26 results about "Andrographis paniculata" patented technology

The invention discloses a herbal composition as well as an extraction method and application thereof. The herbal composition is prepared from the following raw materials in parts by weight: 4-8 parts of flos chrysanthemi indici, 1-4 parts of herba andrographitis, 4-8 parts of herba pogostemonis and 8-12 parts of purple perilla. The composition has remarkable relieving, anti-oxidation and anti-inflammatory effects, and can prevent eczema from occurring from the source. According to the herbal composition extraction method, ultrasonic extraction and supercritical CO2 extraction are combined, and a pretreatment agent is added in the process, so that the extraction rate of water-soluble and oil-soluble active ingredients is increased, and the medicinal effect of the herbal composition is enhanced.

The application provides a light irradiation method for improving the quality of Andrographis paniculata, and belongs to the technical field of agricultural planting. The method for improving the quality of Andrographis paniculata provided by the application comprises the following steps: starting to irradiate Andrographis paniculata with blue light when the Andrographis paniculata sprouts for 15 days. The method for improving the quality of Andrographis paniculata provided by the application is simple and easy to implement, has low cost, can promote the growth and development of Andrographis paniculata plants, can effectively improve the accumulation of terpene lactone components of Andrographis paniculata, and further improves the quality of Andrographis paniculata, thereby providing strong technical support for the high-quality development of the Andrographis paniculata industry.

A herbal composition for supporting restoration of digestive system function comprising the following components: a Leucaena leucocephala extract, an eleutherin extract component from Eleutherine bulbosa, an Andrographis paniculata extract, a Panax vietnamensis extract, a Pouzolzia zeylanica extract, a first herbal mixture extract, a second herbal mixture extract, a sugar, a salt, a honey, a royal jelly, a vegetable oil, and a plant powder. Method for producing the composition comprising: (i) preparing materials; (ii) creating a base mixture; (iii) creating a first temporary mixture; (iv) creating a second temporary mixture; (v) creating a third temporary mixture; (vi) creating a fermented mixture; and (vii) packaging the fermented mixture to obtain the herbal composition for supporting restoration of digestive system function.

The application discloses a composition for lightening dark circles under eyes containing camellia chrysantha extract and a preparation method and application thereof, and relates to the technical field of cosmetics.The composition comprises component A, component B and component C;the component A comprises andrographis paniculata extract and camellia chrysantha extract;the component B comprises ubiquinone and safflower extract;and the component C is menthol lactate.The andrographis paniculata extract, the camellia chrysantha extract, the ubiquinone, the safflower extract and the menthol lactate are combined to have a synergistic effect; the composition formed by the specific combination of the components can promote blood microcirculation, inhibit microvascular generation, increase epidermal thickness, relieve cell hypoxia and eye fatigue, reduce blood vessel type dark circles, relieve redness and strengthen skin, and is mild and non-irritating to skin, and is suitable for people with sensitive skin.

The invention discloses a livestock and poultry breeding feed additive capable of reducing cost and improving effect. The livestock and poultry breeding feed additive is prepared from the following raw materials through compound fermentation: probiotic components: bacillus subtilis, clostridium butyricum and enterococcus; the enzyme preparation components comprise cellulose decomposition enzyme and xylanase; a fermentation medium: brown sugar and water; the traditional Chinese medicine auxiliary materials comprise wormwood, health sand and andrographis paniculata. The preparation method of the cost-reducing and effect-improving livestock and poultry breeding feed additive comprises the following steps of bacterium expanding culture, secondary fermentation and product treatment. The invention belongs to the technical field of livestock and poultry breeding, and particularly provides a livestock and poultry breeding feed additive and a preparation method thereof, and the livestock and poultry breeding feed additive can improve the intestinal microecological balance of livestock and poultry, improve the digestion and utilization rate of feed, enhance the immunity of livestock and poultry and reduce the breeding cost through scientific matching of probiotics, enzyme preparations, traditional Chinese medicine components and nutritional auxiliary materials.

