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Human cytomegalovirus (HCMV) is a beta-herpesvirus that causes lifelong infection in humans. HCMV has a prevalence of 55-100% within the human population, depending on different socioeconomic and geographical factors.
Application of cudrania tricuspidata fruit polysaccharide in preparation of medicine for treating or preventing HCMV infection
The invention provides an application of cudrania tricuspidata polysaccharide in preparation of a medicine for treating or preventing HCMV infection, the cudrania tricuspidata polysaccharide ZGs-1 shows a remarkable inhibition effect on expression of immediate early protein IE1 / 2 and early protein p52 and copy numbers of virus genes UL123, UL44 and UL32 in a plurality of key links of HCMV infection, and has definite antiviral activity. Due to the natural source characteristic of the cudrania tricuspidata polysaccharide ZGs-1, the cudrania tricuspidata polysaccharide ZGs-1 is high in safety and low in cytotoxicity, and the cudrania tricuspidata raw material is easy to obtain, so that a candidate drug or functional component with remarkable potential is provided for preventing and treating the HCMV, and the cudrania tricuspidata polysaccharide ZGs-1 has a good development prospect and application value.
Owner:ZHEJIANG HOSPITAL