138 results about "Crocin" patented technology

The invention relates to an exosome composition for improving sleep quality. The exosome composition comprises a lavender exosome, a chamomile exosome and a saffron crocus exosome. The exosome composition disclosed by the invention can be used for improving the expression level of GABA (gamma-aminobutyric acid) related proteins of neuronal cells, promoting the expression of brain-derived neurotrophic factors (BDNF) of the neuronal cells, promoting the synaptic growth of the neuronal cells, improving the CL <-> level of the neuronal cells and inhibiting the inflammatory factor level of microglial cells. The exosome composition disclosed by the invention can be used for improving sleep quality reduction caused by various body discomfort, and has a more obvious using effect than that of the same Chinese herbal medicine extract.

The present invention discloses a saffron crocus petal fermentation broth, which is characterized in that the saffron crocus petal fermentation broth is obtained by fermenting saffron crocus petals by using plant lactobacillus (Lactiplantarum), and the saffron crocus petal fermentation broth is obtained by using the plant lactobacillus (Lactiplantarum) to ferment the saffron crocus petals. The fermentation method is simple and rapid, and the obtained saffron crocus petal fermentation liquor has skin care effects on skin whitening, anti-aging and the like.

The invention relates to the technical field of nano drug loading, in particular to chlorin e6 composite liposome as well as a preparation method and application thereof. The preparation method comprises the following steps: dissolving egg yolk lecithin, cholesterol and chlorin e6 in an organic solvent, carrying out rotary evaporation in a constant-temperature water bath kettle to evaporate the solvent to dryness to form a lipoid film, adding a crocin aqueous solution, carrying out high-shear dispersion on the film, carrying out ultrasonication, and filtering with a 0.22 [mu] m filter membrane to obtain the chlorin e6 composite liposome. The chlorin e6 composite liposome prepared by the invention is high in encapsulation efficiency and good in stability, and has the effects of enhancing tumor cell uptake and killing tumor cells through photodynamic.

The invention relates to the technical field of functional food, in particular to an eye-protecting and brain-strengthening composition as well as a preparation method and application thereof. The aronia, the astaxanthin, the DHA, the medlar, the hovenia dulcis thunb and the saffron crocus extract are compounded, various functional raw materials have a synergistic effect, the visual problem is improved through multiple channels, the cognitive ability is synchronously improved, and the astaxanthin eye drops have the effects of preventing retina oxidative damage, promoting eye blood circulation, relieving visual fatigue, protecting nerve cells and improving the cognitive state. Through reasonable proportioning, the composition for protecting eyes and strengthening brain has better effects of relieving visual discomfort, improving vision and improving brain health.

The invention relates to an anti-aging composition for strengthening a skin supporting network and application thereof, and the anti-aging composition comprises the following components: a golden camellia flower extract, a saffron crocus extract, camellia seed oil, tranexamic acid and epigallocatechin gallate glucoside, the weight ratio of the golden camellia flower extract to the saffron crocus extract to the camellia seed oil to the tranexamic acid to the epigallocatechin gallate glucoside is (0.1 to 5) to (0.01 to 5) to (0.1 to 10) to (0.01 to 2) to (0.001 to 0.1). The composition provided by the invention can synergistically strengthen a skin support network and comprehensively improve skin elasticity and compactness by promoting growth of two core structural proteins and three macromolecular adhesives of skin, and is mild, non-irritant and suitable for people with sensitive skin.

The invention relates to the technical field of healthy food, and discloses a healthy food composition for protecting liver and relieving fatigue and a preparation method of the healthy food composition for protecting liver and relieving fatigue. 5 to 10 parts of propolis; 5-7 parts of a chrysanthemum extract; 2-4 parts of a wolfberry extract; 7-10 parts of a cassia seed extract; 2-5 parts of a ginseng extract; 1.3 to 1.7 parts of a saffron crocus extract; the royal jelly and the propolis are combined according to the formula proportion, the prepared composition finished product has the effect of effectively relieving physical fatigue under the specific dosage, metabolite after exercise can be removed, the composition has the effect of increasing glycogen reserve, and the composition can be used for treating alcoholic liver injury model mice, and has the advantages that the composition finished product can be used for treating alcoholic liver injury; the composition can reduce the content of malondialdehyde and triglyceride in liver tissue and increase the content of glutathione, so that the composition provided by the invention not only has a liver protection effect, but also can relieve physical fatigue, reduce generation of serum urea and lactic acid after exercise and increase in-vivo glycogen reserve.

