Composition for protecting eyes and strengthening brain as well as preparation method and application of composition

Abstract

The invention relates to the technical field of functional food, in particular to an eye-protecting and brain-strengthening composition as well as a preparation method and application thereof. The aronia, the astaxanthin, the DHA, the medlar, the hovenia dulcis thunb and the saffron crocus extract are compounded, various functional raw materials have a synergistic effect, the visual problem is improved through multiple channels, the cognitive ability is synchronously improved, and the astaxanthin eye drops have the effects of preventing retina oxidative damage, promoting eye blood circulation, relieving visual fatigue, protecting nerve cells and improving the cognitive state. Through reasonable proportioning, the composition for protecting eyes and strengthening brain has better effects of relieving visual discomfort, improving vision and improving brain health.

Description

Technical Field

[0001] The present invention relates to the technical field of functional foods, and in particular to an eye-protecting and brain-strengthening composition and a preparation method and application thereof. Background Art

[0003] As people pay more and more attention to eye health issues and their awareness of eye protection increases, the demand for eye protection products is becoming more and more urgent. In recent years, eye protection nutritional supplement products represented by blueberry lutein ester gummies and pressed candies have been very popular among consumers. Blueberry and lutein, as the most well-known star eye protection ingredients, are used in almost all eye protection products, resulting in too much single raw materials and serious product homogeneity.

[0004] In addition, the efficacy of current eye protection products is also quite simple, only targeting eye problems. For example, Chinese patent CN113197307A discloses an eye protection composition, which contains 12 raw materials, most of which are carotenoids and anthocyanins, and the efficacy is only aimed at eye protection. However, whether it is teenagers studying in school or adults working at work, they use their brains while using their eyes. They not only need to protect their eyes, but also need to improve their brain power at the same time; and as the elderly grow older, their eyes and brain functions will gradually decline, and they need to prevent them in advance. Therefore, it is necessary to develop a product that can protect the eyes and strengthen the brain at the same time. Summary of the invention

[0005] The purpose of the present invention is to overcome the shortcomings of the prior art and provide a composition for protecting eyes and strengthening brain, which can be used in food, health products and medicines to have the best effect of protecting eyesight and improving cognition.

[0006] To achieve the above object, the technical solution adopted by the present invention is:

[0007] In a first aspect, the present invention provides an eye-protecting and brain-strengthening composition, comprising the following components in parts by weight: 3-12 parts of aronia powder, 0.5-5 parts of astaxanthin microcapsule powder, 2-8 parts of DHA powder, 1-5 parts of wolfberry powder, 2-10 parts of Hovenia dulcis powder, and 1-5 parts of saffron extract.

[0008] The aronia berry provided by the present invention, also known as the "immortal berry", is known as the "king of anthocyanins". The anthocyanin content ranks first among all currently known fruits. Anthocyanins, as a powerful antioxidant, play an important role in maintaining the health of the retina and optic nerve; astaxanthin has a similar structure to lutein and zeaxanthin (both belong to the carotenoid family), has excellent antioxidant capacity, and has the effects of improving eye circulation, reducing eye oxidative stress, etc. In addition, astaxanthin helps to improve age-related cognitive degeneration; DHA is a major element that assists the growth and maintenance of nervous system cells and is an important component of the brain and retina. Its content in the human cerebral cortex is as high as 20%, and its proportion in the retina of the eye is the largest, about 50%, and it is vital to the human body, especially brain development and vision protection. Important role; Lycium barbarum is considered to have the effect of nourishing liver and kidney and improving eyesight in traditional Chinese medicine theory, and modern scientific research has found that the eye protection effect of Lycium barbarum is closely related to its rich nutrients, and Lycium barbarum is rich in carotene, vitamin A, C, E and various trace elements, which are essential for the health of eyes; Hovenia dulcis has a long history in my country and is an important medicinal and edible plant. Modern scientific research has found that the bioactive substances in Hovenia dulcis have multiple biological activities, have a protective effect on different similar liver injuries, and also have anti-inflammatory effects. Traditional Chinese medicine believes that the health of the eyes is closely related to the function of liver and kidney, and Hovenia dulcis can protect the liver, thereby achieving the purpose of eye protection; Studies have shown that saffron extract can prevent the death of retinal ganglion cells and also has a neuroprotective effect. The present invention compounds aronia, astaxanthin, DHA, Lycium barbarum, Hovenia dulcis and saffron extract, and multiple functional raw materials are synergistic, with the effect of preventing retinal oxidative damage, promoting eye blood circulation, alleviating visual fatigue, protecting nerve cells, and improving cognitive status. When the weight ratio of each component of aronia, astaxanthin, DHA, wolfberry, Hovenia dulcis, and saffron extract changes, it will directly affect the effect of improving vision and cognition. The effect of gradually increasing or decreasing the content of a single component on the effect of the composition is not linear. The present invention uses a reasonable ratio to make the eye-protecting and brain-healthy composition have better effects of relieving visual discomfort, improving vision and improving brain health.

