127results about How to "Inhibition of lesions" patented technology

Excitation light for normal light observation with wavelengths in the visible spectrum, which is output from a lamp, and excitation light with wavelengths in the infrared spectrum for exciting a fluorescent substance characteristic of being accumulated readily in a lesion are irradiated simultaneously to a living tissue, to which the fluorescent substance has been administered, through an endoscope. Fluorescence components are separated from light stemming from the living tissue by means of a separator such as a dichroic mirror, introduced to a first imaging device, and then imaged. Light components with wavelengths in the visible spectrum are introduced to a second imaging device and then imaged. Signals representing the images are subjected to signal processing, whereby a video signal is produced. For better diagnosis, two images are displayed while, for example, one of the images is superimposed on the other.

Excitation light for normal light observation with wavelengths in the visible spectrum, which is output from a lamp, and excitation light with wavelengths in the infrared spectrum for exciting a fluorescent substance characteristic of being accumulated readily in a lesion are irradiated simultaneously to a living tissue, to which the fluorescent substance has been administered, through an endoscope. Fluorescence components are separated from light stemming from the living tissue by means of a separator such as a dichroic mirror, introduced to a first imaging device, and then imaged. Light components with wavelengths in the visible spectrum are introduced to a second imaging device and then imaged. Signals representing the images are subjected to signal processing, whereby a video signal is produced. For better diagnosis, two images are displayed while, for example, one of the images is superimposed on the other.

The invention relates to a device that can be used to monitor the penetration of a penetration member into anatomical structures and, in particular, bone structures of a living body, the structures having at least two different electrical impedance areas. The device is characterized in that it comprises: at least one impedance meter which can be connected to at least two electrodes, at least one of the electrodes being located at a distal end of the penetration member; and at least one alert device which can produce an alert signal if the impedance meter detects an impedance variation. The invention also relates to a penetration member for the device and to an electronic board for the device.

Methods and systems are disclosed for phototreatment in which replaceable containers comprising one or more adjuvant (consumable or re-useable) substances are employed. The adjuvant substance can be, for example, a topical substance or a coolant. Systems are disclosed for using a topical substance to detect contact of a phototreatment device with a tissue, detect speed of a phototreatment device over the tissue, detect regions of tissue that have been treated by a phototreatment device and / or to provide other benefits to the tissue such as improved skin tone and texture, tanning, etc. Safety systems are also disclosed that ensure that a proper consumable substance and / or container is connected to a phototreatment device and / or directed to a proper target. Additionally, cooling systems and methods that utilize phase change materials for extracting heat from a light generating device are disclosed.

The invention relates to a device that can be used to monitor the penetration of a penetration member into anatomical structures and, in particular, bone structures of a living body, the structures having at least two different electrical impedance areas. The device is characterized in that it comprises: at least one impedance meter which can be connected to at least two electrodes, at least one of the electrodes being located at a distal end of the penetration member; and at least one alert device which can produce an alert signal if the impedance meter detects an impedance variation. The invention also relates to a penetration member for the device and to an electronic board for the device.

Methods and systems are disclosed for phototreatment in which replaceable containers comprising one or more adjuvant (consumable or re-useable) substances are employed. The adjuvant substance can be, for example, a topical substance or a coolant. Systems are disclosed for using a topical substance to detect contact of a phototreatment device with a tissue, detect speed of a phototreatment device over the tissue, detect regions of tissue that have been treated by a phototreatment device and / or to provide other benefits to the tissue such as improved skin tone and texture, tanning, etc. Safety systems are also disclosed that ensure that a proper consumable substance and / or container is connected to a phototreatment device and / or directed to a proper target. Additionally, cooling systems and methods that utilize phase change materials for extracting heat from a light generating device are disclosed.

An automated skin lesion assessment system may automatically assess a suspect skin lesion. An electronic image library may contain diagnosed skin lesion image data representative of images of a plurality of diagnosed skin lesions and, for each, a diagnosis of the skin lesion. An image capture system may capture an image of the suspect skin lesion. A computer processing system may compare the image of the suspect skin lesion with the diagnosed skin lesion image data and, based on this comparison, identify one or more diagnosed skin lesions which match the suspect skin lesion. A user interface may report the diagnoses of the diagnosed skin lesions that match the image of the suspect skin lesion.

This invention relates to methods of treating early enamel lesions comprising applying an effective amount of a basic amino acid in free or salt form, together with fluoride to a patient in need thereof.

