Solid dispersion of beta-1, 3 / alpha-1, 3-glucan as well as preparation method and application of solid dispersion

Abstract

The invention discloses a solid dispersion of beta-1, 3 / alpha-1, 3-glucan as well as a preparation method and application thereof, and belongs to the technical field of biology. The solid dispersion of beta-1, 3 / alpha-1, 3-glucan provided by the invention comprises beta-1, 3 / alpha-1, 3-glucan and polysaccharide, wherein the beta-1, 3 / alpha-1, 3-glucan and the polysaccharide are compounded to form the solid dispersion; the mass ratio of the beta-1, 3 / alpha-1, 3-glucan to the polysaccharide is 3: (1.5-3); the polysaccharide comprises one or more of curdlan, carrageenan and microcrystalline cellulose; the solid dispersion of beta-1, 3 / alpha-1, 3-glucan has lower viscosity and higher solubility in application, and the stability of a beverage can be effectively improved; and the preparation method is simple and easy to implement and suitable for industrial mass production, and the obtained solid dispersion does not contain a surfactant, is safer and has smaller irritation.

Description

Technical Field

[0001] The invention relates to a solid dispersion of beta-1,3 / alpha-1,3-glucan and a preparation method and application thereof, belonging to the field of biotechnology. Background Art

[0002] β-1,3 / α-1,3-glucan is a soluble dietary fiber, which is composed of glucose units connected alternately by glycosidic bonds. Many research reports show that a small amount of glucan has good effects on lowering blood lipids and blood sugar, but in order to exert its effects, a large amount of glucan needs to be added. However, when a certain dose of β-1,3 / α-1,3-glucan is added to food, its viscosity is very high, which seriously affects the texture of food, and the dissolution rate is very slow, which greatly limits its application in the industry.

[0003] To address this problem, WO2020 / 108495A1 discloses a solid dispersion of β-glucan and a method for preparing the same. The method comprises a solid dispersion formed by compounding a high-viscosity polymer with β-glucan, wherein the high-viscosity polymer is selected from xanthan gum, konjac gum, guar gum, locust bean gum, carrageenan, sodium carboxymethyl cellulose or a combination thereof; although the solubility characteristics of β-glucan are improved to a certain extent, the effect is still not good, and the viscosity value is large, which greatly limits its application.

[0004] Therefore, there is an urgent need to develop a method for improving the solubility of β-1,3 / α-1,3-glucan and reducing its viscosity. Summary of the invention

[0005] [Technical issues]

[0006] In the prior art, the solid dispersion of β-1,3 / α-1,3-glucan has high viscosity and poor solubility when used, which greatly limits its application in the food industry.

[0007] [Technical solution]

[0008] In view of the defects and shortcomings of the prior art, the present invention provides a solid dispersion of β-1,3 / α-1,3-glucan and a preparation method and application thereof. The solid dispersion of β-1,3 / α-1,3-glucan has lower viscosity and higher solubility when used, and can effectively improve the stability of beverages; and the preparation method is simple and easy, suitable for large-scale industrial production, and the obtained solid dispersion does not contain surfactant, is safer and less irritating.

[0009] In order to achieve the above purpose, the technical solutions provided are as follows:

[0010] A solid dispersion of β-1,3 / α-1,3-glucan, comprising β-1,3 / α-1,3-glucan and polysaccharide, wherein the β-1,3 / α-1,3-glucan and the polysaccharide are compounded to form the solid dispersion.

[0011] In one embodiment, the polysaccharide comprises one or more of curdlan, carrageenan, and microcrystalline cellulose.

[0012] In one embodiment, the mass ratio of the β-1,3 / α-1,3-glucan to the polysaccharide is 3:1.5-3; preferably 1:1 or 2:1.

[0013] In one embodiment, the molecular weight of the β-1,3 / α-1,3-glucan is 2 to 2.5 million Da.

[0014] In one embodiment, the solid dispersion has a solution viscosity of 30 to 52 cp at 25° C. and 60 r / min when the β-1,3 / α-1,3-glucan content is 0.6%.

