24 results about "Hashimoto thyroiditis" patented technology

The invention relates to the technical field of biological medicine, in particular to application of a Yupingfeng pharmaceutical preparation in preparation of a medicine for preventing and treating hashimoto thyroiditis. The Yupingfeng pharmaceutical preparation provided by the invention has a good prevention and treatment effect on hashimoto thyroiditis, can be used for the whole course of hashimoto thyroiditis, including hashimoto thyroiditis in a transient hyperthyroidism stage, clinical and subclinical hypothyroidism stage and the like, and can play a role in improvement from two aspects of prevention and treatment; the pharmaceutical composition is used for preventing generation of hashimoto thyroiditis and / or treating related diseases of hashimoto thyroiditis in progress.

The invention discloses a pharmaceutical composition for treating hashimoto thyroiditis, and belongs to the technical field of traditional Chinese medicines. According to the pharmaceutical composition, astragalus membranaceus and codonopsis pilosula are used as monarch drugs to tonify qi, raise yang, tonify qi and strengthen body resistance; radix bupleuri, rhizoma cyperi and radix curcumae are used as ministerial drugs for soothing liver-qi stagnation, expelling evil, soothing liver-qi, regulating qi and harmonizing blood; humifuse euphorbia herb, lucid ganoderma and oldenlandia diffusa are used as adjuvant drugs for clearing away heat and toxic materials, reinforcing qi, nourishing blood and tranquilizing; the whole formula has the effects of tonifying qi, soothing the liver and clearing heat together. All the medicines are combined to effectively improve the symptoms of patients with hashimoto thyroiditis and reduce the thyroid autoantibody level. In addition, the pharmaceutical composition is good in safety, and a traditional Chinese and western medicine combined treatment strategy for hashimoto thyroiditis can be further popularized in the future.

The invention belongs to the technical field of traditional Chinese medicines, and relates to a traditional Chinese medicine composition for treating hashimoto thyroiditis related depression anxiety disorder and application. The traditional Chinese medicine composition comprises astragalus membranaceus, radix pseudostellariae, bighead atractylodes rhizome, pericarpium citri reticulatae, selfheal, thunberg fritillary bulb, oyster, rhizoma cyperi, angelica sinensis, radix bupleuri and liquorice. The traditional Chinese medicine composition can effectively improve the thyroid lymphocyte infiltration degree and the overall inflammatory response level of AIT mice, effectively reduce the number of depression behaviors of the mice and relieve the depression anxiety state. According to the traditional Chinese medicine composition disclosed by the invention, the effects of all the medicines generate a synergistic effect and can be prepared into a traditional Chinese medicine preparation, so that depression and anxiety disorders related to hashimoto thyroiditis can be effectively treated.

The invention discloses a combined medicine composition of a thyroid Qixia patch and a selenium yeast tablet and application of the combined medicine composition, and belongs to the technical field of medicines. The composition is composed of a thyroid and astragalus mongholicus summer patch and a selenium yeast tablet, the thyroid and astragalus mongholicus summer patch is prepared by grinding astragalus mongholicus, selfheal, radix clematidis, turmeric, airpotato yam and semen brassicae as raw materials, and adding vaseline to prepare paste. The selenium yeast tablet is used for oral administration and is matched with the thyroid qi-summer patch for external application on the neck, and the treatment course is 3 months. Clinical verifications show that the total effective rate of the composition reaches 87.80%, the composition can effectively improve symptoms such as anterior cervical mass, dysphoria, irritability and the like, reduce the level of serum TPOAb, reduce thyroid and nodule volumes and improve nodule blood flow, the safety is good, the curative effect is superior to that of pure western medicine treatment, and an effective treatment scheme is provided for related diseases.

