113 results about "Crocin" patented technology

The invention relates to an exosome composition for improving sleep quality. The exosome composition comprises a lavender exosome, a chamomile exosome and a saffron crocus exosome. The exosome composition disclosed by the invention can be used for improving the expression level of GABA (gamma-aminobutyric acid) related proteins of neuronal cells, promoting the expression of brain-derived neurotrophic factors (BDNF) of the neuronal cells, promoting the synaptic growth of the neuronal cells, improving the CL <-> level of the neuronal cells and inhibiting the inflammatory factor level of microglial cells. The exosome composition disclosed by the invention can be used for improving sleep quality reduction caused by various body discomfort, and has a more obvious using effect than that of the same Chinese herbal medicine extract.

The invention relates to the technical field of nano drug loading, in particular to chlorin e6 composite liposome as well as a preparation method and application thereof. The preparation method comprises the following steps: dissolving egg yolk lecithin, cholesterol and chlorin e6 in an organic solvent, carrying out rotary evaporation in a constant-temperature water bath kettle to evaporate the solvent to dryness to form a lipoid film, adding a crocin aqueous solution, carrying out high-shear dispersion on the film, carrying out ultrasonication, and filtering with a 0.22 [mu] m filter membrane to obtain the chlorin e6 composite liposome. The chlorin e6 composite liposome prepared by the invention is high in encapsulation efficiency and good in stability, and has the effects of enhancing tumor cell uptake and killing tumor cells through photodynamic.

The invention relates to an anti-aging composition for strengthening a skin supporting network and application thereof, and the anti-aging composition comprises the following components: a golden camellia flower extract, a saffron crocus extract, camellia seed oil, tranexamic acid and epigallocatechin gallate glucoside, the weight ratio of the golden camellia flower extract to the saffron crocus extract to the camellia seed oil to the tranexamic acid to the epigallocatechin gallate glucoside is (0.1 to 5) to (0.01 to 5) to (0.1 to 10) to (0.01 to 2) to (0.001 to 0.1). The composition provided by the invention can synergistically strengthen a skin support network and comprehensively improve skin elasticity and compactness by promoting growth of two core structural proteins and three macromolecular adhesives of skin, and is mild, non-irritant and suitable for people with sensitive skin.

The invention relates to the technical field of skin care product raw materials, and particularly discloses a soothing anti-inflammatory composition as well as a preparation method and application thereof. The preparation method of the soothing anti-inflammatory composition comprises the following steps: step 1) mixing saffron crocus, radix sophorae flavescentis, houttuynia cordata, moringa seeds and astragalus membranaceus to obtain a composite raw material; the invention discloses a soothing and anti-inflammatory composition and a preparation method thereof.The soothing and anti-inflammatory composition and the preparation method thereof.The soothing and anti-inflammatory composition has the advantages that soothing, anti-inflammatory and skin barrier repairing effects are further improved.

The invention belongs to the technical field of biological medicines, and discloses a fish collagen and rose double-effect anti-aging composition, and the core active ingredients of the fish collagen and rose double-effect anti-aging composition comprise fish collagen peptide, red roses with double petals, dried cranberries, Chinese wolfberry fruits, roxburgh rose puree and saffron. According to the preparation method, specific degradation of intestinal flora is realized by virtue of the targeting effect of the xylooligosaccharide on bifidobacteria through the compound polysaccharide microcapsules, so that collagen peptide and antioxidant components are accurately released in colon, gastric acid damage is effectively avoided, and meanwhile, the piperine nanoparticles inhibit the activity of UGT enzyme, so that the anti-oxidation effect of the collagen peptide on the colon is improved, and the anti-oxidation effect of the collagen peptide on the colon is improved. The bioavailability of crocin is increased to 45% or above from 2%, the absorption rate of rose polyphenol is increased by 3 times, the intestinal absorption efficiency of collagen peptide reaches 95%, a remarkable breakthrough is achieved compared with 60-80% of a traditional process, and an efficient delivery mode of targeted release-absorption enhancement is constructed.

