241 results about "Sphingosine" patented technology

The invention relates to a construction method of a multi-class lipid retention time general prediction model and a prediction system. The method comprises the following steps: by taking experimental retention time tRE of a lipid compound in a training set as a dependent variable and characteristic structure parameters of the lipid compound as an independent variable, carrying out quantitative processing on the independent variable and then carrying out regression modeling analysis, the characteristic structure parameters comprise the total carbon number c and the total carbon-carbon double bond number d of a fatty acyl chain, an ether chain, an alkenyl ether chain or / and a sphingosine skeleton, the types of skeletons contained in the lipid compound and the number of corresponding skeletons, and the types of characteristic groups and residues in the lipid compound and the number of corresponding residues; carrying out numerical quantization on parameters according to the number of skeletons, characteristic groups or residues of the corresponding types; the QSRR general prediction model of the retention time of the multi-class lipid compounds is obtained by adopting regression modeling, a more accurate MRM data acquisition window can be set for the lipid compounds, and the sensitivity, stability and coverage can be improved.

The invention discloses a bacterial strain for degrading aspartame, a bacterial-algae symbiotic system and application of the bacterial strain and the bacterial-algae symbiotic system, the bacterial strain is corn sphingomonas zeae NCU J1, and the preservation number of the bacterial strain is CCTCC (China Center for Type Culture Collection) NO: M 20251462. And an algal-bacterial symbiotic system is constructed by adopting an oriented symbiotic combination of the corn sphingomonas NCU J1 and the chlorella sp. The corn sphingomonas NCU J1 can metabolize an artificial sweetening agent aspartame and degradation products thereof, metabolism complementation can be achieved through an algal-bacterial symbiotic interface, and bacteria preferentially promote aspartame to be subjected to photohydrolysis to generate degradation products such as diketopiperazine derivatives. The microalgae synchronously start isomerism enzymatic reaction to convert degradation products such as diketopiperazine derivatives into low-toxicity products, the risk of secondary pollution is reduced by 40% or above compared with that of a traditional physical and chemical method, 150 mg / L aspartame can be efficiently degraded within 2 days, generation of derivatives of aspartame can be greatly reduced, secondary pollution is reduced, and the method is suitable for industrial production. And the method has a good application prospect in the aspect of rapidly treating aspartame-containing wastewater.

Provided herein are lipid nanoparticles composition comprising a lipid component which comprises: (i) a first ionizable cationic lipid, (ii) a PEG-lipid, wherein the PEG-lipid comprises a PEG-Ceramide. Further provided are lipid nanoparticle compositions comprising a lipid component which comprises: (i) a first ionizable cationic lipid, (ii) a PEG-lipid, wherein the PEG-lipid comprises a PEG-Ceramide selected from: N-octanoyl-sphingosine-1-{succinyl[methoxy(polyethylene glycol)5000]} (C8 PEG5000-Ceramide), N-octanoyl-sphingosine-1-{succinyl[methoxy(polyethylene glycol)2000]}(C8 PEG2000-Ceramide), N-octanoyl-sphingosine-1-{succinyl[methoxy(polyethylene glycol)750]} (C8 PEG750-Ceramide), N-palmitoyl-sphingosine-1-{succinyl[methoxy(polyethylene glycol)5000]} (C16 PEG5000-Ceramide), N-palmitoyl-sphingosine-1-{succinyl[methoxy(polyethylene glycol)2000]} (C16 PEG200-Ceramide), and N-palmitoyl-sphingosine-1-{succinyl[methoxy(polyethylene glycol)750]} (C16 PEG750-Ceramide) (iii) a phospholipid, and (iv) a permanently cationic lipid, an anionic lipid, or a second ionizable cationic lipid separate from the first ionizable cationic lipid.

