70 results about "Crocin" patented technology

The invention relates to the technical field of skin care product raw materials, and particularly discloses a soothing anti-inflammatory composition as well as a preparation method and application thereof. The preparation method of the soothing anti-inflammatory composition comprises the following steps: step 1) mixing saffron crocus, radix sophorae flavescentis, houttuynia cordata, moringa seeds and astragalus membranaceus to obtain a composite raw material; the invention discloses a soothing and anti-inflammatory composition and a preparation method thereof.The soothing and anti-inflammatory composition and the preparation method thereof.The soothing and anti-inflammatory composition has the advantages that soothing, anti-inflammatory and skin barrier repairing effects are further improved.

The present application relates to the field of compound medicine and female private part nursing technology, and particularly relates to a compound traditional Chinese medicine composition, a preparation method and application thereof.The compound traditional Chinese medicine composition is prepared from raw medicinal materials including the following components by weight: 8-10 parts of extractum of macaranga denticulata, 8-10 parts of extractum of calycopteris floribunda, 7-9 parts of extractum of panax notoginseng, 7-9 parts of extractum of saffron, 9-11 parts of extractum of camellia sinensis, and 7-9 parts of extractum of ganoderma lucidum.The compound traditional Chinese medicine composition has antibacterial and firming effects on female private parts, and has obvious performance advantages when applied to female private part nursing products such as sanitary napkins.

The utility model relates to the field of saffron crocus cultivation, and provides an air circulation saffron crocus soilless cultivation growth square bin which comprises a bin body. According to the crocus sativus cultivation device, when crocus sativus is cultivated, a bin door of the bin body is opened, crocus sativus is placed on the upper sides of a plurality of storage plates, an external power switch of a conveying pump is turned on, then suction force is generated at the output end of the conveying pump, and the crocus sativus is conveyed to the storage plates through the conveying pump; furthermore, liquid in a liquid storage box is discharged into a second guide pipe through a first guide pipe under the action of a conveying pump, and is further discharged into two connecting pipes through a flow dividing pipe, liquid medicine is discharged into a hollow pipe through an inclined surface of a drainage plate, and the liquid medicine flows into the liquid storage box through a filter plate, so that when the square growth bin is used, the liquid medicine is discharged into the liquid storage box through a water inlet pipe and a water outlet pipe; the pesticide liquid does not need to be manually sprayed, and the pesticide liquid can be repeatedly utilized.

The present invention discloses a β-carotene-grape seed extract eye-care preparation for retinal protection, relating to functional health foods. The preparation comprises active components and food-acceptable excipients. In parts by weight, the active components include 1–4 parts lutein, 0.5 –2 parts meso-zeaxanthin, 2 – 6 parts β-carotene, 8 – 25 parts blueberry extract, 5 – 18 parts grape seed extract, 0.2–1 part L-ergothioneine, 0.5–3 parts saffron extract, and 1–5 parts phosphatidylserine. The excipients comprise a filler, disintegrant, binder, and lubricant, with a weight ratio of active components to excipients of 1:1 to 1:4. By combining these eight components at specific ratios, the invention achieves synergistic effects, protects retinal health, and reduces blue-light damage. Dual-phase microencapsulation based on solubility, together with standardized preparation steps, improves stability and utilization efficiency.

The application discloses a liposome drug carrier with mucosal adhesion, a preparation method and application thereof, and specifically, the drug carrier is DSPE-PEG-PBA, which can be used for loading cyclosporine A and crocin I, and the carrier of the application is used for loading cyclosporine A and crocin I. The liposome loaded with the two drugs has good stability and adhesion, can inhibit the side effect of cyclosporine A on the increase of ROS level, and has a wide application prospect in the treatment of inflammation and epithelial tissue damage.

Liposomal trans-crocetin pharmaceutical compositions, dosing regimens and methods of treating or preventing disorders and conditions associated with, but not limited to, infection, ischemia, hypoxia, ARDS, inflammation, sepsis, shock, stroke, traumatic injury, and proliferative disorders such as cancer are provided. Methods of using the provided trans-crocetin pharmaceutical compositions and dosing regimens to treat cardiovascular, renal, liver, inflammatory, metabolic, pulmonary, neurological, and other disorders and conditions are also provided, as are methods of increasing the delivery of oxygen and increasing the efficacy of a therapeutic agent using the provided compositions and dosing regimens.