The invention relates to the technical field of food preparation, and discloses a healthy food composition with breast enlarging efficacy, which comprises kudzuvine root, pawpaw, dandelion and Chinese angelica. The composition further comprises at least one of ginseng, red dates, colla corii asini, mulberries, black beans, red roses with double petals, collagen peptide, skipjack elastin peptide, fish collagen tripeptide, cubilose and saffron crocus extract. Compared with the prior art, the food composition capable of being used for breast enlargement, provided by the invention, has the advantages that all the components are selected from natural components, no additive is added, the breast enlargement effect is realized under the condition of ensuring no side effect and health hidden danger, and the vacancy in the existing market is made up.

The invention relates to the technical field of skin care product raw materials, and particularly discloses a soothing anti-inflammatory composition as well as a preparation method and application thereof. The preparation method of the soothing anti-inflammatory composition comprises the following steps: step 1) mixing saffron crocus, radix sophorae flavescentis, houttuynia cordata, moringa seeds and astragalus membranaceus to obtain a composite raw material; the invention discloses a soothing and anti-inflammatory composition and a preparation method thereof.The soothing and anti-inflammatory composition and the preparation method thereof.The soothing and anti-inflammatory composition has the advantages that soothing, anti-inflammatory and skin barrier repairing effects are further improved.

The invention discloses a dark circle fading composition containing a golden camellia extract as well as a preparation method and application of the dark circle fading composition, and relates to the technical field of cosmetics. The composition comprises a component A, a component B and a component C, the component A comprises a common andrographis herb extract and a golden camellia extract; the component B comprises ubiquinone and a saffron crocus extract; and the component C is menthol lactate. The herba andrographitis extract, the camellia nitidissima extract, the ubiquinone, the saffron crocus extract and the menthol lactate are combined and found to have a synergistic interaction effect, and the composition formed by the components through specific compatibility can promote blood microcirculation, inhibit microangiogenesis, increase epidermal thickness and relieve cell hypoxia and eye fatigue; moreover, the eye cream is mild and non-irritating to the skin, and is suitable for people with sensitive skin to use.

The invention belongs to the technical field of biological medicines, and discloses a fish collagen and rose double-effect anti-aging composition, and the core active ingredients of the fish collagen and rose double-effect anti-aging composition comprise fish collagen peptide, red roses with double petals, dried cranberries, Chinese wolfberry fruits, roxburgh rose puree and saffron. According to the preparation method, specific degradation of intestinal flora is realized by virtue of the targeting effect of the xylooligosaccharide on bifidobacteria through the compound polysaccharide microcapsules, so that collagen peptide and antioxidant components are accurately released in colon, gastric acid damage is effectively avoided, and meanwhile, the piperine nanoparticles inhibit the activity of UGT enzyme, so that the anti-oxidation effect of the collagen peptide on the colon is improved, and the anti-oxidation effect of the collagen peptide on the colon is improved. The bioavailability of crocin is increased to 45% or above from 2%, the absorption rate of rose polyphenol is increased by 3 times, the intestinal absorption efficiency of collagen peptide reaches 95%, a remarkable breakthrough is achieved compared with 60-80% of a traditional process, and an efficient delivery mode of targeted release-absorption enhancement is constructed.

The present application relates to the field of compound medicine and female private part nursing technology, and particularly relates to a compound traditional Chinese medicine composition, a preparation method and application thereof.The compound traditional Chinese medicine composition is prepared from raw medicinal materials including the following components by weight: 8-10 parts of extractum of macaranga denticulata, 8-10 parts of extractum of calycopteris floribunda, 7-9 parts of extractum of panax notoginseng, 7-9 parts of extractum of saffron, 9-11 parts of extractum of camellia sinensis, and 7-9 parts of extractum of ganoderma lucidum.The compound traditional Chinese medicine composition has antibacterial and firming effects on female private parts, and has obvious performance advantages when applied to female private part nursing products such as sanitary napkins.

