13results about How to "Anti-inflammatory" patented technology

The present application relates to a kind of probiotic oil agent for improving non-alcoholic fatty liver disease, preparation method and application, the probiotic oil agent includes active ingredient A and active ingredient B, the active ingredient A is mucinophilic Akkermansia Akk11, and the preservation number is CCTCC NO:M2024119;The active ingredient B is Omega-3 fatty acid.The present application is combined with mucinophilic Akkermansia Akk11 and Omega-3 fatty acid, and is prepared into oil agent, and the improvement of NAFLD symptom can play the coordinated synergistic effect, can be used for the prevention and treatment of NAFLD.

This invention relates to the field of traditional Chinese medicine preparation technology, and particularly to a traditional Chinese medicine composition for treating cancer pain and numbness, as well as its preparation and application. This invention designs a traditional Chinese medicine composition for cancer pain and numbness, comprising: *Houttuynia cordata*, *Aconitum carmichaelii*, processed *Aconitum carmichaelii*, centipede, *Astragalus membranaceus*, *Ephedra sinica*, clove, frankincense, ephedra, menthol, and azone. The scientifically formulated combination of principal, assistant, and adjuvant herbs allows for multi-target action on both "cancer pain" (inflammation, compression, nerve infiltration) and "CIPN" (nerve damage), resulting in a superior analgesic effect, while also possessing anti-inflammatory, anti-swelling, potential tumor-suppressing, and nerve-repairing effects. The traditional Chinese medicine composition is prepared into a traditional Chinese medicine ointment, which is administered transdermally, allowing a high concentration of the drug to act directly on the lesion, avoiding the systemic side effects (addiction, constipation, etc.) associated with oral opioids. This is especially suitable for patients who cannot take oral opioids or cannot tolerate them.

This invention belongs to the field of traditional Chinese medicine chemistry and natural product separation technology, specifically relating to a novel triterpenoid compound and its epimerical form from *Eleutherococcus senticosus*, along with its extraction and separation methods and applications. The new compound is named 22α-Hydroxy-19-epi-chiisanogenin, and its epimerical form is named 22α-Hydroxychiisanogenin. The extraction and separation method provided by this invention employs acid hydrolysis / ethanol reflux extraction, macroporous resin column adsorption, silica gel column chromatography, ODS column chromatography, and high-performance liquid chromatography for separation, purification, and preparation. The compound was successfully extracted and separated. This method involves only five steps, is simple and rapid, and mainly uses conventional reagents such as ethanol, dichloromethane, and methanol. The process is simple and environmentally friendly, and the purity of the compound obtained by this method is high, exceeding 90%. Furthermore, studies have shown that this compound has anti-inflammatory effects. Therefore, the compound of this invention can be used as a lead compound for the synthesis of other compounds, as well as a raw material for new drug development and pharmacological activity research, and can also be used to prepare anti-inflammatory drugs.

The application belongs to the technical field of biological nanomaterials, and particularly relates to a nano-enzyme material and a preparation method and application thereof. The application reacts dimethyl imidazole and metal salt in an aqueous solution to obtain a metal-dimethyl imidazole composite material solution, wherein the metal salt comprises copper salt and / or zinc salt; and reacts the metal-dimethyl imidazole composite material solution and tannic acid to obtain a nano-enzyme material. The nano-enzyme material provided by the application has excellent antioxidant enzyme-like catalytic activity and good biocompatibility, can effectively remove abnormally increased reactive oxygen species (ROS) in the process of myocardial infarction and myocardial ischemia-reperfusion injury, inhibit inflammatory response and myocardial cell apoptosis, improve the mitochondrial function state, thereby promoting the repair of damaged myocardial tissue and significantly improving the cardiac function, and provides a new technical solution for the treatment of myocardial infarction and related ischemic cardiovascular diseases.

