16 results about "Kidney transplantation" patented technology

This disclosure relates to RNAi agents capable of inhibiting complement factor B (CFB) gene expression. Pharmaceutical compositions containing CFB RNAi agents and methods of use thereof are also disclosed. The CFB RNAi agents disclosed herein may be conjugated to a targeted ligand containing an N-acetyl-galactosamine ligand to facilitate in vivo delivery to hepatocytes. RNAi agents can be used in methods of treating diseases, disorders, or conditions partially mediated by CFB gene expression, including IgA nephropathy (IgAN), C3 glomerulopathy (C3G), immune complex-mediated membrane proliferative glomerulonephritis (IC-MPGN), lupus nephritis (LN), anti-glomerular basement membrane antibody disease (anti-GBM), ischemia-reperfusion injury and T-cell-mediated rejection in kidney transplantation (TCMR), anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis, age-related macular degeneration (AMD) including early and / or intermediate-stage AMD, geographic atrophy (GA), glaucoma, Doyne honeycomb retinal dystrophy, paroxysmal nocturnal hemoglobinuria (PNH), atypical hemolytic uremic syndrome (aHUS), pre-eclampsia, rheumatoid arthritis (RA), and / or other complement-mediated disorders.

The technical scheme of the present application discloses a kidney transplantation single disease follow-up database system based on a hospital intranet environment, comprising a data integration layer, an intelligent analysis layer and a doctor-patient linkage layer. Through the cooperative operation of the three-layer technical architecture designed by the present application, the three core problems of the prior art are comprehensively solved, and the following technical effects are achieved: at the data integration level, automatic and real-time integration of multi-port medical data of kidney transplantation patients is realized, the data integration efficiency is improved by 90%, the accuracy rate reaches 99.5%, and the traceability and privacy security are significantly improved; at the data analysis level, the AI-driven analysis model realizes automatic generation of patient whole-cycle health reports, large-sample group feature mining and real-time abnormality early warning, and the doctor data analysis workload is reduced by 80%, and the abnormal data response time is shortened to the minute level.

The invention provides a kidney transplantation recipient health management platform system based on digital therapy, which comprises a digital target point unit, a data analysis module, a digital library and a treatment module, the digital target point unit is used for acquiring acquired data, the data analysis module is used for acquiring the acquired data uploaded by the digital target point unit, and the treatment module is used for treating the acquired data. Analyzing and modeling the acquired data to form a recipient model; the digital library is a cloud data center, the digital library is in communication connection with the data analysis module, and the digital library is used for comparing the recipient model with the medical information data to obtain reference data; and the treatment module obtains the reference data, formulates a corresponding treatment scheme and provides the treatment scheme to a transplantation recipient.

The invention relates to the technical field of medical instruments, in particular to a multifunctional postoperative monitoring device based on kidney transplantation, which comprises a main control module, a data transmission module and a power supply module, the main control module comprises an integrated monitoring vest, a detachable mattress and a multi-dimensional mechanical linkage assembly; the integrated monitoring vest is provided with a magnetic attraction type mounting groove for fixing an electrode slice, the electrode slice is detachably mounted in the magnetic attraction type mounting groove, cuffs of the integrated monitoring vest are integrated with cuffs, the armpits of the integrated monitoring vest are provided with mounting bags, and the body temperature sensor is in signal connection with the data transmission module. Urine bag fixing hooks are arranged on the two sides of the waist of the integrated monitoring vest; a pressure sensor array is embedded in the detachable mattress, fixing pieces are installed on the edge of the detachable mattress, and the detachable mattress is in wireless connection with the integrated monitoring vest through a data transmission module. According to the invention, the postoperative care risk is reduced, and the patient prognosis is improved.

Methods for desensitization of patients requiring organ transplantation are provided. Human leukocyte antigen-sensitized patients awaiting incompatible kidney transplants who are treated with clazakizumab exhibit reduced or absent levels of donor-specific antibodies, indicating improved transplant rates. Clazakizumab and variants are provided for use in various embodiments of the method. In some embodiments, clazakizumab or a variant thereof is administered simultaneously or sequentially with intravenous immune globulin.

