28 results about "Fluorescence endoscopy" patented technology

The utility model relates to a 4K fluorescent endoscope optical system, which comprises an objective lens system, a relay lens system and an eyepiece system which are sequentially arranged along the light propagation direction, and is characterized in that the objective lens system is of a reverse long-distance structure; the system comprises a sapphire protection lens, a negative focal power lens, a prism or a steering prism, a positive focal power plano-convex cemented lens, a positive focal power triple cemented lens and a first positive focal power double cemented lens which are arranged along a light propagation direction, the relay lens system comprises n relay lens groups, and each relay lens group is of a double telecentric structure. And the eyepiece system is arranged in the light transmission direction and is formed by symmetrically arranging two doublet rod lenses, n is an odd number, the eyepiece system is of an object space telecentric structure, and the eyepiece system comprises a second positive-focal-power doublet lens, a positive-focal-power lens and a sapphire lens which are glued into a whole in the light transmission direction. The structure of an optical system can be simplified, production and processing cost can be reduced, and 4K ultra-high-definition fluorescent laparoscopic imaging can be realized at the same time.

The present invention relates to a fluorescence endoscope system, including a light source module, a camera module, a main control module, and a display module. The light source module is configured to emit an illumination beam, the camera module includes an endoscope configured to propagate the illumination beam and its reflected beam, and an operation unit configured to collect the reflected beam and convert the collected reflected beam into video data therefrom. The main control module includes a control unit configured to drive the light source module to emit a first illumination beam or a second illumination beam, and an image processing unit configured to process the video data frame by frame. The display module is configured to play the video data. The present invention can provide at least two operation modes including a white light mode and a fluorescence mode, and a first button of the operation unit can switch between the white light mode and the fluorescence mode, and has the advantage that the fluorescence imaging can provide a fluorescence image of tissue below the tissue surface, and can visualize and accurately identify lesions that are difficult to observe or early lesions, thereby improving the safety of surgery.

The utility model relates to a device for testing the imaging performance of a fluorescent endoscope, which comprises a mounting frame, and a clamp assembly, a container placing disc and an integrating sphere which are sequentially distributed on the mounting frame from top to bottom, and a lighting device arranged on one side of the integrating sphere, and exciting light of the lighting device illuminates the container placing disc through the integrating sphere. The container placing disc is provided with observation holes which are distributed in a circumferential mode, the clamp assembly comprises a double-screw clamp used for fixing the fluorescent endoscope and an adjusting frame used for adjusting the irradiation angle of the fluorescent endoscope, and the main purpose of the utility model is to enable a light source in the container placing disc to be more uniform through the reflection effect of an integrating sphere; according to the fluorescent endoscope, the sensitivity and definition of the fluorescent endoscope are improved, three important indexes including the radiance response characteristic, the fluorescent signal-to-noise ratio and the fluorescent static image latitude of the fluorescent endoscope are analyzed through real-time data of a fluorescent image collected by the fluorescent endoscope, and important parameters are provided for judging the imaging performance of the fluorescent endoscope.

The present disclosure relates to a fluorescence endoscope system. The fluorescence endoscope system comprises a light source module, a camera module, a main control module and a display module. The light source module is configured to emit illumination beams. The camera module comprises an endoscope and an operation portion. The endoscope is configured to propagate the illumination beams and reflected beams thereof. The operation portion is configured to receive the reflected beams and convert the reflected beams into video data. The main control module comprises a control unit and an image processing unit. The control unit is configured to control the light source module to emit a first illumination beam or a second illumination beam. The image processing unit is configured to process the video data frame by frame. The display module is configured to play the video data. The present disclosure can provide a white-light mode and a fluorescence mode, and switch between the white-light mode and the fluorescence mode by a first button on an operation portion. A fluorescence image of a tissue under a tissue surface is provided by means of fluorescence imaging, such that inconspicuous lesions and early lesions can be visually and precisely identified, thereby improving the safety of surgery.

