39 results about "Kidney transplantation" patented technology

Provided herein are methods and compositions for treating a subject having an autoimmune disorder, such as multiple sclerosis, autoimmune encephalitis, Sjogren's syndrome, kidney transplantation, IgG4-related disease, ANCA-associated vasculitis, chronic inflammatory demyelinating polyradiculoneuropathy, neuromyelitis optica spectrum disorder, and idiopathic inflammatory myopathy (e.g., antisynthetase syndrome, dermatomyositis, immune-mediated necrotizing myopathy, or polymyositis), using T cells engineered with a chimeric antigen receptor that binds CD19.

The present invention discloses a combined prediction method for the risk of pulmonary infection after kidney transplantation, comprising the following steps: S1, quantifying a clinical data set; S2, designing a feature extraction network for preoperative static data and extracting features of the preoperative static data; S3, designing a feature extraction network for postoperative dynamic data sequences and extracting features of the postoperative dynamic data sequences; S4, fusing the features obtained in step S3 and the features obtained in step S4; S5, performing binary classification calculation on the fused features obtained in step S5 using a linear classifier, and inversely obtaining an intelligent prediction result of whether there is an infection from the classification result. The present invention can be applied to predicting in advance the occurrence of the risk of pulmonary infection at each time node after kidney transplantation for patients, and providing clinical auxiliary decision-making support for the diagnosis and treatment plan after kidney transplantation.

The present disclosure relates to a method for reducing or hindering development of renal ischemia-reperfusion injury in a subject the method comprising administering an antibody that inhibits granulocyte colony stimulating factor (G-CSF) signaling. In some examples, the ischemia-reperfusion injury is due to or associated with tissue or organ transplantation.

The invention provides a method for determining the content of an anti-SLA antibody in swine xenograft receptor serum, and belongs to the technical field of biology. The method comprises the following steps: respectively incubating swine xenograft receptor serum, SLA-knocked-out swine PBMC and SLA-unknocked-out swine PBMC by utilizing the difference between swine PBMC surface xenoantigen and swine RBC surface xenoantigen, detecting antibody combination, and calculating a flow type difference value to obtain the anti-SLA antibody content in the swine xenograft receptor serum. When a heterologous kidney transplantation recipient has a rejection reaction, the method provided by the invention can effectively and quickly determine whether the rejection reaction is caused by the SLA antigen, so that targeted treatment is performed, and effective control of the rejection reaction of the heterologous recipient is facilitated.

This disclosure relates to RNAi agents capable of inhibiting complement factor B (CFB) gene expression. Pharmaceutical compositions containing CFB RNAi agents and methods of use thereof are also disclosed. The CFB RNAi agents disclosed herein may be conjugated to a targeted ligand containing an N-acetyl-galactosamine ligand to facilitate in vivo delivery to hepatocytes. RNAi agents can be used in methods of treating diseases, disorders, or conditions partially mediated by CFB gene expression, including IgA nephropathy (IgAN), C3 glomerulopathy (C3G), immune complex-mediated membrane proliferative glomerulonephritis (IC-MPGN), lupus nephritis (LN), anti-glomerular basement membrane antibody disease (anti-GBM), ischemia-reperfusion injury and T-cell-mediated rejection in kidney transplantation (TCMR), anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis, age-related macular degeneration (AMD) including early and / or intermediate-stage AMD, geographic atrophy (GA), glaucoma, Doyne honeycomb retinal dystrophy, paroxysmal nocturnal hemoglobinuria (PNH), atypical hemolytic uremic syndrome (aHUS), pre-eclampsia, rheumatoid arthritis (RA), and / or other complement-mediated disorders.

The technical scheme of the present application discloses a kidney transplantation single disease follow-up database system based on a hospital intranet environment, comprising a data integration layer, an intelligent analysis layer and a doctor-patient linkage layer. Through the cooperative operation of the three-layer technical architecture designed by the present application, the three core problems of the prior art are comprehensively solved, and the following technical effects are achieved: at the data integration level, automatic and real-time integration of multi-port medical data of kidney transplantation patients is realized, the data integration efficiency is improved by 90%, the accuracy rate reaches 99.5%, and the traceability and privacy security are significantly improved; at the data analysis level, the AI-driven analysis model realizes automatic generation of patient whole-cycle health reports, large-sample group feature mining and real-time abnormality early warning, and the doctor data analysis workload is reduced by 80%, and the abnormal data response time is shortened to the minute level.

