391 results about "Sphingosine" patented technology

The invention relates to a preparation method and application of an artificially synthesized exosome with an anti-aging effect, and belongs to the technical field of cosmetics and biology. The artificially synthesized exosome is prepared from hydrogenated lecithin, phytosphingosine, cholesterol, ceramide, squalane, sodium stearoyl glutamate, a surface modification structure, polyol, an active component and water. The preparation method comprises the steps of preparation of an alcohol phase, preparation of a water phase, preparation of a mixed solution and high-pressure homogenization treatment. The artificially synthesized exosome prepared by the preparation method provided by the invention is good in stability and high in anti-aging activity.

The invention relates to a construction method of a multi-class lipid retention time general prediction model and a prediction system. The method comprises the following steps: by taking experimental retention time tRE of a lipid compound in a training set as a dependent variable and characteristic structure parameters of the lipid compound as an independent variable, carrying out quantitative processing on the independent variable and then carrying out regression modeling analysis, the characteristic structure parameters comprise the total carbon number c and the total carbon-carbon double bond number d of a fatty acyl chain, an ether chain, an alkenyl ether chain or / and a sphingosine skeleton, the types of skeletons contained in the lipid compound and the number of corresponding skeletons, and the types of characteristic groups and residues in the lipid compound and the number of corresponding residues; carrying out numerical quantization on parameters according to the number of skeletons, characteristic groups or residues of the corresponding types; the QSRR general prediction model of the retention time of the multi-class lipid compounds is obtained by adopting regression modeling, a more accurate MRM data acquisition window can be set for the lipid compounds, and the sensitivity, stability and coverage can be improved.

The invention relates to a bionic exosome for anti-inflammation and repair as well as a preparation method and application thereof, and belongs to the field of cosmetics. The bionic exosome provided by the invention comprises a membrane structure and an internal load phase, the membrane structure comprises a phospholipid bilayer, a stabilizer and a targeting ligand; the internal load phase comprises a solvent and an active component; the phospholipid bilayer is composed of phospholipid compounds; preferably, at least one of the distearoyl phosphatidyl ethanolamine-polyethylene glycol 2000 and the 1, 2-dioleoyl-sn-glycerol-3-phosphoethanolamine is adopted as the phospholipid compound, and at least one of the distearoyl phosphatidyl ethanolamine-polyethylene glycol 2000 and the 1, 2-dioleoyl-sn-glycerol-3-phosphoethanolamine is adopted as the phospholipid compound; at least one of cholesterol, phytosphingosine and sodium stearoyl glutamate is preferably adopted as a stabilizer, so that the stabilizer of the obtained bionic exosome is improved, and the bionic exosome has the advantages of high encapsulation efficiency, good encapsulation efficiency stability, simplicity in operation, excellent anti-inflammatory and repairing effects and the like.

The invention discloses a bacterial strain for degrading aspartame, a bacterial-algae symbiotic system and application of the bacterial strain and the bacterial-algae symbiotic system, the bacterial strain is corn sphingomonas zeae NCU J1, and the preservation number of the bacterial strain is CCTCC (China Center for Type Culture Collection) NO: M 20251462. And an algal-bacterial symbiotic system is constructed by adopting an oriented symbiotic combination of the corn sphingomonas NCU J1 and the chlorella sp. The corn sphingomonas NCU J1 can metabolize an artificial sweetening agent aspartame and degradation products thereof, metabolism complementation can be achieved through an algal-bacterial symbiotic interface, and bacteria preferentially promote aspartame to be subjected to photohydrolysis to generate degradation products such as diketopiperazine derivatives. The microalgae synchronously start isomerism enzymatic reaction to convert degradation products such as diketopiperazine derivatives into low-toxicity products, the risk of secondary pollution is reduced by 40% or above compared with that of a traditional physical and chemical method, 150 mg / L aspartame can be efficiently degraded within 2 days, generation of derivatives of aspartame can be greatly reduced, secondary pollution is reduced, and the method is suitable for industrial production. And the method has a good application prospect in the aspect of rapidly treating aspartame-containing wastewater.

