43results about How to "Anti-inflammatory" patented technology

The invention discloses a preparation method of a polyphenol-containing medical adhesive. The preparation method comprises the following steps: respectively preparing a gelatin solution, a gallic acid solution and a tea polyphenol solution; mixing the gelatin solution and the gallic acid solution, and reacting at 40-60 DEG C for 6-12 hours to obtain a modified gelatin solution; mixing the tea polyphenol solution with the modified gelatin solution, adding an alkaline solution to adjust the pH value to 6.5-8.0, and uniformly mixing to obtain a mixed solution; the mixed solution is aged at 20-40 DEG C, water generated in the aging process is removed, and the polyphenol-containing medical adhesive is obtained. According to the preparation method of the polyphenol-containing medical adhesive, a gelatin protein molecular chain is used as a framework material, gallic acid is introduced into the protein molecular chain, tea polyphenol is used as a main chain cross-linking agent, the polyphenol-containing medical adhesive is prepared, a phenolic hydroxyl group can penetrate through a water boundary layer on the surface of a base material to form an adhesive bond with the base material, and the medical adhesive has the advantages that the water boundary layer can penetrate through the water boundary layer; good wet adhesion is shown on tissues.

The invention discloses a synthesis method of a 6-trifluoromethylthio phenanthridine compound, and belongs to the technical field of organic synthesis. The phenanthridine compound containing the trifluoromethylthio group is prepared in one step by taking phenanthridine thione as a raw material and taking bromotrifluoromethane which is low in price and easy to obtain as a fluorinating reagent through a C = S free radical addition reaction under the action of visible light induction and a photocatalyst and alkali. The method has the characteristics of being green and safe, cheap and easily available in raw materials, high in atom economy, good in reaction regioselectivity, mild in reaction condition, wide in substrate application range, high in yield, easy in product purification and the like, and belongs to green synthesis.

The invention discloses a special composition for resisting superficial fungal bacterial infection and a preparation method thereof. The composition mainly comprises an antibacterial agent, a synergist, a repairing agent and a solubilizer. The component of the antibacterial agent is epsilon-polylysine hydrochloride; the synergist is prepared from oxymatrine, hexanediol, caprylyl glycol and sodium diacetate; the repairing agent comprises the following components: glycerol, urea, allantoin and dipotassium glycyrrhizinate; the solubilizer is prepared from the following components: triton X-100, polyvinylpyrrolidone, sodium pyrrolidone carboxylate, sodium pyrithione and polyvinyl alcohol. According to the invention, food-grade and traditional Chinese medicine-derived antibacterial components are used, so that the cleaning agent is free of hormones and irritant substances, is non-corrosive and is friendly to human bodies. Meanwhile, the composition disclosed by the invention is in a water-soluble and spray form, is convenient to use, can soften cutin and dead skin, has good permeability, continuously plays a role in killing fungi and bacteria, and achieves the purpose of treating the root causes.

The invention belongs to the technical field of compositions, and particularly relates to a traditional Chinese medicine composition with bacteriostatic, anti-inflammatory, antioxidant and whitening effects and a preparation method and application thereof. The composition provided by the invention comprises the following raw materials in parts by weight: 1-5 parts of rhodiola rosea; 5-10 parts of licorice root; and 1-5 parts of phyllanthus emblica. The composition is obtained by crushing rhodiola rosea, liquorice and phyllanthus emblica into powder raw materials and adding the powder raw materials into an extraction solvent for extraction. Compared with a composition with a single purpose, the composition disclosed by the invention has the effects of inhibiting bacteria, resisting inflammation, resisting oxidation and whitening at the same time, and the four effects of the product can be met at the same time.

The invention discloses a solid dispersion of beta-1, 3 / alpha-1, 3-glucan as well as a preparation method and application thereof, and belongs to the technical field of biology. The solid dispersion of beta-1, 3 / alpha-1, 3-glucan provided by the invention comprises beta-1, 3 / alpha-1, 3-glucan and polysaccharide, wherein the beta-1, 3 / alpha-1, 3-glucan and the polysaccharide are compounded to form the solid dispersion; the mass ratio of the beta-1, 3 / alpha-1, 3-glucan to the polysaccharide is 3: (1.5-3); the polysaccharide comprises one or more of curdlan, carrageenan and microcrystalline cellulose; the solid dispersion of beta-1, 3 / alpha-1, 3-glucan has lower viscosity and higher solubility in application, and the stability of a beverage can be effectively improved; and the preparation method is simple and easy to implement and suitable for industrial mass production, and the obtained solid dispersion does not contain a surfactant, is safer and has smaller irritation.