[0009] Preferably, the following components are included in parts by weight: 5-10 parts of aronia powder, 2-4 parts of astaxanthin microcapsule powder, 3-6 parts of DHA microcapsule powder, 2-4 parts of wolfberry powder, 4-8 parts of Hovenia dulcis powder, and 2-4 parts of saffron extract.

[0010] After a large number of experiments and investigations, the present invention found that the compounding of aronia powder, astaxanthin microcapsule powder, DHA powder, wolfberry powder, Hovenia dulcis powder and saffron extract within the above-mentioned weight ratio range has a better effect of protecting eyesight and improving cognition.

[0011] Preferably, the following components are included in parts by weight: 8 parts of aronia powder, 3 parts of astaxanthin microcapsule powder, 5 parts of DHA powder, 3 parts of wolfberry powder, 6 parts of Hovenia dulcis powder, and 3 parts of saffron extract.

[0012] After a large number of experiments and explorations, the present invention found that the compounding of aronia powder, astaxanthin microcapsule powder, DHA powder, wolfberry powder, Hovenia dulcis powder and saffron extract in the above-mentioned specific weight ratio can achieve the best effect on relieving visual discomfort and improving brain health.

[0013] Preferably, the astaxanthin microcapsule powder is extracted from Haematococcus pluvialis as raw material.

[0014] Astaxanthin is a fat-soluble substance and is insoluble in water. By encapsulating astaxanthin through an encapsulation technique and then making it into a powder product through a drying technique, it can be used as a powder and better applied to the production of food, health products, and medicines. The astaxanthin microcapsule powder of the present invention comes from Haematococcus pluvialis. The astaxanthin content in Haematococcus pluvialis is as high as 1.5%-3.0%, which is the highest among all organisms and is regarded as a "concentrated product" of astaxanthin.

[0015] Preferably, the DHA powder is extracted from at least one of algae oil, fish oil and egg yolk as raw material.

[0016] DHA is a fat-soluble substance and is insoluble in water. DHA is embedded by embedding technology and then made into a powder product by drying technology, so that it can be used as a powder and better applied to the production of food, health products and medicines. The DHA of the present invention comes from fish oil, algae oil and egg yolk. Fish oil DHA is extracted from fish bodies and varies depending on factors such as fish species, diet, and growth environment; algae oil DHA is extracted from algae, with higher purity and higher content. Algae is a natural and sustainable resource, and the raw materials have not passed through the food chain and are not polluted; the DHA in egg yolk belongs to lecithin-type DHA, which is decomposed into lecithin and DHA in the human body. DHA derived from egg yolk is biological DHA, which has not undergone chemical processing, so there is no chemical residue and no heavy metal pollution, and it is the safest DHA.

[0017] In a second aspect, the present invention provides the use of the above-mentioned eye-protecting and brain-enhancing composition in food, health products and medicines.

[0018] In a third aspect, the present invention provides a compressed candy for protecting eyes and strengthening brain, wherein the compressed candy for protecting eyes and strengthening brain comprises the above-mentioned composition for protecting eyes and strengthening brain; and further comprises at least one of a sweetener, an acidity regulator, a flavoring agent, a lubricant, and a filler.

[0019] Preferably, the sweetener includes at least one of maltitol, sorbitol, xylitol, erythritol, mannitol, and isomalt; the acidity regulator includes at least one of citric acid, sodium citrate, and malic acid; the flavoring agent includes berry flavor; the lubricant includes magnesium stearate; and the filler includes at least one of maltodextrin, resistant dextrin, starch, and fruit powder.

[0020] Preferably, the compressed candy for protecting eyes and strengthening brain comprises the following components in parts by weight based on 100 parts by total weight: 26-29 parts of the eye and brain protecting composition, 60-70 parts of sweetener, 0.1-2 parts of acidity regulator, 0-2.5 parts of flavoring agent, 0.5-2 parts of lubricant, and the remainder of filler.