The invention relates to a pharmaceutical composition for treating hashimoto thyroiditis, and further relates to application of the pharmaceutical composition. The pharmaceutical composition comprises crocin and oxymatrine as active pharmaceutical ingredients, has an obvious improvement effect on serum TPO-Ab, TG-Ab, TSH, FT4, IFN-gamma, TNF-alpha and IL-10 levels of rats suffering from hashimoto thyroiditis, and is obviously superior to crocin and oxymatrine with the same dosage; the crocin and the oxymatrine have a synergistic effect in treatment of hashimoto thyroiditis, and the combination of the crocin and the oxymatrine has enhanced safety and wider application scenarios.

The invention relates to the technical field of medical instruments, in particular to a medical hashimoto thyroiditis traditional Chinese medicine ointment smearing device which comprises a smearing shell, an ointment storage part is fixedly connected to the smearing shell, a bandage assembly is arranged on the smearing shell, and a supporting assembly is arranged at the bottom of the smearing shell; a plurality of vertical grooves are formed in the smearing shell, sliding blocks are arranged in the vertical grooves in a sliding fit mode, driving assemblies are arranged in the vertical grooves, smearing heads are arranged on one sides of the sliding blocks, height adjusting air bags are fixedly connected to the surfaces of the smearing heads, medicine outlet bags are fixedly connected to the surfaces of the height adjusting air bags, and a plurality of medicine outlet holes are formed in the sides, away from the height adjusting air bags, of the medicine outlet bags. Connecting assemblies are arranged between the smearing heads and the sliding blocks. The plane applicator is designed to be fit with the neck contour shell of a hashimoto thyroiditis patient for fixation, the application angle and height are dynamically adjusted according to the features of the neck contour of different patients after illness, and the technical defects that a traditional plane applicator is poor in fitting performance and uneven in application are overcome.

The invention relates to the technical field of medicine component extraction, and discloses a medicine for resisting hashimoto thyroiditis disease, the medicine comprises an active component and an auxiliary material, the active component is an andrographis paniculata general flavone extract, andrographis paniculata general flavone is used as a main component, and the andrographis paniculata general flavone can reduce exudation of capillary walls, so that the medicine can be used for preventing and treating the hashimoto thyroiditis disease. The andrographis paniculata total flavone extract has an anti-inflammatory effect, is especially effective for symptoms such as upper respiratory tract and diarrhea caused by bacteria and viruses, shows strong antibacterial and antiviral capabilities, can inhibit ADP-induced human platelet aggregation, shortens the dissolution time of euglobulin, and has a good anti-inflammatory effect. The andrographis paniculata extract has a certain protective effect on myocardial injury caused by isoprenaline and experimental myocardial infarction ischemic injury, and the andrographis paniculata extract can enhance the function of phagocytes and improve the staphylococcus aureus phagocytosis capacity of peripheral blood leukocytes, and is used for enhancing immunity and overcoming immunity diseases.

The invention provides artemisia capillaris decoction powder as well as a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine compositions. The artemisia capillaris decoction powder is prepared from 8-10 parts of artemisia capillaris, 2-4 parts of cape jasmine and 2-4 parts of rheum officinale through soaking, decocting, filtering, vacuum drying and freeze drying. The artemisia capillaris decoction powder disclosed by the invention can be used for improving the protection rate of thyroid follicular cells, promoting the regeneration and repair development of tissues and improving the damage of TgAb to the thyroid follicular cells, and can be used for preparing medicines for treating hashimoto thyroiditis.

The invention relates to application of a traditional Chinese medicine composition in preparation of a medicine for hashimoto thyroiditis and / or recurrent abortion, and relates to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition can effectively prevent and / or treat hashimoto thyroiditis (HT) and / or recurrent abortion (RSA) aiming at the problem that no medicine for effectively controlling thyroid antibodies and hormone levels and preventing and treating abortion exists at present.