The invention discloses a traditional Chinese medicine preparation for repairing damaged cranial nerves, which is prepared by mixing gastrodia elata, radix angelicae, radix paeoniae rubra, arisaema cum bile, ligusticum wallichii, fructus viticis, divaricate saposhnikovia root, ligusticum, poria cocos, radix polygoni multiflori preparata, turmeric, silkworm larva, asarum, mint, semen brassicae, achyranthes root, schizonepeta spike, liquorice, Korean monkshood root, scorpion, radix aconiti preparata, earthworm, leech, ground beetle and centipede according to a certain weight ratio. The traditional Chinese medicine composition is simple to prepare, quick to absorb, remarkable in curative effect, long in drug effect duration, free of side effects, high in safety and low in production cost, diseases are relieved in time, and effective restorative treatment is carried out on cranial nerve injury diseases.

The present invention belongs to the field of biomedicine and discloses a ceramide derived from linolenic acid, which has a structure of general formula I or an isomer of general formula I: #imgabs0# wherein R 1 Selected from #imgabs1#R 2 Selected from one of the following structures: #imgabs2# The present invention also discloses its preparation method and use. The present invention reacts long-chain linolenic acid with sphingosine and phytosphingosine to obtain a class of novel ceramide compounds, which have a significant inhibitory effect on tyrosinase and can effectively prevent the formation of melanin, thereby having a good skin whitening effect and can be used in the fields of cosmetics.

The invention provides a composition containing a marine extract, especially a coralline algae extract and deep-sea fish collagen, and a liposome containing the composition. The composition prepared by the invention is green, healthy, safe, effective and good in lasting effect, and solves the problem of skin aging of people.

The invention discloses an oral medicament for lumbar disc herniation and a preparation method thereof, and relates to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from the following materials in parts by mass: 4 to 8 parts of black prepared aconite root, 10 to 20 parts of poria cocos, 5 to 15 parts of rhizoma atractylodis macrocephalae, 10 to 14 parts of radix paeoniae alba, 4 to 8 parts of fresh ginger, 10 to 20 parts of cortex eucommiae, 10 to 14 parts of radix dipsaci, 10 to 20 parts of herba taxilli, 10 to 14 parts of rhizoma cibotii, 4 to 8 parts of ground beeltle, 1 to 5 parts of radix notoginseng and 30 to 55 parts of honey. According to the oral medicament for lumbar disc herniation and the pills prepared by the preparation method, the uncomfortable symptoms such as waist pain, lower limb radiation pain and numbness of a patient with lumbar disc herniation can be effectively relieved, and the life quality of the patient is improved.

The invention relates to the technical field of oral cavity medicines, and discloses an antioxidant polyphenol sustained-release ointment suitable for oral cavity and a preparation method and application thereof, the antioxidant polyphenol sustained-release ointment comprises the following raw materials by weight: 0.5%-5% of antioxidant polyphenol, 20%-45% of a drug solvent, 1%-10% of a water-soluble polymer substance, 15%-40% of a water-based thickener, 1%-10% of a hydrophobic polymer, and 15%-40% of an ester plasticizer. The natural polyphenol is used as a main medicine, and the natural polyphenol has multiple functions of oxidation resistance, inflammation resistance, bacterium resistance, metal ion chelation, biological adhesion and the like; the slow-release ointment is prepared from an antioxidant polyphenol substance, and a slow-release system does not contain antibiotics, has no bacterial drug resistance problem and has relatively high biological safety; the antioxidant polyphenol sustained-release ointment does not contain water, can absorb peripheral gingival crevicular fluid after being coated in a periodontal pocket, and is converted into gel with higher strength to be more stably released locally; the preparation process is simple, mild in condition and low in cost.

The invention relates to the technical field of masks, in particular to a preservative-free mask composition, which is prepared from the following components in parts by weight: 1 to 1.5 parts of green tea extract, 0.5 to 1 part of vitamin E, 1 to 1.5 parts of muskmelon extract, 1 to 1.5 parts of artichoke extract, 1 to 3 parts of nicotinamide, 4 to 6 parts of glycerol and 0.5 to 1 part of fibroin. The composition is prepared by combining a plurality of groups of plant extracts, and through the synergistic effect of all the components, the composition can be preserved, slow down the skin aging process and deeply moisturize the skin due to the natural characteristics of the composition without adding chemical preservatives.

