38 results about "Crocin" patented technology

The utility model relates to the field of saffron crocus cultivation, and provides an air circulation saffron crocus soilless cultivation growth square bin which comprises a bin body. According to the crocus sativus cultivation device, when crocus sativus is cultivated, a bin door of the bin body is opened, crocus sativus is placed on the upper sides of a plurality of storage plates, an external power switch of a conveying pump is turned on, then suction force is generated at the output end of the conveying pump, and the crocus sativus is conveyed to the storage plates through the conveying pump; furthermore, liquid in a liquid storage box is discharged into a second guide pipe through a first guide pipe under the action of a conveying pump, and is further discharged into two connecting pipes through a flow dividing pipe, liquid medicine is discharged into a hollow pipe through an inclined surface of a drainage plate, and the liquid medicine flows into the liquid storage box through a filter plate, so that when the square growth bin is used, the liquid medicine is discharged into the liquid storage box through a water inlet pipe and a water outlet pipe; the pesticide liquid does not need to be manually sprayed, and the pesticide liquid can be repeatedly utilized.

The present invention discloses a β-carotene-grape seed extract eye-care preparation for retinal protection, relating to functional health foods. The preparation comprises active components and food-acceptable excipients. In parts by weight, the active components include 1–4 parts lutein, 0.5 –2 parts meso-zeaxanthin, 2 – 6 parts β-carotene, 8 – 25 parts blueberry extract, 5 – 18 parts grape seed extract, 0.2–1 part L-ergothioneine, 0.5–3 parts saffron extract, and 1–5 parts phosphatidylserine. The excipients comprise a filler, disintegrant, binder, and lubricant, with a weight ratio of active components to excipients of 1:1 to 1:4. By combining these eight components at specific ratios, the invention achieves synergistic effects, protects retinal health, and reduces blue-light damage. Dual-phase microencapsulation based on solubility, together with standardized preparation steps, improves stability and utilization efficiency.

The application discloses a liposome drug carrier with mucosal adhesion, a preparation method and application thereof, and specifically, the drug carrier is DSPE-PEG-PBA, which can be used for loading cyclosporine A and crocin I, and the carrier of the application is used for loading cyclosporine A and crocin I. The liposome loaded with the two drugs has good stability and adhesion, can inhibit the side effect of cyclosporine A on the increase of ROS level, and has a wide application prospect in the treatment of inflammation and epithelial tissue damage.

Liposomal trans-crocetin pharmaceutical compositions, dosing regimens and methods of treating or preventing disorders and conditions associated with, but not limited to, infection, ischemia, hypoxia, ARDS, inflammation, sepsis, shock, stroke, traumatic injury, and proliferative disorders such as cancer are provided. Methods of using the provided trans-crocetin pharmaceutical compositions and dosing regimens to treat cardiovascular, renal, liver, inflammatory, metabolic, pulmonary, neurological, and other disorders and conditions are also provided, as are methods of increasing the delivery of oxygen and increasing the efficacy of a therapeutic agent using the provided compositions and dosing regimens.

The application discloses a kind of bionic transmembrane protein affinity chromatography column and its preparation method and application.The system (iSTAC) realizes the in-situ construction of transmembrane protein in highly bionic dynamic microenvironment by integrating cell-free protein synthesis, functional mesoporous silica modification and amphiphilic (AH) peptide stabilized planar lipid bilayer technology.The core is to use long-chain PEG-24 crosslinking agent to retain lipid bilayer on the surface of silica gel, provide sufficient conformational dynamic space for multi-transmembrane protein, and introduce AH peptide to repair membrane defects, ensure that the receptor realizes directional embedding while maintaining natural functional attributes.The preparation cycle is shortened from 168 hours to 5 hours, which significantly improves the efficiency of targeted drug screening and in-situ analysis of binding sites.Using this platform, 5-HT 1A Receptor agonists crocin I and crocin II with anti-insomnia and neuroprotective effects are successfully screened from saffron, and the action site is accurately depicted.

