148 results about "Sphingosine" patented technology

The invention belongs to the technical field of agricultural microorganisms, and particularly relates to rice endophytic sphingosine vector SY02 and application thereof. The preservation number of the rice endophytic sphingobium yanoikuyae SY02 provided by the invention is CCTCC (China Center For Type Culture Collection) NO: M2026182, and the sphingobium yanoikuyae SY02 has the functions of producing indoleacetic acid, promoting plant growth and seed germination, promoting adventitious bud proliferation of tissue culture seedlings and relieving browning. The sphingosine vector bacterium and the microbial agent prepared through strain fermentation have the advantages of being green, safe, efficient, long-acting and the like, and have good application prospects in the aspects of promoting plant growth and seedling breeding.

The invention discloses a co-fermentation method based on sphingomonas and a rhodiola rosea extracting solution and application of a product, and belongs to the technical field of microorganisms. By utilizing a special rich enzyme system of sphingomonas and combining with an early-stage composite enzymolysis process and synergistic effect, the wall breaking efficiency of rhodiola rosea cell walls and the conversion degree of active components of rhodiola rosea are greatly improved, the bottlenecks of low efficiency and low bioavailability of a traditional rhodiola rosea extraction method are successfully overcome, and the rhodiola rosea extraction method is suitable for industrial production. The functional components such as salidroside and flavone can be fully released and converted. Secondly, different from non-symbiotic bacteria (such as lactic acid bacteria and saccharomycetes) which are commonly used for fermentation in the prior art, a potential symbiotic bacterium of sphingomonas XJL-TP07 from a special environment is innovatively selected and has better metabolic suitability with the rhodiola rosea component, the fermentation process is milder and safer (no irritant is produced), and the rhodiola rosea fermentation method is suitable for large-scale production. And a synergistic interaction effect can be generated through a unique biotransformation path.

The invention discloses a functional lipid compound for nano-liposome wrapping and a preparation method, and relates to the technical field of functional lipid compounds, the functional lipid compound comprises (a) a polyphenol-lipid covalent conjugate which is composed of a polyphenol active unit selected from curcumin, dihydroquercetin or derivatives thereof, and (b) a lipid covalent conjugate which is composed of a polyphenols active unit selected from curcumin, dihydroquercetin or derivatives thereof and a polyphenols active unit selected from curcumin, dihydroquercetin or derivatives thereof; the conjugate is covalently linked to a phosphatidyl ethanolamine or cholesterol skeleton through a cleavable linking group, and the conjugate can be integrated into a nano-liposome membrane and has the functions of structural support and biological activity; (b) a microenvironment-responsive functional phospholipid, which is a phospholipid derivative having a functional group responsive to an inflammatory microenvironment specific stimulus modified on a hydrophilic head group or a hydrophobic chain of a phospholipid molecule, the specific stimulus being selected from local pH < = 6.5, reactive oxygen species (ROS) concentration > = 10 [mu] M or matrix metalloproteinase MMP-2 / 9 overexpression; and (c) a bionic exosome membrane lipid component, wherein the bionic exosome membrane lipid component comprises sphingosine-based glycolipid or sulfated cholesterol separated from the plant-derived exosome.

202300151 Foreign Filing 48 Abstract The invention relates to compositions comprising (pseudo-) ceramide and / or sphingoid base and a solvent composed of at least two components, a process for producing a formulation (pseudo-) ceramide and / or sphingoid base and the use of at least one of said composed solvent for 5 stabilization of (pseudo-) ceramide and / or sphingoid base containing composition.