[0015] In one embodiment, the solid dispersion takes 18 to 21 minutes to completely dissolve and form a solution at 25° C. and when the β-1,3 / α-1,3-glucan content is 0.6%.

[0016] In one embodiment, the solid dispersion can be prepared in the form of gel, aqueous solution, spray or powder.

[0017] In one embodiment, the solid dispersion is in the form of capsules, tablets, pills, powders or granules.

[0018] The present invention also provides a method for preparing the solid dispersion of the above-mentioned β-1,3 / α-1,3-glucan, which specifically comprises the following steps:

[0019] (1) Weigh β-1,3 / α-1,3-glucan and polysaccharide and mix them evenly; then add water and stir until the powder is completely dissolved;

[0020] (2) subjecting the solution obtained by completely dissolving the product in step (1) to ultrasonic treatment;

[0021] (3) freeze-drying the solution after ultrasonic treatment in step (2), grinding it into powder, and obtaining a solid dispersion.

[0022] In one embodiment, the mass volume ratio of the β-1,3 / α-1,3-glucan and polysaccharide to water in step (1) is 3:1.5 to 3:150 to 200; g:g:ml; preferably 3:1.5 to 3:200; g:g:ml.

[0023] In one embodiment, the ultrasonic conditions in step (2) are: temperature 20-40°C, time 20-30 min, power 100-300W.

[0024] In one embodiment, the ultrasonic conditions in step (2) are: temperature 40°C, time 25 min, power 100W.

[0025] In one embodiment, the freeze-drying conditions of step (3) are: pre-freezing at -40 to -60°C for 7 to 9 hours; vacuuming at -20 to -35°C for 7 to 10 hours; primary drying at 35 to 40°C for 10 to 16 hours, and secondary drying at 20 to 25°C for 2 to 5 hours.

[0026] The present invention also provides the use of the above-mentioned solid dispersion of β-1,3 / α-1,3-glucan in the preparation of food, medicine and cosmetics.

[0027] The present invention also provides a method for improving the solubility of β-1,3 / α-1,3-glucan and reducing its viscosity, the method comprising the following steps:

[0028] (1) Weigh β-1,3 / α-1,3-glucan and polysaccharide and mix them evenly; then add water and stir until the powder is completely dissolved;

[0029] (2) subjecting the solution obtained by completely dissolving the product in step (1) to ultrasonic treatment;

[0030] (3) freeze-drying the solution after ultrasonic treatment in step (2), grinding it into powder, and obtaining a solid dispersion.

[0031] The present invention also provides a method for preparing a β-1,3 / α-1,3-glucan-based plant protein beverage, the method specifically comprising the following steps:

[0032] (1) Weighing plant-based food and mixing it with water, refining it, and heating it at a temperature of 95 to 100° C., and then filtering it to obtain plant-based pulp;

[0033] (2) adding sucrose and the solid dispersion of β-1,3 / α-1,3-glucan prepared above to the plant source slurry obtained in step (1), mixing evenly, performing shearing treatment, and homogenizing;

[0034] (3) performing UHT sterilization and filling on the solution homogenized in step (2) to obtain the product.

[0035] In one embodiment, the plant-based food in step (1) includes one or more of peanuts, soybeans, oats, black beans, chickpeas, and almonds.

[0036] In one embodiment, the mass volume ratio of the plant-based food to water in step (1) is 2 to 3:10, g:ml.

[0037] In one embodiment, the refining speed in step (1) is 1000-1200 r / min, the coarse grinding is 80-100 s, the fine grinding is 180-200 s, and the fine grinding is cycled 3-5 times.

[0038] In one embodiment, the mass ratio of the plant-derived food to sucrose and solid dispersion in step (2) is 100-200:15:6.

[0039] In one embodiment, the shearing conditions in step (2) are: a rotation speed of 3000 to 5000 r / min for 10 to 20 min.

[0040] In one embodiment, the homogenization pressure in step (2) is 100-300 kPa.

[0041] In one embodiment, the UHT sterilization conditions in step (3) are: 121-135° C., 15-30 s.

[0042] The present invention also provides a plant protein beverage prepared by the method for preparing a beta-1,3 / alpha-1,3-glucan-based plant protein beverage.