The invention discloses a natural component composition for conditioning skin micro-ecology, a preparation method of the natural component composition and application of the natural component composition in skin care products for children. The composition comprises a synergistic combination of a sphingomonas fermentation product extract, a haematococcus pluvialis extract rich in astaxanthin, an abelmoschus esculentus fruit extract rich in polysaccharides, and a yeast / zinc fermentation product. The present invention provides improvements in astaxanthin in terms of chemical stability and transdermal permeability. The composition aims to enhance the immature skin barrier, provide a good effect, and support the healthy development of skin microecology, thereby solving the unique physiological needs of children's skin. The invention also describes a preparation method of the composition and application of the composition in cosmetics for children and dermatological products.

The invention belongs to the technical field of agricultural microorganisms, and particularly relates to rice endophytic sphingosine vector SY02 and application thereof. The preservation number of the rice endophytic sphingobium yanoikuyae SY02 provided by the invention is CCTCC (China Center For Type Culture Collection) NO: M2026182, and the sphingobium yanoikuyae SY02 has the functions of producing indoleacetic acid, promoting plant growth and seed germination, promoting adventitious bud proliferation of tissue culture seedlings and relieving browning. The sphingosine vector bacterium and the microbial agent prepared through strain fermentation have the advantages of being green, safe, efficient, long-acting and the like, and have good application prospects in the aspects of promoting plant growth and seedling breeding.

The invention discloses a co-fermentation method based on sphingomonas and a rhodiola rosea extracting solution and application of a product, and belongs to the technical field of microorganisms. By utilizing a special rich enzyme system of sphingomonas and combining with an early-stage composite enzymolysis process and synergistic effect, the wall breaking efficiency of rhodiola rosea cell walls and the conversion degree of active components of rhodiola rosea are greatly improved, the bottlenecks of low efficiency and low bioavailability of a traditional rhodiola rosea extraction method are successfully overcome, and the rhodiola rosea extraction method is suitable for industrial production. The functional components such as salidroside and flavone can be fully released and converted. Secondly, different from non-symbiotic bacteria (such as lactic acid bacteria and saccharomycetes) which are commonly used for fermentation in the prior art, a potential symbiotic bacterium of sphingomonas XJL-TP07 from a special environment is innovatively selected and has better metabolic suitability with the rhodiola rosea component, the fermentation process is milder and safer (no irritant is produced), and the rhodiola rosea fermentation method is suitable for large-scale production. And a synergistic interaction effect can be generated through a unique biotransformation path.

The invention relates to the technical field of pharmaceutical preparations, and discloses a biological beauty skin care product containing nicotinamide adenine dinucleotide (NAD < + >) and cell exosomes, and the biological beauty skin care product comprises the following components by weight: 10-50 parts of a pH responsive nicotinamide mononucleotide liposome; 1 to 10 parts of cell exosome sustained release microspheres; 0.1 to 2 parts of ergothioneine; 0.1 to 1 part of copper peptide; 1 to 10 parts of phytosphingosine; 0.01 to 0.5 part of water-soluble fullerene; 1-8 parts of 1, 2-pentanediol as a transdermal enhancer; 0.05 to 0.5 part of acetylated polypeptide-8; wherein the particle size of the pH response type nano-liposome is 50-200 nm, and the particle size of the hyaluronic acid microspheres is 100-500 nm, so that the skin health is promoted, and the metabolic function is regulated.

The invention relates to an artificial biological crust material as well as a preparation method and application thereof. Specifically, the artificial biological crust material comprises the following components: kaolin, a polymer material and sphingomonas. In the soil matrix, the addition amount of the components in parts by mass per square meter is as follows: 1.0-6.0 g / m < 2 > of kaolin, 0.3-2.5 kg / m < 2 > of polymer material and 0.02-0.2 g / m < 2 > of sphingomonas by dry weight. The kaolin, the sphingomonas and the polymer are used for synergistically modifying the artificial biological crust material, and the thickness and the microscopic compactness of the biological crust are remarkably improved through synergic modification.