The invention relates to a composition for improving mildness and stability of a sunscreen product and application of the composition. The composition comprises a sphingomonas fermentation product extract, bis (lauramide glutamine) lysine sodium and a wild soybean seed extract. The invention creatively discovers that the three components of the sphingomonas fermentation product extract, the bis (lauramide glutamine) lysine sodium and the wild soybean seed extract are compounded for use, have a synergistic effect and can play a role under a low addition amount, so that the stability of the sunscreen product is improved, the irritation is reduced, the use experience is improved, and the sunscreen effect is improved. And moreover, the cost is effectively and reasonably reduced, and great market potential and economic value prospects are achieved.

The invention relates to the technical field of new strains, and provides a new strain which is screened from Xinjiang saline-alkali soil, is classified and named as sphingomonas sp. And is preserved in the China General Microbiological Culture Collection Center (CGMCC), and the preservation number is CGMCCNO.32220. Research finds that the strain can remarkably reduce the soil conductivity, the exchangeable sodium content, the alkalization degree and the total salt content, so that the soil quality is improved. The organic matter content and the acid phosphatase activity of the soil are remarkably improved, and the quality of the saline-alkali soil can be efficiently improved. Meanwhile, the invention provides a compound bacterial fertilizer for effectively improving saline-alkali soil, the compound bacterial fertilizer comprises bacillus subtilis, Exiguobacterium acetylbacter, Bacillus velezensis, Pseudomonas fluorescens, Rhodococcus capsulatus and a new strain Sphingomonas sp., and research finds that compared with a single bacterial solution, the compound bacterial solution has a more prominent remediation effect on saline-alkali soil.

Provided herein are lipid nanoparticles composition comprising a lipid component which comprises: (i) a first ionizable cationic lipid, (ii) a PEG-lipid, wherein the PEG-lipid comprises a PEG-Ceramide. Further provided are lipid nanoparticle compositions comprising a lipid component which comprises: (i) a first ionizable cationic lipid, (ii) a PEG-lipid, wherein the PEG-lipid comprises a PEG-Ceramide selected from: N-octanoyl-sphingosine-1-{succinyl[methoxy(polyethylene glycol)5000]} (C8 PEG5000-Ceramide), N-octanoyl-sphingosine-1-{succinyl[methoxy(polyethylene glycol)2000]}(C8 PEG2000-Ceramide), N-octanoyl-sphingosine-1-{succinyl[methoxy(polyethylene glycol)750]} (C8 PEG750-Ceramide), N-palmitoyl-sphingosine-1-{succinyl[methoxy(polyethylene glycol)5000]} (C16 PEG5000-Ceramide), N-palmitoyl-sphingosine-1-{succinyl[methoxy(polyethylene glycol)2000]} (C16 PEG200-Ceramide), and N-palmitoyl-sphingosine-1-{succinyl[methoxy(polyethylene glycol)750]} (C16 PEG750-Ceramide) (iii) a phospholipid, and (iv) a permanently cationic lipid, an anionic lipid, or a second ionizable cationic lipid separate from the first ionizable cationic lipid.

The invention relates to the technical field of kitchen waste treatment, in particular to a solid fungicide, a preparation method and application. The solid microbial inoculum comprises a microbial inoculum and a carrier; the microbial agent is prepared from pseudoochrobactrum saccharum, alcaligenes faecalis, achromobacter xylosoxidans, paenibacillus amyloliquefaciens, bacillus cereus, sphingobium nicotianae, serratia marcescens, stenotrophomonas maltophilia, sphingobium humus, sphingobium aquaticum and bacillus subtilis; the carrier for carrying the liquid compound bacteria is bagasse, and the maximum number of released bacteria is 2.2 * 10 < 9 > CFU / g. When the solid microbial inoculum is added into a 18 L kitchen waste reactor, the waste decrement rate is 80% within 7 days, and the COD removal rate can reach 79.1% at most. According to the solid microbial agent disclosed by the invention, organic substances in the kitchen waste can be degraded while the kitchen waste is converted from a solid state to a liquid state, so that volume reduction and weight reduction of the kitchen waste are realized; and the solid microbial inoculum is convenient to transport and operate and low in cost, has positive significance on difficulties faced by kitchen waste treatment, and has a good application prospect.