The present application relates to the field of compound medicine and female private part nursing technology, and particularly relates to a compound traditional Chinese medicine composition, a preparation method and application thereof.The compound traditional Chinese medicine composition is prepared from raw medicinal materials including the following components by weight: 8-10 parts of extractum of macaranga denticulata, 8-10 parts of extractum of calycopteris floribunda, 7-9 parts of extractum of panax notoginseng, 7-9 parts of extractum of saffron, 9-11 parts of extractum of camellia sinensis, and 7-9 parts of extractum of ganoderma lucidum.The compound traditional Chinese medicine composition has antibacterial and firming effects on female private parts, and has obvious performance advantages when applied to female private part nursing products such as sanitary napkins.

The utility model relates to the field of saffron crocus cultivation, and provides an air circulation saffron crocus soilless cultivation growth square bin which comprises a bin body. According to the crocus sativus cultivation device, when crocus sativus is cultivated, a bin door of the bin body is opened, crocus sativus is placed on the upper sides of a plurality of storage plates, an external power switch of a conveying pump is turned on, then suction force is generated at the output end of the conveying pump, and the crocus sativus is conveyed to the storage plates through the conveying pump; furthermore, liquid in a liquid storage box is discharged into a second guide pipe through a first guide pipe under the action of a conveying pump, and is further discharged into two connecting pipes through a flow dividing pipe, liquid medicine is discharged into a hollow pipe through an inclined surface of a drainage plate, and the liquid medicine flows into the liquid storage box through a filter plate, so that when the square growth bin is used, the liquid medicine is discharged into the liquid storage box through a water inlet pipe and a water outlet pipe; the pesticide liquid does not need to be manually sprayed, and the pesticide liquid can be repeatedly utilized.

The present invention discloses a β-carotene-grape seed extract eye-care preparation for retinal protection, relating to functional health foods. The preparation comprises active components and food-acceptable excipients. In parts by weight, the active components include 1–4 parts lutein, 0.5 –2 parts meso-zeaxanthin, 2 – 6 parts β-carotene, 8 – 25 parts blueberry extract, 5 – 18 parts grape seed extract, 0.2–1 part L-ergothioneine, 0.5–3 parts saffron extract, and 1–5 parts phosphatidylserine. The excipients comprise a filler, disintegrant, binder, and lubricant, with a weight ratio of active components to excipients of 1:1 to 1:4. By combining these eight components at specific ratios, the invention achieves synergistic effects, protects retinal health, and reduces blue-light damage. Dual-phase microencapsulation based on solubility, together with standardized preparation steps, improves stability and utilization efficiency.

The invention provides an agilawood leaf-containing sleep-aiding beverage and a preparation method thereof, the agilawood leaf-containing sleep-aiding beverage takes agilawood leaf, spina date seed, lily and longan as main raw materials, and is added with South African drunken solanum extract, shiitake mushroom theanine, crocetin nano-liposome and other components. The agilawood leaves are subjected to alkaline aqueous solution soaking debitterizing and CO2 supercritical degreasing, and the processes of raw material gradient extraction, nano-liposome preparation and the like are combined, so that a finished product is prepared. All the components have a synergistic effect, so that neurotransmitter is adjusted, brain circulation is improved, the sleep latency is effectively shortened, and the sleep duration is prolonged. Animal experiments and electronic tongue tests show that the beverage is remarkable in sleep aiding effect, smooth in taste, low in bitter taste and astringent taste and good in stability, and a natural and healthy sleep aiding beverage choice is provided for people suffering from mild sleep disorder.

The invention relates to a pharmaceutical composition for treating hashimoto thyroiditis, and further relates to application of the pharmaceutical composition. The pharmaceutical composition comprises crocin and oxymatrine as active pharmaceutical ingredients, has an obvious improvement effect on serum TPO-Ab, TG-Ab, TSH, FT4, IFN-gamma, TNF-alpha and IL-10 levels of rats suffering from hashimoto thyroiditis, and is obviously superior to crocin and oxymatrine with the same dosage; the crocin and the oxymatrine have a synergistic effect in treatment of hashimoto thyroiditis, and the combination of the crocin and the oxymatrine has enhanced safety and wider application scenarios.