The application discloses a kind of bionic transmembrane protein affinity chromatography column and its preparation method and application.The system (iSTAC) realizes the in-situ construction of transmembrane protein in highly bionic dynamic microenvironment by integrating cell-free protein synthesis, functional mesoporous silica modification and amphiphilic (AH) peptide stabilized planar lipid bilayer technology.The core is to use long-chain PEG-24 crosslinking agent to retain lipid bilayer on the surface of silica gel, provide sufficient conformational dynamic space for multi-transmembrane protein, and introduce AH peptide to repair membrane defects, ensure that the receptor realizes directional embedding while maintaining natural functional attributes.The preparation cycle is shortened from 168 hours to 5 hours, which significantly improves the efficiency of targeted drug screening and in-situ analysis of binding sites.Using this platform, 5-HT 1A Receptor agonists crocin I and crocin II with anti-insomnia and neuroprotective effects are successfully screened from saffron, and the action site is accurately depicted.

To provide a composition for preventing and / or improving deterioration of focal point adjusting function caused by asthenopia.SOLUTION: A composition for preventing and / or improving focal adjustment hypofunction due to asthenopia, comprising lactic acid bacteria WB2000, trans-resveratrol, and a crocetin-containing gardenia extract.SELECTED DRAWING: Figure 1

The invention discloses a fat-reducing slimming composition formula and a preparation method thereof. The fat-reducing slimming composition formula comprises a component A and a component B, wherein the component A is prepared from the following components: phoenix grass, beautiful millettia root, saussurea involucrata, angelica sinensis, saffron crocus, hawthorn, semen cassiae, lotus leaf, rhizoma alismatis, poria cocos, bighead atractylodes rhizome, radix ophiopogonis, lily and radix polygoni multiflori preparata; and the component B is protease. Traditional Chinese medicines and protease are prepared into a solid preparation to be directly coated on the skin surface of a human body, components in the preparation are directly introduced into the skin through an ion introduction instrument or an ultrasonic introduction instrument, so that the fat reducing effect is achieved, the traditional Chinese medicines are prepared into powder, and the powder is prepared into cellulose capsules or tablets for oral administration, so that satiety is enhanced, and the effect of reducing fat is achieved. The method has the advantages that the surface of human skin is directly coated with protease, ingredients in the preparation are directly introduced into the skin through an ion introduction instrument or an ultrasonic introduction instrument, the fat reducing effect is further improved, and the fat reducing effect is improved by adopting the internal and external synergistic effect.

The invention relates to the technical field of aquaculture feeds, in particular to a traditional Chinese medicine fish feed for improving skin texture of fancy carp, which is prepared from the following components in parts by weight: 40-60g of schisandra chinensis, 40-60g of platycladi seed, 50-70g of medlar, 15-20g of fructus amomi, 20-30g of agastache rugosus, 20-40g of mulberry, 1-5g of saffron crocus, 10-15g of black ant, 5-15g of gardenia, 15-20g of raw liquorice, 20-30g of pericarpium citri reticulatae and 20-40g of malt. The preparation method comprises the following steps: S1, pretreatment: carrying out ultraviolet sterilization for 20-40s; sterilizing with hot air at 60-80 DEG C; s2, drying: drying at a low temperature of 40-60 DEG C until the moisture is less than or equal S3, crushing: mechanically pulverizing, sieving with a 100-200-mesh sieve, repeating for 3-5 times, and uniformly stirring; s4, mixing: mixing and stirring with basic fish feed according to a ratio of 1: (5-10); and S5, packaging: bagging in vacuum in a dark place. The traditional Chinese medicine fish feed for improving the skin texture of the fancy carp has the beneficial effects of homology of medicine and food, safety and no toxicity; materials are easy to obtain, and cost is reduced; the fish physique is enhanced, the meat quality is improved, and the body type of the ornamental fish is improved; the skin texture of the fancy carp is improved and enhanced, and the fancy carp is bright, healthy and anti-stress.

The application belongs to the field of treating blood vessel-bone coupling imbalance diseases in traditional Chinese medicine, and particularly relates to a composition for treating blood vessel-bone coupling imbalance diseases, a pharmaceutical preparation and application. Geniposide alone or in combination with crocin I can effectively reduce endothelial cell damage under pathological stimulation conditions, reduce the level of cell apoptosis and the degree of oxidative stress, improve the vascular endothelial function state, and can also significantly inhibit osteoclast differentiation, reduce the number of mature osteoclasts, and reduce bone resorption activity, thereby being conducive to restoring the dynamic balance between bone formation and bone resorption.