The present invention provides a composition for topical treatment of skin and mucosal membrane lesions comprising a synergistic combination of copper compound and hypericum perforatum extract.

The present invention provides methods, compositions and kits for storing red blood cells for extended periods of time. In particular, the present invention provides methods, compositions and kits for storing red blood cells for extended periods of time while preventing red blood cell storage lesions, retaining red blood cell deformability, and increasing survival of the red blood cells following transfusion.

Disclosed is a method for extracting dihydro quercetin from larch. The invention is an improved production method. Due to different production materials and extraction processes, the dihydro quercetin products in U.S. and European markets are very expensive, at a price of 200-1000 euros per gram. Such a high market price economically limits the wide range of practicability of dihydro quercetin products. During the pretreatment of raw materials, 50 kilograms of larch wood chips and 500-800 liters of 50% ethanol solution are added into a reactor to get fully stirred and mixed; then the mixture is extracted and filtered for the second extraction; the filtrates are combined and adsorbed; the organic solvents are collected and dried by a vacuum evaporator through organic phase vacuum distillation; according to a weight proportion of 10:1, the residues are dissolved with hot water, decolorized with activated carbon and then crystallized at a temperature of 3-5 DEG C to precipitate the dihydro quercetin product which is then crushed after vacuum drying to finished product. The invention is used to extract dihydro quercetin from larch.

A method for treating or preventing cardiovascular pathologies by administering a compound of the formula (I):wherein Z is C═O or a covalent bond; Y is H or O(C1–C4)alkyl, R1 and R2 are individually (C1–C4)alkyl or together with N are a saturated heterocyclic group, R3 is ethyl or chloroethyl, R4 is H or together with R3 is —CH2—CH2— or —S—, R5 is I, O(C1–C4)alkyl or H, and R6 is I, O(C1–C4)alkyl or H with the proviso that when R4, R5, and R6 are H, R3 is not ethyl; or a pharmaceutically acceptable salt thereof, effective to activate or stimulate production of TGF-beta to treat and / or prevent conditions such as atherosclerosis, thrombosis, myocardial infarction, and stroke is provided. Useful compounds include idoxifene and salts thereof. Further provided is a method for identifying a compound that is a TGF-beta activator or production stimulator is provided. Another embodiment of the invention is an assay or kit to determine TGF-beta in vitro. Also provided is a therapeutic method comprising inhibiting smooth muscle cell proliferation associated with procedural vascular trauma employing the administration of tamoxifen or structural analogs thereof, including compounds of formula (I).

Dosimeters 140 are housed in dosimeter housing pockets 130 of a dosimeter fitting wear including: wear main bodies 120, 150 which cover measuring positions on at least subject bodies 100, 102, and 110, and can be detachably fitted on the subject bodies, and the dosimeter housing pockets 130 provided at positions that come to the measuring positions when the wear main bodies are fitted on the subject bodies, and then the wear main bodies are fitted on the subject bodies. Thereby, a number of dosimeters can be easily fitted on or detached from the surfaces of subject bodies without hindering medical activities, and set positions of the dosimeters can be easily reproduced.

In an image-processing method for the detection of radiological signs in series of 3D data, an algorithm is used to detect radiological signs in a digital volume according to their contrasts. This algorithm is applied to reconstructed slices or directly to the series of projections. This algorithm is made by means of linear differential filters for signal analysis. It is used to color or enhance the intensity of the detected radiological signals according to the degree of malignancy.

Dosimeters 140 are housed in dosimeter housing pockets 130 of a dosimeter fitting wear including: wear main bodies 120, 150 which cover measuring positions on at least subject bodies 100, 102, and 110, and can be detachably fitted on the subject bodies, and the dosimeter housing pockets 130 provided at positions that come to the measuring positions when the wear main bodies are fitted on the subject bodies, and then the wear main bodies are fitted on the subject bodies. Thereby, a number of dosimeters can be easily fitted on or detached from the surfaces of subject bodies without hindering medical activities, and set positions of the dosimeters can be easily reproduced.

The present invention is an apparatus for learning and leading a user to have a posture according to a corresponding purpose at his / her foot, and can cure and improve a state of a target human body according to the corresponding purpose. The apparatus for curing a human body using a pressure under foot, is characterized in that a protrusion part and a sinking part are provided under the foot.