The invention discloses an andrographis paniculata transcription factor ApMYB9 and an application of the andrographis paniculata transcription factor ApMYB9 in positive regulation of biosynthesis of andrographolide. The key regulatory factor ApMYB9 for andrographolide synthesis is explored, the molecular mechanism of the key regulatory factor ApMYB9 for positively regulating and controlling andrographolide synthesis through an important enzyme gene isopentene diphosphate isomerase ApIPPI of a targeted andrographolide synthesis pathway is verified, and the application of the key regulatory factor ApMYB9 for improving the content of andrographolide by utilizing a biotechnology is provided. And a theoretical basis is provided for culturing a new variety of andrographis paniculata with high diterpene lactone content.

The Invention provides an enhanced Polyherbal Nano-admixture to retain and regain metabolic health with balanced detoxification, synergistic effect and preparation method thereof. The present invention discloses a polyherbal composition comprising a Andrographis paniculata herb extract; a Boerhavia diffusa herb extract; a Abelia triflora herb extract; a Terminalia bellerica herb extract; a Picrorhiza kurroa herb extract; a Tinospora cordifolia herb extract; a Phyllanthus emblica herb extract; a Acalypha fructicosa herb extract; a Phyllanthus niruri herb extract; a Terminalia chebula herb extract; and a Abutilon persicum herb extract.

The utility model discloses a coating machine for processing andrographis paniculata dripping pills, which relates to the technical field of medicine production, and comprises a dripping pill screening device, a coating machine with a feeding hole connected with a pill core outlet of the dripping pill screening device, a diameter screening mechanism connected with a discharging hole of a pill core machine, and a roundness screening mechanism connected with the diameter screening mechanism, the roundness screening mechanism comprises a first pellet core inlet, a pellet core batch release mechanism connected with the first pellet core inlet, and a roundness classification slide way connected with the pellet core batch release mechanism. The diameter screening mechanism is used for performing diameter screening, the roundness screening mechanism is used for performing roundness screening on standard-diameter pill cores, the roundness is screened in the mode that the rotating rollers release the standard-diameter pill cores in batches, dropping pills naturally roll down from the roundness classification slide way, and the pill cores with good roundness enter the pill core outlet and enter the coating machine. And the pill cores with lower roundness deviate from the rolling track and enter a defective pill core outlet.

This invention relates to the field of pharmaceutical composition technology, and more particularly to a pharmaceutical composition for treating sepsis and its preparation method. A pharmaceutical composition for treating sepsis is prepared from the following components in parts by weight: 20-26 parts of Andrographis paniculata, 18-24 parts of Forsythia suspensa, 17-21 parts of Anemarrhena asphodeloides, 15-19 parts of Vaccaria segetalis, 14-18 parts of Achyranthes bidentata, 12-16 parts of Scrophularia ningpoensis, 10-14 parts of Coptis chinensis, 7-11 parts of Melia toosendan, 5-9 parts of Prunus persica leaf, and 3-7 parts of Trillium tsao-ko. The formulation of this invention can reduce the inflammatory response of sepsis, alleviate apoptosis of intestinal mucosal epithelial cells in sepsis, promote cell survival, and thereby inhibit organ damage following sepsis.

The invention discloses an isopentene diphosphate isomerase ApIPPI and an application of the isopentene diphosphate isomerase ApIPPI. According to the present invention, the isopentene diphosphate isomerase ApIPPI is found, and the experimental verification results show that the synthesis amount of andrographolide can be effectively improved by overexpressing the gene of the isopentene diphosphate isomerase ApIPPI in andrographis paniculata, such that the theoretical basis is provided for the improvement of the andrographolide content and the cultivation of the new andrographolide variety with the high diterpene lactone content by using the biotechnology.

The invention provides a plant extraction compound factor with anti-inflammatory and anti-allergy functions and a preparation method thereof, and relates to the technical field of skin care product processing, the plant extraction compound factor is prepared from the following raw materials by weight: 8-10 parts of gentiana macrophylla, 5-7 parts of swertia mileensis, 4-6 parts of stephania tetrandra, 6-8 parts of phellinus igniarius, and 7-9 parts of peony. The plant extraction compound factor is prepared from the following raw materials in parts by weight: 5-7 parts of eucommia ulmoides, 4-6 parts of magnolia sieboldii, 6-8 parts of andrographis paniculata and 3-5 parts of polygala tenuifolia, and the plant extraction compound factor is prepared from the following raw materials in parts by weight: 8-10 parts of centella asiatica, 3-5 parts of bamboo shavings, 5-7 parts of fructus forsythiae and 4-6 parts of amur corktree. The plant extraction compound factor is prepared from the following raw materials in parts by weight: 3-5 parts of coreopsis tinctoria, 7-9 parts of liquorice, 2-4 parts of pelargonium graveolens and 3-5 parts of broom leaf Australian tea.