The invention discloses an anti-aging and anti-allergy spray suitable for pregnant women based on micro-ecology-barrier-immune synergistic repair and a preparation method of the anti-aging and anti-allergy spray. The spray is prepared from 2.00 percent to 4.00 percent of hydrolyzed quinoa protein, 1.00 percent to 5.00 percent of lactobacillus / soybean milk fermentation filtrate, 0.30 percent to 1.00 percent of radix stellariae extract, 0.20 percent to 1.50 percent of perilla leaf extract, 0.01 percent to 0.50 percent of three-layer liposome tetrahydrocurcumin, 1.00 percent to 10.00 percent of Tibetan plateau freeze-dried tricholoma matsutake extracting solution, an active peptide combination and a ceramide compound. According to a quadruple synergistic mechanism, (1) the pH value of the fermentation filtrate is adjusted to 5.3, and the fermentation filtrate and the hydrolyzed quinoa extract synergistically construct a micro-ecological foundation; (2) repairing the barrier by ceramide NP, cholesterol, phytosphingosine and the like; (3) multiple anti-allergy effects of radices stellariae dichotomae, purple perilla, asiaticoside and dipotassium glycyrrhizinate; and (4) liposome curcumin, glabridin liposome and active peptide cooperate to resist aging, and a'micro-ecological balance-barrier reconstruction-immunosuppression-targeted anti-aging 'quadruple synergistic effect system is constructed. The preparation method comprises the steps of A-phase / B-phase preparation, emulsification, active addition and sterile filling, and the skin requirements in the pregnancy period and the lactation period are met.

The invention discloses a compound with high water dispersibility and a preparation method and application thereof.The preparation method of the compound with the high water dispersibility comprises the steps that an oil phase containing a water-insoluble compound, an amphiphilic substance and at least two surfactants is mixed with a water phase to obtain a mixed emulsion, then the mixed emulsion is diluted, and the compound with the high water dispersibility is obtained. The compound with high water dispersibility is obtained. The prepared compound with high water dispersibility can be subjected to freeze-drying treatment to obtain compound powder with high water dispersibility, the content of ceramide substances and / or sphingosine substances is high, the compound powder is easily dispersed in water, and the compound powder can stably exist and be dispersed in water under a long-time storage condition, so that the compound powder has good water dispersibility. The phenomena of layering, floccules, precipitation and the like are not easy to occur, and the preparation of daily chemical products is facilitated.

KERATIN CARE COMPOSITION AND MASK COMPRISING IT The present invention relates to a composition, preferably for the care of keratinous materials, comprising: (i) at least 0.01% by weight of Sphingomonas ferment extract, relative to the total weight of the composition; (ii) at least one hydroxylated carboxylate; and (iii) at least one compound A selected from beta-hydroxy acids and their derivatives. The present invention also relates to a mask comprising said composition and a non-therapeutic method for the care of keratinous materials. Figure for the abstract: none

This invention discloses a genetically engineered bacterium capable of synthesizing large quantities of natural cyclic diguanylate (c-di-GMP) and its applications. It involves knocking out the major phosphodiesterase gene chr1_233 as described in claim 1 within the sphingobium xenophagum C2 strain. This invention rationally designs and modifies the c-di-GMP synthesis and degradation pathways and the inhibitory site of major diguanylate cyclase activity in heterologous sphingobium-consuming bacteria, constructing a series of genetically engineered bacteria capable of synthesizing large quantities of natural c-di-GMP. This provides the industry with a green, simple, economical, and efficient method for producing natural c-di-GMP, and offers a series of high-quality and inexpensive raw materials for the preparation of STING agonists or immune adjuvants, or for the preparation of drugs for treating diseases related to STING protein function.

To provide a method of treating an inflammatory neurological disease or condition that can result in destruction or degeneration of axons or myelin.SOLUTION: Provided is a combination comprising a) a compound of formula (I) or a pharmaceutically or veterinarily acceptable salt thereof; and b) one or more drugs selected from the group consisting of I) a compound of a particular formula or a pharmaceutically or veterinarily acceptable salt thereof; ii) a sphingosine-1-phosphate receptor inhibitor (S1PR modulator); and iii) a signal transducer and activator of transcription 3 (STAT3) inhibitor.SELECTED DRAWING: None