The application discloses a liposome drug carrier with mucosal adhesion, a preparation method and application thereof, and specifically, the drug carrier is DSPE-PEG-PBA, which can be used for loading cyclosporine A and crocin I, and the carrier of the application is used for loading cyclosporine A and crocin I. The liposome loaded with the two drugs has good stability and adhesion, can inhibit the side effect of cyclosporine A on the increase of ROS level, and has a wide application prospect in the treatment of inflammation and epithelial tissue damage.

Liposomal trans-crocetin pharmaceutical compositions, dosing regimens and methods of treating or preventing disorders and conditions associated with, but not limited to, infection, ischemia, hypoxia, ARDS, inflammation, sepsis, shock, stroke, traumatic injury, and proliferative disorders such as cancer are provided. Methods of using the provided trans-crocetin pharmaceutical compositions and dosing regimens to treat cardiovascular, renal, liver, inflammatory, metabolic, pulmonary, neurological, and other disorders and conditions are also provided, as are methods of increasing the delivery of oxygen and increasing the efficacy of a therapeutic agent using the provided compositions and dosing regimens.

The application discloses a kind of bionic transmembrane protein affinity chromatography column and its preparation method and application.The system (iSTAC) realizes the in-situ construction of transmembrane protein in highly bionic dynamic microenvironment by integrating cell-free protein synthesis, functional mesoporous silica modification and amphiphilic (AH) peptide stabilized planar lipid bilayer technology.The core is to use long-chain PEG-24 crosslinking agent to retain lipid bilayer on the surface of silica gel, provide sufficient conformational dynamic space for multi-transmembrane protein, and introduce AH peptide to repair membrane defects, ensure that the receptor realizes directional embedding while maintaining natural functional attributes.The preparation cycle is shortened from 168 hours to 5 hours, which significantly improves the efficiency of targeted drug screening and in-situ analysis of binding sites.Using this platform, 5-HT 1A Receptor agonists crocin I and crocin II with anti-insomnia and neuroprotective effects are successfully screened from saffron, and the action site is accurately depicted.

To provide a composition for preventing and / or improving deterioration of focal point adjusting function caused by asthenopia.SOLUTION: A composition for preventing and / or improving focal adjustment hypofunction due to asthenopia, comprising lactic acid bacteria WB2000, trans-resveratrol, and a crocetin-containing gardenia extract.SELECTED DRAWING: Figure 1

The invention discloses a fat-reducing slimming composition formula and a preparation method thereof. The fat-reducing slimming composition formula comprises a component A and a component B, wherein the component A is prepared from the following components: phoenix grass, beautiful millettia root, saussurea involucrata, angelica sinensis, saffron crocus, hawthorn, semen cassiae, lotus leaf, rhizoma alismatis, poria cocos, bighead atractylodes rhizome, radix ophiopogonis, lily and radix polygoni multiflori preparata; and the component B is protease. Traditional Chinese medicines and protease are prepared into a solid preparation to be directly coated on the skin surface of a human body, components in the preparation are directly introduced into the skin through an ion introduction instrument or an ultrasonic introduction instrument, so that the fat reducing effect is achieved, the traditional Chinese medicines are prepared into powder, and the powder is prepared into cellulose capsules or tablets for oral administration, so that satiety is enhanced, and the effect of reducing fat is achieved. The method has the advantages that the surface of human skin is directly coated with protease, ingredients in the preparation are directly introduced into the skin through an ion introduction instrument or an ultrasonic introduction instrument, the fat reducing effect is further improved, and the fat reducing effect is improved by adopting the internal and external synergistic effect.