The invention discloses a Chinese herbal medicine preparation capable of preventing alopecia and growing hair as well as a preparation method and application of the Chinese herbal medicine preparation. The Chinese herbal medicine preparation is prepared from the following raw materials in parts by weight: 10-20 parts of ginseng, 3-6 parts of vallisneria natans, 4-6 parts of lycium ruthenicum, 5-10 parts of folium mori, 1-2 parts of saffron crocus, 2-3 parts of polygonum multiflorum, 1-2 parts of flaccid knotweed herb, 1-3 parts of Chinese lobelia, 1-2 parts of phoenix-tail fern and 1-2 parts of dandelion. The preparation method of the Chinese herbal medicine preparation comprises the following steps: 1) weighing the Chinese herbal medicine raw materials in parts by weight, and carrying out primary cleaning treatment to remove impurities; 2) uniformly mixing the treated Chinese herbal medicine raw materials, and putting the mixture into a proper container; 3) adding high-degree white spirit which is 5-10 times of the total weight of the medicinal materials, and ensuring that all the medicinal materials are fully soaked; 4) sealing the container, placing the container in a shady, cool and ventilated place, and soaking for 2-4 weeks; and 5) after the soaking is finished, filtering to remove medicine residues to obtain a clear leaching solution, namely a target product.

The utility model relates to the field of saffron crocus cultivation, and provides an air circulation saffron crocus soilless cultivation growth square bin which comprises a bin body. According to the crocus sativus cultivation device, when crocus sativus is cultivated, a bin door of the bin body is opened, crocus sativus is placed on the upper sides of a plurality of storage plates, an external power switch of a conveying pump is turned on, then suction force is generated at the output end of the conveying pump, and the crocus sativus is conveyed to the storage plates through the conveying pump; furthermore, liquid in a liquid storage box is discharged into a second guide pipe through a first guide pipe under the action of a conveying pump, and is further discharged into two connecting pipes through a flow dividing pipe, liquid medicine is discharged into a hollow pipe through an inclined surface of a drainage plate, and the liquid medicine flows into the liquid storage box through a filter plate, so that when the square growth bin is used, the liquid medicine is discharged into the liquid storage box through a water inlet pipe and a water outlet pipe; the pesticide liquid does not need to be manually sprayed, and the pesticide liquid can be repeatedly utilized.

The present invention discloses a β-carotene-grape seed extract eye-care preparation for retinal protection, relating to functional health foods. The preparation comprises active components and food-acceptable excipients. In parts by weight, the active components include 1–4 parts lutein, 0.5 –2 parts meso-zeaxanthin, 2 – 6 parts β-carotene, 8 – 25 parts blueberry extract, 5 – 18 parts grape seed extract, 0.2–1 part L-ergothioneine, 0.5–3 parts saffron extract, and 1–5 parts phosphatidylserine. The excipients comprise a filler, disintegrant, binder, and lubricant, with a weight ratio of active components to excipients of 1:1 to 1:4. By combining these eight components at specific ratios, the invention achieves synergistic effects, protects retinal health, and reduces blue-light damage. Dual-phase microencapsulation based on solubility, together with standardized preparation steps, improves stability and utilization efficiency.

The invention belongs to the field of daily chemicals, and particularly relates to an anti-hair-loss composition, anti-hair-loss liquid and a preparation method of the anti-hair-loss composition. The anti-hair loss composition is prepared from the following raw materials: cacumen biotae, pine needles, Chinese honey locust, selaginella tamariscina, fleece-flower root, radix rehmanniae, astragalus membranaceus, cortex pseudolaricis, fructus kochiae, saffron crocus, folium mori, mulberry, fructus lycii and radix paeoniae alba. The anti-alopecia liquid is prepared from the anti-alopecia composition, is suitable for seborrheic alopecia and phlegm-dampness type physique, and has the effects of preventing alopecia, growing and blackening hair, promoting blood circulation of scalp, enabling the scalp to be healthier and inhibiting various skin fungi. The preparation method of the anti-hair loss liquid is simple, and the anti-hair loss liquid has a good application prospect in the anti-hair loss field.