Described herein is a method of treating an autoimmune and / or inflammatory condition in an individual in need thereof, the method comprising (a) systemic administration of a first inhibitor to the individual in need thereof, wherein the first inhibitor comprises an inhibitor of interleukin-23 (IL-23), an inhibitor of tumor necrosis factor alpha (TNF-alpha), or combinations thereof; and (b) local administration of a second inhibitor to the individual in need thereof, wherein the second inhibitor comprises an inhibitor of interleukin-23 (IL-23), an inhibitor of tumornecrosis factor alpha (TNF-alpha), a Janus kinase (JAK) inhibitor, a sphingosine- 1 phosphate (SIP) modulator, an inhibitor of TNF-like ligand 1 A (TL1 A), or combinations thereof, thereby treating the autoimmune and / or inflammatory condition in the individual in need thereof.

The invention discloses a natural component composition for conditioning skin micro-ecology, a preparation method of the natural component composition and application of the natural component composition in skin care products for children. The composition comprises a synergistic combination of a sphingomonas fermentation product extract, a haematococcus pluvialis extract rich in astaxanthin, an abelmoschus esculentus fruit extract rich in polysaccharides, and a yeast / zinc fermentation product. The present invention provides improvements in astaxanthin in terms of chemical stability and transdermal permeability. The composition aims to enhance the immature skin barrier, provide a good effect, and support the healthy development of skin microecology, thereby solving the unique physiological needs of children's skin. The invention also describes a preparation method of the composition and application of the composition in cosmetics for children and dermatological products.

The invention relates to a sunscreen synergistic composition and application thereof. The sunscreen synergistic composition is prepared from a sphingomonas fermentation product extract, wax powder, a dextrin thickener and butyl octanol salicylate, the dextrin thickening agent is prepared from dextrin palmitate and / or dextrin palmitate / ethyl hexanoate. The invention creatively finds that the four components, namely the sphingomonas fermentation product extract, the wax powder, the dextrin thickener and the butyl octanol salicylate, can interact and positively influence one another, and have a synergistic promotion effect which is unexpected by technicians in the field in the aspect of sunscreen synergism. The sunscreen synergistic composition provided by the invention is very suitable for skin care products, mild, non-irritant and good in stability.

The invention discloses an organic contaminated soil remediation method based on a compound bacterium remediation agent. The organic contaminated soil remediation method comprises the following steps: S1, biochar modification: FeCl3 and LaCl3. 7H2O modified biochar is obtained; s2, culturing compound bacteria, namely mixing the ectotrophic substance sphingosine bacterium suspension and the staphylococcus xylosus suspension in an equal volume manner to obtain a compound bacteria suspension, wherein the sphingosine bacterium suspension and the staphylococcus xylosus suspension are mixed in an equal volume manner; s3, immobilizing compound bacteria; and S4, soil remediation. Aiming at the soil jointly polluted by a plurality of organic polluted soils, two microbial bacteria which are relatively good in synergism and relatively good in degradation effect on organic pollutants are screened out as compound bacteria, and meanwhile, in order to further improve the action effect and activity of the compound bacteria, the compound bacteria are loaded on specific biochar through a series of means, so that the compound bacteria can be used for preparing the biochar. The activity can be further improved, so that the synergistic degradation of various organic pollutants in the soil is improved, and a good effect is achieved.