The invention relates to the technical field of aquaculture feeds, in particular to a traditional Chinese medicine fish feed for improving skin texture of fancy carp, which is prepared from the following components in parts by weight: 40-60g of schisandra chinensis, 40-60g of platycladi seed, 50-70g of medlar, 15-20g of fructus amomi, 20-30g of agastache rugosus, 20-40g of mulberry, 1-5g of saffron crocus, 10-15g of black ant, 5-15g of gardenia, 15-20g of raw liquorice, 20-30g of pericarpium citri reticulatae and 20-40g of malt. The preparation method comprises the following steps: S1, pretreatment: carrying out ultraviolet sterilization for 20-40s; sterilizing with hot air at 60-80 DEG C; s2, drying: drying at a low temperature of 40-60 DEG C until the moisture is less than or equal S3, crushing: mechanically pulverizing, sieving with a 100-200-mesh sieve, repeating for 3-5 times, and uniformly stirring; s4, mixing: mixing and stirring with basic fish feed according to a ratio of 1: (5-10); and S5, packaging: bagging in vacuum in a dark place. The traditional Chinese medicine fish feed for improving the skin texture of the fancy carp has the beneficial effects of homology of medicine and food, safety and no toxicity; materials are easy to obtain, and cost is reduced; the fish physique is enhanced, the meat quality is improved, and the body type of the ornamental fish is improved; the skin texture of the fancy carp is improved and enhanced, and the fancy carp is bright, healthy and anti-stress.

The utility model discloses a film covering device for saffron crocus planting, and relates to the technical field of planting and film covering, the film covering device comprises a bottom plate, a movable plate is arranged in the bottom plate in a sliding mode, a vertical plate is fixedly arranged on the top surface of the movable plate, a fixing piece is fixedly arranged on the top surface of the vertical plate, a storage barrel is fixedly arranged in the fixing piece, and the storage barrel is fixedly connected with the movable plate. A conveying pipe is fixedly arranged at the bottom end of the storage barrel and fixedly penetrates through the moving plate, the outer surface of the conveying pipe is sleeved with a sealing cover in a threaded mode, a third motor is installed on the bottom face of the bottom plate, a rotating plate is fixedly arranged at the output end of the third motor, and the rotating plate rotates by starting the third motor; and under the action of a guide rod, the outer surface of a connecting rod is rotated, the other end of the connecting rod is rotated on the outer surface of a lug plate, then a movable plate can be adjusted, the width of a film needing to be laid and the distance of a storage barrel are adjusted, and the device can adapt to different planting environments.

The invention belongs to the field of cosmetics, and particularly relates to a saffron crocus flower extract as well as a preparation method and application thereof. The preparation method of the saffron crocus flower extract comprises the following steps: (1) crushing and sieving saffron crocus flowers to obtain saffron crocus powder, adding deionized water, adjusting the pH value, adding a nonionic surfactant and a compound enzyme for enzymolysis, inactivating the enzyme, and centrifuging to obtain supernate A and saffron crocus residues; (2) adding a green eutectic solvent into the saffron crocus residues, solubilizing, extracting and centrifuging to obtain supernate B and the saffron crocus residues; and (3) mixing the supernatant A and the supernatant B to obtain a crude extract, separating and purifying the crude extract, eluting, removing ethanol by a vacuum membrane distillation method, and drying to obtain the traditional Chinese medicine composition. According to the method disclosed by the invention, more active ingredients in saffron crocus can be more fully solubilized and extracted, and the content of effective ingredients is obviously increased. When the saffron crocus flower extract is added into cosmetics, the effects of resisting oxidation and delaying senescence can be achieved.

The application belongs to the field of treating blood vessel-bone coupling imbalance diseases in traditional Chinese medicine, and particularly relates to a composition for treating blood vessel-bone coupling imbalance diseases, a pharmaceutical preparation and application. Geniposide alone or in combination with crocin I can effectively reduce endothelial cell damage under pathological stimulation conditions, reduce the level of cell apoptosis and the degree of oxidative stress, improve the vascular endothelial function state, and can also significantly inhibit osteoclast differentiation, reduce the number of mature osteoclasts, and reduce bone resorption activity, thereby being conducive to restoring the dynamic balance between bone formation and bone resorption.

The invention provides a method for promoting weight increase of saffron crocus progeny corms by enhancing illumination, which comprises the following steps: picking filaments, transplanting mother corms into soil for vegetative growth under the illumination intensity of 20000Lux, implementing periodic maintenance management, supplementing water once every two weeks, observing morphological indexes of the progeny corms, and harvesting the progeny corms after all leaves are withered. Experimental results show that the expression level of CsCCD2L in leaves is reduced by increasing illumination intensity, so that the content of zeaxanthin is increased, photosynthesis is further facilitated, and nutrition is provided for development of filial generation corms; the increase of the corm weight of the filial generation can significantly increase the flowering number, improve the yield of saffron crocus, and hopefully solve the bottleneck problem of low yield of saffron crocus.