The present application relates to a kind of probiotic oil agent for improving non-alcoholic fatty liver disease, preparation method and application, the probiotic oil agent includes active ingredient A and active ingredient B, the active ingredient A is mucinophilic Akkermansia Akk11, and the preservation number is CCTCC NO:M2024119;The active ingredient B is Omega-3 fatty acid.The present application is combined with mucinophilic Akkermansia Akk11 and Omega-3 fatty acid, and is prepared into oil agent, and the improvement of NAFLD symptom can play the coordinated synergistic effect, can be used for the prevention and treatment of NAFLD.

The invention discloses supramolecular hydrogel capable of being used as a carrier as well as a synthesis method and application of the supramolecular hydrogel. The drug-loaded supramolecular hydrogel is prepared from the following raw materials: laponite, beta-cyclodextrin modified sodium hyaluronate, (ferrocenyl methyl) trimethyl ammonium bromide and the balance of deionized water. Wherein the hectorite is a substance for forming the network structure of the supramolecular hydrogel serving as the carrier. The supramolecular hydrogel can be used as a macrophage extracellular vesicle carrier for treating burn wounds, has injectable, proper viscosity, porous structure, antibacterial property and the like, is beneficial to wound closure, tissue regeneration, collagen synthesis, cell proliferation and angiogenesis, and is beneficial to tissue regeneration and remodeling.

The present application belongs to the technical field of cosmetic production, and discloses an acid-free acne-removing composition, comprising 10-20% of dipeptide-15, 1-5% of olive leaf extract, 5-10% of acetyl glucosamine, 0.1-1% of 10-hydroxydecanoic acid, 5-10% of yeast / zinc fermentation product, 1-5% of bisabolol, 5-10% of tetrahydromethylpyrimidine carboxylic acid, 1-10% of capryloyl glycine, 0.01-1% of polylysine, 28-32% of polyol and the balance of deionized water. Through the synergistic effect among the above multiple components, the antibacterial ability of the composition and the inhibitory effect on inflammatory factors 1L-1α and 5α-reductase are further improved. Moreover, the composition disclosed in the present application also has good anti-allergic ability. In addition, the present application also discloses the application of the acid-free acne-removing composition and a daily chemical product.

The invention relates to the technical field of medicine component extraction, and discloses a medicine for resisting hashimoto thyroiditis disease, the medicine comprises an active component and an auxiliary material, the active component is an andrographis paniculata general flavone extract, andrographis paniculata general flavone is used as a main component, and the andrographis paniculata general flavone can reduce exudation of capillary walls, so that the medicine can be used for preventing and treating the hashimoto thyroiditis disease. The andrographis paniculata total flavone extract has an anti-inflammatory effect, is especially effective for symptoms such as upper respiratory tract and diarrhea caused by bacteria and viruses, shows strong antibacterial and antiviral capabilities, can inhibit ADP-induced human platelet aggregation, shortens the dissolution time of euglobulin, and has a good anti-inflammatory effect. The andrographis paniculata extract has a certain protective effect on myocardial injury caused by isoprenaline and experimental myocardial infarction ischemic injury, and the andrographis paniculata extract can enhance the function of phagocytes and improve the staphylococcus aureus phagocytosis capacity of peripheral blood leukocytes, and is used for enhancing immunity and overcoming immunity diseases.

This invention relates to the field of traditional Chinese medicine preparation technology, and particularly to a traditional Chinese medicine composition for treating cancer pain and numbness, as well as its preparation and application. This invention designs a traditional Chinese medicine composition for cancer pain and numbness, comprising: *Houttuynia cordata*, *Aconitum carmichaelii*, processed *Aconitum carmichaelii*, centipede, *Astragalus membranaceus*, *Ephedra sinica*, clove, frankincense, ephedra, menthol, and azone. The scientifically formulated combination of principal, assistant, and adjuvant herbs allows for multi-target action on both "cancer pain" (inflammation, compression, nerve infiltration) and "CIPN" (nerve damage), resulting in a superior analgesic effect, while also possessing anti-inflammatory, anti-swelling, potential tumor-suppressing, and nerve-repairing effects. The traditional Chinese medicine composition is prepared into a traditional Chinese medicine ointment, which is administered transdermally, allowing a high concentration of the drug to act directly on the lesion, avoiding the systemic side effects (addiction, constipation, etc.) associated with oral opioids. This is especially suitable for patients who cannot take oral opioids or cannot tolerate them.