The invention provides a biological gel acid liquid system as well as a preparation method and application thereof, and belongs to the technical field of fracturing fluids. The biogel acid liquid system comprises the following components in percentage by mass: 15%-20% of hydrochloric acid, 0.2%-0.8% of biogel, 0.5%-2% of a fluorocarbon discharge aiding agent, 1%-3% of an aldehyde ketone amine condensate corrosion inhibitor, 0.5%-2% of an iron ion stabilizer and the balance of water; wherein the biological glue is a fermentation product of a production strain, and the production strain is sphingomonas sp.WG (sphingomonas sp.WG). Through interaction of the components with specific mass percentage content, the biogel is promoted to form a three-dimensional space network structure in an acid liquid system, so that the acid liquid system has good resistance reduction performance, temperature-resistant stability and low damage performance, and safe, efficient and green carbonate reservoir transformation can be realized.

The present disclosure relates to engineered phospholipid or lysophospholipid (e.g., sphingosine 1-phosphate (S1P)) chaperones derived from apolipoprotein M (ApoM)-Fc fusion proteins with extended half-life in vivo. The disclosed ApoM-Fc fusion proteins provide a safe, highly efficient and effective way of delivering S1P to endothelial cells and all tissues of the body.

The application discloses a kind of phytosphingosine inclusions and its preparation method and application, belong to daily chemical technical field.The phytosphingosine inclusion of the application uses maltodextrin and gum arabic as embedding carrier, and the mass ratio of maltodextrin and gum arabic in embedding carrier is 1:1~3.The phytosphingosine of the application is modified by screening embedding carrier and optimizing embedding process, and the water solubility of the obtained phytosphingosine inclusion is significantly improved, which can increase the addition amount in daily chemical products, improve the skin care effect of moisturizing, repairing skin barrier and anti-aging, etc.The embedding carrier used in the application has good biocompatibility, no skin irritation, high safety;Moreover, the embedding process step is simple, without complex equipment, easy for large-scale industrial production, and the production cost is controllable, with good market application prospect.

The invention discloses a genetically engineered bacterium for producing triacetyl sphingosine as well as a construction method and application of the genetically engineered bacterium, and relates to the technical field of biology. According to the present invention, the sphingosine C-4 hydroxylase gene in the Schiff Hammosaccharomyces cerevisiae is inactivated, such that the metabolic pathway of the Schiff Hammosaccharomyces cerevisiae is reconstructed, and the metabolic flow is efficiently guided to the synthesis of the triacetyl dihydrosphingosine, such that the large-scale production of the triacetyl dihydrosphingosine is stably achieved, and the significant industrial application potential and the significant economic benefit are represented.

The invention discloses an enrichment culture method and application of a lignin degrading bacterial system. The enrichment culture method comprises the following steps: inoculating an inoculum into an enrichment culture medium for culture; the enrichment culture medium comprises sodium salt, ammonium salt, potassium salt, magnesium salt, 3, 4-dimethyl pyrazole phosphate and lignin; the inoculum is derived from an organic material containing lignin degrading microorganisms. Through the enrichment culture, the efficient lignin degrading bacterial system can be obtained; the lignin degrading bacterial system can degrade lignin at the temperature of 15 DEG C and has the characteristic of low temperature resistance; the lignin degrading bacterial system is subjected to passage for many times, and the degradation rate is stable; the bacterial system is mainly prepared from the following components: pseudomonas (Pseudomonas), Achromobacter (Achromobacter) and sphingobium (Sphingobium).

The present invention provides the use of at least one sphingolipid for a hair treatment for inducing hair growth and / or inhibiting hair loss, including eyelashes and eyebrows. Said sphingolipid is preferably a ceramide having a fatty acid with a long hydrocarbon chain of C18-C24, mostly C20-C22, and a phytosphingosine base. Furthermore, and advantageously, the treatment is global, capable to also improve the properties of the scalp and hair themselves.