The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for treating postnatal myopia, and particularly relates to a traditional Chinese medicine composition for treating postnatal myopia. , Szechuan fritillary bulb, kudzuvine root and sweet osmanthus; the invention relates to a compound preparation composed of rhizoma gastrodiae, dendrobium and menthol. The invention aims to provide the traditional Chinese medicine composition which can obviously reduce myopia until the vision of eyes is recovered to 1.0 or above and has small side effects.

The invention relates to a method for extracting crocin by using gardenia processing residues, which comprises the following steps of: firstly, drying, crushing and sieving residual gardenia meal after cold pressing gardenia fruits, and storing for later use; and mixing a deep eutectic solvent composed of an ammonium chloride hydrogen bond acceptor and a hydrogen bond donor according to a molar ratio, heating to be clear and transparent, cooling and standing to room temperature. And finally, weighing a certain amount of gardenia meal powder, putting the gardenia meal powder into a beaker, respectively mixing the gardenia meal powder with eight deep eutectic solvents according to a certain solid-liquid ratio, putting the mixture into a water bath, carrying out ultrasonic-assisted extraction, concentrating the obtained solution, and fixing the volume to obtain the crocin crude extract. Compared with a traditional method, the method has the advantages that the crocin extraction rate is high, the extraction solvent is green and environment-friendly, and the method is simple to operate, green, environment-friendly and efficient in extraction.

The application discloses a use of a topical preparation containing crocetin or a pharmaceutically acceptable salt thereof. The topical preparation developed in the application is used for treating cheilitis simplex actinica caused by chemotherapy, is convenient to use, has few toxic and side effects, and can effectively relieve symptoms such as cheilitis simplex actinica, lip crack, desquamation, erosion and scabbing caused by chemotherapy. The application also expands the application field of crocetin drugs, and finds a new use of crocetin and the salt thereof, which can be prepared into a topical preparation for preventing / treating skin inflammation or skin damage, especially for preventing / treating cheilitis simplex actinica caused by chemotherapy and skin damage caused by oxidative stress, and has better effects. When the crocetin and the salt thereof are used in combination with chlorogenic acid, they have better therapeutic effects. The crocetin and the salt thereof have higher stability when prepared into the topical preparation, are easier to obtain high-purity products, and are more suitable for pharmaceutical development.

A cultivation system for indoor farming of saffron plants (Crocus sativus) and other plants can include one or more compartments coupled with one or more climate modules which are controlled by one or more control systems. The control system can be configured to control the climate modules to provide different climate conditions to different compartments for different stages of the plants growth. Further, the temperature, humidity, and lighting in the compartments can include cyclic sequences configured to accelerate the life cycle of the plants. In addition, the plants can be trimmed, genome-specific fertilizer can be added to growth medium, absorbance pads can be used under the plant corms.

The invention relates to the technical field of Tibetan medicines, in particular to a preparation containing Tibetan medicine musk, a preparation method of the preparation and application of the preparation in preparation of liver cancer medicines. The preparation is prepared from the following raw materials: musk, swertia mussotii, rheum tanguticum, dracocephalum tanguticum, delphinium delphinium, phyllanthus emblica, salviae miltiorrhizae, herpetospermum pedunculosum, saussurea hypoglauca, saffron crocus, trogopterus dung, fructus chebulae and plantago asiatica. According to the invention, a plurality of medicinal materials are compatible, all the raw materials have a synergistic effect, the effects of compound components are effectively exerted, and the traditional Chinese medicine composition can resist cancer, protect liver, clear away heat and toxic materials and inhibit tumor growth, has a good anti-liver cancer effect and does not generate an immunosuppressive effect on a body.