The invention relates to the technical field of medical image processing, in particular to an image processing system for a fluorescent endoscope, the system comprises a control layer, an equipment layer and a database layer, the equipment layer comprises a camera group, a display and an illumination light source, the camera group is used for collecting visible light images and fluorescent light images, and the display is used for displaying the visible light images and the fluorescent light images; the illumination light source comprises a white light source, a fluorescence excitation light source and a light splitting filtering assembly, the database layer is used for storing data collected by the system, the control layer comprises a CPU, an image processing module, a calculation module and an image output module, the CPU is used for managing and controlling operation of the system, and the image output module is used for outputting the image. The image processing module is used for fusing the visible light image and the fluorescence image to generate a visible light fusion image which only emits fluorescence by the diseased tissue; and the image output module is used for connecting the host with a display to output the visible light fusion image which only emits fluorescence by the diseased tissue in real time.

An imaging device 52 comprises: a color separation optical element 521 for separating incident light into three light beams, specifically light L1 in a first wavelength band including a wavelength band of first fluorescence which is emitted from a first fluorescent reagent and in which the peak wavelength of fluorescence emission is 700-800 nm, light L2 in a second wavelength band including a wavelength band of second fluorescence which is emitted from a second fluorescent reagent and in which the peak wavelength of fluorescence emission is on the longer-wavelength side of the peak wavelength of the first fluorescence, and light L3 in a third wavelength band including a portion of the wavelength band of visible light; a first imaging element 522 for imaging the light L1 in the first wavelength band; a second imaging element 523 for imaging the light L2 in the second wavelength band; and a third imaging element 524 for imaging the light L3 in the third wavelength band.

The utility model discloses an anti-drop dual-fluorescence endoscope plug-in structure, which comprises an endoscope body, a first wiring port and a second wiring port are respectively arranged on the endoscope body, and a first optical fiber cable and a second optical fiber cable are respectively connected onto the first wiring port and the second wiring port. One end of the first optical fiber cable and one end of the second optical fiber cable are respectively provided with a connector, one end of the endoscope body is fixedly connected with a mounting seat, an endoscope tube is mounted on the mounting seat, a light guide hole is formed in the tail end of the endoscope tube, and a camera is mounted at the tail end of the endoscope tube. According to the utility model, through the modular design, each functional part can be disassembled according to needs so as to facilitate maintenance and replacement, the wire body can be effectively fixed after being plugged so as to prevent falling off, the wire body can be disassembled and assembled without any need, and the difficulty of part maintenance and replacement is reduced.

The invention discloses an automatic exposure method of a fluorescent endoscope for an endoscope shooting object based on deep reinforcement learning and a self-group iteration upgrading device. Comprising the following steps: establishing an information acquisition device of the fluorescent endoscope camera system; dividing an observation area; collecting fluorescence image data as the state of the reinforcement learning environment, and inputting the fluorescence image data into an intelligent agent to obtain the exposure time of a fluorescence image; the fluorescence image of each spectral band is collected again, and the observation area is divided again; and collecting visible light image data as the state of the reinforcement learning environment, inputting the visible light image data into the intelligent agent to obtain the exposure time of the visible light image, and achieving automatic image exposure processing based on the fluorescent object. The system is suitable for narrow space imaging under the endoscope, and a good multi-spectral endoscope automatic exposure imaging result can be obtained. According to the self-group iteration upgrading device, model training iteration upgrading can be carried out in multiple modes, and the performance of the device is continuously improved.

A processor 9 constituting a fluorescent endoscopic apparatus 1 alternately turns on first and second laser diodes 321, 322, detects differences in brightness level between pixels of a first captured image obtained by capturing one of first and second fluorescent lights with an imaging element 523 at a timing when the first laser diode 321 is turned on and the corresponding pixels of a second captured image obtained by capturing the one fluorescent light with the imaging element 523 at a timing when the second laser diode 322 is turned on, and determines, on the basis of the differences, a region where the one fluorescent light has been emitted.