[0021] In a fourth aspect, the present invention provides a method for preparing the above-mentioned eye-protecting and brain-strengthening compressed candy, comprising the following steps:

[0022] (1) weighing the eye-protecting and brain-nourishing composition, the acidity regulator, the flavoring agent, and the filler according to weight, mixing them evenly, and sieving them to obtain a mixture A;

[0023] (2) mixing the mixture A obtained in step (1), a sweetener, and a lubricant to obtain a mixture B;

[0024] (3) Compressing the mixture B obtained in step (2) into tablets to prepare the eye-protecting and brain-boosting compressed candy.

[0025] Preferably, in the sieving step, the mesh size of the sieve is 40-60 meshes.

[0026] Preferably, the specification of the compressed candy in step (3) is 0.8-1.2 g / tablet.

[0027] The beneficial effects of the present invention are:

[0028] The present invention compounds aronia, astaxanthin, DHA, wolfberry, Hovenia dulcis and saffron extracts, and multiple functional raw materials synergize to improve visual problems in multiple ways and simultaneously improve cognitive ability, thereby preventing retinal oxidative damage, promoting eye blood circulation, relieving visual fatigue, protecting nerve cells and improving cognitive status. The present invention uses a reasonable ratio to make the eye-protecting and brain-strengthening composition have better effects of relieving visual discomfort, improving vision and improving brain health. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] Figure 1 The compressed candy for protecting eyes and strengthening brain prepared in Example 3 is used.

[0030] Figure 2 The compressed candy for protecting eyes and strengthening brain prepared by using Comparative Example 7. DETAILED DESCRIPTION

[0031] In order to better illustrate the purpose, technical solutions and advantages of the present invention, the present invention will be further described below in conjunction with specific embodiments.

[0032] In the examples, the experimental methods used are conventional methods unless otherwise specified, and the materials, reagents, etc. used are all commercially available unless otherwise specified.

[0033] The specific sources of the raw materials used in the present invention are as follows: wild aronia powder was purchased from Shanghai Yingku Business Consulting Co., Ltd.; astaxanthin microcapsule powder (derived from Haematococcus pluvialis), DHA powder (derived from algal oil) and lutein ester microcapsule powder were all purchased from Dalian Yinuo Biological Co., Ltd.; wolfberry powder was purchased from Guangdong Qingyunshan Pharmaceutical Co., Ltd.; Hovenia dulcis powder was purchased from Xi'an Nuozhong Kangjian Biotechnology Co., Ltd.; saffron extract was purchased from Guangzhou Kanglai Food Additive Co., Ltd.; DHA powder (derived from fish oil) was purchased from Qingdao Haizhiyuan Life Science Technology Co., Ltd.; DHA powder (derived from egg yolk) was purchased from Linyi Youkang Biotechnology Co., Ltd.

[0034] Embodiment 1:

[0035] An embodiment of the eye-protecting and brain-nourishing composition of the present invention; the eye-protecting and brain-nourishing composition comprises the following components in parts by weight: 3 parts of aronia powder, 5 parts of astaxanthin microcapsule powder, 2 parts of DHA powder, 5 parts of wolfberry powder, 10 parts of Hovenia dulcis powder, and 1 part of saffron extract.

[0036] The astaxanthin microcapsule powder is extracted from Haematococcus pluvialis as a raw material.

[0037] The DHA powder is extracted from algae oil as raw material.

[0038] Embodiment 2:

[0039] An embodiment of the eye-protecting and brain-nourishing composition of the present invention; the eye-protecting and brain-nourishing composition comprises the following components in parts by weight: 5 parts of aronia powder, 4 parts of astaxanthin microcapsule powder, 3 parts of DHA powder, 2 parts of wolfberry powder, 8 parts of Hovenia dulcis powder, and 4 parts of saffron extract.

[0040] The astaxanthin microcapsule powder is extracted from Haematococcus pluvialis as a raw material.

[0041] The DHA powder is extracted from algae oil as raw material.

[0042] Embodiment 3:

[0043] An embodiment of the eye-protecting and brain-nourishing composition of the present invention; the eye-protecting and brain-nourishing composition comprises the following components in parts by weight: 8 parts of aronia powder, 3 parts of astaxanthin microcapsule powder, 5 parts of DHA powder, 3 parts of wolfberry powder, 6 parts of Hovenia dulcis powder, and 3 parts of saffron extract.

[0044] The astaxanthin microcapsule powder is extracted from Haematococcus pluvialis as a raw material.

[0045] The DHA powder is extracted from algae oil as raw material.

[0046] Embodiment 4:

[0047] An embodiment of the eye-protecting and brain-nourishing composition of the present invention; the eye-protecting and brain-nourishing composition comprises the following components in parts by weight: 10 parts of aronia powder, 2 parts of astaxanthin microcapsule powder, 6 parts of DHA powder, 4 parts of wolfberry powder, 4 parts of Hovenia dulcis powder, and 2 parts of saffron extract.