This invention discloses a pharmaceutical composition, its formulation, and its application for treating rheumatic arthralgia. The pharmaceutical composition comprises the following components in parts by weight: 20-40 parts of Salvia miltiorrhiza, 10-20 parts of Paeonia lactiflora, 20-40 parts of Panax notoginseng rootlets, 10-20 parts of Ligusticum chuanxiong, 9-20 parts of Angelica sinensis, 9-20 parts of Clematis chinensis, 9-20 parts of Angelica pubescens, 9-20 parts of Chaenomeles speciosa, 9-20 parts of Saposhnikovia divaricata, 9-20 parts of Achyranthes bidentata (processed with wine), and 9-20 parts of Carthamus tinctorius. Pharmaceutically acceptable excipients may be added to the pharmaceutical composition to prepare a formulation. The pharmaceutical composition and its formulation can be used to treat rheumatic arthralgia.

This invention discloses a traditional Chinese medicine mouthwash, its preparation method, and its application, relating to the field of traditional Chinese medicine technology. The mouthwash is prepared from the following raw materials in parts by weight: 8-20 parts Rehmannia glutinosa, 8-15 parts Lonicera japonica, 6-15 parts Scutellaria baicalensis, 5-8 parts Coptis chinensis, 10-20 parts Forsythia suspensa, 10-25 parts Gypsum fibrosum, 5-10 parts Mentha haplocalyx, 3-6 parts Stevia repens, 4-8 parts honey, and 10-20 parts Crataegus pinnatifida. It has the effects of clearing heat and detoxifying, relieving pain and stopping bleeding, is non-irritating, does not produce drug resistance, and has no toxic side effects on the human body. It has anti-inflammatory and antibacterial effects, while preventing the occurrence and development of oral diseases. It utilizes the basic thinking of traditional Chinese medicine to apply the compatibility of natural herbs, and the raw materials are abundant, readily available, low in cost, and the preparation method is simple, suitable for industrial production. It has a significant and definite therapeutic effect on gingival redness, swelling, bleeding, purulent discharge, alveolar bone resorption, and loose teeth caused by kidney yin deficiency and excessive stomach fire.

The invention discloses a biological polysaccharide wound dressing with the effects of diminishing inflammation, promoting healing and reducing scars and a preparation method of the biological polysaccharide wound dressing. According to the dressing, chitosan, sodium hyaluronate and the like are used as matrixes, modified biological polysaccharide and an active compound additive are compounded, and a three-dimensional network structure is constructed through a biological cross-linking agent; the preparation process adopts an isopropanol-water mixed solvent and mild conditions such as low-temperature alkalization, and is green and environment-friendly; experiments show that the dressing can achieve synergistic effects of diminishing inflammation, promoting healing and reducing scars, is excellent in biocompatibility, stable in mechanical property and controllable in sustained release of active ingredients, can remarkably shorten the wound healing time and reduce the scar hyperplasia rate, and is suitable for repairing multiple wounds such as burns and chronic ulcers.

The invention relates to the technical field of body armor, and discloses an outer protective layer. The auxetic structural layer comprises an upper functional layer, a middle functional layer and a lower functional layer from outside to inside, a plurality of polygonal concave buffer grooves distributed at equal intervals are formed in the auxetic structural layer, and the buffer grooves of the auxetic structural layer are filled with shear thickening liquid; when the body armor is impacted by external force, the groove wall fiber network of the multilateral concave buffer groove buffers the external impact force through stretching deformation, the shear thickening liquid is thickened, and the fiber network around the damage bearing part of the body armor is locked to form a local rigid supporting area; the inner protective layer and the auxetic structure layer are located between the outer protective layer and the inner protective layer, the beneficial effects of being excellent in synergistic protective performance, uniform in impact energy dispersion and capable of assisting nursing are achieved, and the problems that a traditional body armor is limited in energy absorption efficiency, blunt injuries are easily caused by impact stress concentration, and the service life is long are solved. The auxiliary nursing function of the injured part is lacked, and primary treatment cannot be carried out on the wound in time.