[0043] Beneficial effects:

[0044] (1) The solid dispersion of β-1,3 / α-1,3-glucan prepared by respectively using curdlan, carrageenan, microcrystalline cellulose and β-1,3 / α-1,3-glucan effectively solves the problem that β-1,3 / α-1,3-glucan takes a long time to dissolve and has a high solution viscosity, which limits its application; and the preparation process is simple and easy, suitable for large-scale industrial production, and the obtained solid dispersion does not contain surfactant, is safer and less irritating;

[0045] (2) The solid dispersion of β-1,3 / α-1,3-glucan of the present invention only takes 18 to 21 minutes to completely dissolve in 100 mL of deionized water at 25°C when the β-1,3 / α-1,3-glucan content is 0.6%. Compared with the solid dispersion formed by the complex of xanthan gum, konjac gum and gellan gum with β-1,3 / α-1,3-glucan, the time is shortened by 39 to 77 minutes. In 100 mL of deionized water at 25°C, the β-1,3 / α-1,3-glucan content is 0.6%, and the viscosity of the completely dissolved solution is 31.40 to 50.94 cp measured at 25°C and 60 r / min. Compared with the solid dispersion formed by the complex of xanthan gum, konjac gum and gellan gum with β-1,3 / α-1,3-glucan, the viscosity is greatly reduced.

[0046] (3) When the solid dispersion of β-1,3 / α-1,3-glucan prepared by the present invention is used in the preparation of plant-based beverages, the beverage solution can be evenly distributed and has good stability. In addition, the plant-based beverages after adding β-1,3 / α-1,3-glucan have anti-inflammatory, antioxidant, lipid-lowering, blood sugar-lowering and other effects, which help improve human health. BRIEF DESCRIPTION OF THE DRAWINGS

[0047] Figure 1 Actual pictures of the plant protein beverages prepared in Example 5 and Comparative Examples 7 to 9. DETAILED DESCRIPTION

[0048] The technical solutions in the embodiments of the present invention are described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work belong to the scope of protection of the present invention. The following specific implementation methods further describe the present invention.

[0049] The present invention relates to a testing method

[0050] 1. Determination of viscosity

[0051] Weigh a certain mass of powder and dissolve it in 100 mL of deionized water. Stir until the powder is completely dissolved to prepare a solution with a β-glucan content of 0.6%. Take 6 mL of the solution and place it in the SSR small sample adapter. Use the No. 18 rotor of the rotational viscometer to measure at 25°C and 60 r / min.

[0052] 2. Dissolution time determination

[0053] Weigh a certain amount of powder and dissolve it in 100 mL of deionized water at 25°C (make sure the β-glucan content is 0.6%), stir, and record the time from the start of stirring to the complete dissolution of the powder.

[0054] 3. Centrifugal sedimentation rate determination

[0055] Accurately weigh 10 mL of glucan-based plant-based beverage sample and place it in a centrifuge tube. Centrifuge at 4500 r / min for 20 min, pour off the supernatant, invert for 15 min, accurately weigh the precipitate mass, and use the precipitation rate SR to represent the stability of the system. The larger the SR value, the worse the stability.

[0056] The calculation formula of SR is as follows:

[0057] SR(%)=m1 / m2×100

[0058] Where:

[0059] m1——The mass of the precipitate after centrifugation of the sample solution, in grams (g);

[0060] m2 – the mass of the sample solution before centrifugation, in grams (g).

[0061] Sources of raw materials involved in the examples and comparative examples of the present invention:

[0062] Xanthan gum, curdlan gum, and carrageenan were purchased from Henan Zhongchen Biotechnology Co., Ltd.

[0063] Microcrystalline cellulose, konjac gum, and gellan gum were purchased from Henan Wanbang Chemical Technology Co., Ltd.;

[0064] Sodium hyaluronate was purchased from Qingzhou Guangyu Biotechnology Co., Ltd.;

[0065] The molecular weight of β-1,3 / α-1,3-glucan is 2 million Da.