[0048] The astaxanthin microcapsule powder is extracted from Haematococcus pluvialis as a raw material.

[0049] The DHA powder is extracted from algae oil as raw material.

[0050] Embodiment 5:

[0051] An embodiment of the eye-protecting and brain-nourishing composition of the present invention; the eye-protecting and brain-nourishing composition comprises the following components in parts by weight: 12 parts of aronia powder, 0.5 parts of astaxanthin microcapsule powder, 8 parts of DHA powder, 1 part of wolfberry powder, 2 parts of Hovenia dulcis powder, and 5 parts of saffron extract.

[0052] The astaxanthin microcapsule powder is extracted from Haematococcus pluvialis as a raw material.

[0053] The DHA powder is extracted from algae oil as raw material.

[0054] Embodiment 6:

[0055] An embodiment of the eye-protecting and brain-nourishing composition of the present invention; the eye-protecting and brain-nourishing composition of this embodiment is different from that of Example 3 only in that: in the eye-protecting and brain-nourishing composition of this embodiment, DHA powder is extracted from fish oil as raw material.

[0056] Embodiment 7:

[0057] An embodiment of the eye-protecting and brain-nourishing composition of the present invention; the eye-protecting and brain-nourishing composition of this embodiment is different from that of Example 3 only in that: in the eye-protecting and brain-nourishing composition of this embodiment, DHA powder is extracted from egg yolk as raw material.

[0058] Comparative Example 1:

[0059] A comparative example of the eye-protecting and brain-nourishing composition of the present invention; the eye-protecting and brain-nourishing composition of this comparative example is different from Example 3 only in that: the eye-protecting and brain-nourishing composition of this comparative example does not contain aronia powder.

[0060] Comparative Example 2:

[0061] A comparative example of the eye-protecting and brain-nourishing composition of the present invention; the eye-protecting and brain-nourishing composition of this comparative example is different from Example 3 only in that: the eye-protecting and brain-nourishing composition of this comparative example does not contain astaxanthin microcapsule powder.

[0062] Comparative Example 3:

[0063] A comparative example of the eye-protecting and brain-nourishing composition of the present invention; the eye-protecting and brain-nourishing composition of this comparative example differs from Example 3 only in that the eye-protecting and brain-nourishing composition of this comparative example does not contain DHA powder. Comparative Example 4:

[0064] A comparative example of the eye-protecting and brain-nourishing composition of the present invention; the eye-protecting and brain-nourishing composition of this comparative example differs from Example 3 only in that the eye-protecting and brain-nourishing composition of this comparative example does not contain wolfberry powder. Comparative Example 5:

[0065] A comparative example of the eye-protecting and brain-nourishing composition of the present invention; the eye-protecting and brain-nourishing composition of this comparative example is different from Example 3 only in that the eye-protecting and brain-nourishing composition of this comparative example does not contain Hovenia dulcis seed powder.

[0066] Comparative Example 6:

[0067] A comparative example of the eye-protecting and brain-nourishing composition of the present invention; the eye-protecting and brain-nourishing composition of this comparative example is different from Example 3 only in that: the eye-protecting and brain-nourishing composition of this comparative example does not contain saffron extract.

[0068] Comparative Example 7:

[0069] A comparative example of the eye-protecting and brain-nourishing composition of the present invention; the eye-protecting and brain-nourishing composition of this comparative example differs from Example 3 only in that this comparative example uses an equal amount of lutein ester microcapsule powder instead of astaxanthin microcapsule powder extracted from Haematococcus pluvialis as a raw material (lutein ester and astaxanthin are both carotenoids).

[0070] Comparative Example 8:

[0071] A comparative example of the eye-protecting and brain-nourishing composition of the present invention; the eye-protecting and brain-nourishing composition in this comparative example comprises the following components in parts by weight: 13 parts of aronia powder, 0.4 parts of astaxanthin microcapsule powder, 8.5 parts of DHA powder, 5.5 parts of wolfberry powder, 1.5 parts of Hovenia dulcis powder, and 0.8 parts of saffron extract.

[0072] The astaxanthin microcapsule powder is extracted from Haematococcus pluvialis as a raw material.

[0073] The DHA powder is extracted from algae oil as raw material.

[0074] Application Examples 1-5:

[0075] Application examples of the eye-protecting and brain-nourishing compressed candies of the present invention; the eye-protecting and brain-nourishing compressed candies of Application Examples 1-5 correspond to the compositions of Examples 1-5, respectively, and their formulas are shown in Table 1.