The invention relates to the technical field of skin care products, and particularly discloses a bionic liposome for simulating intercellular lipid components and a preparation method of the bionic liposome. The bionic liposome for simulating the intercellular lipid component comprises the following components in parts by mass: 30-38 parts of a solvent; 35 to 43 parts of a humectant; 1.34 to 1.66 parts of grease; 2.4 to 2.6 parts of a lipid substance; 2.58 to 3.22 parts of an emulsifier; 18 to 26 parts of a skin conditioner; 4.9 to 5.1 parts of composite ceramide; 1 to 3 parts of phytosphingosine; 0.09 to 0.11 part of a sphingomonas fermentation product extract; and the emulsifier is a compound of olive alcohol, polyglycerol-10 stearate, sodium stearoyl glutamate and sodium lauroyl lactylate. The method has the advantage that ceramide is not easy to crystallize and separate out.

The invention belongs to the technical field of agricultural microorganisms, and particularly relates to rice endophytic sphingosine vector SY02 and application thereof. The preservation number of the rice endophytic sphingobium yanoikuyae SY02 provided by the invention is CCTCC (China Center For Type Culture Collection) NO: M2026182, and the sphingobium yanoikuyae SY02 has the functions of producing indoleacetic acid, promoting plant growth and seed germination, promoting adventitious bud proliferation of tissue culture seedlings and relieving browning. The sphingosine vector bacterium and the microbial agent prepared through strain fermentation have the advantages of being green, safe, efficient, long-acting and the like, and have good application prospects in the aspects of promoting plant growth and seedling breeding.

The invention relates to a polyacid composite oil-controlling and acne-removing gel and a preparation method thereof, and belongs to the technical field of skin care products. The polyacid composite oil-controlling and acne-removing gel is prepared from the following components in percentage by mass: 2% of salicylic acid, 3%-4% of glycolic acid, 0.5%-1.5% of mandelic acid, 0.5%-1.0% of lactobionic acid, 0.5%-1.0% of gluconolactone, 1.2%-1.6% of microcrystalline cellulose (and) sphingomonas fermentation product extract (and) cellulose gum, 2%-5% of butanediol, 0.3%-0.5% of asiaticoside-II, 0.5%-1.5% of centella asiatica, 0.5%-1.5% of vitamin E and the balance of water. And the balance of deionized water. By adding micro-crystalline cellulose (and) sphingomonas fermentation extract (and) cellulose gum, system stability under compounding of five organic acids is realized, semitransparent gelatinous texture is obtained, the composition is suitable for point coating use mode, impression is not affected, oil-controlling and acne-removing effects are improved under the condition of low organic acid content, and the composition belongs to skin-care polyacid products and has a broad market prospect. The mild oil control and acne removal effects are realized, and the cream is suitable for oil-sensitive skin crowds.

The invention discloses a bisphenol A degrading bacterium XYQ100 as well as a culture method and application thereof, and relates to the technical field of microbial pollution degradation and environmental pollution, the bisphenol A degrading bacterium XYQ100 provided by the invention is classified and named as sphingobacterium sp., and is preserved in the China General Microbiological Culture Collection Center on April 18, 2025, and the preservation number of the strain is CGMCC NO.34264. The bisphenol A degrading bacterium XYQ100 provided by the invention is named as sphingobacterium sp. The strain can realize efficient removal of bisphenol A pollutants, and the degradation rate of bisphenol A within 54 hours reaches 100%.

The invention belongs to the technical field of biology, and particularly relates to an immunogenic peptide fragment aiming at a human sphingosine 1-phosphate receptor 2 and application of the immunogenic peptide fragment. The amino acid sequence of the immunogenic peptide fragment is SEQ ID No.1. The immunogenic vector vaccine aiming at the human sphingosine 1-phosphate receptor 2 is prepared by coupling the immunogenic peptide fragment of the human sphingosine 1-phosphate receptor 2 and a vector, and the vector is Q beta-2aa bacteriophage virus-like particle protein. According to the invention, the preferentially designed immunogenic peptide fragment of the human sphingosine 1-phosphate receptor 2 is coupled with the Qbeta-2aa bacteriophage virus-like particle protein carrier to successfully prepare the carrier vaccine. The immunogenic vector vaccine can be used for preparing drugs for preventing and treating abdominal aortic aneurysm.