A method of inactivating viruses comprises contacting the virus with a virucidally effective amount of a composition consisting essentially of a C1 to C3 monohydroxy alcohol or a C2 to C4 diol and a sufficient amount of an acid to adjust the pH of the composition to below 4.6. Topical administration of the composition is preferred and is effective in treating lesions associated infections by viruses such as herpes simplex. Nasal deliverable forms are effective in treating symptoms due to viruses that cause the common cold. Pharmaceutical compositions for use in the present method are provided.

The invention relates to fig natural face-nourishing and weight-reducing cold herbal tea and a preparation method thereof, belonging to face-nourishing and weight-reducing cold herbal tea and a preparation method thereof. The cold herbal tea is prepared from fig, tea, Chinese dates, yam, vine roots, poria extract, hawthorn, alginate polysaccharide, soybean isoflavone, lotus leaf flavone, gypenosides, curcumin and white granulated sugar through the steps of crushing, extraction, preparation and the like. The cold herbal tea has the functions of beautifying the features, nourishing the face, reducing fat, losing weight, augmenting the breasts and getting sexy; and the cold herbal tea has the peculiar fruit tea taste of fig and is sour and sweet.

The invention provides a multi-layer network research method and application with cancer-related SNP, gene, miRNA and protein interaction and belongs to the technical field of cancer bioinformatics analysis. The method comprises steps that 1), significantly different SNP locus data between a cancer tissue sample and a normal tissue sample are screened; 2), the xgboost method is utilized to separately analyze the cancer tissue sample and the normal tissue sample to obtain significantly different gene expression data, miRNA data and protein data; 3), the significantly different SNP locus data, the gene expression data, the miRNA data and the protein data are respectively taken one layer, and the maximum information coefficient method MIC is utilized to analyze the relationship between the two; and 4), the SNP locus-gene expression data-miRNA data-protein data multi-layer network association relationship is obtained. The method is advantaged in that a tumor marker can be accurately analyzed.

Disclosed is a preparation method for extracting dihydro quercetin from larch. The invention is an improved production method. Due to different production materials and extraction processes, the dihydro quercetin products in U.S. and European markets are very expensive, at a price of 200-1000 euros per gram. Such a high market price economically limits the wide range of practicability of dihydro quercetin products. During the pretreatment of raw materials, 50 kilograms of larch wood chips and 500-800 liters of 50% ethanol solution are added into an extractor to get fully stirred and mixed; then the mixture is extracted and filtered for the second extraction; the filtrates are combined and adsorbed; the organic solvents are collected and dried by a vacuum evaporator through organic phase vacuum distillation; according to a weight proportion of 10:1, the residues are dissolved with hot water, decolorized with activated carbon and then crystallized at a temperature of 3-5 DEG C to precipitate the dihydro quercetin product which is then crushed after vacuum drying to finished product. The invention is used to extract dihydro quercetin from larch.

The present invention relates to agents for suppressing pulmonary emphysematous lesions and agents for suppressing emphysematous lesions which are suitable for treating and / or preventing COPD, which comprise as an active ingredient a substance having an activity of promoting CSPG degradation, inhibiting CSPG synthesis, or inhibiting CSPG sulfation (examples of such agents are: chondroitinase ABC, C6ST antisense agents, and GalNAc antisense agents); agents for treating and / or preventing COPD; methods for suppressing emphysematous lesions; and methods for treating and / or preventing COPD.

The invention relates to the field of fish feed, in particular to special feed formulation for giant salamanders. The special feed formulation is composed of, by weight, 20-30 parts of sorghum, 45-60 parts of meat meal, 1-3 parts of pollen, 2-3 parts of Radix Astragali, 0.05-0.1 part of Ganoderma, 4-6 parts of Rhizoma Dioscoreae, 10-15 parts of sweet potatoes, 5-10 parts of peeled soybean meal, 15-20 parts of egg yolk powder, 3-4 parts of complex vitamins, 1-2 parts of mineral substances, 0.03-0.04 part of aspartic acid, 0.04-0.06 part of glutamic acid, 0.02-0.03 part of lysine, 0.02-0.03 part of leucine, 0.01-0.02 part of tryptophan and 0.35-0.4 part of salt. The special feed formulation for the giant salamanders has the advantages that by scientific matching according to actual nutritional requirements of the giant salamanders, autoimmunity of the giant salamanders can be improved, morbidity of the giant salamanders is reduced, and growth cycle of the giant salamanders can be shortened.

