The invention discloses an acne removing essence with added pearl hydrolyzate liposomes, which is prepared by mixing and stirring glycerol, 1,3-butanediol, ethylenediaminetetraacetic acid disodium salt, pearl hydrolyzate liposomes, plant sphingosine, dipotassium glycyrrhizate, imidazolidinyl urea and deionized water; the preparation process is that the glycerol, the 1,3-butanediol, the ethylenediaminetetraacetic acid disodium salt and the deionized water are mixed and evenly stirred, the pearl hydrolyzate liposomes, the plant sphingosine, the dipotassium glycyrrhizate and the imidazolidinyl urea are added for stirring after the heating, heat preservation and cooling, and the discharge obtains the finished product. The pearl hydrolyzate liposomes containing a variety of amino acids are added in the acne removing essence, which is not only anti-inflammatory, bactericidal and can remove acnes, but also can effective enhance the metabolic function of skin cells, dredge the pores of the skin cells and promote the regeneration of the surface cells, so the acne removing essence can effectively repair the damaged skin, accelerate the healing of damaged skin open sores and acne spots and ensuring the skin to be delicate, smooth, white and moist.