The invention relates to the field of medical instruments, and discloses a fluorescence exposure compensation method, system and device for a 3D fluorescence endoscope camera system, and the method comprises the following steps: S1, parameter calibration: before a 3D fluorescence endoscope operation is carried out, calibration of key parameters of the system needs to be completed, and an accurate reference basis is provided for real-time fluorescence exposure compensation in the operation; s2, fluorescent camera exposure parameter estimation: in the 3D fluorescent endoscopic surgery process, estimating and adjusting the fluorescent camera exposure parameters in real time based on the parameters calibrated in S1, so as to realize stable fluorescent exposure. According to the method, the relation curve of the shooting distance and the parallax is established through preoperative dual-target calibration, the parallax image is estimated based on the binocular visible light image and the weighted average parallax value is calculated in the operation, and compared with an existing distance estimation mode based on white light exposure parameters and brightness, the estimation precision of the shooting distance is greatly improved, and the accuracy of shooting distance estimation is improved. And an accurate distance basis is provided for fluorescence exposure compensation.

The utility model discloses a 4K fluorescent 3D endoscope for minimally invasive surgery navigation. The 4K fluorescent 3D endoscope comprises a camera; one end of the signal line is connected with the camera; the signal transmission device comprises a first signal connector, the other end of the signal line is detachably connected with the first signal connector, an insertion column is arranged at the end, close to the first signal connector, of the signal transmission device, and a first groove is formed in the top of the insertion column; the limiting assembly comprises a limiting sleeve and an elastic buckle, the limiting sleeve is arranged on the outer side of the insertion column in a sleeving mode, a through hole is formed in the position, corresponding to the first groove, of the limiting sleeve, and the elastic buckle is arranged on the inner wall of the limiting sleeve; when the signal line is inserted into an insertion column in the signal transmission device, the elastic buckle is extruded by the insertion column, the elastic buckle shrinks towards the interior of the limiting sleeve, meanwhile, elastic deformation is generated, and automatic locking connection of the signal line and the signal transmission device is achieved.

Devices, kits, and methods for in vivo imaging, such as fluorescent imaging, are provided. Specifically, fluorescent endoscopy accessory devices may be utilized with any prior endoscopy equipment to allow fluorescent imaging of tissue properties (e.g. tissue autofluorescence) or applied fluorescent molecular probes or tracers. Various kits incorporating one or more fluorescent endoscopy accessory devices as well as other endoscopy-related tools, products, or materials is further detailed. Also disclosed are methods of using the fluorescent endoscopy accessory devices and kits.

A fluorescence endoscope device (1) comprises: a WLI light source (31) that emits WLI light; excitation light sources (32, 33) that emit excitation light for exciting a fluorescent reagent; a first imaging element (522) that images return light, which is the WLI light from an object being observed; a second imaging element (523) that images fluorescence emitted from the fluorescent reagent contained in the object being observed; and a processor (93). The processor (93) can switch between a superimposed fluorescence mode for outputting a superimposed image in which a fluorescence image obtained through imaging by the second imaging element (523) is superimposed on a WLI light image obtained through imaging by the first imaging element (522), and a single fluorescence mode for only outputting the fluorescence image. The processor (93) sets the amount of WLI light that is emitted by the WLI light source (31) for each exposure time per frame in the second imaging element (523) to be smaller in the single fluorescence mode than in the superimposed fluorescence mode.

The invention provides a compensation method for fluorescence signal uniformity in a fluorescence endoscope system deployed to an FPGA (Field Programmable Gate Array) based on deep reinforcement learning and a self-group iteration upgrading device. The compensation method comprises the following steps: dividing an imaging visual field of a fluorescence camera into a plurality of rectangular areas with the same size; a fluorescent contrast agent with a certain concentration is selected and placed in the center of each rectangular area successively, and images are collected; respectively calculating an average gray value in each rectangular region; and constructing and training a gray scale compensation multi-agent of the fluorescence imaging system by using a PPO algorithm, wherein the gray scale compensation agent outputs a compensation value of each pixel for performing compensation transformation on a gray scale value of the acquired fluorescence image. According to the method, the trouble caused by unreasonable change of the gray value of the fluorescence image in the operation process can be solved, and the defects which are difficult to solve in the hardware structure are overcome from the perspective of a software algorithm. According to the self-group iteration upgrading device, model training iteration upgrading can be carried out in multiple modes, and the performance of the device is continuously improved.