The application relates to the technical field of intelligent medical treatment, and provides a kidney transplantation graft prognosis evaluation method and system based on multi-modal deep learning, wherein the method comprises the following steps: pre-processing and feature extraction are performed on text data and image data; text vector features and image features are fused to obtain fused training features; the fused training features are input into a deep neural network model for model training; donor medical record data is input into an optimized training model, and the last layer features output by the optimized training model are saved into a database; the receiver medical record data is input into the optimized training model, the last layer features of the receiver are extracted, the last layer features of the receiver are matched with all the last layer features of the donors in the database in terms of similarity, and several donor medical records with the highest scores are screened out for transplantation selection. The application combines the existing transplantation patient medical history and prognosis, and predicts and evaluates a kidney transplantation scheme with good postoperative matching and small rejection reaction through a deep neural network.

Disclosed in the present disclosure are a heterocyclic derivative represented by formula (I), or a stereoisomer, a pharmaceutically acceptable salt thereof. The heterocyclic derivative or the stereoisomer thereof has high HCMV inhibiting activity, which is increased in potency by 8-40 folds compared with letermovir, and clinically it may provide better protection for patients suffering from HCMV infection after allogeneic hematopoietic stem cell transplantation, kidney transplantation, and lung transplantation.

The invention provides a preparation method and application of a human erythropoietin transgenic pig, and belongs to the field of gene engineering. According to the invention, a human EPO gene is knocked into a fibroblast line of a pig to construct a humanized EPO transgenic pig, and genotype DNA identification and protein expression analysis of a cloned pig are further carried out to obtain a transgenic human EPO gene editing xenogenic organ transplantation donor pig. According to the invention, the problems of renal anemia and the like in the process of xenogeneic organ kidney transplantation are improved by modifying the pig transferred humanized gene, and the method has an important application value for promoting pre-clinical research of xenogeneic organ transplantation of pig-non-human primates and clinical application of xenogeneic organ transplantation of pig-human.

The present invention provides IdeS polypeptide for use in a method of treating or pre-venting a disease mediated by pathogenic polymeric IgA complexes. wherein said dis-ease or disorder is progressive IgA nephropathy (IgAN) or recurrent IgAN following re-nal transplantation. The IdeS polypeptides finds particular use in induction therapy of progressive or recurrent IgAN disease or disorder.

The invention provides a kidney transplantation recipient health management platform system based on digital therapy, which comprises a digital target point unit, a data analysis module, a digital library and a treatment module, the digital target point unit is used for acquiring acquired data, the data analysis module is used for acquiring the acquired data uploaded by the digital target point unit, and the treatment module is used for treating the acquired data. Analyzing and modeling the acquired data to form a recipient model; the digital library is a cloud data center, the digital library is in communication connection with the data analysis module, and the digital library is used for comparing the recipient model with the medical information data to obtain reference data; and the treatment module obtains the reference data, formulates a corresponding treatment scheme and provides the treatment scheme to a transplantation recipient.

The invention relates to the technical field of operation drag hooks, and discloses a kidney transplantation full-process universal operation drag hook which comprises a stand column, an adjusting block is arranged on the outer wall of the stand column through a locking assembly, a supporting block is fixedly connected to the top of the adjusting block, and a half gear is rotationally connected to one side of the supporting block; the side, away from the half gear, of the supporting block is rotationally connected with a second shifting piece, one end of the second shifting piece is fixedly connected with a limiting piece, the limiting piece is connected with the half gear in a clamped mode, the top of the half gear is fixedly connected with a connecting ring, and a drag hook piece is arranged in the middle of the connecting ring. One end of a second shifting piece is pressed to extrude a second spring, the second shifting piece extrudes the second spring and drives a limiting piece to move at the same time, so that the limiting piece is separated from a half gear, a connecting ring and an adjusting rod can be conveniently driven to move after the limiting piece is separated from the half gear, and then the angle of the drag hook can be conveniently adjusted.

The utility model discloses a kidney protection bag, which belongs to the field of medical instruments and comprises a protection bag body, a kidney inlet is arranged at the top of the protection bag body, a kidney pedicle inlet and outlet is arranged at the edge of the top of the protection bag body, a support framework is arranged on the outer side of the protection bag body, and an operation part is arranged at the bottom of the support framework. The protection bag body comprises an inner layer and an outer layer, and an interlayer between the inner layer and the outer layer is arranged to be a cooling water flowing cavity. According to the kidney protection bag, the supporting frameworks on the front side and the rear side are unfolded outwards by pressing the operation part, the protection bag body is completely unfolded, the kidney inlet is enlarged, the kidney can be conveniently put in, the operation part is loosened, the supporting frameworks on the front side and the rear side are close to the middle, the kidney inlet is shrunk, the protection bag body is attached to the surface of the kidney, and the kidney is protected; the kidney transplantation quality is improved, the operation is simple, and the use is convenient; cold water continuously passes through the cooling water flowing cavity between the inner layer and the outer layer, so that the kidney can be continuously cooled, and the kidney is always in a low-temperature state.