The invention provides an agilawood leaf-containing sleep-aiding beverage and a preparation method thereof, the agilawood leaf-containing sleep-aiding beverage takes agilawood leaf, spina date seed, lily and longan as main raw materials, and is added with South African drunken solanum extract, shiitake mushroom theanine, crocetin nano-liposome and other components. The agilawood leaves are subjected to alkaline aqueous solution soaking debitterizing and CO2 supercritical degreasing, and the processes of raw material gradient extraction, nano-liposome preparation and the like are combined, so that a finished product is prepared. All the components have a synergistic effect, so that neurotransmitter is adjusted, brain circulation is improved, the sleep latency is effectively shortened, and the sleep duration is prolonged. Animal experiments and electronic tongue tests show that the beverage is remarkable in sleep aiding effect, smooth in taste, low in bitter taste and astringent taste and good in stability, and a natural and healthy sleep aiding beverage choice is provided for people suffering from mild sleep disorder.

The invention relates to a pharmaceutical composition for treating hashimoto thyroiditis, and further relates to application of the pharmaceutical composition. The pharmaceutical composition comprises crocin and oxymatrine as active pharmaceutical ingredients, has an obvious improvement effect on serum TPO-Ab, TG-Ab, TSH, FT4, IFN-gamma, TNF-alpha and IL-10 levels of rats suffering from hashimoto thyroiditis, and is obviously superior to crocin and oxymatrine with the same dosage; the crocin and the oxymatrine have a synergistic effect in treatment of hashimoto thyroiditis, and the combination of the crocin and the oxymatrine has enhanced safety and wider application scenarios.

The application discloses a liposome drug carrier with mucosal adhesion, a preparation method and application thereof, and specifically, the drug carrier is DSPE-PEG-PBA, which can be used for loading cyclosporine A and crocin I, and the carrier of the application is used for loading cyclosporine A and crocin I. The liposome loaded with the two drugs has good stability and adhesion, can inhibit the side effect of cyclosporine A on the increase of ROS level, and has a wide application prospect in the treatment of inflammation and epithelial tissue damage.

Liposomal trans-crocetin pharmaceutical compositions, dosing regimens and methods of treating or preventing disorders and conditions associated with, but not limited to, infection, ischemia, hypoxia, ARDS, inflammation, sepsis, shock, stroke, traumatic injury, and proliferative disorders such as cancer are provided. Methods of using the provided trans-crocetin pharmaceutical compositions and dosing regimens to treat cardiovascular, renal, liver, inflammatory, metabolic, pulmonary, neurological, and other disorders and conditions are also provided, as are methods of increasing the delivery of oxygen and increasing the efficacy of a therapeutic agent using the provided compositions and dosing regimens.

The application discloses a kind of bionic transmembrane protein affinity chromatography column and its preparation method and application.The system (iSTAC) realizes the in-situ construction of transmembrane protein in highly bionic dynamic microenvironment by integrating cell-free protein synthesis, functional mesoporous silica modification and amphiphilic (AH) peptide stabilized planar lipid bilayer technology.The core is to use long-chain PEG-24 crosslinking agent to retain lipid bilayer on the surface of silica gel, provide sufficient conformational dynamic space for multi-transmembrane protein, and introduce AH peptide to repair membrane defects, ensure that the receptor realizes directional embedding while maintaining natural functional attributes.The preparation cycle is shortened from 168 hours to 5 hours, which significantly improves the efficiency of targeted drug screening and in-situ analysis of binding sites.Using this platform, 5-HT 1A Receptor agonists crocin I and crocin II with anti-insomnia and neuroprotective effects are successfully screened from saffron, and the action site is accurately depicted.