[0066] Example 1

[0067] A method for preparing a solid dispersion of β-1,3 / α-1,3-glucan comprises the following steps:

[0068] (1) Weigh 3 g of β-1,3 / α-1,3-glucan and 3 g of curdlan and mix them evenly; then add 200 mL of deionized water and stir for 60 min until the powder is completely dissolved;

[0069] (2) subjecting the solution after complete dissolution in step (1) to ultrasonic treatment at a temperature of 40° C., a time of 25 min, and a power of 100 W;

[0070] (3) freeze-drying the solution after ultrasonic treatment in step (2), the freeze-drying conditions are: pre-freezing at -40°C for 7 to 9 hours; vacuuming at -35°C for 7 to 10 hours; primary drying at 35°C for 10 hours, secondary drying at 20°C for 2 hours, grinding to obtain a solid dispersion.

[0071] Example 2

[0072] A method for preparing a solid dispersion of β-1,3 / α-1,3-glucan comprises the following steps:

[0073] (1) Weigh 3 g of β-1,3 / α-1,3-glucan and 1.5 g of curdlan and mix them evenly; then add 200 mL of deionized water and stir for 60 min until the powder is completely dissolved;

[0074] (2) subjecting the solution after complete dissolution in step (1) to ultrasonic treatment at a temperature of 40° C., a time of 25 min, and a power of 100 W;

[0075] (3) freeze-drying the solution after ultrasonic treatment in step (2), the freeze-drying conditions are: pre-freezing at -40°C for 7 to 9 hours; vacuuming at -35°C for 7 to 10 hours; primary drying at 35°C for 10 hours, secondary drying at 20°C for 2 hours, grinding to obtain a solid dispersion.

[0076] Example 3

[0077] A method for preparing a solid dispersion of β-1,3 / α-1,3-glucan comprises the following steps:

[0078] (1) Weigh 3 g of β-1,3 / α-1,3-glucan and 3 g of carrageenan and mix them evenly; then add 200 mL of deionized water and stir for 60 min until the powder is completely dissolved;

[0079] (2) subjecting the solution after complete dissolution in step (1) to ultrasonic treatment at a temperature of 40° C., a time of 25 min, and a power of 100 W;

[0080] (3) freeze-drying the solution after ultrasonic treatment in step (2), the freeze-drying conditions are: pre-freezing at -40°C for 7 to 9 hours; vacuuming at -35°C for 7 to 10 hours; primary drying at 35°C for 10 hours, secondary drying at 20°C for 2 hours, grinding to obtain a solid dispersion.

[0081] Example 4

[0082] A method for preparing a solid dispersion of β-1,3 / α-1,3-glucan comprises the following steps:

[0083] (1) Weigh 3 g of β-1,3 / α-1,3-glucan and 3 g of microcrystalline cellulose and mix them evenly; then add 200 mL of deionized water and stir for 60 min until the powder is completely dissolved;

[0084] (2) subjecting the solution after complete dissolution in step (1) to ultrasonic treatment at a temperature of 40° C., a time of 25 min, and a power of 100 W;

[0085] (3) freeze-drying the solution after ultrasonic treatment in step (2), the freeze-drying conditions are: pre-freezing at -40°C for 7 to 9 hours; vacuuming at -35°C for 7 to 10 hours; primary drying at 35°C for 10 hours, secondary drying at 20°C for 2 hours, grinding to obtain a solid dispersion.

[0086] Comparative Example 1

[0087] A method for preparing a solid dispersion of β-1,3 / α-1,3-glucan comprises the following steps:

[0088] (1) Weigh 1.5 g of β-1,3 / α-1,3-glucan and 3 g of curdlan and mix them evenly; then add 200 mL of deionized water and stir for 60 min until the powder is completely dissolved;

[0089] (2) subjecting the solution after complete dissolution in step (1) to ultrasonic treatment at a temperature of 40° C., a time of 25 min, and a power of 100 W;

[0090] (3) freeze-drying the solution after ultrasonic treatment in step (2), the freeze-drying conditions are: pre-freezing at -40°C for 7 to 9 hours; vacuuming at -35°C for 7 to 10 hours; primary drying at 35°C for 10 hours, secondary drying at 20°C for 2 hours, grinding to obtain a solid dispersion.