To provide a composition for preventing and / or improving deterioration of focal point adjusting function caused by asthenopia.SOLUTION: A composition for preventing and / or improving focal adjustment hypofunction due to asthenopia, comprising lactic acid bacteria WB2000, trans-resveratrol, and a crocetin-containing gardenia extract.SELECTED DRAWING: Figure 1

The invention discloses a fat-reducing slimming composition formula and a preparation method thereof. The fat-reducing slimming composition formula comprises a component A and a component B, wherein the component A is prepared from the following components: phoenix grass, beautiful millettia root, saussurea involucrata, angelica sinensis, saffron crocus, hawthorn, semen cassiae, lotus leaf, rhizoma alismatis, poria cocos, bighead atractylodes rhizome, radix ophiopogonis, lily and radix polygoni multiflori preparata; and the component B is protease. Traditional Chinese medicines and protease are prepared into a solid preparation to be directly coated on the skin surface of a human body, components in the preparation are directly introduced into the skin through an ion introduction instrument or an ultrasonic introduction instrument, so that the fat reducing effect is achieved, the traditional Chinese medicines are prepared into powder, and the powder is prepared into cellulose capsules or tablets for oral administration, so that satiety is enhanced, and the effect of reducing fat is achieved. The method has the advantages that the surface of human skin is directly coated with protease, ingredients in the preparation are directly introduced into the skin through an ion introduction instrument or an ultrasonic introduction instrument, the fat reducing effect is further improved, and the fat reducing effect is improved by adopting the internal and external synergistic effect.

The application belongs to the field of treating blood vessel-bone coupling imbalance diseases in traditional Chinese medicine, and particularly relates to a composition for treating blood vessel-bone coupling imbalance diseases, a pharmaceutical preparation and application. Geniposide alone or in combination with crocin I can effectively reduce endothelial cell damage under pathological stimulation conditions, reduce the level of cell apoptosis and the degree of oxidative stress, improve the vascular endothelial function state, and can also significantly inhibit osteoclast differentiation, reduce the number of mature osteoclasts, and reduce bone resorption activity, thereby being conducive to restoring the dynamic balance between bone formation and bone resorption.

The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for treating postnatal myopia, and particularly relates to a traditional Chinese medicine composition for treating postnatal myopia. , Szechuan fritillary bulb, kudzuvine root and sweet osmanthus; the invention relates to a compound preparation composed of rhizoma gastrodiae, dendrobium and menthol. The invention aims to provide the traditional Chinese medicine composition which can obviously reduce myopia until the vision of eyes is recovered to 1.0 or above and has small side effects.

A cultivation system for indoor farming of saffron plants (Crocus sativus) and other plants can include one or more compartments coupled with one or more climate modules which are controlled by one or more control systems. The control system can be configured to control the climate modules to provide different climate conditions to different compartments for different stages of the plants growth. Further, the temperature, humidity, and lighting in the compartments can include cyclic sequences configured to accelerate the life cycle of the plants. In addition, the plants can be trimmed, genome-specific fertilizer can be added to growth medium, absorbance pads can be used under the plant corms.

The present invention provides an oral composition containing (A) a lipid-soluble substance and (B) crocin, which exhibits excellent stability against light and / or heat and excellent oral absorption. [Solution] Prepare an oral composition containing (A) a lipid-soluble substance and (B) an amphiphilic carotenoid, which form a complex in the composition.

The application belongs to the technical field of exosomes, and particularly relates to a saffron exosome and a preparation method and application thereof. The preparation method comprises the following steps: collecting saffron stigmas and petals, washing and drying, crushing to 80-100 meshes to obtain saffron powder; soaking the saffron powder in a specific solvent according to a solid-liquid ratio of 1:6-10, and then performing ultrasonic extraction to obtain an extraction liquid; wherein the ultrasonic power is set to 200-300 W, the time is 30-60 minutes, and the temperature is controlled at 4-8 DEG C; the specific solvent formula is as follows: 0.005-0.01 g of potassium nitrate or 0.01-0.02 g of potassium sulfate is added to each liter of PBS buffer solution; the extraction liquid is first centrifuged at a speed of 8000-10000 g to remove impurity precipitates, and the supernatant is filtered through a 100-120 kDa ultrafiltration membrane, and the filtrate is collected; the filtrate is subjected to ultracentrifugation at a speed of 100000-110000 g for 70-90 minutes to obtain exosome precipitates, which are saffron exosomes. The application can stimulate the release of exosomes, stabilize and retain saffron exosomes, and finally significantly improve the extraction efficiency of saffron exosomes, so that the best activity is achieved.

The invention discloses mitochondria-targeted carthamin yellow nanoparticles and application thereof. The mitochondria-targeted carthamin yellow nanoparticles comprise a soft shell and a foldable inner core, the inner core is of a nano-particle frame structure and is formed by forming a G-quadruplex by ATP and trivalent gadolinium ions through pi-pi coordination; cY is packaged in the nano-particle frame; the inner core is obtained by synthesizing trivalent gadolinium ions growing through in-situ coordination and ATP in a DSPE-PEG-NH2 nano template, and the soft shell is generated by combining diselenide bonds with the DSPE-PEG-NH2 nano template on the inner core through an amidation reaction and connecting mitochondrial targeting peptide SS-31 with dienylation bonds. Efficient loading and stable delivery of the CY are realized; responsive release under the ROS condition; targeting mitochondria and delivering ATP to restore energy metabolism; mRI imaging is realized through Gd < 3 + >; and ferroptosis is inhibited synergistically, inflammation is resisted, and neurons are protected.