To provide a composition for preventing and / or improving deterioration of focal point adjusting function caused by asthenopia.SOLUTION: A composition for preventing and / or improving focal adjustment hypofunction due to asthenopia, comprising lactic acid bacteria WB2000, trans-resveratrol, and a crocetin-containing gardenia extract.SELECTED DRAWING: Figure 1

The invention discloses a fat-reducing slimming composition formula and a preparation method thereof. The fat-reducing slimming composition formula comprises a component A and a component B, wherein the component A is prepared from the following components: phoenix grass, beautiful millettia root, saussurea involucrata, angelica sinensis, saffron crocus, hawthorn, semen cassiae, lotus leaf, rhizoma alismatis, poria cocos, bighead atractylodes rhizome, radix ophiopogonis, lily and radix polygoni multiflori preparata; and the component B is protease. Traditional Chinese medicines and protease are prepared into a solid preparation to be directly coated on the skin surface of a human body, components in the preparation are directly introduced into the skin through an ion introduction instrument or an ultrasonic introduction instrument, so that the fat reducing effect is achieved, the traditional Chinese medicines are prepared into powder, and the powder is prepared into cellulose capsules or tablets for oral administration, so that satiety is enhanced, and the effect of reducing fat is achieved. The method has the advantages that the surface of human skin is directly coated with protease, ingredients in the preparation are directly introduced into the skin through an ion introduction instrument or an ultrasonic introduction instrument, the fat reducing effect is further improved, and the fat reducing effect is improved by adopting the internal and external synergistic effect.

The invention relates to the technical field of aquaculture feeds, in particular to a traditional Chinese medicine fish feed for improving skin texture of fancy carp, which is prepared from the following components in parts by weight: 40-60g of schisandra chinensis, 40-60g of platycladi seed, 50-70g of medlar, 15-20g of fructus amomi, 20-30g of agastache rugosus, 20-40g of mulberry, 1-5g of saffron crocus, 10-15g of black ant, 5-15g of gardenia, 15-20g of raw liquorice, 20-30g of pericarpium citri reticulatae and 20-40g of malt. The preparation method comprises the following steps: S1, pretreatment: carrying out ultraviolet sterilization for 20-40s; sterilizing with hot air at 60-80 DEG C; s2, drying: drying at a low temperature of 40-60 DEG C until the moisture is less than or equal S3, crushing: mechanically pulverizing, sieving with a 100-200-mesh sieve, repeating for 3-5 times, and uniformly stirring; s4, mixing: mixing and stirring with basic fish feed according to a ratio of 1: (5-10); and S5, packaging: bagging in vacuum in a dark place. The traditional Chinese medicine fish feed for improving the skin texture of the fancy carp has the beneficial effects of homology of medicine and food, safety and no toxicity; materials are easy to obtain, and cost is reduced; the fish physique is enhanced, the meat quality is improved, and the body type of the ornamental fish is improved; the skin texture of the fancy carp is improved and enhanced, and the fancy carp is bright, healthy and anti-stress.

The utility model discloses a film covering device for saffron crocus planting, and relates to the technical field of planting and film covering, the film covering device comprises a bottom plate, a movable plate is arranged in the bottom plate in a sliding mode, a vertical plate is fixedly arranged on the top surface of the movable plate, a fixing piece is fixedly arranged on the top surface of the vertical plate, a storage barrel is fixedly arranged in the fixing piece, and the storage barrel is fixedly connected with the movable plate. A conveying pipe is fixedly arranged at the bottom end of the storage barrel and fixedly penetrates through the moving plate, the outer surface of the conveying pipe is sleeved with a sealing cover in a threaded mode, a third motor is installed on the bottom face of the bottom plate, a rotating plate is fixedly arranged at the output end of the third motor, and the rotating plate rotates by starting the third motor; and under the action of a guide rod, the outer surface of a connecting rod is rotated, the other end of the connecting rod is rotated on the outer surface of a lug plate, then a movable plate can be adjusted, the width of a film needing to be laid and the distance of a storage barrel are adjusted, and the device can adapt to different planting environments.