The present invention provides an oral composition containing (A) a lipid-soluble substance and (B) crocin, which exhibits excellent stability against light and / or heat and excellent oral absorption. [Solution] Prepare an oral composition containing (A) a lipid-soluble substance and (B) an amphiphilic carotenoid, which form a complex in the composition.

The utility model discloses a seed screening device for saffron crocus planting, which relates to the technical field of seed screening and comprises a screening box, a feeding port is arranged at the top end of the screening box, a first screen is slidably mounted in the screening box, a second screen is fixedly mounted in the screening box, and an auger is rotatably mounted in the second screen. A chute is fixedly installed in the screening box, a discharging port is formed in one side of the screening box, and a first impurity discharging port and a second impurity discharging port which are distributed up and down are formed in the side, away from the discharging port, of the screening box. According to the saffron crocus seed screening device, seeds screened by the first screen fall into the second screen, impurities and waste seeds smaller than standard seeds can be screened out by the second screen and fall into the chute, and the standard seeds screened out by the second screen can be discharged through the discharging port by the auger, so that screening of saffron crocus seeds is completed instead of manual work, and the screening efficiency is improved.

The invention discloses a compound preparation based on traditional Chinese medicine extracts and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine. The preparation is prepared from the following raw materials in parts by weight: 10 to 20 parts of cortex eucommiae, 15 to 25 parts of poria cocos, 5 to 15 parts of gallnut, 10 to 20 parts of fructus cnidii, 15 to 25 parts of herba cistanche, 10 to 20 parts of herba epimedii, 10 to 20 parts of herba cynomorii, 5 to 10 parts of saffron crocus, 5 to 15 parts of fossil fragments, 5 to 10 parts of flos caryophylli and 10 to 20 parts of rhizoma chuanxiong. The traditional Chinese medicine extract is prepared into a spray; the traditional Chinese medicinal materials or decoction pieces are adopted as raw materials, effective components in the traditional Chinese medicinal materials or decoction pieces are extracted through a special extraction method and then prepared into different preparations such as sprays, and the traditional Chinese medicinal composition has a remarkable effect on male sexual dysfunction, has obviously fewer side effects than that of the traditional Chinese medicinal materials and the like, and is high in safety, definite in curative effect, low in cost and suitable for clinical popularization and application; meanwhile, the antibacterial effect is achieved, and safety and effectiveness are achieved.

The invention relates to a saffron crocus eye pad and a method for controlling eye axis growth, and belongs to the technical field of eye care products. The eye patch comprises a patch carrier and a plant extraction gel layer coated on the patch carrier, the plant extract gel layer is composed of mulberry leaf extract, chrysanthemum extract, butterflybush flower extract, amur corktree extract, crocus sativus flower extract, lithospermum extract, madder extract, lycium ruthenicum extract, beet root juice powder, natural borneol, menthol, xanthan gum, purified water and other natural components. The crocus sativus flower extract can enhance the blood flow speed of choroid, thicken the choroid and effectively control the growth of an ocular axis, so that the effect of delaying or improving the development of myopia is achieved. According to the gel layer, a hydrogel structure is formed through xanthan gum, natural borneol and menthol are combined to provide cooling and soothing effects, and the gel layer has good skin affinity and use safety.

The invention relates to a traditional Chinese medicine composition for inhibiting HPV (human papilloma virus) and treating cervical precancerous lesions after conization, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition comprises the following traditional Chinese medicinal materials in parts by weight: 8-12 parts of inonotus obliquus, 6-10 parts of ganoderma applanatum, 0.5-1 part of saffron crocus, 2-3 parts of radix sophorae flavescentis, 5-8 parts of wild ganoderma lucidum, 4-8 parts of laetiporus sulphureus, 2-3 parts of ganoderma sinensis, 3-6 parts of golden cypress, 1-1.5 parts of fructus cnidii and 10-15 parts of phellinus igniarius. The traditional Chinese medicine composition has the advantages of remarkable clinical effect, natural traditional Chinese medicine components, no drug resistance, no side effect and small burden on the body of a patient, improves the local immunity of the vagina, enhances the capability of automatically removing pathogens of the body and effectively prevents the recurrence of diseases, and has remarkable progress compared with the prior art.