65 results about "Andrographis paniculata" patented technology

The invention relates to the field of pharmacy, and discloses a Chinese herbal medicine and marine extract combined antibacterial and anti-inflammatory pharmaceutical composition which comprises the following components in parts by weight: 5-10 parts of baicalin extract; 3 to 7 parts of an andrographolide extract; 2-5 parts of sulfated brown algae polysaccharide; 0.2 to 1 part of sponge extract; wherein the baicalin extract is derived from roots of scutellaria baicalensis and is obtained by extracting with an ethanol-water mixed solvent; the andrographolide extract is derived from the whole herb of andrographis paniculata and is obtained by extracting with an ethanol-water mixed solvent; the sulfated fucoidan is derived from fucoidan and is prepared by enzymolysis and alcohol precipitation methods; the sponge extract is derived from sponge and is obtained by organic solvent extraction, separation and purification. By adopting the technical scheme of synergistically compounding the Chinese herbal medicine active ingredients and the marine extract, the technical effects of destroying a biological membrane barrier and removing stubborn infection lesions in treatment of bacterial vaginitis, candida vaginitis associated biological membrane infection and cervicitis are achieved.

1. The name of this design product: Packaging box (Andrographis paniculata tablets). 2. Purpose of this design product: used for product packaging. 3. The key design point of this design product lies in the combination of shape and pattern. 4. The picture or photo that best illustrates the design points: reference picture of the expanded state.

To provide an andrographis paniculata diterpene lactone compound as well as extraction method and application thereof.SOLUTION: The andrographis paniculata diterpene lactone compound provided by the invention has a structure as shown in any one of formulas 1-7 and is novel in structure. The andrographis paniculata diterpene lactone compound extracted and separated from andrographis paniculata has a good anti-inflammatory effect, and has a good down-regulation effect on secretion of NO, interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) in a lipopolysaccharide (LPS) induced mouse mononuclear macrophage (RAW264.7 cell) inflammation model; the compound also has a good inhibition effect on expression of inducible nitric oxide synthase (INOS) and cyclooxygenase-2 (COX-2) proteins, and can be applied to preparation of anti-inflammatory drugs.SELECTED DRAWING: Figure 1

The invention discloses a herbal composition as well as an extraction method and application thereof. The herbal composition is prepared from the following raw materials in parts by weight: 4-8 parts of flos chrysanthemi indici, 1-4 parts of herba andrographitis, 4-8 parts of herba pogostemonis and 8-12 parts of purple perilla. The composition has remarkable relieving, anti-oxidation and anti-inflammatory effects, and can prevent eczema from occurring from the source. According to the herbal composition extraction method, ultrasonic extraction and supercritical CO2 extraction are combined, and a pretreatment agent is added in the process, so that the extraction rate of water-soluble and oil-soluble active ingredients is increased, and the medicinal effect of the herbal composition is enhanced.

The application provides a light irradiation method for improving the quality of Andrographis paniculata, and belongs to the technical field of agricultural planting. The method for improving the quality of Andrographis paniculata provided by the application comprises the following steps: starting to irradiate Andrographis paniculata with blue light when the Andrographis paniculata sprouts for 15 days. The method for improving the quality of Andrographis paniculata provided by the application is simple and easy to implement, has low cost, can promote the growth and development of Andrographis paniculata plants, can effectively improve the accumulation of terpene lactone components of Andrographis paniculata, and further improves the quality of Andrographis paniculata, thereby providing strong technical support for the high-quality development of the Andrographis paniculata industry.

The invention discloses a preparation method of a compound double-flower oral liquid with optimized taste, and relates to the technical field of biological medicine, and the preparation method comprises the steps of medicinal material pretreatment, effective component extraction, filtrate concentration and alcohol precipitation, filtrate extraction, additive mixing, nano-filtration purification, blending and constant volume and standing sterilization. Honey has natural sweetness, hydroxypropyl-beta-cyclodextrin and medicine components form an inclusion compound, strong bitter taste caused by andrographis paniculata can be effectively masked, sensory evaluation shows that the bitter taste masking rate is increased, the taste of the oral liquid is obviously improved, the oral liquid is especially suitable for children and other people sensitive to bitter taste, the medicine taking compliance of patients is greatly improved, and the oral liquid is suitable for clinical application. Through compatibility of the common andrographis herb, the honeysuckle flower, the dark plum and other medicinal materials, the body immunity is improved on the basis of maintaining the effects of clearing away heat and toxic materials, relieving sore throat and diminishing swelling, and the medicine effect is optimized and improved.