The invention belongs to the technical field of biology, and relates to a heavy metal tolerant sphingomonas strain 1PPS-Zn1 and application thereof, the heavy metal tolerant sphingomonas strain 1PPS-Zn1 is preserved in China Center for Type Culture Collection on March 20, 2025, the preservation number is CCTCC NO: M 2025544, the sphingomonas strain 1PPS-Zn1 can adsorb and tolerate high-concentration zinc, the highest tolerable concentration reaches 80 mmol / L, and the sphingomonas strain 1PPS-Zn1 also has the capabilities of producing IAA, fixing nitrogen and promoting plant growth, and can be applied to the field of heavy metal tolerant plants. And the absorption, enrichment and transfer capabilities of the black nightshade to heavy metal zinc in the soil can be improved, finally, the remediation efficiency of the zinc-polluted soil is improved, a new way is provided for soil remediation and ecological environment remediation, and the method has wide development and application prospects.

The invention discloses a functional lipid compound for nano-liposome wrapping and a preparation method, and relates to the technical field of functional lipid compounds, the functional lipid compound comprises (a) a polyphenol-lipid covalent conjugate which is composed of a polyphenol active unit selected from curcumin, dihydroquercetin or derivatives thereof, and (b) a lipid covalent conjugate which is composed of a polyphenols active unit selected from curcumin, dihydroquercetin or derivatives thereof and a polyphenols active unit selected from curcumin, dihydroquercetin or derivatives thereof; the conjugate is covalently linked to a phosphatidyl ethanolamine or cholesterol skeleton through a cleavable linking group, and the conjugate can be integrated into a nano-liposome membrane and has the functions of structural support and biological activity; (b) a microenvironment-responsive functional phospholipid, which is a phospholipid derivative having a functional group responsive to an inflammatory microenvironment specific stimulus modified on a hydrophilic head group or a hydrophobic chain of a phospholipid molecule, the specific stimulus being selected from local pH < = 6.5, reactive oxygen species (ROS) concentration > = 10 [mu] M or matrix metalloproteinase MMP-2 / 9 overexpression; and (c) a bionic exosome membrane lipid component, wherein the bionic exosome membrane lipid component comprises sphingosine-based glycolipid or sulfated cholesterol separated from the plant-derived exosome.

The present application provides a kind of cosmetic composition for acne and its preparation method, it is related to the technical field of cosmetics.The cosmetic composition comprises by mass percentage 0.01-2.0% of acacia gum, 0.01-2.0% of sphingomonad ferment product extract, 0.01-10% of exfoliating agent, 0.01-1.0% of oil control agent, 0.001-0.005% of bacteriostatic agent, 0.01-2.0% of anti-inflammatory agent and 0.01-2.0% of soothing and repairing agent; the balance is cosmetic base; wherein the exfoliating agent includes one or more of coated multi-fruit acid, coated azelaic acid and coated salicylic acid; the anti-inflammatory agent includes 100 and 1609; and the soothing and repairing agent includes 100, which solves the technical problems of difficult thickening, insufficient mildness and insufficient refreshing after absorption of acne-removing products.

The invention provides a metabolic marker for auxiliary diagnosis of schizophrenia, a construction method and application. Wherein the metabolic marker comprises lysophosphatidylcholine (LPC) (17: 0 / 0: 0), oleamide, lysophosphatidyl ethanolamine LysoPE (18: 0 / 0: 0), palmitamide, lysophosphatidyl ethanolamine LysoPE (0: 0 / 20: 4), lysophosphatidyl ethanolamine LysoPE (22: 6 / 0: 0), p-methylphenol sulfate, lactic acid, 3-hydroxybutyric acid, lysophosphatidyl ethanolamine LysoPE (18: 2 / 0: 0), lysophosphatidyl ethanolamine LysoPE (16: 0 / 0: 0) and sphingosine 1-phosphate. By utilizing the metabolic marker, auxiliary diagnosis of schizophrenia can be rapidly and accurately completed in the early stage of disease attack.

202300151 Foreign Filing 48 Abstract The invention relates to compositions comprising (pseudo-) ceramide and / or sphingoid base and a solvent composed of at least two components, a process for producing a formulation (pseudo-) ceramide and / or sphingoid base and the use of at least one of said composed solvent for 5 stabilization of (pseudo-) ceramide and / or sphingoid base containing composition.