The invention discloses a tacrolimus blood concentration prediction method based on multi-factor regression analysis, which comprises the following steps: step 1, clinical data acquisition, blood concentration monitoring and patient grouping comparison, step 2, obtaining independent risk factors by adopting multi-factor Logistic regression analysis, step 3, establishing a column diagram risk prediction model, and step 4, establishing a tacrolimus risk prediction model. 4, evaluating the column graph risk prediction model; the risk that the postoperative tacrolimus blood concentration of the kidney transplantation patient does not reach the standard can be effectively predicted through the constructed column diagram risk prediction model, the model has good accuracy and distinguishing ability, meanwhile, the model has good calibration ability, the situation that the tacrolimus blood concentration of the kidney transplantation patient does not reach the standard can be accurately predicted, and the risk of clinical application is effectively predicted. The clinical application value is relatively high.

The invention discloses a kidney perfusion device and a use method thereof. The kidney perfusion device comprises a blood / perfusate reservoir, a normal temperature / low temperature mode switching module, a normal temperature blood perfusion passage, a low temperature perfusate perfusion passage, a renal artery connector and a renal vein connector. The kidney perfusion device mainly aims at autologous kidney transplantation, not only supports conventional low-temperature perfusate perfusion through a low-temperature perfusion passage, but also supports ischemia-free perfusion through a normal-temperature perfusion passage. Necessary substances and conditions needed by kidney repair are provided through the normal-temperature perfusion module, the original function of the kidney can be rapidly recovered, if no-ischemia perfusion cannot be smoothly achieved under the conditions or no-ischemia perfusion needs to be stopped, conventional low-temperature perfusion can be rapidly converted, the thrombosis risk is reduced, and the kidney survival rate is increased.

The invention discloses a kidney transplantation donor organ activity real-time monitoring system and method in the technical field of isolated organ perfusion, and the system comprises a multi-modal sensing module which is used for sensing multi-modal data of molecular action generation, cell mechanical characteristics and organ functions of an isolated kidney in a cross-scale manner; the perfusion dynamic regulation and control module is used for fusing multi-modal data based on a learning algorithm and optimizing perfusion parameters in real time; and the bionic normal-temperature perfusion module is used for simulating a human physiological environment and maintaining kidney activity by using a micro-fluidic chip technology and a self-adaptive oxygenation technology based on the optimized perfusion parameters. A cross-scale multi-modal monitoring system is constructed, multi-modal data of the in-vitro kidney is sensed, dynamic perfusion regulation and control based on a learning algorithm are developed by fusing the multi-modal data, self-adaptive optimization of perfusion parameters is achieved, a perfusion environment similar to human physiology is created for the in-vitro kidney, and therefore the DGF risk is effectively reduced, and the in-vitro kidney perfusion system is suitable for in-vitro kidney perfusion. The success rate of kidney transplantation and the long-term survival rate of donor organs are improved.

The invention relates to the technical field of medical instruments, in particular to a multifunctional postoperative monitoring device based on kidney transplantation, which comprises a main control module, a data transmission module and a power supply module, the main control module comprises an integrated monitoring vest, a detachable mattress and a multi-dimensional mechanical linkage assembly; the integrated monitoring vest is provided with a magnetic attraction type mounting groove for fixing an electrode slice, the electrode slice is detachably mounted in the magnetic attraction type mounting groove, cuffs of the integrated monitoring vest are integrated with cuffs, the armpits of the integrated monitoring vest are provided with mounting bags, and the body temperature sensor is in signal connection with the data transmission module. Urine bag fixing hooks are arranged on the two sides of the waist of the integrated monitoring vest; a pressure sensor array is embedded in the detachable mattress, fixing pieces are installed on the edge of the detachable mattress, and the detachable mattress is in wireless connection with the integrated monitoring vest through a data transmission module. According to the invention, the postoperative care risk is reduced, and the patient prognosis is improved.