The invention relates to a skin care composition capable of fully relieving itching and application thereof, the skin care composition comprises the following components: kelp extract, kadsura longepedunculata extract, andrographis paniculata leaf extract and roselle flower extract, and the weight ratio of the kelp extract to the kadsura longepedunculata extract to the andrographis paniculata leaf extract to the roselle flower extract is (0.01-3): (0.01-3): (0.1-5): (0.1-3). The four components cooperate with one another in multiple dimensions of skin barrier repair, nerve regulation, anti-inflammation, micro-ecological regulation, oxidation resistance and the like, and the synergistic itching relieving effect is achieved.

A herbal composition for supporting restoration of digestive system function comprising the following components: a Leucaena leucocephala extract, an eleutherin extract component from Eleutherine bulbosa, an Andrographis paniculata extract, a Panax vietnamensis extract, a Pouzolzia zeylanica extract, a first herbal mixture extract, a second herbal mixture extract, a sugar, a salt, a honey, a royal jelly, a vegetable oil, and a plant powder. Method for producing the composition comprising: (i) preparing materials; (ii) creating a base mixture; (iii) creating a first temporary mixture; (iv) creating a second temporary mixture; (v) creating a third temporary mixture; (vi) creating a fermented mixture; and (vii) packaging the fermented mixture to obtain the herbal composition for supporting restoration of digestive system function.

The application discloses a composition for lightening dark circles under eyes containing camellia chrysantha extract and a preparation method and application thereof, and relates to the technical field of cosmetics.The composition comprises component A, component B and component C;the component A comprises andrographis paniculata extract and camellia chrysantha extract;the component B comprises ubiquinone and safflower extract;and the component C is menthol lactate.The andrographis paniculata extract, the camellia chrysantha extract, the ubiquinone, the safflower extract and the menthol lactate are combined to have a synergistic effect; the composition formed by the specific combination of the components can promote blood microcirculation, inhibit microvascular generation, increase epidermal thickness, relieve cell hypoxia and eye fatigue, reduce blood vessel type dark circles, relieve redness and strengthen skin, and is mild and non-irritating to skin, and is suitable for people with sensitive skin.

The invention relates to the technical field of feed additives, and discloses a preparation method of a novel disease-resistant digestion-aiding feed additive. The radix tinosporae, andrographis paniculata saponin and polysaccharide have good antibacterial and disease-resistant effects, and can effectively prevent livestock from being infected by germs. The inorganic composite product is prepared from inorganic matters and has the effects of promoting digestion, sterilizing and expelling parasites. The powdery fermentation product is prepared by mixing and fermenting myristica fragrans, sweet wormwood, hawthorn and sea-buckthorn, has the effects of promoting digestion, resisting diseases, increasing appetite and the like, and promotes the growth of poultry. The membrane material is a good antibacterial and corrosion-resistant material, and can effectively prevent the feed additive from being rotten and prolong the shelf life. The feed additive disclosed by the invention has good disease-resistant and digestion-aiding effects and can be widely applied to production of feeds and medicines, and the process production is green, safe and efficient.