The application discloses a heterocyclic derivative with a structure shown in formula (I) or a stereoisomer, a pharmaceutically acceptable salt thereof. The heterocyclic derivative or the stereoisomer has high activity in inhibiting HCMV, and the activity is increased by 8-40 times compared with that of letermovir, and the patients with HCMV virus infection after allogeneic hematopoietic stem cell transplantation, kidney transplantation and lung transplantation can be better protected in clinic.

The invention provides application of a reagent for detecting SNP sites in preparation of a product for detecting immunological rejection of organ transplantation patients. According to the present invention, the acute rejection reaction and the infection of the allogeneic organ transplantation patient can be simultaneously monitored, the genome concentration of the dd-cfDNA in the plasma can be quantified, the accurate detection of the dd-cfDNA of less than 0.5% can be achieved, the concentration calculation of the sample level can be performed on the dd-cfDNA, the sensitivity is high, and the stability is good. According to the system and the method, the physical condition of a patient subjected to allogeneic organ transplantation such as kidney transplantation, heart transplantation and lung transplantation after transplantation is regularly monitored, and a basis and a corresponding treatment scheme can be provided for dynamic monitoring and timely adjustment of the treatment scheme.

A kidney supply storage bag applied to a robot kidney transplantation operation belongs to the technical field of kidney storage for kidney transplantation, and is characterized by comprising thermal insulation cloth and a plurality of medical rubber mats which are transversely and uniformly distributed and connected to the upper edges of the upper and lower surfaces of the thermal insulation cloth, medical cloth liners are symmetrically connected to the left and right edges of the upper surface of the thermal insulation cloth front and back, a drainage device is inserted in an interlayer in the thermal insulation cloth, a feeding connector is connected to the circle center of the surface of one end of the drainage device, and a discharging connector is connected to the circle center of the surface of the other end of the drainage device. Low-temperature liquid is completely led out in the pipeline in a sealed mode, so that the low-temperature liquid cannot flow into the abdominal cavity, and the storage bag is separated from the intestinal canal through thick large gauze.

The invention relates to the technical field of electrical nerve stimulators, in particular to a portable electrical nerve stimulator for relieving pain after kidney transplantation, which comprises a device main body with a hollow cavity structure, the middle position of the top end face of the device body is fixedly connected with the adjusting assembly; the end, away from the device body, of the adjusting assembly is detachably connected with the portable dismounting and mounting mechanism, the portable dismounting and mounting mechanism comprises a horizontally-arranged mounting base, and an electro-therapeutic apparatus body is arranged on the top end face of the mounting base in an attached mode; vertically arranged transverse cutting blocks are fixedly connected to two sides of the electro-therapeutic apparatus main body on the top end surface of the mounting base; at least two sets of protection mechanisms are evenly distributed in the circumferential direction of the outer side wall of the portable dismounting and mounting mechanism and fixedly connected with the protection mechanisms, the portable nerve electrical stimulator is used for relieving pains after kidney transplantation, the device body is fixedly connected with the adjusting assembly, and the adjusting assembly is detachably connected with the portable dismounting and mounting mechanism.

The application provides a method for quantitatively partially reprogramming pig somatic cells and application thereof, and belongs to the technical field of animal biotechnology, genetic engineering and regenerative medicine. The method comprises reversing the epigenetic age of pig somatic cells to 57%-77% of the initial epigenetic age. The pig somatic cell epigenetic age is reversed by an mRNA reprogramming method or a small molecule composition reprogramming method. The partially reprogrammed pig somatic cells prepared by the method can tolerate extreme editing of more than 22 genes. In vitro, the partially reprogrammed pig somatic cells show immune compatibility close to human cells (a comprehensive protection index of 0.94), survive for more than 35 days in pig-monkey skin transplantation, and have a 28-day coverage rate of 62%. In xenogeneic kidney transplantation, all recipients survive for a long time. The application solves the fundamental bottleneck of pig somatic cell gene editing, and provides a safe, effective and industrialized donor pig solution for clinical xenotransplantation.