Methods for desensitization of patients requiring organ transplantation are provided. Human leukocyte antigen-sensitized patients awaiting incompatible kidney transplants who are treated with clazakizumab exhibit reduced or absent levels of donor-specific antibodies, indicating improved transplant rates. Clazakizumab and variants are provided for use in various embodiments of the method. In some embodiments, clazakizumab or a variant thereof is administered simultaneously or sequentially with intravenous immune globulin.

The invention discloses a water-soluble self-assembled chitosan nano-composite and a preparation method thereof.The nano-composite is an amphiphilic polymer NCH composite formed by quaternized chitosan (O-HTCC) and 5 beta-cholanic acid through covalent coupling, the particle size of nano-particles is 110 + / -8.48 nm, the solubility of Alda-1 can be effectively improved by wrapping the Alda-1, the encapsulation efficiency is 36.1%, and the nano-particles can be used for preparing nano-particles. IRI injury after DCD kidney transplantation is remarkably reduced, mitochondrial ALDH2 activity is improved, and serum creatinine is reduced to the lowest level 3 days after rat transplantation. The technology is suitable for improvement of mechanical perfusate of isolated organs, and has clinical transformation potential.

The invention discloses a medicine taking device, and belongs to the technical field of medicine taking devices. A medicine taking device comprises a shell, a gear ring, a first motor, four long plates, an upper disc plate, a lower disc plate, an electric telescopic rod, a second motor, a chassis and a power gear, four sector plates are hinged to the upper end of the inner wall of the shell at equal intervals, limiting grooves are formed in one ends of the four sector plates, square grooves are formed in the middle positions of the inner bottom faces of the four limiting grooves, and the square grooves are connected with the gear ring. Four limiting blocks are irregularly arranged on the inner wall of the gear ring, and first jacking columns are fixedly arranged on the adjacent sides of the upper end faces of the four long plates correspondingly. Through the cooperation of the limiting block and the limiting groove on the toothed ring, the medicine taking device can be opened at a specified time, a patient after kidney transplantation is prevented from taking medicine mistakenly at a wrong time, medicine can be automatically supplemented through the middle column, the workload of the patient after kidney transplantation is reduced, and the medicine taking efficiency is improved. And the gradual change alarm which gradually loud can prevent sudden sound from frightening the patient after the kidney transplantation operation.

The application discloses a heterocyclic derivative with a structure shown in formula (I) or a stereoisomer, a pharmaceutically acceptable salt thereof. The heterocyclic derivative or the stereoisomer has high activity in inhibiting HCMV, and the activity is increased by 8-40 times compared with that of letermovir, and the patients with HCMV virus infection after allogeneic hematopoietic stem cell transplantation, kidney transplantation and lung transplantation can be better protected in clinic.

The mouse kidney transplantation ureter-bladder anastomat comprises a needle tube, a needle tip is formed at the front end of the needle tube, a lead hole is formed in the needle tip, a depth control mechanism is arranged on the outer wall of the needle tube, and the depth control mechanism can control the depth of the needle tip penetrating into the mouse bladder. By adopting the depth control mechanism, an operator can be allowed to preset the puncture depth according to individual differences of mice, so that the risk that seminal vesicles, blood vessels and other visceral organs on the back side of the bladder of the mice are punctured is avoided, and the safety and repeatability of an operation are improved. The invention further discloses a mouse kidney transplantation ureter-bladder anastomosis method.

The invention provides application of a reagent for detecting SNP sites in preparation of a product for detecting immunological rejection of organ transplantation patients. According to the present invention, the acute rejection reaction and the infection of the allogeneic organ transplantation patient can be simultaneously monitored, the genome concentration of the dd-cfDNA in the plasma can be quantified, the accurate detection of the dd-cfDNA of less than 0.5% can be achieved, the concentration calculation of the sample level can be performed on the dd-cfDNA, the sensitivity is high, and the stability is good. According to the system and the method, the physical condition of a patient subjected to allogeneic organ transplantation such as kidney transplantation, heart transplantation and lung transplantation after transplantation is regularly monitored, and a basis and a corresponding treatment scheme can be provided for dynamic monitoring and timely adjustment of the treatment scheme.

The medicine taking device for kidney transplantation nursing comprises a medicine storage shell, a top sleeve shell is fixedly installed on the upper surface of the medicine storage shell, a bottom sleeve shell is fixedly installed on the lower surface of the medicine storage shell, a threaded groove A is formed in the outer side of the top sleeve shell, and the top sleeve shell is in threaded connection with the inner wall of a cover shell through the threaded groove A; a threaded groove B is formed in the inner wall of the bottom sleeve shell, and the bottom sleeve shell is in threaded connection with the outer wall of the connecting sleeve shell through the threaded groove B. The connecting sleeve shell is fixedly installed on the upper surface of the oral shell. A plurality of inserting grooves are uniformly formed in the inner bottom surface of the medicine storage shell, and medicine storage pipes are vertically and movably inserted into the inserting grooves; a timer is arranged on the upper surface of the cover shell; a simple and convenient medicine management device is provided for a patient, and the medicine taking treatment effect of the patient is greatly improved.