The invention discloses application of a compound in preparation of a skin and / or scalp care product, the structural formula of the compound is # imgabs0, and compared with retinoic acid, the compound provided by the invention has higher cell safety concentration and lower irritation, has a more excellent effect in the aspect of cell damage repair, and has a better cell moisturizing effect; compared with the retinyl phytosphingosine, the compound provided by the invention has a better effect in the aspects of inhibiting the activity of elastase and improving type I collagen; compared with retinoyl phytosphingosine, the compound provided by the invention shows a better effect in the aspects of resisting lipid peroxidation and inhibiting malassezia reproduction, and also has better stability. The compound provided by the invention has good application value in the field of preparing cosmetics, medicines and health care products with corresponding effects or indications.

The invention relates to the field of cosmetics, in particular to a ceramide compound-containing liquid crystal emulsifier and application thereof, and the ceramide compound-containing liquid crystal emulsifier comprises ceramide EOP, ceramide NP, ceramide AP, phytosphingosine, phytosterols, hydrogenated lecithin, stearyl alcohol, dioctyldodecanol lauroyl glutamate, cetostearyl alcohol and cetearyl glucoside. The liquid crystal emulsifier disclosed by the invention is good in stability, and cream and emulsion can be kept in a stable state in the storage and use processes; the mask is safe, mild, non-irritant to skin and suitable for various skin types; the product has good spreadability and can be uniformly distributed on the skin surface after being used, so that the use effect is improved; by combining a part of ceramide bionic liposome, the moisturizing and repairing effects are achieved while emulsification is performed, and the moisture content and the barrier function of the skin can be improved.

The invention relates to the technical field of chemical purification, and particularly discloses an extraction and purification method of tetraacetyl phytosphingosine. The invention provides an extraction and purification method of tetraacetyl phytosphingosine. The extraction and purification method comprises the following steps: sample treatment, ethanol extraction, C8 chromatography, PA308 chromatography and PS-5 chromatography. Wherein an eluent used in the steps of C8 chromatography and PA308 chromatography is a 50-60v / v% acetonitrile-water solution; an eluent used in the PS-5 chromatography step is an acetonitrile-water solution with the concentration of 65-85v / v%. According to the extraction and purification method of the tetraacetyl phytosphingosine provided by the invention, the tetraacetyl phytosphingosine in thalli can be fully extracted, and the purity of the tetraacetyl phytosphingosine in the obtained tetraacetyl phytosphingosine extract is greater than or equal to 95%.

The invention discloses a co-fermentation method based on sphingomonas and a rhodiola rosea extracting solution and application of a product, and belongs to the technical field of microorganisms. By utilizing a special rich enzyme system of sphingomonas and combining with an early-stage composite enzymolysis process and synergistic effect, the wall breaking efficiency of rhodiola rosea cell walls and the conversion degree of active components of rhodiola rosea are greatly improved, the bottlenecks of low efficiency and low bioavailability of a traditional rhodiola rosea extraction method are successfully overcome, and the rhodiola rosea extraction method is suitable for industrial production. The functional components such as salidroside and flavone can be fully released and converted. Secondly, different from non-symbiotic bacteria (such as lactic acid bacteria and saccharomycetes) which are commonly used for fermentation in the prior art, a potential symbiotic bacterium of sphingomonas XJL-TP07 from a special environment is innovatively selected and has better metabolic suitability with the rhodiola rosea component, the fermentation process is milder and safer (no irritant is produced), and the rhodiola rosea fermentation method is suitable for large-scale production. And a synergistic interaction effect can be generated through a unique biotransformation path.