The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for treating postnatal myopia, and particularly relates to a traditional Chinese medicine composition for treating postnatal myopia. , Szechuan fritillary bulb, kudzuvine root and sweet osmanthus; the invention relates to a compound preparation composed of rhizoma gastrodiae, dendrobium and menthol. The invention aims to provide the traditional Chinese medicine composition which can obviously reduce myopia until the vision of eyes is recovered to 1.0 or above and has small side effects.

The application discloses a use of a topical preparation containing crocetin or a pharmaceutically acceptable salt thereof. The topical preparation developed in the application is used for treating cheilitis simplex actinica caused by chemotherapy, is convenient to use, has few toxic and side effects, and can effectively relieve symptoms such as cheilitis simplex actinica, lip crack, desquamation, erosion and scabbing caused by chemotherapy. The application also expands the application field of crocetin drugs, and finds a new use of crocetin and the salt thereof, which can be prepared into a topical preparation for preventing / treating skin inflammation or skin damage, especially for preventing / treating cheilitis simplex actinica caused by chemotherapy and skin damage caused by oxidative stress, and has better effects. When the crocetin and the salt thereof are used in combination with chlorogenic acid, they have better therapeutic effects. The crocetin and the salt thereof have higher stability when prepared into the topical preparation, are easier to obtain high-purity products, and are more suitable for pharmaceutical development.

A cultivation system for indoor farming of saffron plants (Crocus sativus) and other plants can include one or more compartments coupled with one or more climate modules which are controlled by one or more control systems. The control system can be configured to control the climate modules to provide different climate conditions to different compartments for different stages of the plants growth. Further, the temperature, humidity, and lighting in the compartments can include cyclic sequences configured to accelerate the life cycle of the plants. In addition, the plants can be trimmed, genome-specific fertilizer can be added to growth medium, absorbance pads can be used under the plant corms.

The present invention provides an oral composition containing (A) a lipid-soluble substance and (B) crocin, which exhibits excellent stability against light and / or heat and excellent oral absorption. [Solution] Prepare an oral composition containing (A) a lipid-soluble substance and (B) an amphiphilic carotenoid, which form a complex in the composition.

The invention relates to a saffron crocus eye pad and a method for controlling eye axis growth, and belongs to the technical field of eye care products. The eye patch comprises a patch carrier and a plant extraction gel layer coated on the patch carrier, the plant extract gel layer is composed of mulberry leaf extract, chrysanthemum extract, butterflybush flower extract, amur corktree extract, crocus sativus flower extract, lithospermum extract, madder extract, lycium ruthenicum extract, beet root juice powder, natural borneol, menthol, xanthan gum, purified water and other natural components. The crocus sativus flower extract can enhance the blood flow speed of choroid, thicken the choroid and effectively control the growth of an ocular axis, so that the effect of delaying or improving the development of myopia is achieved. According to the gel layer, a hydrogel structure is formed through xanthan gum, natural borneol and menthol are combined to provide cooling and soothing effects, and the gel layer has good skin affinity and use safety.

The application belongs to the technical field of exosomes, and particularly relates to a saffron exosome and a preparation method and application thereof. The preparation method comprises the following steps: collecting saffron stigmas and petals, washing and drying, crushing to 80-100 meshes to obtain saffron powder; soaking the saffron powder in a specific solvent according to a solid-liquid ratio of 1:6-10, and then performing ultrasonic extraction to obtain an extraction liquid; wherein the ultrasonic power is set to 200-300 W, the time is 30-60 minutes, and the temperature is controlled at 4-8 DEG C; the specific solvent formula is as follows: 0.005-0.01 g of potassium nitrate or 0.01-0.02 g of potassium sulfate is added to each liter of PBS buffer solution; the extraction liquid is first centrifuged at a speed of 8000-10000 g to remove impurity precipitates, and the supernatant is filtered through a 100-120 kDa ultrafiltration membrane, and the filtrate is collected; the filtrate is subjected to ultracentrifugation at a speed of 100000-110000 g for 70-90 minutes to obtain exosome precipitates, which are saffron exosomes. The application can stimulate the release of exosomes, stabilize and retain saffron exosomes, and finally significantly improve the extraction efficiency of saffron exosomes, so that the best activity is achieved.

