17results about How to "Reduce background noise" patented technology

A sample collection system includes a housing including an air inlet configured to receive an exhaled airflow; a porous sample collection medium disposed within the housing, the porous sample collection medium comprising a sample receiving region; an airflow passage extending from the air inlet through the sample receiving region of the porous sample collection medium; an assay device configured to receive the eluted sample from the porous sample collection medium; and a liquid flow passage extending from the sample receiving region of the porous sample collection medium to the assay device. The porous sample collection medium includes one or more reagents disposed on the porous sample collection medium along a liquid flow path.

This invention provides a split-type cold screen for an infrared detector and its assembly method. The split-type cold screen for the infrared detector includes a cold screen body and matte fins. The assembly method includes: applying a black coating to both the cold screen body and the matte fins, pre-baking them, then initially assembling the pre-baked cold screen body and the matte fins, and finally baking the pre-assembled cold screen to complete the assembly. This invention places the cold screen assembly step after pre-baking and before baking, using the bonding force of the black coating to connect the cold screen body and the matte fins. This eliminates the adhesive bonding step in the split-type cold screen assembly process, solving the problem of using adhesives to bond the cold screen body and matte fins in the split-type cold screen assembly process. This ensures good mechanical reliability of the cold screen assembly in low-temperature vibration environments and also improves the performance of the detector components and the efficiency of the cold screen assembly process.

The invention provides a method for detecting perfluorinated and polyfluorinated alkyl substances in human early pregnancy villus tissues and application, and relates to the technical field of biological detection.The method comprises the following steps that a sample is obtained, digestive juice, a process monitoring standard solution and an internal standard mixed solution are added into the sample, then zirconium oxide grinding beads and methyl alcohol are sequentially added, homogenate, ultrasonic treatment and centrifugation are conducted, and the content of perfluorinated and polyfluorinated alkyl substances in the human early pregnancy villus tissues is obtained; sediment and supernate are obtained, and the supernate is collected; adding methanol into the sediment again, carrying out homogenization, ultrasonic treatment and centrifugation again to obtain supernate, and mixing the supernate obtained in the two steps to obtain an extracting solution; diluting the extracting solution, and carrying out WAX solid-phase extraction; and performing quantitative detection on the perfluoro and polyfluoroalkyl substances in the liquid to be detected in a multi-reaction monitoring mode by adopting a high performance liquid chromatography-tandem mass spectrometry method. The method can realize detection of human early pregnancy villus tissues, and has high sensitivity, high selectivity, high accuracy and strong anti-interference capability.

A microphone noise reduction circuit and a conference microphone are disclosed. The noise reduction circuit includes a decoding unit, a DSP unit, and a microphone array. The output terminal of the decoding unit is connected to a first terminal of the DSP unit, and the microphone array is connected to a second terminal of the DSP unit. The microphone array is used to collect audio data, the DSP unit is used to reduce noise in the audio data and output the noise-reduced audio signal, and the decoding unit is used to decode or encode the noise-reduced call audio signal. This embodiment of the invention, by combining a microphone array, a DSP unit, and a decoding unit, effectively reduces background noise and echo interference, improves the clarity and recognition accuracy of the audio signal, and significantly improves the audio processing quality.

The invention discloses a preparation method and application of an electrochemical biosensor based on a self-protection palindromic DNA (deoxyribonucleic acid) nanosphere. The electrochemical biosensor comprises an HP-trigger, a target miRNA (micro ribonucleic acid) and a self-protection DNA palindromic nanosphere core structure. The DNA nanosphere is of a three-dimensional spherical structure formed by four single-stranded DNAs through complementary base pairing, the three single strands of SEP-Sa, SEP-Sb and SEP-Sc contain 12 nt palindromic cohesive ends and 15 nt single-stranded arms, the single strand of HP-Sc contains 35 nt prolonged hairpin structures, the structural stability is enhanced through a self-protection mechanism of a palindromic sequence, and structural dissociation triggered by target miRNA is achieved. The target miRNA is combined with an HP-Sc hairpin structure to trigger conformational change, release complementary chains and dissociate palindromic nanospheres, and exposed DNA sites are combined with MB to generate electrochemical signals, so that a novel tool is provided for early diagnosis of tumors.

The invention relates to a training method, an audio-visual segmentation method, an electronic device and a storage medium, and the method comprises the steps: obtaining a training sample which comprises an audio signal, an image, a target semantic tag and a segmentation tag; extracting audio features and image features, and performing self-attention enhancement on the audio features based on the target semantic tag to apply target semantic consistency constraint to obtain enhanced audio features; performing cross attention reweighting on the unenhanced audio features based on the guidance of the enhanced audio features to obtain target pointing audio features; bidirectional interactive fusion is executed based on the image features and the target pointing audio features, and a sparse self-attention network is adopted in the image feature fusion process to suppress unmatched image region response; generating a segmentation prediction result based on the fused image features and audio features, and training to obtain an audiovisual segmentation model; and inputting a to-be-processed video into the trained audio-visual segmentation model, and outputting a segmentation result. The image segmentation accuracy of the sounding target can be improved.