The invention belongs to the field of enzymes, and relates to glycosyltransferase for synthesizing crocin compounds and application of the glycosyltransferase. According to the present invention, BoUGT1, SaUGT5961 and SaUGT8661 genes capable of catalyzing crocetin glycosylation to specifically generate crocin V are cloned from Buddleja officinal Maxim. And Mimosa pudica L for the first time, the BoUGT1 gene can further catalyze crocetin to generate crocin IV, and the BoUGT1, the SaUGT5961 and the SaUGT8661 can further catalyze crocin III to generate crocin II, in addition, the BoUGT2 gene capable of further catalyzing crocin II to generate crocin I is obtained through cloning. According to the invention, the resource acquisition way of crocin is widened, an important theoretical basis is provided for producing crocin compounds by using a synthetic biological method in the future, and the application prospect is wide and the economic value is higher.

The invention relates to a compound medicine for treating oral mucositis caused by luconobutuzumab and a preparation method of the compound medicine, and the compound medicine realizes the comprehensive curative effects of resisting inflammation, easing pain and promoting mucosal repair through combination of traditional Chinese medicines and western medicines and synergism of multi-ethnic medicines. The compound medicine is prepared from the following components in parts by weight: 0.1 to 0.5 part of recombinant human epidermal growth factor, 0.5 to 2.0 parts of lidocaine, 0.01 to 0.1 part of vitamin B12, 1.0 to 5.0 parts of astragalus polysaccharide, 0.5 to 3.0 parts of honeysuckle chlorogenic acid, 0.2 to 1.5 parts of glycyrrhizic acid, 0.1 to 1.0 part of crocin, 0.3 to 2.0 parts of saussurea involucrata flavone, 0.2 to 1.8 parts of paris polyphylla saponin and 0.4 to 2.5 parts of sculellaria barbata flavone. The compound provided by the invention is suitable for tumor patients receiving treatment of luconatobutuzumab, is especially suitable for patients suffering from I-III grade oral mucositis, can be used as a hospital preparation or new drug development, and has wide clinical application and market prospects.

The application discloses a composition containing rose extract, and mainly comprises the following components in parts by weight: rose flower extract 1-50 parts, gardenia flower extract 1-30 parts, saffron extract 1-30 parts, medlar fructan 1-30 parts and tremella polysaccharide 1-30 parts; and the preparation method and application of the composition are also disclosed. The composition mainly comprises three kinds of flower components and cooperates with plant polysaccharide, can play good anti-aging and moisturizing effects, has good effects of removing excess free radicals in human bodies and promoting collagen synthesis, can effectively relieve symptoms such as skin dullness, obvious wrinkles and dry skin, and the composition itself is natural, safe and non-irritating, and has a good application prospect in daily chemical product application.

The application provides a traditional Chinese medicine composition for treating depression, a traditional Chinese medicine preparation and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine compositions. The traditional Chinese medicine composition comprises Astragalus membranaceus, Bupleurum chinense, Atractylodes macrocephala, Suanzaoren, Crocus sativus, Atractylodes lancea and Glycyrrhiza uralensis. The above-mentioned drugs are combined in the application, and jointly play the functions of activating qi and soothing liver, promoting blood circulation and relieving depression, especially can improve depression induced or aggravated by improper emotion and accompanied by psychotic symptoms, are suitable for clinical popularization and application, and have wide application prospect.

The invention belongs to the field of gene engineering and enzyme engineering, and particularly relates to an activity-improved UDP glycosyl transferase mutant and application thereof. The glycosyl transferase mutant is a four-combination mutant N2HN1I, and the amino acid sequence of the glycosyl transferase mutant is as shown in SEQ ID NO. 4. The mutant provided by the invention has higher catalytic activity, the conversion rate of a substrate crocetin is high, and the mutant has important industrial application value.