The invention discloses a livestock and poultry breeding feed additive capable of reducing cost and improving effect. The livestock and poultry breeding feed additive is prepared from the following raw materials through compound fermentation: probiotic components: bacillus subtilis, clostridium butyricum and enterococcus; the enzyme preparation components comprise cellulose decomposition enzyme and xylanase; a fermentation medium: brown sugar and water; the traditional Chinese medicine auxiliary materials comprise wormwood, health sand and andrographis paniculata. The preparation method of the cost-reducing and effect-improving livestock and poultry breeding feed additive comprises the following steps of bacterium expanding culture, secondary fermentation and product treatment. The invention belongs to the technical field of livestock and poultry breeding, and particularly provides a livestock and poultry breeding feed additive and a preparation method thereof, and the livestock and poultry breeding feed additive can improve the intestinal microecological balance of livestock and poultry, improve the digestion and utilization rate of feed, enhance the immunity of livestock and poultry and reduce the breeding cost through scientific matching of probiotics, enzyme preparations, traditional Chinese medicine components and nutritional auxiliary materials.

This invention proposes a soothing andrographolide, its preparation method, and its applications, belonging to the field of cosmetic technology. The method involves sterilizing and inducing culture of *Andrographis paniculata* leaves, followed by crushing, enzymatic hydrolysis, and extraction with a deep eutectic solvent to obtain the extract. This extract is then added to an adsorbent, stirred for adsorption, filtered, desorbed, and reacted with salicylic acid to obtain andrographolide salicylate ester. Alcoholic esters are then prepared, thus yielding the soothing andrographolide. The soothing andrographolide prepared by this invention significantly improves the product's water solubility and bioavailability, is safe and non-irritating to the skin, and has anti-redness, anti-allergic, anti-inflammatory, and soothing effects. The addition of alcohol improves the flexibility and extensibility of the structure, resulting in better skin permeability than liposomes and stronger transdermal penetration, thereby expanding its application scope.

The invention relates to the technical field of medicine component extraction, and discloses a medicine for resisting hashimoto thyroiditis disease, the medicine comprises an active component and an auxiliary material, the active component is an andrographis paniculata general flavone extract, andrographis paniculata general flavone is used as a main component, and the andrographis paniculata general flavone can reduce exudation of capillary walls, so that the medicine can be used for preventing and treating the hashimoto thyroiditis disease. The andrographis paniculata total flavone extract has an anti-inflammatory effect, is especially effective for symptoms such as upper respiratory tract and diarrhea caused by bacteria and viruses, shows strong antibacterial and antiviral capabilities, can inhibit ADP-induced human platelet aggregation, shortens the dissolution time of euglobulin, and has a good anti-inflammatory effect. The andrographis paniculata extract has a certain protective effect on myocardial injury caused by isoprenaline and experimental myocardial infarction ischemic injury, and the andrographis paniculata extract can enhance the function of phagocytes and improve the staphylococcus aureus phagocytosis capacity of peripheral blood leukocytes, and is used for enhancing immunity and overcoming immunity diseases.

The invention discloses an andrographis paniculata transcription factor ApMYB9 and an application of the andrographis paniculata transcription factor ApMYB9 in positive regulation of biosynthesis of andrographolide. The key regulatory factor ApMYB9 for andrographolide synthesis is explored, the molecular mechanism of the key regulatory factor ApMYB9 for positively regulating and controlling andrographolide synthesis through an important enzyme gene isopentene diphosphate isomerase ApIPPI of a targeted andrographolide synthesis pathway is verified, and the application of the key regulatory factor ApMYB9 for improving the content of andrographolide by utilizing a biotechnology is provided. And a theoretical basis is provided for culturing a new variety of andrographis paniculata with high diterpene lactone content.

The Invention provides an enhanced Polyherbal Nano-admixture to retain and regain metabolic health with balanced detoxification, synergistic effect and preparation method thereof. The present invention discloses a polyherbal composition comprising a Andrographis paniculata herb extract; a Boerhavia diffusa herb extract; a Abelia triflora herb extract; a Terminalia bellerica herb extract; a Picrorhiza kurroa herb extract; a Tinospora cordifolia herb extract; a Phyllanthus emblica herb extract; a Acalypha fructicosa herb extract; a Phyllanthus niruri herb extract; a Terminalia chebula herb extract; and a Abutilon persicum herb extract.