The application belongs to the technical field of genetic engineering, and particularly relates to application of CtGSTU32 gene in promoting accumulation of crocin, and the nucleotide sequence of the CtGSTU32 gene is shown as SEQ ID NO. 1. The application first proves that overexpression of the CtGSTU32 gene can promote accumulation of crocin, and the result lays a foundation for breeding crocus varieties with high crocin, and has important economic value and social benefits.

The invention discloses mitochondria-targeted carthamin yellow nanoparticles and application thereof. The mitochondria-targeted carthamin yellow nanoparticles comprise a soft shell and a foldable inner core, the inner core is of a nano-particle frame structure and is formed by forming a G-quadruplex by ATP and trivalent gadolinium ions through pi-pi coordination; cY is packaged in the nano-particle frame; the inner core is obtained by synthesizing trivalent gadolinium ions growing through in-situ coordination and ATP in a DSPE-PEG-NH2 nano template, and the soft shell is generated by combining diselenide bonds with the DSPE-PEG-NH2 nano template on the inner core through an amidation reaction and connecting mitochondrial targeting peptide SS-31 with dienylation bonds. Efficient loading and stable delivery of the CY are realized; responsive release under the ROS condition; targeting mitochondria and delivering ATP to restore energy metabolism; mRI imaging is realized through Gd < 3 + >; and ferroptosis is inhibited synergistically, inflammation is resisted, and neurons are protected.

The invention discloses a pharmaceutical composition containing curdione. The pharmaceutical composition is characterized in that it is found that curdione can improve the cardiac function of myocardial ischemia / reperfusion model rats. The combined use of curdione and stigma croci glucose ester E has a synergistic effect, and when the curdione and the stigma croci glucose ester E are taken together with trehalose, the effect is the best. Moreover, the invention accidentally finds that after the curdione is compounded with the crocus sativus glucose ester E and the trehalose, not only can the injury caused by oxidative stress in reperfusion therapy be effectively improved, but also the injury of the curdione to the liver can be reduced.

The present invention discloses a viscera conditioning prescription, which comprises the following raw materials: 1000 jin of beef, 360 jin of water, 1.3 jin of saffron crocus, 1.6 jin of cordyceps sinensis, 100-800 jin of wild boar meat, and 100-500 jin of venison, and relates to the technical field of conditioning prescriptions, the viscera conditioning prescription internally contains a variety of amino acid components required by human bodies, is helpful for assisting Chinese herbal medicines to condition viscera and eliminate diseases, and has the effects of nourishing the liver, nourishing the liver and the kidney. The long-term taking is suitable.

The invention belongs to the field of enzymes, and relates to glycosyltransferase for synthesizing crocin compounds and application of the glycosyltransferase. According to the present invention, BoUGT1, SaUGT5961 and SaUGT8661 genes capable of catalyzing crocetin glycosylation to specifically generate crocin V are cloned from Buddleja officinal Maxim. And Mimosa pudica L for the first time, the BoUGT1 gene can further catalyze crocetin to generate crocin IV, and the BoUGT1, the SaUGT5961 and the SaUGT8661 can further catalyze crocin III to generate crocin II, in addition, the BoUGT2 gene capable of further catalyzing crocin II to generate crocin I is obtained through cloning. According to the invention, the resource acquisition way of crocin is widened, an important theoretical basis is provided for producing crocin compounds by using a synthetic biological method in the future, and the application prospect is wide and the economic value is higher.

The invention relates to a compound medicine for treating oral mucositis caused by luconobutuzumab and a preparation method of the compound medicine, and the compound medicine realizes the comprehensive curative effects of resisting inflammation, easing pain and promoting mucosal repair through combination of traditional Chinese medicines and western medicines and synergism of multi-ethnic medicines. The compound medicine is prepared from the following components in parts by weight: 0.1 to 0.5 part of recombinant human epidermal growth factor, 0.5 to 2.0 parts of lidocaine, 0.01 to 0.1 part of vitamin B12, 1.0 to 5.0 parts of astragalus polysaccharide, 0.5 to 3.0 parts of honeysuckle chlorogenic acid, 0.2 to 1.5 parts of glycyrrhizic acid, 0.1 to 1.0 part of crocin, 0.3 to 2.0 parts of saussurea involucrata flavone, 0.2 to 1.8 parts of paris polyphylla saponin and 0.4 to 2.5 parts of sculellaria barbata flavone. The compound provided by the invention is suitable for tumor patients receiving treatment of luconatobutuzumab, is especially suitable for patients suffering from I-III grade oral mucositis, can be used as a hospital preparation or new drug development, and has wide clinical application and market prospects.