The invention discloses a method for rapidly evaluating the quality of an andrographis paniculata medicinal material, which adopts a near infrared spectrum technology, can be used for determination after a sample is crushed, does not need complex pretreatment operation on the sample, is simple, convenient and rapid, only needs several minutes for detection, does not need chemical reagents for dissolution, and can be used for rapidly evaluating the quality of the andrographis paniculata medicinal material. The contents of chlorogenic acid, andrographolide and dehydroandrographolide can be measured at the same time, and the content of limited components in the andrographis paniculata medicinal material is comprehensively evaluated.

The invention belongs to the technical field of plant extract preparations, and discloses a plant disinfectant and a preparation method thereof. The preparation method comprises the following preparation steps: (1) mixing and crushing dried liquorice, fructus forsythiae, radix isatidis, honeysuckle, dandelion, golden cypress, cyrtomium fortunei, andrographis paniculata and oldenlandia diffusa, and then adding into hot water for standing and soaking treatment; and (2) filtering the mixture soaked in the step (1), filling a percolation column with a wet solid material, and performing low-temperature percolation extraction at the temperature of 0-30 DEG C by adopting an ethanol water solution as an extraction solvent to obtain the plant disinfectant. The preparation method of the plant disinfectant is simple, the process conditions are easy to control, and the production cost is low. Through verification, good killing effects on candida albicans, staphylococcus aureus, escherichia coli, pseudomonas aeruginosa, tortoise mycobacterium abscess subspecies, natural bacteria, human coronavirus and influenza A virus can be achieved.

The application belongs to the technical field of biology, and particularly relates to a bidirectional promoter of Andrographis paniculata and application thereof. The nucleotide sequence of the promoter is shown as SEQ ID NO. 1. The bidirectional promoter of Andrographis paniculata provided in the application contains a natural regulatory element, has high compatibility with a plant genome, can realize precise spatiotemporal regulation of genes, avoid silencing risks, and is compatible with the concept of green breeding. Meanwhile, the bidirectional promoter of Andrographis paniculata can drive the synergistic expression of multiple genes through a single promoter, optimize the stability of a vector and the balance of gene expression, and improve the stacking efficiency of multiple genes.

The application discloses a herbal composition and an extraction method and application thereof. The herbal composition is prepared from raw materials in the following proportions by weight: wild chrysanthemum 4-8 parts, Andrographis paniculata 1-4 parts, pachouli 4-8 parts, and perilla 8-12 parts. The composition has significant soothing, antioxidant and anti-inflammatory effects and can block the occurrence of eczema from the root. The extraction method of the herbal composition combines ultrasonic extraction and supercritical CO2 extraction, and a pretreatment agent is added in the process, so that the extraction rate of water-soluble and oil-soluble active ingredients is improved, and the medicinal effect of the herbal composition is enhanced.

The invention belongs to the field of medicinal plant genetic engineering. The invention relates to a P450 oxidase ApCYP71D587 derived from andrographis paniculata and an application of the P450 oxidase. In particular provides a novel enzyme for catalyzing C-19 hydroxylation of bicyclic diterpene enantiomer-copal, the enzyme is a cytochrome P450 oxidase ApCYP71D587 derived from andrographis paniculata, a nucleic acid sequence for coding the enzyme, an expression vector containing a nucleic acid molecule and a host cell containing the vector. An enzyme catalysis experiment proves that the compound has the function of catalyzing C-19 hydroxylation of an andrographolide biosynthesis intermediate enantiocopal, analysis of an andrographolide biosynthesis pathway is further promoted, and an important synthesis element is provided for andrographolide synthesis biology.