This invention belongs to the field of traditional Chinese medicine chemistry and natural product separation technology, specifically relating to a novel triterpenoid compound and its epimerical form from *Eleutherococcus senticosus*, along with its extraction and separation methods and applications. The new compound is named 22α-Hydroxy-19-epi-chiisanogenin, and its epimerical form is named 22α-Hydroxychiisanogenin. The extraction and separation method provided by this invention employs acid hydrolysis / ethanol reflux extraction, macroporous resin column adsorption, silica gel column chromatography, ODS column chromatography, and high-performance liquid chromatography for separation, purification, and preparation. The compound was successfully extracted and separated. This method involves only five steps, is simple and rapid, and mainly uses conventional reagents such as ethanol, dichloromethane, and methanol. The process is simple and environmentally friendly, and the purity of the compound obtained by this method is high, exceeding 90%. Furthermore, studies have shown that this compound has anti-inflammatory effects. Therefore, the compound of this invention can be used as a lead compound for the synthesis of other compounds, as well as a raw material for new drug development and pharmacological activity research, and can also be used to prepare anti-inflammatory drugs.

The present invention relates to the field of genetic engineering, protein engineering technology and its application, and discloses a novel recombinant collagen and its application, including any one of the recombinants COL17-CO-1, COL17-CO-2, COL17-CO-3 or COL17-CO-4 of the specific functional region of human type XVII collagen and the 1232-1466 region of human type III collagen, wherein the amino acid sequences of the specific functional regions in the COL17-CO-1, COL17-CO-2, COL17-CO-3 and COL17-CO-4 are SEQ ID No.2, SEQ ID No.6, SEQ ID No.8 and SEQ ID No.10, respectively. The recombinant exhibits better ability to promote cell proliferation, promotes the expression of proline hydroxylase (HYP), improves the antioxidant capacity of skin cells, improves the expression of multiple collagens in skin cells, and better reduces the expression of collagen degradation-related bases MMP-3 and MMP-9.

The invention discloses a traditional Chinese medicine composition for treating hypertension and a preparation method thereof, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition for treating hypertension is prepared from dracocephalum moldavica, leontopodium leontopodum, uncaria, corn stigma and Chinese dates. The traditional Chinese medicine composition is simple in medicine flavor, clear in medicine effect and capable of relaxing blood vessels and effectively reducing the blood pressure value of hypertensive rats, and all the medicines act together to promote hypertension treatment. The composition disclosed by the invention takes effect quickly and has an exact effect when being used for treating hypertension, and has a good clinical application prospect.

The utility model discloses a silk fibroin zinc oxide bone bar which comprises a first bone bar body, a connecting groove is formed in the top of the first bone bar body, a second bone bar body is arranged in an inner cavity of the connecting groove, sliding grooves are formed in the two sides of the inner wall of the connecting groove, and sliding blocks are arranged on the front face and the back face of the first bone bar body. A lantern ring is arranged on the outer ring of the first bone bar body. The screw rod is taken out by anticlockwise rotating in the inner cavities of the threaded grooves, every two of which form one group, so that the fixation of the sliding block and the first bone bar body in the sliding groove is relieved, and then the second bone bar body can slide up and down in the sliding groove through the sliding block; therefore, the overall length of the first bone bar body and the second bone bar body can be adjusted according to the length matched with the human body, and meanwhile, the first bone bar body and the second bone bar body can be conveniently disassembled and assembled; the first bone bar body and the second bone bar body are made of the zinc material and the silk fibroin material, so that the effect of improving actual use can be achieved.

The application belongs to the technical field of biological nanomaterials, and particularly relates to a nano-enzyme material and a preparation method and application thereof. The application reacts dimethyl imidazole and metal salt in an aqueous solution to obtain a metal-dimethyl imidazole composite material solution, wherein the metal salt comprises copper salt and / or zinc salt; and reacts the metal-dimethyl imidazole composite material solution and tannic acid to obtain a nano-enzyme material. The nano-enzyme material provided by the application has excellent antioxidant enzyme-like catalytic activity and good biocompatibility, can effectively remove abnormally increased reactive oxygen species (ROS) in the process of myocardial infarction and myocardial ischemia-reperfusion injury, inhibit inflammatory response and myocardial cell apoptosis, improve the mitochondrial function state, thereby promoting the repair of damaged myocardial tissue and significantly improving the cardiac function, and provides a new technical solution for the treatment of myocardial infarction and related ischemic cardiovascular diseases.