A traditional Chinese medicine composition for treating Hashimoto's thyroiditis comprises the following raw materials in the indicated weight ratios: 50-200 parts Rehmannia glutinosa (processed), 10-60 parts Cinnamomum cassia, 30-100 parts Ephedra sinica, 10-60 parts Cervi cornu slices, 10-60 parts Zingiber officinale (dried), 30-80 parts Glycyrrhiza uralensis (processed), 50-200 parts Paeonia lactiflora (white), 50-200 parts Paeonia veitchii (red), 30-100 parts Paeonia suffruticosa (moutan bark), 50-200 parts Codonopsis pilosula, 50-200 parts Angelica sinensis, 50-200 parts Prunus persica, and 30-100 parts Carthamus tinctorius. The preparation method is as follows: Place Rehmannia glutinosa, Cinnamomum cassia, Ephedra sinica, deer antler slices, dried ginger, prepared licorice root, white peony root, red peony root, peony bark, Codonopsis pilosula, Angelica sinensis, peach kernel, and safflower in a container, add 8 times the total weight of the herbs in cold water, soak for 30 minutes to fully moisten the herbs, bring to a boil over high heat, then simmer over low heat for another 30 minutes; for the second decoction, filter out the liquid from the first decoction, add the remaining herbs and 6 times the total weight of the herbs in warm water, just enough to cover the herbs; soak for 30 minutes, bring to a boil over high heat, then simmer over low heat for another 20 minutes; after the decoction is completed, combine the two decoctions, filter out the dregs, and obtain the traditional Chinese medicine decoction.

The invention discloses a medicine for preventing hashimoto thyroiditis as well as a preparation method and application thereof, the medicine is a 10 [mu] g / [mu] l sterile pig thyroid freeze-dried powder solution, and the active ingredients of the medicine are thyroglobulin and thyroid peroxidase. The preparation method comprises the following steps: separating thyroid tissues from necks of just slaughtered pigs; removing connective tissues in the thyroid tissues in an ice bath, and grinding the thyroid tissues from which the connective tissues are removed by using a grinding machine to obtain a thyroid extract; freezing the thyroid extract overnight and placing the thyroid extract in liquid nitrogen for a preset time so as to pre-treat the thyroid extract; and carrying out freeze-drying treatment on the pretreated thyroid extract to obtain pig thyroid freeze-dried powder, and carrying out cryopreservation on the pig thyroid freeze-dried powder. Immune tolerance can be induced by oral administration or subcutaneous injection of the pig thyroid freeze-dried powder prepared by the invention for a newborn CBA / J mouse, so that autoimmune thyroiditis after adult can be prevented.

This invention provides a traditional Chinese medicine preparation for treating Hashimoto's thyroiditis and its preparation method, belonging to the field of traditional Chinese medicine pharmaceutical technology. The preparation is made from Curcuma zedoaria, oyster shell, Eclipta prostrata, Ligustrum lucidum, Sargassum, processed Aconitum carmichaelii, Cremastra appendiculata, Duchesnea indica, Hedyotis diffusa, Artemisia capillaris, Oroxylum indicum, and cinnamon. The formula is meticulously formulated, closely addressing the core pathogenesis of Hashimoto's thyroiditis: "phlegm and blood stasis, spleen and kidney deficiency, and nutritional imbalance." It focuses on "eliminating masses and dispersing nodules, promoting qi and blood circulation," fully embodying the TCM diagnostic and treatment approach of "differentiating syndromes and treating accordingly, addressing both the root cause and symptoms." This invention's preparation has a good therapeutic effect on Hashimoto's thyroiditis, effectively improving thyroid autoimmune disorders, regulating thyroid function, and alleviating symptoms of local thyroid inflammation in experimentally induced Hashimoto's thyroiditis rats. Further clinical observation studies have found that this preparation significantly improves the overall effective rate of clinical treatment for Hashimoto's thyroiditis patients, providing a new approach to the treatment of this condition.