The invention discloses a method for establishing andrographis paniculata quality control by using a QAMS (quantitative analysis of multi-components by single marker) method. Comprising the following steps: preparing a test sample solution, preparing a reference solution, determining chromatographic conditions and mass spectrum conditions, determining main components of a test sample, establishing a standard curve, performing methodological investigation by using an external standard method, determining an internal reference and a relative correction factor of the quantitative analysis of multi-components by single marker, and investigating the durability of the relative correction factor and positioning of a chromatographic peak. And comparing and verifying the content of the measured sample. The invention further discloses an andrographis paniculata quality control method. According to the method, relative correction factors of an internal reference substance and other to-be-detected components are established on the basis of an ultra-high performance liquid chromatography-tandem mass spectrometry-based quantitative analysis of multi-components by single marker, and the contents of four components including desoxidized andrographolide, andrographolide, dehydroandrographolide and andrographolide in andrographis paniculata are determined as a quality control method of the andrographis paniculata medicinal material, so that the quality of the andrographis paniculata medicinal material is improved. The calculated value and the measured value meet the requirements of quantitative methodology, the requirements of reference substances are reduced, and the quality control level of andrographis paniculata is improved.

The invention relates to the technical field of bubble bath liquid preparation, and particularly discloses a bubble bath liquid capable of clearing heat and decreasing internal heat and a preparation method thereof.The preparation method comprises the steps that fructus forsythiae, coptis chinensis roots, the root of kudzu vine, gleditsia sinensis seeds, honeysuckle, honeysuckle flowers, folium mori, andrographis paniculata leaves, mint, chrysanthemum and lophatherum gracile leaves are subjected to targeted pretreatment; the preparation method comprises the following steps: performing stepped synergistic extraction on pretreated raw materials, mixing an extracting solution, preparing a water phase, mixing and grinding borneol, ethanol, peppermint oil and a cyclodextrin inclusion compound into an oil phase, dynamically mixing the water phase and the oil phase to form an oil-in-water system, performing gradient concentration, staged sterilization and standing in sequence, and filling to obtain a finished product. The bath foam capable of clearing heat and decreasing internal heat is obtained. According to the method, the total extraction rate is increased by adopting synergistic pretreatment of composite enzymolysis and low-temperature freeze thawing activation, and meanwhile, the retention rate of various active ingredients is greatly increased by using a combined process of water extraction, alcohol extraction and ultrasonic extraction, so that the limitation of single solvent extraction is solved.

The utility model discloses a coating machine for processing andrographis paniculata dripping pills, which relates to the technical field of medicine production, and comprises a dripping pill screening device, a coating machine with a feeding hole connected with a pill core outlet of the dripping pill screening device, a diameter screening mechanism connected with a discharging hole of a pill core machine, and a roundness screening mechanism connected with the diameter screening mechanism, the roundness screening mechanism comprises a first pellet core inlet, a pellet core batch release mechanism connected with the first pellet core inlet, and a roundness classification slide way connected with the pellet core batch release mechanism. The diameter screening mechanism is used for performing diameter screening, the roundness screening mechanism is used for performing roundness screening on standard-diameter pill cores, the roundness is screened in the mode that the rotating rollers release the standard-diameter pill cores in batches, dropping pills naturally roll down from the roundness classification slide way, and the pill cores with good roundness enter the pill core outlet and enter the coating machine. And the pill cores with lower roundness deviate from the rolling track and enter a defective pill core outlet.

The utility model discloses a tablet counting device for packaging andrographis paniculata dropping pills, which relates to the technical field of medicine production and comprises a tablet counting box, a guide box connected below the tablet counting box, a first grid hole plate arranged at the bottom of the tablet counting box, and a second grid hole plate tightly attached to the lower bottom surface of the first grid hole plate, the grain distributing groove is arranged in the grain counting box in a sliding manner; one hole of the first grid hole plate can only contain one andrographis paniculata dropping pill, and the second grid hole plate and the first grid hole plate are the same in specification; the upper end of the guide box is provided with a first slot for accommodating the second grid hole plate in a sliding manner. The andrographis paniculata dripping pills are arranged in the holes of the first grid hole plate through the pill distribution groove, then the second grid hole plate is moved, the holes of the second grid hole plate are concentrically aligned with the holes of the second grid hole plate, and the dripping pills can smoothly fall into the guide box. Then, the holes are filled by moving the first grid hole plate of the particle distribution groove, the holes of the first grid hole plate are regular arrays, counting is facilitated, and the column number of the dropping pills is controlled through the particle distribution groove.