This invention discloses a pharmaceutical composition, its formulation, and its application for treating rheumatic arthralgia. The pharmaceutical composition comprises the following components in parts by weight: 20-40 parts of Salvia miltiorrhiza, 10-20 parts of Paeonia lactiflora, 20-40 parts of Panax notoginseng rootlets, 10-20 parts of Ligusticum chuanxiong, 9-20 parts of Angelica sinensis, 9-20 parts of Clematis chinensis, 9-20 parts of Angelica pubescens, 9-20 parts of Chaenomeles speciosa, 9-20 parts of Saposhnikovia divaricata, 9-20 parts of Achyranthes bidentata (processed with wine), and 9-20 parts of Carthamus tinctorius. Pharmaceutically acceptable excipients may be added to the pharmaceutical composition to prepare a formulation. The pharmaceutical composition and its formulation can be used to treat rheumatic arthralgia.

This invention discloses a traditional Chinese medicine mouthwash, its preparation method, and its application, relating to the field of traditional Chinese medicine technology. The mouthwash is prepared from the following raw materials in parts by weight: 8-20 parts Rehmannia glutinosa, 8-15 parts Lonicera japonica, 6-15 parts Scutellaria baicalensis, 5-8 parts Coptis chinensis, 10-20 parts Forsythia suspensa, 10-25 parts Gypsum fibrosum, 5-10 parts Mentha haplocalyx, 3-6 parts Stevia repens, 4-8 parts honey, and 10-20 parts Crataegus pinnatifida. It has the effects of clearing heat and detoxifying, relieving pain and stopping bleeding, is non-irritating, does not produce drug resistance, and has no toxic side effects on the human body. It has anti-inflammatory and antibacterial effects, while preventing the occurrence and development of oral diseases. It utilizes the basic thinking of traditional Chinese medicine to apply the compatibility of natural herbs, and the raw materials are abundant, readily available, low in cost, and the preparation method is simple, suitable for industrial production. It has a significant and definite therapeutic effect on gingival redness, swelling, bleeding, purulent discharge, alveolar bone resorption, and loose teeth caused by kidney yin deficiency and excessive stomach fire.

The invention discloses a biological polysaccharide wound dressing with the effects of diminishing inflammation, promoting healing and reducing scars and a preparation method of the biological polysaccharide wound dressing. According to the dressing, chitosan, sodium hyaluronate and the like are used as matrixes, modified biological polysaccharide and an active compound additive are compounded, and a three-dimensional network structure is constructed through a biological cross-linking agent; the preparation process adopts an isopropanol-water mixed solvent and mild conditions such as low-temperature alkalization, and is green and environment-friendly; experiments show that the dressing can achieve synergistic effects of diminishing inflammation, promoting healing and reducing scars, is excellent in biocompatibility, stable in mechanical property and controllable in sustained release of active ingredients, can remarkably shorten the wound healing time and reduce the scar hyperplasia rate, and is suitable for repairing multiple wounds such as burns and chronic ulcers.

The invention relates to the technical field of body armor, and discloses an outer protective layer. The auxetic structural layer comprises an upper functional layer, a middle functional layer and a lower functional layer from outside to inside, a plurality of polygonal concave buffer grooves distributed at equal intervals are formed in the auxetic structural layer, and the buffer grooves of the auxetic structural layer are filled with shear thickening liquid; when the body armor is impacted by external force, the groove wall fiber network of the multilateral concave buffer groove buffers the external impact force through stretching deformation, the shear thickening liquid is thickened, and the fiber network around the damage bearing part of the body armor is locked to form a local rigid supporting area; the inner protective layer and the auxetic structure layer are located between the outer protective layer and the inner protective layer, the beneficial effects of being excellent in synergistic protective performance, uniform in impact energy dispersion and capable of assisting nursing are achieved, and the problems that a traditional body armor is limited in energy absorption efficiency, blunt injuries are easily caused by impact stress concentration, and the service life is long are solved. The auxiliary nursing function of the injured part is lacked, and primary treatment cannot be carried out on the wound in time.

This invention belongs to the field of biomaterials technology, specifically an antibacterial magnesium and strontium-reinforced bioactive glass ceramic and its applications. Its composition, by weight percentage, is as follows: SiO2: 30-50; P2O5: 5-20; CaO: 10-35; Na2O: 10-20; SrO: 5-20; MgO: 2-10; ZnO: 5-15; B2O3: 0-10; K2O: 3-10; CuO: 0.05-5; F: 1.5-5; Ag: 0.05-0.9. It possesses good biocompatibility, is non-toxic and harmless to the human body, and effectively inhibits and kills bacteria. It can be used as a special additive in oral care products such as toothpaste, mouthwash, tooth powder, tooth gel, and chewing gum, promoting tooth surface mineralization and reducing dentin hypersensitivity during the teeth cleaning process.