[0076] Table 1 Tablet candy formula of application examples 1-5 (unit: weight parts, total parts are 100 parts)

[0077]

[0078]

[0079] The method for preparing the eye-protecting and brain-strengthening tablet candy comprises the following steps:

[0080] (1) Weighing each component according to the above weight portion, mixing aronia powder, astaxanthin microcapsule powder, DHA powder, wolfberry powder, Hovenia dulcis powder, saffron extract, citric acid, berry flavor, and maltodextrin evenly and sieving (40-60 mesh) to obtain a mixture A;

[0081] (2) mixing the mixture A obtained in step (1), maltitol and magnesium stearate to obtain a mixture B;

[0082] (3) Adding the mixture B obtained in step (2) into a tablet press, setting tabletting parameters (specification: 0.8-1.2 g / tablet), and preparing the eye-protecting and brain-enhancing tablet candy.

[0083] Application Examples 6-7:

[0084] Application examples of the compressed candies for protecting eyes and strengthening brain according to the present invention; the difference between Application Examples 6-7 and Application Example 3 is only that: the compressed candies for protecting eyes and strengthening brain according to Application Examples 6-7 correspond to the compositions of Examples 6-7 respectively, that is, the sources of DHA microcapsule powder are different, the DHA powder in Application Example 6 is derived from fish oil, and the DHA powder in Application Example 7 is derived from egg yolk.

[0085] The preparation method of the eye-protecting and brain-strengthening compressed candy is the same as that of Application Example 3.

[0086] Application Comparative Examples 1-8:

[0087] Comparative examples of the application of the compressed candies for protecting eyes and strengthening brain according to the present invention; the compressed candies for protecting eyes and strengthening brain according to comparative examples 1-8 respectively correspond to the compositions of comparative examples 1-8, and the missing components are replaced by an equal amount of fillers, and the formulas are shown in Table 2.

[0088] Table 2 Tablet candy formulas for comparative examples 1-8 (unit: weight parts, total parts are 100 parts)

[0089]

[0090] The preparation method of the eye-protecting and brain-strengthening compressed candy is the same as that of the application example.

[0091] Test Example 1: Test on the effect of improving visual problems

[0092] Subject selection criteria: ① Age 25-40 years old; ② Long-term eye use (using electronic devices such as mobile phones and computers for more than 6 hours a day); ③ Mild eye discomfort symptoms (such as dry eyes, sore eyes, blurred vision after long-term viewing, etc.); ④ Mild memory loss; ⑤ Volunteers understand the purpose of the test and voluntarily participate.

[0093] Test samples: Tablet candies prepared using Examples 1-7 and Comparative Examples 1-8.

[0094] Test method: The subjects who met the requirements were randomly divided into 16 groups (including a control group, a test sample group (Application Examples 1-7, Application Comparative Examples 1-8), each group of 6 people, half male and half female. The subjects took 2 tablets of the test sample in the morning and afternoon every day. The control group took a placebo (the difference between its formula and that of Application Example 3 is that it does not contain a tablet candy of the eye-protecting and brain-nourishing composition, and is replaced by an equal amount of filler). During the test, the diet and living habits of the subjects were not adjusted. The test lasted for 60 consecutive days. An ocular surface disease questionnaire (OSDI) was conducted before and after the trial.

[0095] The OSDI Ocular Surface Disease Questionnaire is a widely used assessment tool in the field of ophthalmology. Through a simple and quick questionnaire filling process, information about eye discomfort, dryness, vision problems, etc. can be obtained. The Ocular Surface Disease Index scale is shown in Table 3.

[0096] Table 3 Ocular Surface Disease Index (OSDI) scale

[0097]

[0098]

[0099] Result calculation: score = 25 × total score / 12.

[0100] Result determination: Normal: 1-12 points; Mild dry eyes: 13-22 points; Moderate dry eyes: 23-32 points; Severe dry eyes: 33-100 points.

[0101] The changes in the ocular surface disease index of the subjects before and after the experiment are shown in Table 4.