The invention discloses an endophytic fungus AP12 capable of promoting growth of andrographis paniculata plants and accumulation of active ingredient content and application of the endophytic fungus AP12. The colletotrichum sp. AP12 endophytic fungus provided by the invention can promote the growth of a common andrographis herb plant and the accumulation of the content of effective components, and after the colletotrichum sp. AP12 is applied and cultured under a pot culture condition, the leaf area of the common andrographis herb can be obviously increased, the fresh weight and the dry weight can be increased, the accumulation of the content of dry matters can be increased, and the growth of the common andrographis herb plant can be obviously promoted; meanwhile, the accumulation of active ingredients of andrographolide, neoandrographolide, 14-deoxidized andrographolide and dehydroandrographolide of andrographis paniculata can be remarkably promoted, the content of total lactone is increased, and it is shown that the endophytic fungi AP12 are beneficial endophytic fungi capable of promoting growth and metabolism of andrographis paniculata; and reference is provided for application and development of the endophytic fungi in promotion of growth of andrographis paniculata and accumulation of effective component content.

This invention relates to the field of pharmaceutical composition technology, and more particularly to a pharmaceutical composition for treating sepsis and its preparation method. A pharmaceutical composition for treating sepsis is prepared from the following components in parts by weight: 20-26 parts of Andrographis paniculata, 18-24 parts of Forsythia suspensa, 17-21 parts of Anemarrhena asphodeloides, 15-19 parts of Vaccaria segetalis, 14-18 parts of Achyranthes bidentata, 12-16 parts of Scrophularia ningpoensis, 10-14 parts of Coptis chinensis, 7-11 parts of Melia toosendan, 5-9 parts of Prunus persica leaf, and 3-7 parts of Trillium tsao-ko. The formulation of this invention can reduce the inflammatory response of sepsis, alleviate apoptosis of intestinal mucosal epithelial cells in sepsis, promote cell survival, and thereby inhibit organ damage following sepsis.

The present invention discloses a whitening composition and application thereof for enhancing skin resistance and self-healing power suitable for sensitive skin, belonging to the technical field of cosmetics; the whitening composition provided by the present invention includes the following components in parts by mass: 0.1-3 parts of mulberry root extract, 0.1-3 parts of golden camellia extract, 0.01-1 parts of wood apple extract, 0.1-3 parts of andrographis paniculata extract, and 0.01-1 parts of epigallocatechin gallate. The present invention is compounded by selecting components in an appropriate mass ratio, and the obtained whitening composition can effectively promote the production and secretion of human beta defensins in the skin barrier, thereby effectively enhancing the tight junction function of the skin barrier, improving the resistance of the skin, and can effectively promote the metabolism of the skin, activate the skin's self-healing power and gently whiten the skin.

The present invention is related to a novel formulation comprising active pharmaceutical ingredients, optionally in combination with other active pharmaceutical ingredients which are capable of inhibiting replication of the virus belonging to the family Coronaviridae. The present invention formulation includes Andrographis paniculata, PVP K30 and Acrylic polymer. The present invention further relates to different pharmaceutical formulations that have different modes of application.

The invention provides an illumination method for improving the quality of andrographis paniculata, and belongs to the technical field of agricultural planting. The method for improving the quality of the andrographis paniculata comprises the following step of irradiating the andrographis paniculata with blue light 15 days after seedling emergence of the andrographis paniculata. The method for improving the quality of the andrographis paniculata is simple, easy to implement and low in required cost, growth and development of andrographis paniculata plants can be promoted, accumulation of andrographis paniculata terpene lactone components can be effectively improved, the quality of the andrographis paniculata is improved, and powerful technical support is provided for high-quality development of the andrographis paniculata industry.