The invention discloses an anti-aging and anti-allergy spray suitable for pregnant women based on micro-ecology-barrier-immune synergistic repair and a preparation method of the anti-aging and anti-allergy spray. The spray is prepared from 2.00 percent to 4.00 percent of hydrolyzed quinoa protein, 1.00 percent to 5.00 percent of lactobacillus / soybean milk fermentation filtrate, 0.30 percent to 1.00 percent of radix stellariae extract, 0.20 percent to 1.50 percent of perilla leaf extract, 0.01 percent to 0.50 percent of three-layer liposome tetrahydrocurcumin, 1.00 percent to 10.00 percent of Tibetan plateau freeze-dried tricholoma matsutake extracting solution, an active peptide combination and a ceramide compound. According to a quadruple synergistic mechanism, (1) the pH value of the fermentation filtrate is adjusted to 5.3, and the fermentation filtrate and the hydrolyzed quinoa extract synergistically construct a micro-ecological foundation; (2) repairing the barrier by ceramide NP, cholesterol, phytosphingosine and the like; (3) multiple anti-allergy effects of radices stellariae dichotomae, purple perilla, asiaticoside and dipotassium glycyrrhizinate; and (4) liposome curcumin, glabridin liposome and active peptide cooperate to resist aging, and a'micro-ecological balance-barrier reconstruction-immunosuppression-targeted anti-aging 'quadruple synergistic effect system is constructed. The preparation method comprises the steps of A-phase / B-phase preparation, emulsification, active addition and sterile filling, and the skin requirements in the pregnancy period and the lactation period are met.

The invention relates to the technical field of biology, in particular to a biological substrate modification composition, a preparation as well as a preparation method and application of the biological substrate modification composition. The biological substrate modification composition provided by the invention is prepared from the following components: bacillus subtilis YXSY-01 bacterial powder, sphingomonas aquatic bacteria HD-01 bacterial liquid, bentonite, oyster shell powder, attapulgite, zeolite powder, fish bone meal of raw fish and water. The biological substrate modification composition is prepared from the following raw materials in parts by weight: 20-30% of corn starch, 20-30% of corn starch, 20-30% of corn starch, 20-30% of corn starch, 20-30% of corn starch, 20-30% of corn starch, 20-30% of corn starch, 20-30% of corn starch, 20-30% of corn starch, 20-30% of corn starch and 20-30% of corn starch. The biological substrate modification composition and the preparation provided by the invention have the capabilities of degrading faeces of bred animals and reducing the content of nitrite. The composition and the preparation can reduce the accumulation of excrement of cultured animals in a culture pond, reduce the nitrite content, purify the water quality of the culture pond and reduce the morbidity of the cultured animals.

In some embodiments, the invention provides a method for identifying an agent beneficial to treat a patient with inflammatory bowel disease comprising: a) determining a status of an intestinal barrier in the patient; and b) categorizing the status as severe dysfunction or moderate dysfunction, wherein a patient categorized as having severe dysfunction is identified as a patient who will benefit from treatment with an agent selected from the group consisting of an anti-TNF agent and / or an anti-IL-12 / 23 agent, and a patient categorized as having moderate dysfunction is identified as a patient who will benefit from treatment with an anti-integrin agent, an anti-janus kinase agent, and / or and a sphingosine-1-phosphate receptor agonist agent.

The present application relates to a kind of anti-aging repair essence containing chlorella active ingredient and preparation method thereof.The component of the anti-aging repair essence containing chlorella active ingredient includes chlorella active ingredient, barrier repair agent, humectant, antioxidant, thickening agent and deionized water;The barrier repair agent includes ceramide, cholesterol and plant sphingosine alcohol.The essence provided by the present application takes chlorella active ingredient as main active ingredient, is supplemented with barrier repair agent, humectant, antioxidant and other components, is synergized by promoting cell regeneration, antioxidant protection, promoting collagen synthesis, repairing skin barrier and other multi-target points, realizes the multiple effects of skin repair, anti-aging, whitening and freckle removal, and safety is good, is suitable for long-term use of various skin qualities.