The utility model relates to an objective optical system of a 4K fluorescent endoscope, which is characterized in that the objective optical system is integrally of a reverse long-distance structure and comprises a sapphire protection lens, a negative-focal-power lens, a prism or a steering prism, a positive-focal-power plano-convex cemented lens, a positive-focal-power triple cemented lens and a positive-focal-power doublet lens which are arranged along the light propagation direction, the plane or convex surface on one side of the negative-focal-power lens is positioned on one side of the sapphire protection lens, and the concave surface on the other side of the negative-focal-power lens and the two sides of the prism or the steering prism are respectively glued with the other side of the negative-focal-power lens and the plane of the positive-focal-power plano-convex glued lens; the convex surface of the positive-focal-power plano-convex cemented lens is located on one side of the convex surface of the positive-focal-power triple cemented lens, and the plane of the positive-focal-power triple cemented lens is located on one side of the convex surface of the positive-focal-power double cemented lens. According to the utility model, the field curvature, the vertical axis chromatic aberration and the distortion of the whole endoscope system are well corrected, the stray light is reduced, and the objective lens requirement of the 4K-resolution fluorescent laparoscope can be met.

The invention relates to a fluorescent endoscope imaging device and method, and belongs to the technical field of image processing. The device comprises a pneumoperitoneum machine, a fluorescent cold light source, a fluorescent mirror, a fluorescent camera, a fluorescent camera cable, a camera host, a signal connecting line and a rear end device, a man-machine interaction module, a fluorescence excitation module, an optical imaging module, a data acquisition module, a GPU image processing module, a white light processing module, a fluorescence processing module, an ISP image processing module, a segmentation module, a registration module, a fusion module, a storage management module, a display output module and the like are adopted. Low-delay and high-pixel transmission is met, image information is completely reserved, a host can better complete image processing, and the final image quality is guaranteed; the problems of module temperature rise, component damage, influence on imaging quality and the like caused by image processing at the fluorescent camera lens module end are solved. The method can be applied to the field of fluorescent endoscope images.

The present invention belongs to the technical field of fluorescent materials and relates to a fluorescence-based color calibration card. The fluorescence-based color calibration card includes a shell portion and a fluorescent material module portion; the fluorescent material module portion is liquid or colloid; the fluorescent material module portion includes a fluorescent dye and a solvent; or, the fluorescent material module portion includes a fluorescent dye, a solvent, and a thermogel substance; the shell portion includes: a substrate and a cover plate, a filling groove is provided on the surface of the substrate, and the cover plate covers the opening of the filling groove to confine the fluorescent material module portion within the filling groove. The fluorescence-based color calibration card provided by the present invention can be used for parameter correction of fluorescent endoscope equipment, judgment of the operating status of fluorescent endoscope equipment, and auxiliary adjustment of the operating status of fluorescent endoscope equipment under different fluorescence modes, making up for the defect that the current fluorescent endoscope lacks a matching color calibration card.

The invention relates to a flexible three-dimensional wide-spectrum endoscopic imaging detection system and an imaging method thereof, and the imaging detection system comprises a flexible imaging detection unit which is used for collecting a visible light image and a near-infrared fluorescence image of a detected part; a light source; the three-dimensional image processing unit is used for processing the visible light image and the near-infrared fluorescence image so as to realize a three-dimensional wide-spectrum image, and the image processing unit has a function of realizing white light multi-source image fusion based on feature recognition; the multi-source image fusion function can fuse the visible light image and the near-infrared fluorescence image into an image with multi-source information in real time. The three-dimensional wide-spectrum (400-2500nm) imaging, including in-vivo focus three-dimensional white light imaging and three-dimensional fluorescent endoscopy, can be realized, and the three-dimensional imaging effect is good.