The invention discloses a compound preparation for improving animal immunity or a feed additive containing the compound preparation as well as a preparation method and application of the compound preparation. The compound preparation is prepared from 10 to 30 parts of lucid ganoderma extract, 15 to 30 parts of herba andrographitis extract, 10 to 20 parts of rhizoma polygoni cuspidati extract, 1 to 6 parts of allicin and 0 to 5 parts of biological composition, the biological composition contains an Amuc1100 protein and an antibacterial peptide. The compound preparation can be mixed according to a certain proportion to be prepared into an oral medicine or a feed additive. The compound preparation has a synergistic effect, can stimulate proliferation and activation of immune cells, promote differentiation, maturation and function exertion of the immune cells, inhibit inflammatory response and pathogen infection and improve the immunity of animals, and is suitable for disease prevention and treatment in the fields of breeding industry, animal husbandry and the like.

The invention belongs to the technical field of carbon nano-enzymes, and particularly relates to an andrographis paniculata carbon dot nano-enzyme and application thereof. According to the andrographis paniculata carbon dot nano-enzyme prepared by a hydrothermal method, the particle size is 1-5nm, and the andrographis paniculata carbon dot nano-enzyme is relatively small in size and uniform in particle size, so that the andrographis paniculata carbon dot nano-enzyme has good biocompatibility, not only has good oxidation resistance, but also can be used for treating inflammatory diseases in vivo. The andrographis paniculata carbon dot nano-enzyme provided by the invention has a scavenging effect on various free radicals such as ABTS free radicals, DPPH free radicals, hydroxyl free radicals, superoxide anions and the like, and can be used for treating ulcerative colitis.

The invention discloses an isopentene diphosphate isomerase ApIPPI and an application of the isopentene diphosphate isomerase ApIPPI. According to the present invention, the isopentene diphosphate isomerase ApIPPI is found, and the experimental verification results show that the synthesis amount of andrographolide can be effectively improved by overexpressing the gene of the isopentene diphosphate isomerase ApIPPI in andrographis paniculata, such that the theoretical basis is provided for the improvement of the andrographolide content and the cultivation of the new andrographolide variety with the high diterpene lactone content by using the biotechnology.

The present invention provides a composition comprising extract of Nyctanthes arbortristis (NAT) and Andrographis paniculata (AP) for use in treating inflammatory conditions.

The invention provides a fermentation product containing keratin and plant extraction essence and application of the fermentation product to an anti-hair loss function, and relates to the technical field of biological fermentation. Wherein the fermentation product is obtained by fermenting pichia pastoris engineering bacteria for expressing recombinant keratin in a fermentation culture medium containing a plant extract; the plant extract is common andrographis herb extract and / or bitter tea extract. The fermentation product has the effects of resisting inflammation, resisting oxidation and promoting cell proliferation, and can effectively relieve alopecia and repair scalp. And the filtrate is mild, skin-friendly, safe and stable, is suitable for the fields of hair loss prevention, cosmetics and skin care products, and has high market value.

The invention provides a plant extraction compound factor with anti-inflammatory and anti-allergy functions and a preparation method thereof, and relates to the technical field of skin care product processing, the plant extraction compound factor is prepared from the following raw materials by weight: 8-10 parts of gentiana macrophylla, 5-7 parts of swertia mileensis, 4-6 parts of stephania tetrandra, 6-8 parts of phellinus igniarius, and 7-9 parts of peony. The plant extraction compound factor is prepared from the following raw materials in parts by weight: 5-7 parts of eucommia ulmoides, 4-6 parts of magnolia sieboldii, 6-8 parts of andrographis paniculata and 3-5 parts of polygala tenuifolia, and the plant extraction compound factor is prepared from the following raw materials in parts by weight: 8-10 parts of centella asiatica, 3-5 parts of bamboo shavings, 5-7 parts of fructus forsythiae and 4-6 parts of amur corktree. The plant extraction compound factor is prepared from the following raw materials in parts by weight: 3-5 parts of coreopsis tinctoria, 7-9 parts of liquorice, 2-4 parts of pelargonium graveolens and 3-5 parts of broom leaf Australian tea.