[0102] Table 4 Changes in the ocular surface disease index of the subjects before and after the test

[0103] Group Before the test After the test Improvement rate Control group 51.0±3.08 49.2±3.35 3.56±1.71％ Application Example 1 48.2±3.03 27.4±2.61 43.24±2.16％ Application Example 2 42.4±1.95 21.0±1.58 50.52±1.61％ Application Example 3 44.4±1.34 19.4±1.52 56.34±2.50％ Application Example 4 46.6±2.41 23.4±2.07 49.86±1.91％ Application Example 5 49.0±3.24 27.2±2.59 44.56±2.13％ Application Example 6 48.0±1.58 21.8±1.30 54.59±2.17％ Application Example 7 49.8±1.92 22.0±1.58 55.85±2.02％ Application Comparative Example 1 48.6±2.61 32.8±1.92 32.50±1.96％ Application Comparative Example 2 52.0±2.83 37.0±2.12 28.84±1.59％ Application Comparative Example 3 51.4±2.07 34.8±1.30 32.28±1.38％ Application Comparative Example 4 45.6±2.41 30.0±2.24 34.25±2.53％ Application Comparative Example 5 48.8±1.92 32.4±1.82 33.63±1.89％ Application Comparative Example 6 49.6±2.07 33.2±1.30 33.04±1.83％ Application Comparative Example 7 48.2±1.30 33.6±1.67 30.30±2.46％ Application Comparative Example 8 50.8±2.39 38.2±2.17 24.83±1.12％

[0104] From the analysis results of the changes in the ocular surface disease index after the subjects took the samples, it can be seen that after 60 days of testing, compared with the control group, the ocular surface disease index of the subjects after taking the test sample compressed candies improved. Compared with the compressed candies taken by the subjects in the application example group, the improvement range was higher, with an improvement rate of ≥40%, and the difference was significant (P≤0.01). Among them, the improvement rate of the compressed candies taken by the subjects in the application example 3 group was the largest, indicating that this application example is the optimal formula combination and has the best effect on improving vision. The visual improvement effect of the compressed candies taken by the subjects in the application examples 6 and 7 groups was close to that of the application example 3 group, indicating that the DHA from the three sources can achieve significant effects, and the effects may fluctuate slightly due to differences in absorption rate and utilization rate.

[0105] After the subjects took the compressed candies of groups 1 to 6 of comparative examples, the improvement rate of the ocular surface disease index was ≥30%, indicating that the aronia, astaxanthin, DHA, wolfberry, Hovenia dulcis and saffron extracts in the composition respectively had certain effects on improving vision.

[0106] Compared with the compressed candies of the group of subjects taking Example 3, the improvement rate of the visual persistence of the compressed candies of the group of subjects taking Comparative Example 7 was lower, indicating that the eye-protecting and brain-tonifying composition of the present invention was selected after experimental verification, and even if the same type of raw materials are replaced, the effect will be significantly worse than the eye-protecting and brain-tonifying composition described in the embodiment of the present invention.

[0107] After the subjects took the compressed candies of Comparative Example 8, the vision improvement rate was significantly lower, indicating that when the weight proportions of the components in the eye-protecting and brain-nourishing composition of the present invention are not within a specific range, even if the components are the same, the effect of improving vision will be greatly reduced.

[0108] Test Example 2: Vision Durability Test

[0109] The persistence of visual acuity is a functional evaluation method specified in the Technical Specifications for Inspection and Evaluation of Health Foods, which is used to evaluate visual fatigue.

[0110] Experimental method: After completing the ocular surface disease questionnaire, the subjects used the "pin" chart for measuring the duration of clear vision to measure the time of clear vision within 3 minutes, and calculated the duration of clear vision according to the following formula.

[0111] Vision persistence = (visual duration / total fixation time) × 100%.

[0112] The results of the subjects' visual persistence before and after the test are shown in Table 5.

[0113] Table 5 Changes in the subjects' visual persistence before and after the experiment

[0114]

[0115]

[0116] From the analysis results of the duration of clear vision after the subjects took the samples, it can be seen that after 60 days of testing, compared with the control group, the subjects had improved duration of clear vision after taking the test sample compressed candies. Compared with the compressed candies in the control group, the subjects who took the compressed candies in the application example group had a higher improvement in duration of clear vision, with an improvement rate of ≥90%, and the difference was significant (P≤0.01). Among them, the improvement rate of the compressed candies in the application example 3 group was the largest, indicating that this application example is the optimal formula combination and has the best effect on improving the duration of clear vision. The compressed candies in the application examples 6 and 7 groups of subjects had a vision improvement effect similar to that in the application example 3 group, indicating that the DHA from the three sources can achieve significant effects, and the effects may fluctuate slightly due to differences in absorption rate and utilization rate.

[0117] After the subjects took the compressed candies of groups 1 to 6 of the comparative examples, the improvement rate of visual persistence was ≥60%, indicating that the aronia berry, astaxanthin, DHA, wolfberry, Hovenia dulcis and saffron extracts in the composition respectively had certain effects on improving vision.