The invention provides a saffron crocus composition and application. The saffron crocus composition at least comprises the following raw materials in parts by weight: 0.2 to 1.8 parts of a saffron crocus oil extraction compound, 0.2 to 1.8 parts of a spanishneedles herb extraction compound and 0.1 to 1 part of phytol, the saffron crocus composition is prepared according to the following method: taking the saffron crocus oil extraction compound, the spanishneedles herb extraction compound and phytol in parts by weight; heating to 40-50 DEG C, and stirring to completely dissolve; and cooling to room temperature. According to the present invention, the saffron crocus oil extraction compound, the spanishneedles herb extraction compound and the phytol are combined according to the ratio, such that the soothing, anti-aging and anti-oxidation effects of the saffron crocus composition can be substantially improved, and the new target can be regulated and controlled.

The invention provides an anthocyanin hydroformylation vitamin-based bridged molecular device as well as a preparation method and application thereof, and belongs to the technical field of plant glue detection. The structural formula of the flower glycoside hydroformylation vitamin-based bridged molecular device is shown in the specification. The preparation method of the flower glycoside hydroformylation vitamin-based bridged molecular device comprises the following steps: mixing a vitamin B1 solution and a bitter crocin solution in a protective atmosphere, and carrying out condensation reaction on the mixed solution to obtain the flower glycoside hydroformylation vitamin-based bridged molecular device. The vitamin-based bridged molecular device can still keep better optical signal intensity under the condition of long-time irradiation, has little change in absorbance in various polar solutions, is suitable for plant glue containing various components and complex liquid environments, has the emission wavelength of about 455nm, and can be used for preparing plant glue. Background fluorescence signal interference possibly caused by various nutritional components in the plant glue can be effectively avoided.

To reduce the soy odor in foods containing textured soy protein that has been heated under pressure. [Solution] A pressurized and heated food containing textured soy protein and a carotenoid pigment, wherein the carotenoid pigment is mixed with the textured soy protein in a state where it is dissolved or dispersed in water in the food. It is also preferable that the carotenoid pigment contains at least one selected from capsanthin, annatto, crocin, and lutein. It is also preferable that the content of the textured soy protein is greater than that of animal-derived protein.

The invention discloses crocetin alkali metal salt type crystals as well as a preparation method and application thereof, belongs to the field of medicinal chemistry, and particularly relates to three crocetin alkali metal salt type crystals, namely a crocetin sodium salt crystal form I and a crocetin potassium salt crystal form II. According to the invention, an insoluble compound is prepared into an alkali metal form, so that the water solubility of the compound is greatly improved. The crystal form provided by the invention is stable in preparation process and good in reproducibility, and the target crystal form can be stably obtained.

The invention discloses a method for enhancing the stability of natural carthamin yellow. The method comprises the steps that natural carthamin yellow powder and tea polyphenol are dissolved in water and stirred evenly to obtain a pigment solution, the pigment solution is stored in a dark place at the temperature of 25 DEG C, the mass concentration of natural carthamin yellow in the pigment solution is 0.1%, and the concentration of the tea polyphenol in the pigment solution is 0.1-0.3%. The tea polyphenol has a color protection effect on the natural carthamin yellow, the stability of the natural carthamin yellow can be effectively improved, 0.1% of tea polyphenol has the best color protection effect, and the pigment loss rates are 9.12% and 15.21% respectively after testing for 12 hours under the conditions of strong light irradiation and high temperature of 60 DEG C.

The invention discloses a whitening and brightening transdermal elastic liposome composition containing saffron crocus and a preparation method of the whitening and brightening transdermal elastic liposome composition, and belongs to the technical field of daily cosmetics. The composition is prepared from a saffron crocus extract, 4-butylresorcinol, an ormosia henryi bark extract, nicotinamide, a plantago major leaf fermentation extract and a gingko fermentation extract, and lipidosome auxiliary materials such as hydrogenated lecithin, deionized water and an absolute ethyl alcohol solvent are supplemented. Wherein the plantago major leaf fermentation extract is prepared by composite fermentation of streptococcus thermophilus and lactobacillus rhamnosus, the ginkgo fermentation extract is prepared by composite fermentation of aspergillus oryzae and aspergillus cristatus, and an elastic liposome structure is constructed through a specific process. The composition can efficiently inhibit in-vitro and intracellular tyrosinase activity, has excellent whitening and brightening effects, and is suitable for preparing various skin care products.

The application discloses a composition for preventing Alzheimer's disease and a preparation method and application thereof, and belongs to the technical fields of functional food, health food and medicines. The composition comprises a basic component and a functional component. The basic component is 50-80 parts of wheat green pigment, and the functional component is 2-10 parts and is composed of saffron extract and spearmint extract. The weight ratio of the saffron extract to the spearmint extract is 1.2:1-1.8:1. The composition has the effects of preventing or treating Alzheimer's disease or delaying the disease condition of Alzheimer's disease, can be applied to health food or functional food in the future, and has a medicinal potential.