The invention discloses lake sphingosine bacteria AT4-200, exopolysaccharides thereof and application of the lake sphingosine bacteria AT4-200 in promoting plant growth and improving plant stress resistance, relates to the technical field of microbial technology and biostimulant application, and discloses the lake sphingosine bacteria AT4-200 separated and purified from tobacco rhizosphere and the exopolysaccharides generated by the lake sphingosine bacteria AT4-200, the molecular weight of the exopolysaccharides is about 1340Da, and the exopolysaccharides can be applied to plant growth promotion and plant stress resistance improvement. The polysaccharide mainly comprises five monosaccharides, namely mannose, glucose, glucosamine, galactosamine and rhamnose. Application verifies that the strain and / or exopolysaccharide thereof can significantly increase agronomic characters such as leaf area and dry weight of tobacco, can effectively improve salt tolerance of soybean under salt stress, and can be used as a novel, low-cost and efficient plant biostimulant or stress-resistant preparation.

The application relates to the field of cosmetics, and relates to an anti-aging cosmetic, grape pomace oil and a preparation method thereof. The anti-aging cosmetic comprises grape pomace oil; characteristic components of the grape pomace oil include oleanolic acid, alpha-guaiacwoodene, beta-tocotrienol, beta-sitosterol, campesterol, soybean sapogenol E, ganoderic acid F, ganoderol I and D-erythro-dihydrosphingosine; the total phenol content of the grape pomace oil is greater than or equal to 1 mg / g, the total sterol content of the grape pomace oil is greater than or equal to 26 mg / g, and the total flavonoid content of the grape pomace oil is greater than or equal to 1 mg / g; the grape pomace oil is extracted from grape pomace; the grape pomace is mainly composed of grape skin, grape stem and grape seed. The compounds have excellent antioxidant properties and can improve the anti-aging effect of the anti-aging cosmetic. The compounds are helpful for protecting the skin from oxidative damage and play a positive role in cosmetics. The grape pomace oil maximally retains active components of all parts of the grape pomace.

The invention provides a composition. The composition comprises the following components in parts by weight: 0.001-5 parts of a PDRN-ergothioneine compound; 0.001 to 5 parts by weight of achillea millefolium extract; and 0.01 to 0.5 part by weight of a sphingomonas fermentation product extract. The invention also provides a preparation method of the composition and a sunscreen composition using the composition. According to the composition provided by the invention, the ergothioneine, the PDRN, the achillea millefolium extract and the sphingomonas fermentation product are scientifically proportioned to construct a functional system covering an ultraviolet injury full path, so that the deep synergy and synergism of all active ingredients in action time sequence, cell target and biological effect are realized. The composition provided by the invention covers a multi-channel synergistic effect system of a light damage whole chain, and the light protection effect is excellent; and the composition has a synergistic effect on the traditional sun-screening agent, and can significantly improve the sun-screening index, enhance the light stability and improve the product experience.

The invention belongs to the technical field of medical materials and tissue regeneration engineering, and provides a composite hydrogel prepolymerization solution and application thereof, and composite hydrogel and application thereof. The composite hydrogel pre-polymerization liquid provided by the invention is prepared from the following components in concentration: 5 to 10 w / v percent of methacrylic anhydride gelatin, 1 to 4 w / v percent of methacrylated hyaluronic acid, 0.5 to 1.5 w / v percent of hectorite, 0.5 to 1.5 w / v percent of a photoinitiator and 20 to 100 nmol / L of sphingosine-1-phosphoric acid loaded nano vesicles based on sphingosine-1-phosphoric acid, the nano vesicles are formed by bone marrow-derived macrophages. The composite hydrogel formed by the composite hydrogel pre-polymerization liquid has good biocompatibility and controllable release performance, can form a stable barrier environment on a wound surface, and significantly accelerates the wound surface healing process through the dual effects of immune regulation and revascularization.