The present invention provides a combination of superior bacteria for liquefying and degrading food waste and its application. The combination includes Pseudomonas aglycones, Bacillus alcaligenes faecalis, Bacillus amyloliquefaciens, Serratia marcescens, Sphingobacillus suis, Bacillus subtilis, Achromobacter xylosoxidans, Bacillus cereus, Sphingobacillus fusoni, Oligotrophomonas maltophilia, and Sphingobacillus humus. The combination of bacteria can effectively reduce the amount of food waste, and the maximum reduction can be 14.66%, and the COD removal rate can reach 98.19%. The combination of bacteria of the present invention can efficiently degrade and liquefy food waste, and can achieve a high reduction rate and liquefaction effect, which is conducive to the absorption and utilization of nutrients in the subsequent food waste biological resource conversion process.

The invention relates to the technical field of pharmaceutical preparations, and discloses a biological beauty skin care product containing nicotinamide adenine dinucleotide (NAD < + >) and cell exosomes, and the biological beauty skin care product comprises the following components by weight: 10-50 parts of a pH responsive nicotinamide mononucleotide liposome; 1 to 10 parts of cell exosome sustained release microspheres; 0.1 to 2 parts of ergothioneine; 0.1 to 1 part of copper peptide; 1 to 10 parts of phytosphingosine; 0.01 to 0.5 part of water-soluble fullerene; 1-8 parts of 1, 2-pentanediol as a transdermal enhancer; 0.05 to 0.5 part of acetylated polypeptide-8; wherein the particle size of the pH response type nano-liposome is 50-200 nm, and the particle size of the hyaluronic acid microspheres is 100-500 nm, so that the skin health is promoted, and the metabolic function is regulated.

The invention relates to the technical field of microbial engineering, and particularly discloses a compound microbial agent for treating cyanobacterial bloom, bacillus velezensis provided by the invention destroys algae cells and inhibits the activity of related biological enzymes by secreting heterocyclic algal killing active substances, and simultaneously causes the leakage of cellular contents (such as algal toxins, polysaccharides and lipids); an extracellular enzyme system (such as alkaline phosphatase and beta-glucosidase) of the sphingomonas decomposes free algal toxins into low-toxicity linear peptide fragments and hydrolyzes beta-1, 4-glucosidic bonds in EPS at the same time, so that algae-derived organic fragments are converted into small-molecular soluble substances, and a substrate is provided for follow-up metabolism of rhodococcus; lipase and esterase secreted by rhodococcus can hydrolyze triglyceride and waxy components, fatty acid is converted into energy and a biosurfactant through a beta-oxidation pathway, and hydrophilicity of frond fragments is enhanced to promote overall degradation efficiency.

The invention relates to an artificial biological crust material as well as a preparation method and application thereof. Specifically, the artificial biological crust material comprises the following components: kaolin, a polymer material and sphingomonas. In the soil matrix, the addition amount of the components in parts by mass per square meter is as follows: 1.0-6.0 g / m < 2 > of kaolin, 0.3-2.5 kg / m < 2 > of polymer material and 0.02-0.2 g / m < 2 > of sphingomonas by dry weight. The kaolin, the sphingomonas and the polymer are used for synergistically modifying the artificial biological crust material, and the thickness and the microscopic compactness of the biological crust are remarkably improved through synergic modification.

The invention discloses a high-stability azelaic acid acne-removing emulsion, and the azelaic acid acne-removing emulsion with long-term stability and high concentration is obtained by using a thickening agent sphingomonas fermentation product which can resist acid and salt at high temperature and normal temperature. The invention also discloses a stability accelerated test evaluation method of the high-stability azelaic acid acne-removing emulsion, in-situ measurement is performed by adopting a Turbiscan stability analyzer, and the stability of the azelaic acid acne-removing emulsion is compared and predicted by replacing a traditional stability test method with key parameters such as a back scattered light change value, a peak thickness, a particle migration rate and the like. Compared with the prior art, the method has the advantages that the stability test process is greatly accelerated, the efficiency is improved by dozens of times, the technical breakthrough not only remarkably shortens the product development period, but also provides a scientific basis for formula optimization of the high-concentration azelaic acid acne-removing emulsion, and the long-term stability and effectiveness of the azelaic acid acne-removing emulsion in clinical application are ensured.