The invention discloses jasmine flower white tea cocktail and a preparation method thereof, and belongs to the technical field of cocktail mixing. The cocktail is prepared from the following raw materials: 40 vol% of white rum with the volume fraction of 10%, a jasmine flower white tea extracting solution with the volume fraction of 30%, a 50g / L sugar source and 100g / L squeezed litchi juice, wherein the sugar source is prepared from jasmine flower honey and white cane sugar according to the mass ratio of 7: 3; according to the cocktail, original jasmine flowers and white tea serve as basic raw materials, the medicinal value and unique flavor of the jasmine flowers and the white tea are effectively combined, the cocktail is rich in crocin and tea polyphenol components, and the ingredients are natural, clean, good in taste, low in alcohol degree, healthy and nutritional.

The invention belongs to the field of cosmetics, and particularly relates to a saffron crocus flower extract as well as a preparation method and application thereof. The preparation method of the saffron crocus flower extract comprises the following steps: (1) crushing and sieving saffron crocus flowers to obtain saffron crocus powder, adding deionized water, adjusting the pH value, adding a nonionic surfactant and a compound enzyme for enzymolysis, inactivating the enzyme, and centrifuging to obtain supernate A and saffron crocus residues; (2) adding a green eutectic solvent into the saffron crocus residues, solubilizing, extracting and centrifuging to obtain supernate B and the saffron crocus residues; and (3) mixing the supernatant A and the supernatant B to obtain a crude extract, separating and purifying the crude extract, eluting, removing ethanol by a vacuum membrane distillation method, and drying to obtain the traditional Chinese medicine composition. According to the method disclosed by the invention, more active ingredients in saffron crocus can be more fully solubilized and extracted, and the content of effective ingredients is obviously increased. When the saffron crocus flower extract is added into cosmetics, the effects of resisting oxidation and delaying senescence can be achieved.

The application belongs to the field of treating blood vessel-bone coupling imbalance diseases in traditional Chinese medicine, and particularly relates to a composition for treating blood vessel-bone coupling imbalance diseases, a pharmaceutical preparation and application. Geniposide alone or in combination with crocin I can effectively reduce endothelial cell damage under pathological stimulation conditions, reduce the level of cell apoptosis and the degree of oxidative stress, improve the vascular endothelial function state, and can also significantly inhibit osteoclast differentiation, reduce the number of mature osteoclasts, and reduce bone resorption activity, thereby being conducive to restoring the dynamic balance between bone formation and bone resorption.

The invention provides a method for promoting weight increase of saffron crocus progeny corms by enhancing illumination, which comprises the following steps: picking filaments, transplanting mother corms into soil for vegetative growth under the illumination intensity of 20000Lux, implementing periodic maintenance management, supplementing water once every two weeks, observing morphological indexes of the progeny corms, and harvesting the progeny corms after all leaves are withered. Experimental results show that the expression level of CsCCD2L in leaves is reduced by increasing illumination intensity, so that the content of zeaxanthin is increased, photosynthesis is further facilitated, and nutrition is provided for development of filial generation corms; the increase of the corm weight of the filial generation can significantly increase the flowering number, improve the yield of saffron crocus, and hopefully solve the bottleneck problem of low yield of saffron crocus.

The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for treating postnatal myopia, and particularly relates to a traditional Chinese medicine composition for treating postnatal myopia. , Szechuan fritillary bulb, kudzuvine root and sweet osmanthus; the invention relates to a compound preparation composed of rhizoma gastrodiae, dendrobium and menthol. The invention aims to provide the traditional Chinese medicine composition which can obviously reduce myopia until the vision of eyes is recovered to 1.0 or above and has small side effects.

The invention belongs to the technical field of functional food detection, and provides a rotatable chromogenic functional molecule as well as a preparation method and application thereof. The preparation method comprises the following steps: mixing a coenzyme derivative solution, an alkaline compound solution and a crocetin solution, and carrying out conjugate coupling reaction to obtain the rotatable chromogenic functional molecule. The method is green, environment-friendly, easy to operate and relatively high in yield; the obtained rotatable chromogenic functional molecule has the advantages of high sensitivity coefficient, good pH stability, good solvent polarity tolerance, excellent light stability and low detection lower limit, and can efficiently, accurately and visually measure the viscosity of the liquid syrup fluid in situ.