[0118] Compared with the compressed candies of the group of subjects taking Example 3, the improvement rate of the visual persistence of the compressed candies of the group of subjects taking Comparative Example 7 was lower, indicating that the eye-protecting and brain-tonifying composition of the present invention was selected after experimental verification, and even if the same type of raw materials are replaced, the effect will be significantly worse than the eye-protecting and brain-tonifying composition described in the embodiment of the present invention.

[0119] After the subjects took the compressed candies of group 8 of comparative example, the improvement rate of visual persistence was significantly low, indicating that when the weight proportions of the components in the eye-protecting and brain-nourishing composition of the present invention are not selected within a specific range, even if the components are the same, the effect of improving vision will be greatly reduced.

[0120] Test Example 3: Assisted memory improvement test

[0121] Test method: After the subjects completed the ocular surface disease questionnaire survey and the visual persistence test, the "Clinical Memory Scale" was used to measure the improvement of the sample on the subjects' memory. The scale includes the following 5 sub-tests:

[0122] ① Pointed memory: It includes two groups of content, each group has 24 words, of which 12 words belong to the same category and are required to be memorized by the subjects. In addition, there are 12 words that are similar to the above words and are not required to be memorized. The above 24 words are mixed together, arranged randomly, and played with a tape recorder. After each group of words is played, the subjects are required to recall immediately and say the words required to be memorized. After the first group of words is tested, the second group of words is tested after an interval of 5s.

[0123] ②Associative learning: It includes 12 pairs of words, including 6 pairs of easy-to-associate words and 6 pairs of difficult-to-associate words. The 12 pairs of words are randomly arranged and played 3 times in different orders using a tape recorder. After each playback, the experimenter reads the first word of each pair of words in another order and the subjects are required to say the second word.

[0124] ③ Free recall of images: There are two groups of black and white pictures, each with 15 pieces. The contents are all common and easily recognizable. The first group of pictures are randomly arranged, and each picture is viewed for 4 seconds, with a 2-second interval. After viewing all 15 pictures, the subject is required to immediately state the contents of the picture. After a 5-second interval, the second group of pictures is tested.

[0125] ④ Meaningless figure recognition: There are 20 memorized pictures, which are closed or unclosed straight lines or curves. There are also 40 recognition pictures, including 20 pictures that are the same or similar to the memorized pictures. The memorized pictures are shown to the subjects for 3 seconds each, with a 3-second interval. After watching 20 pictures, the recognition pictures are shown in a random order, and the subjects are asked to point out the pictures they have seen.

[0126] ⑤ Recall of portrait characteristics: There are 6 black and white portraits of people, which are randomly arranged for the subjects to look at. At the same time, their names, occupations and hobbies are told twice. Each portrait is looked at for 9 seconds, with a 5-second interval. After the 6 portraits are looked at, they are presented in another order and asked to name 3 characteristics of each portrait.

[0127] Calculation of results: The above ①, ②, ③, and ⑤ are scored based on the number of correct answers. The recognition score of item ④ = (number of correct recognitions - number of incorrect recognitions) × 2; the crude scores of the 5 subtests are respectively checked against the "equivalent scale score table" to convert them into scale scores, and the sum is the total scale score. According to the age, the MQ of the subject can be obtained by checking the "equivalent memory quotient (MQ) table of total scale scores". MQ can be divided into seven levels: 130 or above is very excellent, 120-129 is excellent, 110-119 is upper middle, 90-109 is medium, 80-89 is lower middle, 70-79 is poor, and below 69 is very poor, which is used to measure the memory level of a person.

[0128] The results of the subjects' memory improvement before and after the experiment are shown in Table 6.

[0129] Table 6 Results of memory improvement of subjects before and after the experiment

[0130]

[0131]

[0132] From the analysis results of the memory quotient of the subjects after taking the samples, it can be seen that after 60 days of the test, compared with the control group, the memory quotient of the subjects after taking the test sample compressed candy was improved.

[0133] Compared with the compressed candies in the control group, the memory quotient of the subjects who took the compressed candies in the application example group was improved to a greater extent, with an improvement rate of ≥50%, and the difference was significant (P≤0.01). Among them, the compressed candies in the application example 3 group had the highest improvement rate, indicating that this application example is the optimal formula combination and has the best effect on improving memory. The compressed candies in the application examples 6 and 7 groups had a memory improvement effect similar to that in the application example 3 group, indicating that the DHA from the three sources can achieve significant effects, and the effects may fluctuate slightly due to differences in absorption rate and utilization rate.