The invention discloses a polyphosphate kinase mutant, a coding gene and application of the polyphosphate kinase mutant, and belongs to the technical field of bioengineering. The polyphosphate kinase mutant disclosed by the invention is obtained by carrying out amino acid mutation on PPK2 from Sphingobium siyangense 1.6855, wherein the amino acid sequence of the PPK2 is as shown in SEQ ID NO.1, and the site of the amino acid mutation is at least one of I125F, I192P and S228A. The PPK2 mutant disclosed by the invention has excellent thermal stability, and the enzymatic activity retention rate of the mutant after thermal treatment can be up to 20 times or more that of a wild type. The PPK2 mutant can efficiently catalyze ADP (adenosine diphosphate) to generate ATP (adenosine triphosphate), the product yield is high, no by-product is generated, and the PPK2 mutant has a good industrial application prospect.

The application relates to a construction method and a prediction system of a multi-category lipid retention time universal prediction model. R E As the dependent variable, the characteristic structure parameters are used as the independent variables, the independent variables are quantitatively processed, and the regression modeling analysis step is adopted, wherein the characteristic structure parameters include the total carbon number c and the total carbon-carbon double bond number d of a fatty acyl chain, an ether chain, an alkenyl ether chain or / and a sphingosine skeleton, and the skeleton types contained in the lipid compound and the corresponding skeleton number, the characteristic groups in the lipid compound and the residue types and the corresponding residue number; the parameters of the corresponding type of skeleton, characteristic group or residue are numerically quantified; the QSRR universal prediction model of the retention time of the multi-category lipid compound is obtained by adopting the regression modeling, the MRM data acquisition window of the lipid compound can be set more accurately, and the sensitivity, stability and coverage can be improved.

This invention provides a soil conditioner prepared from Phyllanthus emblica pomace and its preparation method, relating to the field of plant by-product processing technology. The soil conditioner comprises Phyllanthus emblica pomace, animal manure, biochar, modified starch, modified pectin, sodium dextran sulfate, a compound microbial agent, and Sphingomonas sphingosine monocytogenes. The Phyllanthus emblica pomace is first soaked in sodium chloride solution, then fermented and filtered with Sphingomonas sphingosine monocytogenes. The filtered residue is then sterilized, mixed with animal manure, and composted. The filtrate is mixed with other substances and then combined with the composted fertilizer. This invention overcomes the shortcomings of existing technologies, effectively regulates alkaline soil, and to a certain extent, can remediate heavy metals in the soil and promote crop growth.

The present invention provides: a liposome-containing composition for cosmetics, which contains gamma-aminobutyric acid and stably contains a fine liposome having a single-layer structure; and a cosmetic obtained by using the liposome-containing composition for cosmetics. Also provided are: a liposome-containing composition for cosmetics, which contains a liposome and water, and which is characterized in that: the liposome-containing composition for cosmetics contains at least one of a plurality of liposomes, a plurality of liposomes, and a plurality of liposomes; and a cosmetic which is obtained using the liposome-containing composition for cosmetics. The liposome contains gamma-aminobutyric acid, polyoxyethylene phytosterol, cholesterol, lecithin, and at least one compound (E) selected from the group consisting of a phytosterol fatty acid ester and a sphingosine base, and has a single-layer structure and an average particle diameter of 100 nm to 500 nm.

This invention discloses a repair composition containing multiple ceramides and its preparation method, belonging to the field of cosmetic technology. The repair composition, by mass parts, comprises ceramide AP, ceramide EOP, ceramide NP, phytosphingosine, Centella asiatica extract, Portulaca oleracea extract, Hydrangea macrophylla extract, ectoine, and tripeptide-1. This invention utilizes multiple ceramides and phytosphingosine to biomimetically replenish the lipids of the stratum corneum, combined with the synergistic effects of various plant active ingredients and active peptides, to effectively achieve multiple effects such as skin barrier repair, soothing and anti-inflammatory properties, and anti-allergy. This invention also provides a barrier repair serum containing this repair composition and its preparation method. The serum has stable physicochemical properties and, verified by in vitro cell experiments and human efficacy tests, can rapidly repair damaged skin barriers, improve sensitive symptoms such as redness and stinging, and is gentle and non-irritating, suitable for daily skincare use by people with sensitive skin and damaged skin barriers.