The invention discloses a human anti-rabies virus neutralizing antibody as well as the preparation method and the application thereof. The heavy chain variable region and the light chain variable region of the antibody respectively have an amino acid sequence represented by sequence 2 and sequence 4 in a sequence list, and the heavy chain variable region and the light chain variable region of a modified body of the antibody irrespectively have an amino acid sequence represented by sequence 8 and sequence 10 in the sequence list. The antibody is prepared according to the following steps: firstly, preparing a CDR region, a variable region, IgG section or the whole genes of the antibody by molecular biology or other methods; expressing in prokaryotic cells such as Escherichia coli, eukaryotic cells such as yeast, insect cells, plant cells or mammal cells such as CHO; and purifying to obtain the antibody. The antibody has the advantages of high specific neutralization activity, high affinity and no toxic and side effects, suits prevention and emergency treatment of rabies as well as detection of rabies virus, and has excellent application prospect.

The present invention is generally directed toward therapeutic compositions for treating infections caused by Herpes Simplex Virus (“HSV”). The therapeutic compositions meet a long felt need in the art of providing a treatment for lesions that result from HSV that drastically reduce the duration of a cold sore when vesicles have already appeared and a treatment that will prevent the outbreak of a lesion and formation of vesicles when applied in the prodormal stage. The therapeutic compound comprises a mixture of Acyclovir (“ACV”), Penciclovir (“PCV”), and 2-Deoxy-D-Glucose (“2-DDG”). The therapeutic compositions of the present invention include multiple formulations of the three active ingredients and may also include inactive ingredients.

The invention discloses an antiviral small nucleic acid and the application of the small nucleic acid in preparing a medicine for suppressing herpes simplex virus (HSV) and human papilloma virus (HPV). The small nucleic acid is a double strand nucleic acid, the positive-sense strand sequence is 5 in a sequence table, and the antisense strand sequence is 6 in the sequence table; the small nucleic acid can be prepared into a temperature-sensitive type gel preparation; the temperature-sensitive type gel preparation is injected (or sprayed) into irregular cavities such as vagina or mouth, the expression of host B2M genes in epithelial cells at the cavities and the cervix uteri and the expression of externalHPV E7 are suppressed, so that the antiviral small nucleic acid can be used for suppressing the infection of the HPV of the HSV-1 virus and / or for treating the precancerous lesions of uterine cervix caused by the HVP.

The invention discloses notoginseng extract and application thereof. In the notoginseng extract, the mass ratio of total flavone matters to total saponin matters is 2-5:1. Tests show that the notoginseng extract has little cytotoxicity, can effectively inhibit pathological changes caused by human cytomegalovirus and has a similar effect as ganciclovir; moreover, the notoginseng extract has a quite effect of preventing and treating cytomegalovirus infection during pregnancy, and can be used as an active component for novel anti-cytomegalovirus medicaments.

The invention uses the gene synthesis technology to obtain the duck alpha interferon gene and carry out pronucleus expression on interferon protein, belonging to the field of biological pharmacy. The invention comprises the following steps: carrying out codon reformation to the duck alpha interferon gene sequence, and combining the sequence by genes, building the pronucleus expression carrier containing the duck alpha interferon gene; converting escherichia coli by the pronucleus expression carrier containing the duck alpha interferon gene, carrying out induction expression, extracting protein, carrying out denaturation and renaturation, and researching antiviral activity. The interferon obtained by the test can resist the attack of vesicular disease viruses, and the specific activity reaches 5.6*103U / mg. The interferon produced by the method has simple technology, high expression amount and high bioactivity.

A system of application for an intra-oral medication characterized by An applicating cannula having a suitable angle in order to reach any place with lesion in the mouth, and a container having a gel with adequate bioadhesive drainage to be inserted in periodontal pockets and mucosa folds that is screwed to the cannula. The composition of the gel consisit of chlorhexidine digluconate alone and together with other active principles such as a bisphosphonate, an analgesic or anesthetic substance, antibiotic, antimycotic, an antiviral, steroidal or non-steroidal anti-inflammatory, a coagulant substance or one aimed to modulate local hemosthasis, a cicatrizing substance, among the most outstanding.

The invention relates to preparation and application of an anti-Coxsackie virus A16 (CA16) monoclonal antibody. The invention reveals a mouse source anti-CA16 monoclonal antibody, which has good binding specificity, can be used for sensitive detection of Coxsackie A16 virus, and has strong anti-virus infection capacity.