The invention relates to a traditional Chinese medicine composition for treating autism spectrum disorder and application thereof, and belongs to the technical field of traditional Chinese medicines. The invention provides a traditional Chinese medicine composition for treating autism spectrum disorder. The traditional Chinese medicine composition comprises the following components in parts by mass: 5-15 parts of saffron crocus, 10-20 parts of wild chrysanthemum flowers, 5-15 parts of astragalus membranaceus, 5-15 parts of beautiful sweetgum fruits, 5-15 parts of medulla tetrapanacis, 5-15 parts of codonopsis pilosula, 1-10 parts of mint, 1-10 parts of agastache rugosus, 7-17 parts of albizia flowers, 0.5-1.5 parts of agilawood, 3-13 parts of sandalwood and 7-17 parts of tuber fleeceflower stems. The components of the traditional Chinese medicine composition are compatible and act together, the traditional Chinese medicine composition has the effect of treating autism spectrum disorder, the preparation method further improves the treatment effect, the effervescent tablets prepared from the traditional Chinese medicine composition are used for medicated bath, use is convenient and fast, the side effects of the medicine can be avoided, meanwhile, the medication conflict psychology of a patient can be prevented, and the curative effect is good. And a better treatment effect can be achieved.

This invention provides a functional composition and its application, belonging to the field of functional food technology. The functional composition of this invention comprises the following components in parts by weight: 10-25 parts of Sichuan pepper extract, 5-10 parts of Gastrodia elata extract, and 2-5 parts of saffron extract; wherein the Sichuan pepper extract contains 60%-80% total flavonoids by weight, and the total flavonoids include hyperoside at 5%-15% by weight of the Sichuan pepper extract. The functional composition of this invention not only shortens sleep latency, but more importantly, it also reduces the frequency of nighttime awakenings, effectively reducing the number of nighttime awakenings at the root cause.

The application discloses application of beta-glucosidase Lf18920 in specifically hydrolyzing crocin-1 into crocin-4 and crocin-5 which are safflor acid monosaccharide derivatives, and the beta-glucosidase Lf18920 is encoded by IT072_18920 gene of leifsonia sp. ZF2019 and is abbreviated as Lf18920 gene. The hydrolysis reaction catalyzed by the enzyme to obtain the safflor acid monosaccharide derivatives crocin-4 and crocin-5 can directly use crocin-1 as a substrate, crocin-1 has good water solubility and is a main crocin compound in plants, and the raw material is abundant. The reaction operation is simple and easy to realize industrial production. The application has important industrial application potential in the preparation of crocin-4 and crocin-5.

The application relates to the technical field of combined medicines, and discloses application of a Dachaihu decoction combined with crocin in preparation of AECOPD medicines, which comprises the Dachaihu decoction and crocin, and the mass ratio of the Dachaihu decoction to the crocin is 284:5; wherein the mass of the Dachaihu decoction is recorded according to the mass of medicinal materials. The Dachaihu decoction has the advantages of small side effect and high safety in treatment of AECOPD, and the crocin can improve the lung function of patients in the acute exacerbation period of chronic obstructive pulmonary disease by down-regulating the expression of NLRP3, inhibit oxidation stress and inflammatory reaction, and inhibit alveolar epithelial cell apoptosis. The Dachaihu decoction is creatively combined with the crocin, and the combination can play a synergistic role in treatment of the acute exacerbation period of chronic obstructive pulmonary disease, so that the Dachaihu decoction combined with the crocin has an application prospect of development into a medicine for treatment of the acute exacerbation period of chronic obstructive pulmonary disease.

This invention discloses a strain of *Yarrowia lipolytica* that produces crocin, classified and named as follows: Yarrowia lipolytica OUC-Cro13-EL8GGP, deposited at the China Center for Type Culture Collection (CCTCC) NO: M 20252999, date of deposit: December 24, 2025. This strain is used in the preparation of crocin. This invention successfully obtained a high-yielding *Yersinia lipolytica* genetically engineered strain capable of producing crocin-1, achieving a yield of 21.3 mg / L, through strategies such as heterologous gene transfer, overexpression of key enzymes, regulation of key metabolic nodes, and modular enzyme assembly and expression. This demonstrates the efficient synthesis of crocin in *Yersinia lipolytica*. The crocin-producing *Yersinia lipolytica* strain of this invention can be used for large-scale crocin production, showing potential for industrial-scale production and promising application prospects.