The invention relates to purine synthesis inhibitors for use in the treatment or prevention of kidney cysts and liver cysts in a patient with a kidney disease, wherein the patient did not underwent a kidney transplantation.

The application discloses a training rehabilitation auxiliary device after kidney transplantation, characterized in that the training rehabilitation auxiliary device comprises a main body frame, wherein the main body frame comprises a base assembly, a backrest assembly, a seat plate assembly, an auxiliary support assembly and a main control box; the base assembly is fixedly connected with the backrest assembly; the seat plate assembly is fixedly connected with the backrest assembly and the base assembly; the auxiliary support assembly is fixedly connected with the backrest assembly and the base assembly; the main control box is arranged in a hollow region in the base assembly; and the main control box is connected with the backrest assembly through a cable. The application can adjust the training according to the rehabilitation condition of a patient, improve the rehabilitation effect of the patient and accelerate the rehabilitation progress of the patient.

The invention relates to the technical field of kidney transplantation, in particular to a kidney transplantation ice water circulation device which has the advantages that the kidney transplantation ice water circulation device comprises a water tank, a water bag and a miniature water pump, the water tank is provided with a locking mechanism for providing position fixation for a catheter and preventing water leakage, and the water bag is provided with an adjusting mechanism capable of providing support for deformation of the water bag; the locking mechanism comprises two connecting rings, two sealing rings and two mounting rings, rubber sheets are fixedly connected to the interiors of the mounting rings, passing grooves are formed in the centers of the rubber sheets, limiting rods which are symmetrically arranged are slidably connected to the connecting rings, and circular rings are fixedly connected to one ends of the limiting rods; the circulating device has the advantages that the condition that internal organs of a patient are frostbitten in the kidney transplantation operation is avoided, the circulating device can be conveniently divided into two parts, follow-up storage of the device is facilitated, and the water bag, the water tank and the air bag can be deeply disinfected conveniently due to the split body of the circulating device.

The application discloses a preparation method and application of an autologous mitochondrion preparation, relates to the technical field of kidney protection and regeneration, and is characterized in that the mitochondrion is derived from heart tissue of a healthy C57 mouse of 8-10 weeks old, is obtained through a kit combined with a differential centrifugation method, and is characterized in that the obtained mitochondrion is continuous in outer membrane and clear in ridge structure under an electron microscope, and has good structural and functional integrity. In an in-vivo experiment, the mitochondrion is delivered to the renal cortex region of a recipient mouse through a subcapsular injection method 30 minutes before ischemia-reperfusion, and the result shows that the blood creatinine and urea nitrogen levels can be significantly reduced, the necrosis and oxidative stress damage of renal tubular epithelial cells can be reduced, and the renal tissue pathological score can be improved. The application provides a repeatable and standardizable organelle treatment strategy for intervention of kidney transplantation and acute kidney injury related IRI.

The application discloses a kind of based on data-driven renal transplantation postoperative pulmonary infection risk factor mining method, first to clinical data set is reduced dimension processing and the comprehensive contribution degree of case pair data set is calculated, then the correlation between candidate infection factor and infection occurrence is calculated, and then the candidate infection factor sorted from high to low according to correlation is searched multiple by neural network prediction model, finally according to the highest prediction accuracy determine the best risk factor set related to pulmonary infection.The method of the application intelligently screens important factors causing pulmonary infection of postoperative patient after renal transplantation from clinical case data in a data-driven manner, selects important factors for the best infection prediction scheme, makes the screening of the best risk factor more accurate and robust, and can be applied to the screening of pulmonary infection factors of postoperative patients after renal transplantation, auxiliary decision-making of postoperative diagnosis and treatment scheme, etc., and can also be expanded to the screening of the best risk factor of other diseases and auxiliary decision-making of clinical diagnosis and treatment.