This invention provides an anti-dandruff, anti-itch, and soothing composition, its preparation method, and its application. The composition includes extracts of Lophatherum gracile leaves, Andrographis paniculata leaves, and Phellodendron amurense bark. This anti-dandruff, anti-itch, and soothing composition can be added to any shampoo and skincare product. Using the extracts of this invention, combined with a reasonable ratio, and prepared through a special method, it achieves a high content of effective ingredients and excellent anti-dandruff, anti-itch, and soothing effects. This invention maximizes the antibacterial and anti-inflammatory effects of the three plants through extraction and fermentation. The resulting composition has significant antibacterial effects, is easy to promote and apply widely in shampoos, and has excellent anti-dandruff and anti-itch effects. It is gentle and comfortable, and has an excellent soothing effect on the skin.

The invention belongs to the technical field of gene engineering, and particularly relates to an agrobacterium tumefaciens-mediated andrographis paniculata instantaneous transformation method. The invention provides an agrobacterium tumefaciens-mediated andrographis paniculata transient transformation technology which can realize high-efficiency expression of exogenous genes in andrographis paniculata plants and makes up for the shortages in the field. A general agrobacterium tumefaciens instantaneous transformation technology needs explant shearing, infection after sterile co-culture and continuous culture observation, the operation is complicated, the disinfection requirement is high, meanwhile, gene expression peaks are only maintained for about 5 days, the subsequent expression effect disappears rapidly, and longer-acting gene function observation cannot be met. The technology can effectively solve the problems, strict sterile conditions and tissue culture operation are not needed in the infection stage, follow-up maintenance and observation are also extremely simple and convenient, and the transgenic effect as long as 30 days can be kept only by simply planting the completely infected seedlings in wet nutrient soil.

The application discloses a Andrographis paniculata transcription factor ApNAC82, wherein the coding region nucleotide sequence of the Andrographis paniculata transcription factor ApNAC82 is shown as SEQ ID NO:2. The application further discloses a cloning method of the Andrographis paniculata transcription factor ApNAC82, comprising the following steps: synthesizing cDNA by reverse transcription of total RNA of Andrographis paniculata as a template for PCR reaction to clone a coding region fragment of the Andrographis paniculata transcription factor ApNAC82, or using DNA of the Andrographis paniculata as a template for PCR reaction to clone a gene fragment of the Andrographis paniculata transcription factor ApNAC82. The application has important significance for understanding the response mechanism of the Andrographis paniculata to multiple adversity stresses, especially for mining and utilizing multifunctional transcription factors capable of improving multiple adversity stresses, and for genetic improvement and adversity-resistant variety cultivation of the Andrographis paniculata and other species.

This invention relates to a plant composition with redness-reducing and itch-relieving effects, its preparation method, and its application, belonging to the field of daily chemical technology; the plant composition contains the following raw materials: peony extract, ophiopogon japonicus extract, scutellaria baicalensis extract, atractylodes macrocephala powder, andrographis paniculata powder, chamomile extract, and forsythia suspensa root extract; the plant composition has the effects of reducing redness and itch-relieving, and is suitable for use in skin care products.

This invention provides a CYP450 enzyme protein, its encoding gene, and its applications that can catalyze the formation of new andrographolide aglycones, belonging to the field of biology. This invention utilizes bioinformatics analysis and differential expression analysis of transcriptome data from different tissue sites to identify the gene ApCYP71BE50, which catalyzes the formation of new andrographolide aglycones from (4R,5S,9R,10S)-labda-8(17),13-dien-15,19-diol. It also verifies that the CYP450 enzyme protein encoded by the ApCYP71BE50 gene can continuously oxidize the C16 position of (4R,5S,9R,10S)-labda-8(17),13-dien-15,19-diol to form new andrographolide aglycones. This invention provides an important gene element for the biosynthesis of andrographolide and also provides a key gene locus for the molecular design breeding of andrographis paniculata.

