nodules according to any one of claims 1 to 3, characterized in that: The following steps are involved: (1) Weighing each raw material according to the above weight parts; (2) Grinding safflower, pollen, millettia, angelica, aconiti lobata, earthworm, gastrodia, notoginseng, cassia twig, and thunbergia thunbergii into powder with an average particle size of 30 to 40 mesh using a pulverizer, extracting the obtained powder by heating and refluxing with deionized water for 3 to 5 times, filtering, combining the extracts, and concentrating them into an extract with a relative density of 1.15 to 1.25 to obtain extract I; (3) Grinding frankincense, chicken gizzard lining, atractylodes, platycodon, zedoaria, kelp seed, bupleurum, and salvia miltiorrhiza into powder with an average particle size of 40 to 60 mesh using a pulverizer, adding the obtained powder into an ethanol solution, performing ultrasound-assisted extraction, filtering, recovering ethanol in the filtrate, and concentrating the filtrate into an extract with a relative density of 1.15 to 1.25 to obtain extract II; (4) Mixing extract I and extract II, and drying under reduced pressure to obtain a Chinese medicine patch.

5. A method for preparing a Chinese medicine patch for treating breast nodules according to claim 4, characterized in that: The mass ratio of the powder to deionized water in step (2) is 1:5-8.

6. A method for preparing a Chinese medicine patch for treating breast nodules according to claim 4, characterized in that: The extraction temperature in step (2) is 80-95° C., and the extraction time is 40-90 min each time.

7. A method for preparing a Chinese medicine patch for treating breast nodules according to claim 4, characterized in that: The volume fraction of the ethanol solution in step (3) is 60-85%.

8. A method for preparing a Chinese medicine patch for treating breast nodules according to claim 4, characterized in that: The power of the ultrasound in step (3) is 800-1000W and the frequency is 20-30kHz.

9. A method for preparing a Chinese medicine patch for treating breast nodules according to claim 4, characterized in that: The extraction temperature in step (3) is 60-70°C and the extraction time is 30-60 minutes.

10. The method for preparing a Chinese medicine patch for treating breast nodules according to claim 4, characterized in that: The temperature of the reduced pressure drying in step (4) is 40-55° C. and the time is 12-20 h.

Images