The application provides a traditional Chinese medicine compound for treating Hashimoto's thyroiditis, and relates to the technical field of traditional Chinese medicine pharmacy.The traditional Chinese medicine compound is composed of traditional Chinese medicinal materials of mountain yam, Humulus scandens, catechu, Sabina tibetica, bitter ground ivy, crossandra infundibuliformis, Usnea, luffa, bergamot, oleander, rootless incense, gardenia leaf, eucommia, mulberry ear, has the effects of resolving phlegm and removing nodules, promoting blood circulation to remove stasis, regulating qi to relieve depression, and clearing heat and resolving toxins, is suitable for treating Hashimoto's thyroiditis.The traditional Chinese medicine compound can effectively regulate the levels of TPOAb, TgAb and thyroid hormone, and has a good anti-inflammatory effect, so that excellent treatment of Hashimoto's thyroiditis is realized.The traditional Chinese medicine compound can be further popularized and applied as a medicine for treating Hashimoto's thyroiditis.

The idea of the patent includes a new principle, which is the detection of immune complexes using ELISA technology, which is a new and modern principle that is added to the four principles of ELISA, the new principle (the fifth ELISA) depends on detection of immune complexes, which consist of two different parts of proteins (an antigen - an antigen). This complex can be detected through this new principle, and it was applied to the immune complex (thyroid-stimulating hormone receptors and antibodies formed against it) Hashimoto's patients. It was considered an example of applying this theory, the immune complex was actually detected, its concentration determined, and compared to other techniques. A standard solution specially designed for this purpose was used to prove this theory. In this patent, a new kit is specifically designed to detect these immune complexes. Immune complex, the group is considered successful. In terms of use.

The present disclosure relates to sequence selective deoxyribonucleic acid (DNA) binding compounds comprising a polyamide moiety configured to bind a DNA sequence. The invention also relates pharmaceutical compositions comprising the compounds, and methods of using the compounds for restoring expression of autoimmune regulator (AIRE) gene. The invention further relates to pharmaceutical compositions comprising the compounds, and methods of using the compounds for and treating an autoimmune disease (e.g., Addison disease, Celiac disease, dermatomyositis. Graves disease, Hashimoto thyroiditis, inflammatory bowel disease, multiple sclerosis (MS), myasthenia gravis, pernicious anemia, reactive arthritis, Sjogren syndrome, systemic lupus erythematosus, and type I diabetes). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

This invention relates to the field of medical information processing and chronic disease risk assessment technology, specifically a Hashimoto's thyroiditis risk assessment and prediction system and method applicable to different scenarios. It includes: S1. Dataset construction; S2. Variable selection; S3. Construction of a three-layer prediction model; S4. Comparison and optimization of machine learning algorithms; S5. Construction of a simplified scoring model; and S6. Development and deployment of a visual web-based assessment tool. This invention features representative real-world data, adapts to different resource configurations, constructs a multi-dimensional prediction system, significantly lowers the application threshold, improves model interpretability and clinical feasibility, and achieves an integrated assessment process of input indicators → output risk level → provision of intervention suggestions, supporting its application in primary healthcare institutions.

The application discloses a Hashimoto's thyroiditis model, a construction method thereof and an antigen, and the construction method comprises the following steps: preparing a pig thyroid lyophilized powder; selecting 8-week-old EAT susceptible strain CBA / J female mice, and injecting phosphate buffered saline solutions containing the pig thyroid lyophilized powder at the 0th day, the 7th day and the 14th day after 8 weeks; injecting phosphate buffered saline solutions containing lipopolysaccharide at a predetermined time interval; when the EAT susceptible strain CBA / J female mice are 12 weeks old, the modeling effect is measured from thyroid pathological morphology and EAT scores, serum TgAb concentration, serum TPOAb concentration and the number of each T lymphocyte subpopulation in the spleen. After the mice are continuously injected with the phosphate buffered saline solutions containing the pig thyroid lyophilized powder and the lipopolysaccharide for three times through the tail vein, the mice produce autoantibodies, and obvious lymphatic infiltration appears in the thyroid tissue, which indicates that the pig thyroid lyophilized powder can induce the occurrence of Hashimoto's thyroiditis, and a new thought is provided for the pathogenesis of Hashimoto's thyroiditis.