The invention discloses supramolecular skin-tendering essence and a preparation method thereof, and relates to the technical field of cosmetic preparation, and the supramolecular skin-tendering essence comprises the following components in percentage by mass: 0.5%-2% of supramolecular azelaic acid, 0.5%-2% of supramolecular salicylic acid, 2%-8% of butanediol, 0.65%-2.6% of arginine, 2%-8% of a humectant, 0.33%-1% of a thickener, 2.2%-6.8% of a preservative and a proper amount of water. The thickening agent is prepared from sodium polyacryloyldimethyl taurate and a sphingomonas fermentation product extract according to the mass ratio of (0.3 to 0.85) to (0.03 to 0.15). The supramolecular skin tendering essence disclosed by the invention is excellent in stability and good in water solubility.

The invention relates to the technical field of biologic detection of metabolomics, in particular to an OSAHS metabolism marker, a diagnosis model and application of the OSAHS metabolism marker and the diagnosis model. The metabolic marker comprises a red blood cell metabolite and / or a plasma metabolite; erythrocyte metabolites comprise L-aspartic acid, D-ribose-5-diphosphoric acid, cadaverine, 12, 13-epoxy octadecenoic acid, L-arginine, N-acetylmethionine, 5-hydroxyeicosatetraenoic acid, 13-oxo-9Z, 9, 10-tetrahydroxy-9Z, 9, 10-tetrahydroxy-9Z, 9, 10-tetrahydroxy-9Z, 9, 10-tetrahydroxy-9Z, 9, 10-tetrahydroxy-9Z, 10-tetrahydroxy-9Z, the component A is one or more of 11E-octadecadienoic acid, inosine monophosphate, nicotinamide, alpha-lactose, sphingosine, hydroxy octadecadienoyl or glyceraldehyde-3-phosphoric acid; the plasma metabolite is prepared from one or more of fumaric acid, cadaverine, L-aspartic acid, malic acid, sphingosine-1-phosphoric acid, L-arginine, cysteine-S-sulfate, thiosulfate, gamma-glutamyl alanine, galacturonic acid or vitamin B2.

The present invention relates to a pharmaceutically acceptable salt of a sphingosine-1-phosphate receptor agonist and a crystalline form thereof, and more specifically, to a potassium salt or methanesulfonate of 1-[1-chloro-6-(3-chloro-1-isopropyl-1H-indazol-5-ylmethoxy)-3,4-dihydro-naphthalen-2-ylmethyl]-piperidine-4-carboxylic acid of formula 1, and a crystalline form thereof.

Methods and medicaments are provided for treating endometriosis in a subject in need thereof, the method comprising administering to the subject an effective amount of a sphingosine-1-phosphate receptor 1 (S1PR1)-antagonist.

The invention discloses sphingomonas CCSM001 separated from human skin and capable of improving skin health and a metagen thereof, and belongs to the field of microbial technology and medicine. The sphingomonas CCSM001 provided by the invention has a good barrier function repairing effect and application prospect in the aspect of external use, and is specifically shown in that the activity of damaged HaCaT cells is improved in vitro, the gene level expression of FLG, IVL, AQP3, ZO-1, Occludin and CLDN is improved in the aspects of functional protein and structural protein after damage. The metagen prepared from the sphingomonas can be used for preparing cosmetics or medicines for repairing skin barriers, and has a huge application prospect.

The problem to be solved by the present invention is to provide an extract of bacteria of the genus Sphingomonas, which may be used as an inhibitor of the kallikrein-kinin system and can reduce the occurrence of redness.SOLUTION: The present invention relates to an extract of bacteria of the genus Sphingomonas, to a composition comprising at least one bacterium of the genus Sphingomonas or said extract, to the uses thereof and to the implementation thereof in a cosmetic method.SELECTED DRAWING: None