[0091] Comparative Example 2

[0092] A method for preparing a solid dispersion of β-1,3 / α-1,3-glucan comprises the following steps:

[0093] (1) Weigh 3 g of β-1,3 / α-1,3-glucan and 3 g of konjac gum and mix them evenly; then add 200 mL of deionized water and stir for 60 min until the powder is completely dissolved;

[0094] (2) subjecting the solution after complete dissolution in step (1) to ultrasonic treatment at a temperature of 40° C., a time of 25 min, and a power of 100 W;

[0095] (3) freeze-drying the solution after ultrasonic treatment in step (2), the freeze-drying conditions are: pre-freezing at -40°C for 7 to 9 hours; vacuuming at -35°C for 7 to 10 hours; primary drying at 35°C for 10 hours, secondary drying at 20°C for 2 hours, grinding to obtain a solid dispersion.

[0096] Comparative Example 3

[0097] A method for preparing a solid dispersion of β-1,3 / α-1,3-glucan comprises the following steps:

[0098] (1) Weigh 3 g of β-1,3 / α-1,3-glucan and 3 g of xanthan gum and mix them evenly; then add 200 mL of deionized water and stir for 60 min until the powder is completely dissolved;

[0099] (2) subjecting the solution after complete dissolution in step (1) to ultrasonic treatment at a temperature of 40° C., a time of 25 min, and a power of 100 W;

[0100] (3) freeze-drying the solution after ultrasonic treatment in step (2), the freeze-drying conditions are: pre-freezing at -40°C for 7 to 9 hours; vacuuming at -35°C for 7 to 10 hours; primary drying at 35°C for 10 hours, secondary drying at 20°C for 2 hours, grinding to obtain a solid dispersion.

[0101] Comparative Example 4

[0102] A method for preparing a solid dispersion of β-1,3 / α-1,3-glucan comprises the following steps:

[0103] (1) Weigh 3 g of β-1,3 / α-1,3-glucan and 3 g of gellan gum and mix them evenly; then add 200 mL of deionized water and stir for 60 min until the powder is completely dissolved;

[0104] (2) subjecting the solution after complete dissolution in step (1) to ultrasonic treatment at a temperature of 40° C., a time of 25 min, and a power of 100 W;

[0105] (3) freeze-drying the solution after ultrasonic treatment in step (2), the freeze-drying conditions are: pre-freezing at -40°C for 7 to 9 hours; vacuuming at -35°C for 7 to 10 hours; primary drying at 35°C for 10 hours, secondary drying at 20°C for 2 hours, grinding to obtain a solid dispersion.

[0106] Comparative Example 5

[0107] A method for preparing a solid dispersion of β-1,3 / α-1,3-glucan comprises the following steps:

[0108] (1) Weigh 3 g of β-1,3 / α-1,3-glucan and 3 g of sodium hyaluronate and mix them evenly; then add 200 mL of deionized water and stir for 60 min until the powder is completely dissolved;

[0109] (2) subjecting the solution after complete dissolution in step (1) to ultrasonic treatment at a temperature of 40° C., a time of 25 min, and a power of 100 W;

[0110] (3) freeze-drying the solution after ultrasonic treatment in step (2), the freeze-drying conditions are: pre-freezing at -40°C for 7 to 9 hours; vacuuming at -35°C for 7 to 10 hours; primary drying at 35°C for 10 hours, secondary drying at 20°C for 2 hours, grinding to obtain a solid dispersion.

[0111] Comparative Example 6

[0112] Untreated beta-1,3 / alpha-1,3-glucan powder.