The application provides a traditional Chinese medicine composition for treating Hashimoto's thyroiditis and a decoction and a powder thereof, and belongs to the technical field of traditional Chinese medicine.The traditional Chinese medicine composition comprises the following components: radix codonopsis, fried atractylodes, poria cocos, dried tangerine or orange peel, salted eucommia ulmoides, huaiyin achyranthes, taxillus, radix rubrascenii, calcined oyster shell, poria cum zygomycetes, albizzia julibrissin bark, fried bitter orange fruit, fried white peony root, radix scrophulariae, zedoary, cassia, licorice root.The various medicines have their own functions, but are interwoven with each other;they not only consider various aspects, but also have certain emphases, so that the whole prescription can jointly play the functions of invigorating the spleen, benefiting the kidney, soothing the liver and tranquilizing the mind.The use of the traditional Chinese medicine composition can significantly inhibit the increase of thyroid-related antibodies of experimental autoimmune thyroiditis (EAT) rats, reduce the degree of hypothyroidism, inhibit the increase of thyroid organ index, reduce the destruction of thyroid follicles and the infiltration of inflammatory cells, and has a good effect on EAT rats.

The invention discloses a hashimoto thyroiditis model, a construction method thereof and an antigen. The construction method comprises the following steps: preparing pig thyroid freeze-dried powder; the method comprises the following steps: selecting 8-week-old EAT susceptible strain CBAA / J female rats, respectively injecting a phosphate buffer saline solution containing pig thyroid freeze-dried powder on the 0th day, the 7th day and the 14th day after 8 weeks, and injecting a phosphate buffer saline solution containing lipopolysaccharide at preset time intervals; when the EAT susceptible strain CBAA / J female mouse is 12 weeks old, the modeling effect is measured according to the thyroid pathological morphology and EAT score, the serum TgAb concentration, the serum TPOAb concentration and the number of all subgroups of spleen T lymphocytes. After a mouse is subjected to continuous three-time caudal vein injection of a phosphate buffer saline solution containing the pig thyroid freeze-dried powder and lipopolysaccharide, autoantibodies are generated, and obvious lymphatic infiltration occurs in thyroid tissues, so that the pig thyroid freeze-dried powder can induce hashimoto thyroiditis, and a new thought is provided for pathogenesis of hashimoto thyroiditis.

The invention provides a traditional Chinese medicine compound preparation for auxiliary nursing of hashimoto thyroiditis, and relates to the technical field of traditional Chinese medicine pharmacy. The traditional Chinese medicine compound preparation is prepared from the following traditional Chinese medicinal materials: resina liquidambaris, homalomena occulta, sword brake herb, walnut twig, resina erythrinae, siberian elm bark, polygonum cuspidatum, red-knees herb, perfoliote knotweed herb, akebia fruit, oroxylum indicum, semen brassicae, kadsura longipedunculata, rhizoma dioscoreae nipponicae, ginseng leaf and rhizoma zingiberis. According to the traditional Chinese medicine compound preparation, the autoantibody titers of HT model rat serum TPOAb and TgAb can be effectively reduced, thyroid function indexes FT3, FT4 and TSH are effectively improved, and meanwhile generation and activity of HT model serum inflammatory factors can be effectively inhibited. The traditional Chinese medicine compound preparation disclosed by the invention has a relatively good treatment effect in the aspects of inhibiting autoantibody generation and reducing thyroid damage and can be used for effectively treating hashimoto thyroiditis by inhibiting inflammatory response. The traditional Chinese medicine compound preparation disclosed by the invention is expected to be further developed and researched as a medicine for treating or assisting in treating hashimoto thyroiditis.