The utility model discloses a device for detecting the optical performance of a 3D (three-dimensional) fluorescent endoscope, relates to the technical field of detection of the optical performance of the endoscope, and solves the problems that in the conventional device, the height of the endoscope cannot be accurately adjusted according to detection requirements due to the fact that a base for mounting the endoscope does not have an adjusting function, so that the application range of the endoscope is limited; and the detection process is difficult to adapt to diversified requirements. Comprising a mounting base, a group of stop blocks arranged on the mounting base and a mounting bin connected in the stop blocks; wherein an inner cavity is formed in the mounting base, an assembling base plate is arranged in the mounting bin, the middle of the assembling base plate protrudes upwards, and a positioning threaded column is arranged on the outer wall of the protrusion; the device further comprises a fine adjustment assembly. By means of the design, the requirement for adjusting the height of the endoscope under different detection requirements can be met, the endoscope can be prevented from deviating in the detection process, and therefore the accuracy of the detection result is improved.

The application relates to a fluorescent image processing method and a fluorescent endoscope system. In a fluorescent mode, a detected object marked by a fluorescent agent is illuminated based on detection light, the detection light comprising white light and excitation light emitted in a set light emission mode; light signals from the detected object are collected based on a collection mode corresponding to the light emission mode, a first image is obtained based on first waveband light signals, and a second image is obtained based on second waveband light signals; the first waveband is set based on a spectral range of fluorescent light excited by the excitation light, and the second waveband is set based on a spectral range of the white light; the first image and the second image are fused to obtain a fluorescent detection image of the detected object, thereby solving the problem of unclear imaging of a fluorescent marking peripheral region and improving overall imaging effect.

This invention relates to a focal plane consistency coefficient testing device for a fluorescence endoscopy system. It includes a fixed plate, a worktable mounted on the fixed plate, and a transmission light box. An endoscope with a camera is mounted on the worktable via a connector. The camera is secured to the endoscope with a clip. A focusing knob is provided on the camera for adjusting image sharpness. The endoscope is positioned directly opposite the transmission light box, and a test card is mounted above the transmission light box. This invention provides a focal plane consistency coefficient testing device for a fluorescence endoscopy system, which boasts advantages such as simple and reasonable structure, practicality, and convenience.

The invention discloses an automatic exposure method for an endoscope shooting object by combining software and hardware with a fluorescent endoscope and a self-iteration upgrading device. The method mainly comprises the following steps: constructing an information acquisition device of the fluorescent endoscope camera system; collecting fluorescence image data as the state of the reinforcement learning environment, inputting the fluorescence image data into a deep noise reduction convolutional neural network, and then inputting the fluorescence image data into an intelligent agent to obtain the exposure time of a fluorescence image; the fluorescence image of each spectral band is collected again, and the observation area is divided again; and collecting visible light image data as the state of the reinforcement learning environment, inputting the visible light image data into the deep noise reduction convolutional neural network, and then inputting the visible light image data into the intelligent agent to obtain the exposure time of the visible light image so as to achieve automatic image exposure processing based on the fluorescent object. The system is suitable for a narrow space under the endoscope, and a good multi-spectral endoscope automatic exposure imaging result can be obtained.

A fluorescent endoscopic device 1 comprises: a first light source 31 that emits ordinary light; a second light source 32 that emits first excitation light for exciting a first fluorescent reagent; a third light source 33 that emits second excitation light for exciting a second fluorescent reagent; a color separation optical element that separates, from first fluorescence emitted from the first fluorescent reagent, second fluorescence emitted from the second fluorescent reagent and reflected light of ordinary light from an object being observed; first and second imaging elements 522, 523; and a processor 9. The processor 9 turns on the second and third light sources 32, 33 alternately. At the timing at which the third light source 33 is turned on, the processor 9 uses, as a display image, a first captured image which is obtained by causing the first imaging element 522 to capture the second fluorescence and the reflected light of the ordinary light. At the timing at which the second light source 32 is turned on, the processor 9 uses, as the display image, a second captured image which is obtained by causing the second imaging element 523 to capture the first fluorescence.