The invention discloses a compound with high water dispersibility and a preparation method and application thereof.The preparation method of the compound with the high water dispersibility comprises the steps that an oil phase containing a water-insoluble compound, an amphiphilic substance and at least two surfactants is mixed with a water phase to obtain a mixed emulsion, then the mixed emulsion is diluted, and the compound with the high water dispersibility is obtained. The compound with high water dispersibility is obtained. The prepared compound with high water dispersibility can be subjected to freeze-drying treatment to obtain compound powder with high water dispersibility, the content of ceramide substances and / or sphingosine substances is high, the compound powder is easily dispersed in water, and the compound powder can stably exist and be dispersed in water under a long-time storage condition, so that the compound powder has good water dispersibility. The phenomena of layering, floccules, precipitation and the like are not easy to occur, and the preparation of daily chemical products is facilitated.

KERATIN CARE COMPOSITION AND MASK COMPRISING IT The present invention relates to a composition, preferably for the care of keratinous materials, comprising: (i) at least 0.01% by weight of Sphingomonas ferment extract, relative to the total weight of the composition; (ii) at least one hydroxylated carboxylate; and (iii) at least one compound A selected from beta-hydroxy acids and their derivatives. The present invention also relates to a mask comprising said composition and a non-therapeutic method for the care of keratinous materials. Figure for the abstract: none

This invention discloses a genetically engineered bacterium capable of synthesizing large quantities of natural cyclic diguanylate (c-di-GMP) and its applications. It involves knocking out the major phosphodiesterase gene chr1_233 as described in claim 1 within the sphingobium xenophagum C2 strain. This invention rationally designs and modifies the c-di-GMP synthesis and degradation pathways and the inhibitory site of major diguanylate cyclase activity in heterologous sphingobium-consuming bacteria, constructing a series of genetically engineered bacteria capable of synthesizing large quantities of natural c-di-GMP. This provides the industry with a green, simple, economical, and efficient method for producing natural c-di-GMP, and offers a series of high-quality and inexpensive raw materials for the preparation of STING agonists or immune adjuvants, or for the preparation of drugs for treating diseases related to STING protein function.

To provide a method of treating an inflammatory neurological disease or condition that can result in destruction or degeneration of axons or myelin.SOLUTION: Provided is a combination comprising a) a compound of formula (I) or a pharmaceutically or veterinarily acceptable salt thereof; and b) one or more drugs selected from the group consisting of I) a compound of a particular formula or a pharmaceutically or veterinarily acceptable salt thereof; ii) a sphingosine-1-phosphate receptor inhibitor (S1PR modulator); and iii) a signal transducer and activator of transcription 3 (STAT3) inhibitor.SELECTED DRAWING: None

Compounds are provided having the structure of Formula (I): or a pharmaceutically acceptable salt, homolog, hydrate or solvate thereof, wherein R is as defined herein. Such compounds serve as modulators of the sphingosine-1-phosphate receptor, and have utility for treatment of a malcondition for which activation of this receptor is medically indicated.

The invention provides a biological gel acid liquid system as well as a preparation method and application thereof, and belongs to the technical field of fracturing fluids. The biogel acid liquid system comprises the following components in percentage by mass: 15%-20% of hydrochloric acid, 0.2%-0.8% of biogel, 0.5%-2% of a fluorocarbon discharge aiding agent, 1%-3% of an aldehyde ketone amine condensate corrosion inhibitor, 0.5%-2% of an iron ion stabilizer and the balance of water; wherein the biological glue is a fermentation product of a production strain, and the production strain is sphingomonas sp.WG (sphingomonas sp.WG). Through interaction of the components with specific mass percentage content, the biogel is promoted to form a three-dimensional space network structure in an acid liquid system, so that the acid liquid system has good resistance reduction performance, temperature-resistant stability and low damage performance, and safe, efficient and green carbonate reservoir transformation can be realized.

The present disclosure relates to engineered phospholipid or lysophospholipid (e.g., sphingosine 1-phosphate (S1P)) chaperones derived from apolipoprotein M (ApoM)-Fc fusion proteins with extended half-life in vivo. The disclosed ApoM-Fc fusion proteins provide a safe, highly efficient and effective way of delivering S1P to endothelial cells and all tissues of the body.