[0113] Results Analysis

[0114] The viscosity and solubility properties of the solid dispersions of β-1,3 / α-1,3-glucan prepared in Examples 1 to 4 and Comparative Examples 1 to 6 were measured. The results are shown in Tables 1 and 2:

[0115] Table 1 Viscosity (viscosity test was performed under the condition that the β-1,3 / α-1,3-glucan content was 0.6%)

[0116]

[0117] Table 2 Dissolution time (dissolution time measured under the condition of β-1,3 / α-1,3-glucan content of 0.6%)

[0118]

[0119] Example 5

[0120] A method for preparing a β-1,3 / α-1,3-glucan-based plant protein beverage comprises the following steps:

[0121] (1) Weighing 200 g of soybeans and 1 L of water, mixing them and grinding the soybeans, heating them at 95° C., grinding at a speed of 1200 r / min, coarse grinding for 100 s, fine grinding for 180 s, and repeating the fine grinding for 5 times, and then filtering through a 120-mesh sieve to obtain soybean milk;

[0122] (2) adding 15 g of sucrose and 6 g of the solid dispersion powder of β-1,3 / α-1,3-glucan prepared in Example 1 to the soy milk obtained in step (1), mixing them evenly, and subjecting them to shearing treatment at a speed of 3000 r / min. After 10 min, subjecting them to homogenization treatment at a homogenization pressure of 300 kPa;

[0123] (3) The solution homogenized in step (2) is subjected to UHT sterilization and filling at a sterilization condition of 121° C. for 15 seconds.

[0124] Comparative Example 7

[0125] A method for preparing a β-1,3 / α-1,3-glucan-based plant protein beverage comprises the following steps:

[0126] (1) Weighing 200 g of soybeans and 1 L of water, mixing them and grinding the soybeans, heating them at 95° C., grinding at a speed of 1200 r / min, coarse grinding for 100 s, fine grinding for 180 s, and repeating the fine grinding for 5 times, and then filtering through a 120-mesh sieve to obtain soybean milk;

[0127] (2) adding 15 g of sucrose and 9 g of the solid dispersion powder of β-1,3 / α-1,3-glucan prepared in Comparative Example 1 to the soy milk obtained in step (1), mixing them evenly, and subjecting them to shearing treatment at a speed of 3000 r / min. After 10 min, subjecting them to homogenization treatment at a homogenization pressure of 300 kPa;

[0128] (3) The solution homogenized in step (2) is subjected to UHT sterilization and filling at a sterilization condition of 121° C. for 15 seconds.

[0129] Comparative Example 8

[0130] A method for preparing a β-1,3 / α-1,3-glucan-based plant protein beverage comprises the following steps:

[0131] (1) Weighing 200 g of soybeans and 1 L of water, mixing them and grinding the soybeans, heating them at 95° C., grinding at a speed of 1200 r / min, coarse grinding for 100 s, fine grinding for 180 s, and repeating the fine grinding for 5 times, and then filtering through a 120-mesh sieve to obtain soybean milk;

[0132] (2) adding 15 g of sucrose and 6 g of the solid dispersion powder of β-1,3 / α-1,3-glucan prepared in Comparative Example 2 to the soy milk obtained in step (1), mixing them evenly, and subjecting them to shearing treatment at a speed of 3000 r / min. After 10 min, subjecting them to homogenization treatment at a homogenization pressure of 300 kPa;

[0133] (3) The solution homogenized in step (2) is subjected to UHT sterilization and filling at a sterilization condition of 121° C. for 15 seconds.

[0134] Comparative Example 9

[0135] A method for preparing a β-1,3 / α-1,3-glucan-based plant protein beverage comprises the following steps:

[0136] (1) Weighing 200 g of soybeans and 1 L of water, mixing them and grinding the soybeans, heating them at 95° C., grinding at a speed of 1200 r / min, coarse grinding for 100 s, fine grinding for 180 s, and repeating the fine grinding for 5 times, and then filtering through a 120-mesh sieve to obtain soybean milk;

[0137] (2) adding 15 g of sucrose and 3 g of the solid dispersion powder of β-1,3 / α-1,3-glucan prepared in Comparative Example 6 to the soy milk obtained in step (1), mixing them evenly, and subjecting them to shearing treatment at a speed of 3000 r / min. After 10 min, subjecting them to homogenization treatment at a homogenization pressure of 300 kPa;

[0138] (3) The solution homogenized in step (2) is subjected to UHT sterilization and filling at a sterilization condition of 121° C. for 15 seconds.