The invention belongs to the technical field of biology, and relates to a heavy metal tolerant sphingomonas strain 1PPS-Zn1 and application thereof, the heavy metal tolerant sphingomonas strain 1PPS-Zn1 is preserved in China Center for Type Culture Collection on March 20, 2025, the preservation number is CCTCC NO: M 2025544, the sphingomonas strain 1PPS-Zn1 can adsorb and tolerate high-concentration zinc, the highest tolerable concentration reaches 80 mmol / L, and the sphingomonas strain 1PPS-Zn1 also has the capabilities of producing IAA, fixing nitrogen and promoting plant growth, and can be applied to the field of heavy metal tolerant plants. And the absorption, enrichment and transfer capabilities of the black nightshade to heavy metal zinc in the soil can be improved, finally, the remediation efficiency of the zinc-polluted soil is improved, a new way is provided for soil remediation and ecological environment remediation, and the method has wide development and application prospects.

The invention provides a metabolic marker for auxiliary diagnosis of schizophrenia, a construction method and application. Wherein the metabolic marker comprises lysophosphatidylcholine (LPC) (17: 0 / 0: 0), oleamide, lysophosphatidyl ethanolamine LysoPE (18: 0 / 0: 0), palmitamide, lysophosphatidyl ethanolamine LysoPE (0: 0 / 20: 4), lysophosphatidyl ethanolamine LysoPE (22: 6 / 0: 0), p-methylphenol sulfate, lactic acid, 3-hydroxybutyric acid, lysophosphatidyl ethanolamine LysoPE (18: 2 / 0: 0), lysophosphatidyl ethanolamine LysoPE (16: 0 / 0: 0) and sphingosine 1-phosphate. By utilizing the metabolic marker, auxiliary diagnosis of schizophrenia can be rapidly and accurately completed in the early stage of disease attack.

The present invention provides A ceramide compound, comprising: a structure of general formula I or an enantiomer or diastereomer of general formula I:in which:R1 is selected from the condensation residues of ferulic acid, sinapic acid, abscisic acid, sotretinoin, tretinoin, fusidic acid, royal jelly acid, sorbic acid, caffeic acid or trans-cinnamic acid;R2 is selected from one of the following structures:—C15H29, —C15H31, —C15H27, —CHOHC14H27, —CHOHC14H29.The present disclosure also provides a ceramide compound containing conjugated carboxylic acid, preparation method therefor and application thereof. The invention reacts functional carboxylic acid with sphingosine base to obtain a class of ceramide compound with novel structure. The introduction of physiologically active molecular fragments of functional carboxylic acids into ceramides will enhance the original efficacy of this type of molecules and also improve the physical and chemical properties of ceramide compound. For example, improving the antioxidant properties of ceramide compound.

The invention provides a saccharomyces cerevisiae strain with high phytosphingosine production. On the basis of the saccharomyces cerevisiae strain with high phytosphingosine production, the invention constructs an engineering saccharomyces cerevisiae strain for efficiently synthesizing phytosphingosine, reduces the expression of proteins encoded by LCB4, SHM2, CHA1, ORM2, ELO3 and SHM1 genes, and increases the expression of proteins encoded by TSC10, SYR2 and LCB2 genes by using a constitutive promoter, and the phytosphingosine shake flask amount reaches 9.52 mg / g dry weight, and then increases the expression of proteins encoded by the HAC1 gene by using a constitutive promoter, and the phytosphingosine shake flask amount is further increased by 4.34 times to 41.33 mg / g dry weight, and the phytosphingosine production reaches the highest production of shake flask fermentation reported so far. The production of phytosphingosine produced by fermentation in a 5L fermenter reaches 150.54 mg / g dry weight, and the titer is 2817 mg / L.