The invention belongs to the field of cosmetics and particular relates to hirudin skin-whitening moisture-keeping conditioning cream and a production process thereof. The conditioning cream is prepared by oil phase raw materials such as squalane, polyoxyethylene stearyl alcohol ether, jojoba oil, white oil, ferulic acid derivative, cetostearyl alcohol and evening primrose oil, and water phase raw materials such as hirudin, oat polypeptide, a saffron crocus extracting solution, collagen polypeptide, caffeine derivative and an epidermal growth factor. The production process comprises the steps of heating, sterilization, stirring, dissolving, emulsifying, homogenizing, cooling, discharging, sampling, detection, filling, and packaging to obtain the conditioning cream. The conditioning cream can permeate into a corium layer of skin autonomously and directly, can be easily absorbed by the skin, can solve the problems such as the lusterless skin caused by pore blockage, has a better skin-whitening, moisture-keeping and skin-softening effect, and can promote regeneration of the skin and improve the skin quality; as multiple skin-whitening, moisture-keeping and skin-tone-improving raw materials are added, the conditioning cream can improve blood circulation and the skin elasticity, and has very good skin-whitening, moisture-keeping and skin-softening effects; and the production process is simple and easy to operate.