The present invention relates to a composition for diagnosing chronic rejection after kidney transplantation and, more specifically, provides a biomarker composition, a diagnostic composition and a kit for diagnosing chronic rejection after kidney transplantation, all of which comprise VSIG4 protein as an active ingredient. The biomarker composition and the like, according to the present invention, can be used to more effectively diagnose chronic rejection after kidney transplantation. Furthermore, a therapeutic drug targeting same can be developed.

The utility model relates to the technical field of medical instruments, in particular to a wound protection device for kidney transplantation. The device comprises a protective cylinder covering the periphery of a wound of a patient, a disinfection assembly horizontally inserted in the protective cylinder, and a fixed seat fixedly arranged below the outer part of the protective cylinder in a surrounding manner, the sticking ring is fixedly arranged below the fixed seat in a surrounding manner; the suction connector is fixedly arranged on one side of the lower part of the protective barrel; one end of the suction connector is communicated with the interior of the protective barrel; the other end of the suction connector is communicated with an external suction mechanism; a slot is formed in the cylinder wall of the upper part of the protective cylinder in a penetrating manner; a limiting clamping groove communicated with the slot is formed in the inner side wall of the upper part of the protective cylinder at a height corresponding to the slot in a surrounding manner; the disinfection assembly comprises a mounting frame inserted into the limiting clamping groove and clamped with the limiting clamping groove, a disinfection net fixedly arranged in the mounting frame and a sealing sleeve fixedly arranged outside the mounting frame in a sleeving manner. The device solves the problem that air with germs is in contact with a wound of a patient in an environment after dressing change of the patient by medical staff.

A kidney supply storage bag applied to a robot kidney transplantation operation belongs to the technical field of kidney storage for kidney transplantation, and is characterized by comprising thermal insulation cloth and a plurality of medical rubber mats which are transversely and uniformly distributed and connected to the upper edges of the upper and lower surfaces of the thermal insulation cloth, medical cloth liners are symmetrically connected to the left and right edges of the upper surface of the thermal insulation cloth front and back, a drainage device is inserted in an interlayer in the thermal insulation cloth, a feeding connector is connected to the circle center of the surface of one end of the drainage device, and a discharging connector is connected to the circle center of the surface of the other end of the drainage device. Low-temperature liquid is completely led out in the pipeline in a sealed mode, so that the low-temperature liquid cannot flow into the abdominal cavity, and the storage bag is separated from the intestinal canal through thick large gauze.

The invention belongs to the technical field of review result quantitative analysis, and discloses a quantitative analysis method for kidney transplantation review result data based on artificial intelligence. First patient reexamination result data are collected and preprocessed, second patient reexamination result data are obtained, and the first patient reexamination result data comprise biochemical index data, image result data and pathological report data; analyzing the second patient review result data to obtain a patient state reference value, and classifying the patient state reference value to obtain a classification result; storing the first patient review result data and the patient state reference value; in general, the method has the remarkable advantages that the auxiliary decision making effect is good, the patient information confidentiality is high, and the ability of assisting doctors in analyzing conditions is high.

The invention relates to the technical field of electrical nerve stimulators, in particular to a portable electrical nerve stimulator for relieving pain after kidney transplantation, which comprises a device main body with a hollow cavity structure, the middle position of the top end face of the device body is fixedly connected with the adjusting assembly; the end, away from the device body, of the adjusting assembly is detachably connected with the portable dismounting and mounting mechanism, the portable dismounting and mounting mechanism comprises a horizontally-arranged mounting base, and an electro-therapeutic apparatus body is arranged on the top end face of the mounting base in an attached mode; vertically arranged transverse cutting blocks are fixedly connected to two sides of the electro-therapeutic apparatus main body on the top end surface of the mounting base; at least two sets of protection mechanisms are evenly distributed in the circumferential direction of the outer side wall of the portable dismounting and mounting mechanism and fixedly connected with the protection mechanisms, the portable nerve electrical stimulator is used for relieving pains after kidney transplantation, the device body is fixedly connected with the adjusting assembly, and the adjusting assembly is detachably connected with the portable dismounting and mounting mechanism.