The application belongs to the technical field of medicine, and discloses skin health antipruritic liquid, which comprises raw material components: angelica, cortex moutan, white alum, forsythia, schizonepeta, baizhi, humulus, zanthoxylum, lotus house, artemisia leaf, duckweed, alkanna, aloe, honeycomb, polygonatum, stemona, sophora, fly Yang grass, cortex periplocae, melaleuca, ophiorrhiza, white milkweed, gallic, spilanthes, kochia, taraxacum, clematis, xuchangqing, biota, radix falcaliae, radix pterostupiae, red plate, snake skin, wind-preventing plant, hollyhock, oak flower, oak, radix scrophulariae, radix paeoniae, radix bupleuri, radix scrophulariae, radix paeoniae, radix scrophulariae, radix paeoniae, radix scrophulariae, borage, borax, the application has multiple effects of clearing heat and cooling blood, sterilizing and resisting inflammation, removing dampness and relieving itching, removing toxicity and resolving mass, etc., can improve or treat various skin problems such as eczema, herpes, allergic dermatitis, tinea pedis, hemorrhoids, acne, psoriasis and skin itching, and is suitable for a wide range of scenes; the process combination of crushing, screening, specific proportion mixing, fermentation, multiple filtration and accurate concentration ensures that the active ingredients in the raw materials are fully extracted and purified, avoids the loss of effective components, improves the curative effect intensity of unit volume of liquid medicine, and has quick effect after spraying, which is beneficial to actual application and operation.

The invention discloses a strain of malleolus striatus as well as application and a method of the malleolus striatus in plant disease control and plant growth promotion. According to the invention, a strain of malleolabrax striata ZDXH-8 is separated from leaves of andrographis paniculata, and tests prove that the strain can significantly inhibit pyricularia oryzae, fusarium graminearum and fusarium oxysporum tomato specialized types, and can promote the growth of rice plants at the same time. The strain is wide in application range, can be used for preventing and treating plant diseases, particularly rice blast, wheat scab and tomato fusarium wilt, can also be used for promoting the growth of rice plants, and has good application value.

The invention discloses application of andrographolide monoester derivatives in prevention and treatment of aphid diseases. The structural general formula of the series of compounds is as shown in formula I in the specification. The andrographolide monoester derivative disclosed by the invention has excellent aphid killing activity, and compared with parent andrographolide (LD50: 2.005 mg / mL), the activity (LD50: 0.125 mg / mL) of a compound 4e is improved by 16 times, is higher than that of botanical pesticide toosendanin (LD50: 0.153 mg / mL), and is equivalent to that of synthetic pesticide imidacloprid (LD50: 0.106 mg / mL). The andrographolide monoester derivative is a novel plant source compound and can be further developed into efficient and low-toxicity plant source pesticides for preventing and treating aphid diseases.

The invention relates to the related technical field of fish feeds, in particular to a compound fermented Chinese herbal medicine feed for enhancing the immunity of groupers and application of the compound fermented Chinese herbal medicine feed, and the feed is prepared from the following components in percentage by weight: 85%-92% of basic feed raw materials, 5%-12% of compound fermented Chinese herbal medicine additives and 2%-5% of functional auxiliary agents. The core of the additive is that the additive consists of astragalus membranaceus, rheum officinale, andrographis paniculata and liquorice according to a specific ratio of (3-4): (2-3): (1-2): (0.5-1), and is prepared by fermenting the astragalus membranaceus, the rheum officinale, the andrographis paniculata and the liquorice with a compound strain of lactobacillus plantarum and bacillus subtilis at 30-37 DEG C for 36-60 hours. According to the feed, the activity of serum lysozyme and superoxide dismutase of groupers can be remarkably improved, the non-specific immunity is enhanced, the survival rate of the groupers infected by vibrio alginolyticus is not lower than 85% in a toxicity attacking experiment, and vibriosis and cryptocaryon irritans are effectively prevented.

The invention relates to self-stabilization type oil-water double-soluble transparent essence oil and a preparation method thereof, and the essence oil comprises the following components by weight: 11-25% of macadamia nut seed oil, 1-3% of Candida bee / glucose / rapeseed methyl oleate fermentation product, 10-20% of plant extract composite liquid, and the balance of caprylic acid / capric triglyceride and 1, 2-hexanediol in a mass ratio of (0.9-1.2): 1. Wherein the plant extraction compound liquid is an aqueous solution of a plant extraction compound, and the plant extraction compound is a composition of a cockscomb extract, an andrographis paniculata leaf extract and a campsis grandiflora extract. The essence oil realizes a self-stabilization transparent system without a traditional emulsifier, can stably contain 10-20% of plant extraction composite liquid, has high-content water-soluble active matters, stable and transparent oil properties and good skin compatibility, also realizes repairing and anti-inflammatory effects, and avoids the problem of weak effect of single plant extraction.