The application relates to a preparation method and application of artificially synthesized exosomes with anti-aging effects, and belongs to the fields of cosmetics and biotechnology. The artificially synthesized exosomes are prepared from components of hydrogenated lecithin, plant sphingosine, cholesterol, ceramide, squalane, sodium stearoyl glutamate, a surface modification structure, a polyhydric alcohol, active ingredients and water; the preparation method comprises the preparation of an alcohol phase, the preparation of an aqueous phase, the preparation of a mixed solution and high-pressure homogenization treatment. The artificially synthesized exosomes prepared by the preparation method have good stability and high anti-aging activity.

The application discloses a kind of phytosphingosine inclusions and its preparation method and application, belong to daily chemical technical field.The phytosphingosine inclusion of the application uses maltodextrin and gum arabic as embedding carrier, and the mass ratio of maltodextrin and gum arabic in embedding carrier is 1:1~3.The phytosphingosine of the application is modified by screening embedding carrier and optimizing embedding process, and the water solubility of the obtained phytosphingosine inclusion is significantly improved, which can increase the addition amount in daily chemical products, improve the skin care effect of moisturizing, repairing skin barrier and anti-aging, etc.The embedding carrier used in the application has good biocompatibility, no skin irritation, high safety;Moreover, the embedding process step is simple, without complex equipment, easy for large-scale industrial production, and the production cost is controllable, with good market application prospect.

The invention provides a nano-emulsion composition, a nano skin care product, a preparation method and application, the nano-emulsion composition comprises a nano-emulsion and nucleic acid loaded on the surface of the nano-emulsion, and the nano-emulsion comprises a functional component, an emulsifier, an emollient, an antioxidant, a humectant and water; the functional component comprises a barrier repair lipid, the barrier repair lipid comprises sphingolipid, the sphingolipid comprises phytosphingosine, and the barrier repair lipid further comprises one or more of ceramide, free fatty acid and cholesterol; the mass ratio of the nucleic acid in the nanoemulsion composition is 0.1%-0.6%. The nanoemulsion composition has excellent permeability, so that the skin permeability of the nucleic acid is improved, and the bioavailability of the nucleic acid is improved; meanwhile, the nucleic acid can be specifically bound with adenosine A2A receptors distributed on keratinocytes, so that the binding speed of the nano-emulsion and the cells can be increased, the absorption and action effects of the nano-emulsion are specifically promoted, and the resistance of the skin to light aging is improved.

The invention belongs to the technical field of biomedicine, and particularly relates to a flora marker for predicting colorectal cancer liver metastasis and application of the flora marker. According to the present invention, the bacterial group marker is the combination of Acinetobacter, Streptococcus, Pseudomonas, Brevundimonas and Sphingomonas, and the bacterial group marker combination provides extremely high specificity (95.29%) and sensitivity (91.43%) when the early liver metastasis of colorectal cancer is predicted, such that the liver metastasis risk of the patient can be accurately assisted in the determination, and the early liver metastasis risk of the colorectal cancer can be accurately determined; the method has the advantages that reliable basis is provided for clinical decision making, the colorectal cancer liver metastasis can be predicted only by taking the abundance of the specific bacteria as an input index, the method is not limited by specific measurement means, and dependence on a detection technology is greatly reduced.

The invention discloses a genetically engineered bacterium for producing triacetyl sphingosine as well as a construction method and application of the genetically engineered bacterium, and relates to the technical field of biology. According to the present invention, the sphingosine C-4 hydroxylase gene in the Schiff Hammosaccharomyces cerevisiae is inactivated, such that the metabolic pathway of the Schiff Hammosaccharomyces cerevisiae is reconstructed, and the metabolic flow is efficiently guided to the synthesis of the triacetyl dihydrosphingosine, such that the large-scale production of the triacetyl dihydrosphingosine is stably achieved, and the significant industrial application potential and the significant economic benefit are represented.