This application relates to the field of imaging technology and provides a high-definition fluorescence endoscopic imaging system. Through the close collaboration and organic integration of a composite light source module, an optical imaging module, an image processing module, and a control feedback module, the imaging system can acquire high-resolution, high-contrast, color-accurate, and detail-rich images in various complex scenarios, providing doctors with clearer and more accurate tissue information, which helps in the early detection and accurate diagnosis of diseases. The information interaction and collaborative control between the various modules of the imaging system realizes the intelligent and automated process from light source excitation, image acquisition, processing to feedback control. The intelligent processing of the imaging system also reduces the impact of human factors on the imaging results and improves the consistency and repeatability of imaging.

The present invention belongs to the technical field of fluorescent materials, and relates to a fluorescent color calibration card for endoscopes, and its preparation method and application. The fluorescent color calibration card for endoscopes includes a color-developing sheet, and the color-developing sheet includes a fluorescent dye, an adsorption material, and a substrate. The preparation method of the color-developing sheet includes the following steps: uniformly mixing the adsorption material with water or an aqueous solution containing an adhesive, then pouring it on a substrate, smoothing it, drying it, and cutting it to a suitable size to form an adsorption sheet; immersing the adsorption sheet in a fluorescent dye solution, taking it out and drying it to obtain a color-developing sheet. The fluorescent color calibration card for endoscopes provided by the present invention can be used for parameter calibration of fluorescent endoscope equipment, judgment of the operating status of fluorescent endoscope equipment, and auxiliary adjustment of the operating status of fluorescent endoscope equipment under different fluorescent modes, which makes up for the defect that the current fluorescent endoscope lacks a matching color calibration card.

The invention discloses an endoscope system based on frequency domain fluorescence lifetime imaging, which is characterized in that an ICG fluorescent agent in tissues is excited by setting a dual-frequency demodulation excitation signal, so that the problem that deviation is easy to occur in fluorescence lifetime calculation if a single-frequency signal is interfered can be solved. A double-frequency modulation mode is adopted, different adjustment frequencies can be set according to sensitivity differences of ICGs in different states, the problem that signals are submerged or analysis resolution is insufficient is avoided, independent life parameters in a free state and a combined state can be directly separated from double-frequency signals through a CNN deep learning model, false images and edge blur are eliminated, and the accuracy of the ICGs in different states is improved. Accurate data are provided for clinical molecular level diagnosis, and the problem that a traditional fluorescent endoscope only depends on fluorescence intensity and is easily interfered by factors such as ICG concentration and uneven illumination is solved.

The invention discloses a self-adaptive dimming fluorescent endoscope system, and particularly relates to the field of fluorescent endoscopes, which comprises an imaging module, a light source module, a self-adaptive dimming control module, a comprehensive evaluation module and a dynamic adjustment module, the imaging module is used for converting the tissue optical signal into an analyzable digital signal and capturing an ambient light interference factor; the light source module is used for providing an adaptive illumination basis for imaging by accurately regulating and controlling the intensity, spectrum and uniformity of light; the adaptive dimming control module generates a precise dimming strategy based on the multi-source data; the comprehensive evaluation module is used for ensuring that the imaging quality meets the clinical diagnosis requirement through multi-dimensional quantitative analysis; and the dynamic adjustment module is used for realizing dimming through accurate correction. According to the invention, the imaging precision in a complex tissue environment is remarkably improved, the light intensity deviation is detected in real time, the adjustment mode is switched for correction, the output stability is ensured, and the adaptation capability in a complex clinical scene is continuously improved.