The invention provides a plaster formula for treating hashimoto thyroiditis as well as a preparation method and an application method of the plaster formula, and provides a plaster formula for treatment aiming at the defects that at present, symptoms such as thyromegaly, neck fullness and tension, swallowing discomfort and foreign body sensation are not special, and regular observation is mostly adopted for treatment. The traditional Chinese medicine composition comprises the following components in parts by mass: 15-20 parts of ephedra, 30-40 parts of codonopsis pilosula, 40-50 parts of astragalus membranaceus, 15-20 parts of peach kernel, 15-20 parts of raw white paeony root, 3-5 parts of edible tulip, 15-20 parts of radix bupleuri, 20-30 parts of thunberg fritillary bulb, 30-40 parts of raw oyster and 20-30 parts of selfheal. The ointment of the formula is taken externally, the state that no medicine can be used for treating hashimoto thyroiditis at present and observation is dominated can be changed, the ointment has a certain effect on improving thyroid diffuse swelling and neck tension of patients suffering from hashimoto thyroiditis and reducing the antibody level, and a treatment method which is more convenient to accept and easy and convenient to operate is provided for the patients.

The present invention provides a method of treating autoimmune diseases, including type 1 diabetes, inflammatory bowel disease, rheumatoid arthritis, multiple sclerosis, systemic lupus erythematosus, psoriasis, myasthenia gravis, and hashimoto thyroiditis. The method comprises the step of administering to a subject in need thereof an effective amount of a micelle having an outer shell comprising one or more polymer-flavonoid conjugates, optionally an inner shell comprising one or more flavonoid oligomers, and a drug encapsulated within these shells. The invention also provides a method of treating an autoimmune disease by administering to a subject in need thereof an effective amount of one or more polymer-flavonoid conjugates or one or more flavonoid oligomers.

The application discloses application of PLEKHO2 and NPM3 autoantibodies in preparation of a kit for detecting hyperactivity of fire due to yin deficiency of Hashimoto's thyroiditis, and the biomarker is at least one of MAP9, IRF9, PLEKHO2, NPM3, DR1, KDM1A, PCGF2, GPCPD1 and IGBP1 related autoantibodies. Among them, the biomarkers for detecting characteristic autoantibodies of the stagnation of liver-Qi of Hashimoto's thyroiditis are MAP9 and IRF9 two related autoantibodies; the biomarkers for detecting characteristic autoantibodies of the hyperactivity of fire due to yin deficiency of Hashimoto's thyroiditis are PLEKHO2 and NPM3 two related autoantibodies; and the biomarkers for detecting characteristic autoantibodies of the deficiency of spleen and kidney yang of Hashimoto's thyroiditis are DR1, KDM1A, PCGF2, GPCPD1 and IGBP1 five related autoantibodies. The serum related autoantibody markers can reflect the syndrome characteristics of Hashimoto's thyroiditis, make the TCM differentiation accurate, and are beneficial to revealing the syndrome essence and molecular connotation of Hashimoto's thyroiditis.

The invention relates to the technical field of preparation and application of traditional Chinese medicine compositions, and discloses a composition capable of improving thyroid function and an antibody, a preparation method and application, and the composition is prepared from the following raw materials: bupleurum chinense, parched white peony root, red peony root, rhizoma pinellinae praeparata, thunberg fritillary bulb, selfheal, vinegar-processed rhizoma cyperi, codonopsis pilosula, inula flower, fried spina date seed, lily and roasted herba epimedii. The composition comprises the following raw materials in parts by mass: 6-30g of bupleurum chinense; 9-30g of parched white peony root; 9-30 g of radix paeoniae rubra; 6 to 30g of rhizoma pinellinae praeparata; 9 to 30g of thunberg fritillary bulb; 9 to 30g of spica prunellae; 6-30 g of vinegar rhizoma cyperi; 6 to 30g of codonopsis pilosula; 9 to 30g of inula flower; 9-30 g of fried spina date seeds; 9 to 30g of lily; 3 to 30g of roasted herba epimedii; the traditional Chinese medicine compound composition provided by the invention has a good effect of improving thyroid function and antibody level, can be used for treating hashimoto thyroiditis combined with subclinical or clinical hypothyroidism, is convenient to clinically take, has no obvious toxic or side effect, and is good in safety.