The application discloses a method for constructing a compound health-care wine fingerprint spectrum, which comprises the following steps: preparing a test sample solution, preparing a control sample solution, performing multi-index quantitative determination, determining the fingerprint spectrum, and performing fingerprint spectrum analysis and processing. The method can simultaneously detect 21 characteristic fingerprint peaks in the compound health-care wine, and 4 fingerprint peaks are identified by comparison with the control sample, which are chlorogenic acid, bitter crocins, p-coumaric acid, ferulic acid and the like; and more fingerprint spectrum characteristic peaks can be obtained in the shortest possible separation time.

The invention relates to a composition comprising a mixture of catechin and / or epicatechin, safranal and crocetin in aglycone and / or glycosylated form. Such a composition can be used as a nutritional product or medicament and has a synergistic action for improving cognitive functions and / or executive functions in humans or animals.

The application discloses RGD modified crocetin-paclitaxel co-loaded drug compound liposomes and a preparation method and application thereof, and belongs to the technical field of biological medicines. The RGD modified crocetin-paclitaxel co-loaded drug compound liposomes comprise RGD modified liposomes, paclitaxel and crocetin, wherein the RGD modified liposomes are used as a drug carrier to target and deliver the paclitaxel and the crocetin to prostate tumor cells, and the RGD modified liposomes are prepared by a film dispersion method or a reverse evaporation method. The prostate cancer targeted compound liposomes prepared by the application can increase the uptake of the prostate cancer cells, improve the in-vitro cytotoxicity of the prostate cancer cell line RM-1, and inhibit the growth of RM-1 ectopic solid tumors in mice, and does not cause obvious damage to other tissues.

To provide a water-soluble crocetin-containing composition that contains crocetin and gentiobiose, and further to provide a method for stabilizing crocetin and gentiobiose.SOLUTION: It was found that, by including a step of saponifying a crocetin glycoside, a step of blending an anionic polysaccharide, and a step of adjusting the pH to 2.0-8.0 with an acidic compound, a water-soluble crocetin-containing composition can be obtained and crocetin and gentiobiose can be further stabilized, thereby completing the present invention.SELECTED DRAWING: None

The invention discloses a pharmaceutical composition and application thereof. The pharmaceutical composition provided by the invention comprises the following active components in percentage by weight: 10-50% of geniposide, 10-50% of a surfactant, and 10-50% of a 10% to 50% of geniposide; 10% to 50% of genipin gentiobioside; 10 to 50 percent of crocin I and 10 to 50 percent of ursolic acid. The composition can effectively inhibit paralysis of tremor, improve the balancing capacity and grasping capacity of mice, reduce the content of interleukin-1beta and tumor necrosis factor-alpha, promote secretion of dopamine, reduce the content of malondialdehyde and improve the total antioxidant capacity in brain tissue. The compound has a good treatment effect on a Parkinson's disease model, so that the effect of treating the Parkinson's disease is expected to be greatly improved, and adverse reactions are reduced.

The invention provides a genetically engineered bacterium as well as a construction method and application thereof. The genetically engineered bacterium comprises a gene combination, and the gene combination comprises a CCD (Charge Coupled Device) gene of optimized beta-carotene cleavage dioxygenase and an ALDH (Aldehyde Dehydrogenase) gene of coded aldehyde dehydrogenase. The genetically engineered bacterium constructed by the invention can be used for producing crocetin, and the crocetin yield can reach 110.4 mu g / L on average at a shake flask level; the obtained strain is good in stability after continuous subculture, and the obtained crocetin can be safely utilized and has a good prospect.

The application discloses a composition containing rose extract, and mainly comprises the following components in parts by weight: rose flower extract 1-50 parts, gardenia flower extract 1-30 parts, saffron extract 1-30 parts, medlar fructan 1-30 parts and tremella polysaccharide 1-30 parts; and the preparation method and application of the composition are also disclosed. The composition mainly comprises three kinds of flower components and cooperates with plant polysaccharide, can play good anti-aging and moisturizing effects, has good effects of removing excess free radicals in human bodies and promoting collagen synthesis, can effectively relieve symptoms such as skin dullness, obvious wrinkles and dry skin, and the composition itself is natural, safe and non-irritating, and has a good application prospect in daily chemical product application.