[0134] After the subjects took the compressed candies of groups 1 to 6 of comparative examples, the memory quotient improvement rate was ≥30%, indicating that the aronia, astaxanthin, DHA, wolfberry, Hovenia dulcis and saffron extracts in the composition respectively had certain effects on improving memory.

[0135] Compared with the compressed candies of the test subjects in the group of Example 3, the improvement rate of the memory quotient of the compressed candies of the group of Comparative Example 7 was lower, indicating that the eye-protecting and brain-tonifying composition of the present invention was selected after experimental verification, and even if the same type of raw materials are replaced, the effect will be significantly worse than the eye-protecting and brain-tonifying composition described in the embodiment of the present invention.

[0136] After the subjects took the compressed candies of group 8 of comparative example, the improvement rate of memory quotient was significantly lower, indicating that when the weight proportions of the components in the eye-protecting and brain-tonifying composition of the present invention are not selected within a specific range, even if the components are the same, the effect of improving memory will be greatly reduced.

[0137] Finally, it should be noted that the above embodiments are only used to illustrate the technical solution of the present invention rather than to limit the scope of protection of the present invention. Although the present invention has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solution of the present invention can be modified or replaced by equivalents without departing from the essence and scope of the technical solution of the present invention.

Claims

1. A composition for protecting eyes and strengthening brain, characterized in that: The invention comprises the following components in parts by weight: 3-12 parts of aronia powder, 0.5-5 parts of astaxanthin microcapsule powder, 2-8 parts of DHA powder, 1-5 parts of wolfberry powder, 2-10 parts of Hovenia dulcis powder and 1-5 parts of saffron extract.

2. The eye-protecting and brain-enhancing composition according to claim 1, characterized in that: The invention comprises the following components in parts by weight: 5-10 parts of aronia powder, 2-4 parts of astaxanthin microcapsule powder, 3-6 parts of DHA powder, 2-4 parts of wolfberry powder, 4-8 parts of Hovenia dulcis powder and 2-4 parts of saffron extract.

3. The eye-protecting and brain-enhancing composition according to claim 2, characterized in that: The invention comprises the following components in parts by weight: 8 parts of aronia powder, 3 parts of astaxanthin microcapsule powder, 5 parts of DHA powder, 3 parts of wolfberry powder, 6 parts of Hovenia dulcis powder and 3 parts of saffron extract.

4. The eye-protecting and brain-enhancing composition according to claim 1, characterized in that: The astaxanthin microcapsule powder is extracted from Haematococcus pluvialis as a raw material.

5. The eye-protecting and brain-enhancing composition according to claim 1, characterized in that: The DHA powder is extracted from at least one of algae oil, fish oil and egg yolk as a raw material.

6. Use of the eye-protecting and brain-enhancing composition according to any one of claims 1 to 5 in food, health products and medicines.

7. A compressed candy for protecting eyes and strengthening brain, characterized in that: The eye-protecting and brain-nourishing compressed candy comprises the eye-protecting and brain-nourishing composition as claimed in any one of claims 1 to 5; and further comprises at least one of a sweetener, an acidity regulator, a flavoring agent, a lubricant, and a filler.

8. The compressed candy for protecting eyes and strengthening brain as claimed in claim 7, characterized in that: The sweetener includes at least one of maltitol, sorbitol, xylitol, erythritol, mannitol, and isomalt; the acidity regulator includes at least one of citric acid, sodium citrate, and malic acid; the flavoring agent includes berry flavor; the lubricant includes magnesium stearate; and the filler includes at least one of maltodextrin, resistant dextrin, starch, and fruit powder.

9. The compressed candy for protecting eyes and strengthening brain as claimed in claim 7, characterized in that: The eye-protecting and brain-nourishing compressed candy comprises the following components in parts by weight based on 100 parts by total weight: 26-29 parts of the eye-protecting and brain-nourishing composition, 60-70 parts of a sweetener, 0.1-2 parts of an acidity regulator, 0-2.5 parts of a flavoring agent, 0.5-2 parts of a lubricant, and the remainder of a filler.

10. The method for preparing the eye-protecting and brain-boosting compressed candy according to any one of claims 7 to 9, characterized in that: The steps include: (1) weighing the eye-protecting and brain-nourishing composition, the acidity regulator, the flavoring agent, and the filler according to weight, mixing them evenly, and sieving them to obtain a mixture A; (2) mixing the mixture A obtained in step (1), a sweetener, and a lubricant to obtain a mixture B; (3) Compressing the mixture B obtained in step (2) into tablets to prepare the eye-protecting and brain-boosting compressed candy.

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