[0139] Results Analysis

[0140] The performance of the β-1,3 / α-1,3-glucan-based plant protein beverages obtained in Example 5 and Comparative Examples 7 to 9 was measured. The results are shown in Tables 3 and Figure 1 As shown:

[0141] Table 3 Centrifugal sedimentation rate

[0142] Example 5 Comparative Example 7 Comparative Example 8 Comparative Example 9 Centrifugal sedimentation rate (%) 11.56±1.79 21.19±2.02 25.61±3.21 20.33±3.88

[0143] Combined with Table 3 Figure 1 It can be further seen from the appearance picture that the β-1,3 / α-1,3-glucan based plant protein beverage prepared in Example 5 has good uniformity, no precipitation and better stability.

[0144] The embodiments provided above are not intended to limit the scope of the present invention, and the steps described are not intended to limit the execution order thereof. Those skilled in the art may make obvious improvements to the present invention in combination with existing common knowledge, which also fall within the scope of protection defined by the claims of the present invention.

Claims

1. A solid dispersion of β-1,3 / α-1,3-glucan, characterized in that: The solid dispersion comprises β-1,3 / α-1,3-glucan and polysaccharide, wherein the β-1,3 / α-1,3-glucan and the polysaccharide are compounded to form a solid dispersion; the mass ratio of the β-1,3 / α-1,3-glucan to the polysaccharide is 3:1.5-3; the polysaccharide comprises one or more of curdlan, carrageenan and microcrystalline cellulose.

2. The solid dispersion according to claim 1, characterized in that The solid dispersion can be prepared in the form of gel, aqueous solution, spray or powder.

3. The solid dispersion according to claim 1, characterized in that The solid dispersion is in the form of capsules, tablets, pills, powders or granules.

4. A method for preparing a solid dispersion of β-1,3 / α-1,3-glucan according to any one of claims 1 to 3, characterized in that: The method comprises the following steps: (1) Weigh β-1,3 / α-1,3-glucan and polysaccharide and mix them evenly; then add water and stir until the powder is completely dissolved; (2) subjecting the solution obtained by completely dissolving the product in step (1) to ultrasonic treatment; (3) freeze-drying the solution after ultrasonic treatment in step (2), grinding it into powder, and obtaining a solid dispersion.

5. The method according to claim 4, characterized in that The ultrasonic conditions of step (2) are as follows: temperature 20-40° C., time 20-30 min, power 100-300 W.

6. The method according to claim 4, characterized in that The freeze-drying conditions of step (3) are: pre-freezing at -40 to -60°C for 7 to 9 hours; vacuuming at -20 to -35°C for 7 to 10 hours; primary drying at 35 to 40°C for 10 to 16 hours, and secondary drying at 20 to 25°C for 2 to 5 hours.

7. Use of the solid dispersion of β-1,3 / α-1,3-glucan according to any one of claims 1 to 3 and the solid dispersion of β-1,3 / α-1,3-glucan prepared by the method according to any one of claims 4 to 6 in the preparation of foods, medicines and cosmetics.

8. A method for improving the solubility of β-1,3 / α-1,3-glucan and reducing its viscosity, characterized in that: The method comprises the following steps: (1) Weigh β-1,3 / α-1,3-glucan and polysaccharide and mix them evenly; then add water and stir until the powder is completely dissolved; (2) subjecting the solution obtained by completely dissolving the product in step (1) to ultrasonic treatment; (3) freeze-drying the solution after ultrasonic treatment in step (2), grinding it into powder, and obtaining a solid dispersion.

9. A method for preparing a β-1,3 / α-1,3-glucan-based plant protein beverage, characterized in that: The method comprises the following steps: (1) Weighing plant-based food and mixing it with water, refining it, and heating it at a temperature of 95 to 100° C., and then filtering it to obtain plant-based pulp; (2) adding sucrose and the solid dispersion of β-1,3 / α-1,3-glucan according to any one of claims 1 to 3 to the plant source slurry obtained in step (1), mixing evenly, shearing and homogenizing; (3) performing UHT sterilization and filling on the solution homogenized in step (2) to obtain the product.

10. A β-1,3 / α-1,3-glucan based plant protein beverage prepared by the preparation method according to claim 9.

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