This invention belongs to the field of biomaterials technology, specifically an antibacterial magnesium and strontium-reinforced bioactive glass ceramic and its applications. Its composition, by weight percentage, is as follows: SiO2: 30-50; P2O5: 5-20; CaO: 10-35; Na2O: 10-20; SrO: 5-20; MgO: 2-10; ZnO: 5-15; B2O3: 0-10; K2O: 3-10; CuO: 0.05-5; F: 1.5-5; Ag: 0.05-0.9. It possesses good biocompatibility, is non-toxic and harmless to the human body, and effectively inhibits and kills bacteria. It can be used as a special additive in oral care products such as toothpaste, mouthwash, tooth powder, tooth gel, and chewing gum, promoting tooth surface mineralization and reducing dentin hypersensitivity during the teeth cleaning process.

The present application relates to the technical field of biomedical materials, in particular to a non-viral gene carrier and a preparation method and application thereof. The non-viral gene carrier prepared by EDC / NHS cross-linking reaction of baicalin and polyethyleneimine can be used for gene delivery and preparation of a gene therapy drug. The present application further provides a nano-complex composed of the non-viral gene carrier and nucleic acid, which can be used for gene delivery and preparation of a gene therapy drug. The nano-complex can not only effectively deliver target genes into cells, but also synergize miR-34a and baicalin to jointly exert an anti-tumor effect, greatly enhancing the anti-tumor treatment efficacy.

The invention belongs to the technical field of fermentation, and particularly relates to pollen residue fermented hypsizigus marmoreus polysaccharide as well as a preparation method and application thereof. The preparation method comprises the following steps: inoculating hypsizigus marmoreus into an aqueous solution culture medium containing 5-10wt% of pine pollen residues, and fermenting. The hypsizigus marmoreus is fermented with the pollen residues as the substrate, the hypsizigus marmoreus crude polysaccharide is produced, and compared with a conventional potato nutrient culture medium, the yield of the crude polysaccharide is greatly increased. The pollen residue fermentation culture medium only contains pollen residues and water, fermentation can be carried out at 30 DEG C after the hypsizigus marmoreus seed liquid is added, the fermentation period is shortened, energy consumption is reduced, and the prepared hypsizigus marmoreus crude polysaccharide has the effects of resisting oxidation, inflammation and sugar and whitening the skin, and is suitable for industrial production. And a core material basis and a technical support are provided for deep development in the fields of medicines, functional foods and the like.

The utility model relates to the technical field of sanitary pads, in particular to a sanitary pad with a double-layer bacteriostatic structure, which comprises a surface layer, a functional core body is arranged on the base surface of the surface layer, and a bacteriostatic layer is arranged on the lower side of the surface layer. The first antibacterial sheet is made of natural bamboo fibers, the bamboo fibers are very good in hygroscopicity and air permeability, can rapidly absorb and evaporate moisture and keep dry and comfortable, the bamboo fibers have natural antibacterial and bacteriostatic performance and can restrain growth of bacteria, and the bamboo fiber sanitary towel not only has an excellent antibacterial effect, but also can effectively reduce peculiar smell in the menstrual period, and is good in antibacterial effect. The sanitary pad is simple in structure and suitable for women who are large in menstrual period and prone to side leakage, tea tree essential oil is arranged in the second antibacterial sheet, the tea tree essential oil is a natural plant antibacterial material and has the advantages of being antibacterial, antiseptic, anti-inflammatory and the like, most bacteria, viruses and fungi can be killed, meanwhile, peculiar smells can be removed, and therefore the antibacterial effect of the sanitary pad is better.

This invention discloses a highly stable, high-brightness, fast-dissolving, dust-free natural blue composition granules, its preparation method, and its applications, belonging to the field of pigment extraction technology. This natural blue composition uses gardenia blue, butterfly pea flower extract, and phycocyanin extract as the ternary coloring components, compounded with buffers (phosphates) and antioxidants (vitamin C and tea polyphenols), and employs an embedding wall material (β-cyclodextrin and sodium caseinate) for emulsification and embedding. Finally, it is produced into composite granules through spray drying and dry granulation processes. The composition granules exhibit a bright and vibrant color, excellent light and heat resistance, rapid dissolution in water without dust generation, and are environmentally friendly. This invention also provides a method for preparing the composition granules and their application as a colorant in food, pharmaceuticals, and cosmetics, offering a safe, stable, and efficient comprehensive solution to replace petroleum-based synthetic blue pigments.