The application discloses a probe and a method for detecting micro residual lesions. The probe for detecting micro residual lesions is a four-layer encrypted imbricated hybrid capture probe, wherein two layers of probes are wild-type probes, and two layers are mutant probes. The nucleic acid sequence of the wild-type probe comprises the sequence described in SEQ ID NO. 1-SEQ ID NO. 74, and the nucleic acid sequence of the mutant probe comprises the sequence described in SEQ ID NO. 75-SEQ ID NO. 149. The four-layer encrypted imbricated hybrid capture probe for detecting micro residual lesions is designed, a micro residual lesion molecular detection method with high sensitivity and good specificity is provided, the low-frequency mutation capture efficiency is high, and the detection limit of the ct DNA mutation frequency containing micro residual lesions can be as low as 0.005%.

This invention discloses a probe for detecting Ox-LDL and its applications, belonging to the field of Ox-LDL detection technology. This invention provides a variety of probe molecules that can specifically and sensitively recognize Ox-LDL and effectively distinguish between high-density lipoprotein (HDL), low-density lipoprotein (LDL), and Ox-LDL. The probe exhibits significantly enhanced fluorescence in the presence of Ox-LDL, while showing almost no fluorescence in pure PBS solution, with low background noise. The probe of this invention is a molecular probe, simple to prepare, stable, easy to store and detect, and can be used as a reagent for detecting Ox-LDL in peripheral blood, cells, and tissues, a lipoprotein identification reagent, an early diagnostic reagent for atherosclerosis, and an early diagnostic reagent for fatty liver.

The invention relates to the technical field of meteorological ecological observation, biological safety detection, environment monitoring and the like, and discloses a biological aerosol automatic identification system and method based on ultraviolet fluorescence imaging, and the system comprises an environment control module, an aerosol sampling module, an adhesive tape transmission module, an ultraviolet microscopic imaging module and a control and data processing module. The environment control module is used for constructing a constant-temperature closed optical darkroom; the aerosol sampling module captures biological particles in the air on the surface of a carrier adhesive tape by utilizing an acceleration nozzle and an inertial impact principle; the adhesive tape transmission module realizes automatic transfer of a sample from a sampling position to a detection position through stepping control; the ultraviolet microscopic imaging module adopts a coaxial incident light path structure and is matched with a dichroic spectroscope and an optical filter to separate exciting light and fluorescence signals. According to the invention, full-process automatic in-situ monitoring of the biological aerosol is realized, the problem of background interference is effectively solved, and the real-time performance of detection and the recognition accuracy are improved.

The present application relates to a kind of adaptive multi-angle variable light field's surface defect detection composite light source system, belong to surface defect optical detection technical field, including imaging unit, composite lighting structure and control module;Composite lighting structure contains coaxial integrated annular bright field illumination component and circumferential discrete independent controllable dark field illumination unit, dark field unit has incident angle adjustment capability, can form multiple illumination modes;Control module is through calculating the actual incidence angle of curved surface, defect contrast and other parameters Adaptive selection optimal illumination scheme, realize the integration process of dark field preliminary examination and bright field precision measurement;The present application significantly improves the detection stability and detection efficiency of the microdefect of curved surface, can adapt to the detection needs of different curvature, different direction defects.

The invention belongs to the technical field of power equipment state monitoring and artificial intelligence, and particularly relates to a transformer fault diagnosis method and device based on an interpretable technology, equipment and a medium. According to the dynamic integral gradient algorithm provided by the invention, the baseline for removing the key features is dynamically generated for each sample, and the gradient weight is dynamically adjusted, so that an explanation result with relatively high fidelity can be obtained under the condition of relatively low gradient calculation times. Therefore, a visual fault diagnosis basis is provided for operation and maintenance personnel, the opaque problem caused by the black box model can be relieved, the interpretation efficiency is improved, and the real-time requirement of an online monitoring system is better met. And a cascade architecture combining lightweight shunting with expert diagnosis is designed. The first-level expert model quickly processes a large number of normal samples and performs preliminary classification at a low calculation cost, and the second-level expert model focuses on fine diagnosis of a specific frequency band, thereby being beneficial to realizing high-precision and low-delay balance and adapting to edge deployment.

The invention discloses an RNA m6A modification detection method with a high signal-to-noise ratio, and belongs to the field of molecular detection in biotechnology. In order to solve the problem that the non-specific background is too high due to the fact that editors widely exist in cytoplasm in existing base editing technologies such as DART-seq, fusion protein containing APOBEC1 deaminase, a YTH structural domain and a nuclear localization signal is constructed, and the editors which are not combined with a target are limited in a cell nucleus through NLS, so that the editors are spatially isolated from mature mRNA in the cytoplasm. Experimental verification shows that compared with the prior art, the design can reduce non-specific background editing in cytoplasm by about 50% while maintaining or improving single base resolution editing of the m6A target site, and the detection signal-to-noise ratio is remarkably improved. The method does not need antibody dependence, is simple and convenient to operate, and provides a more reliable and efficient detection tool for RNA epigenetic modification research.

The invention discloses a method for improving MALDI-TOF MS (Matrix-Assisted Laser Desorption / Ionization Time-of-Flight Mass Spectrometry) microbial identification capability. Microorganisms comprise bacteria, the method comprises sample pretreatment and mass spectrometry, the sample pretreatment comprises in-situ enzymolysis, and an in-situ enzymolysis system comprises a bacterial wall breaking reagent composed of acetonitrile and deionized water and a protein enzymolysis reagent composed of trypsin and deionized water; the sample pretreatment comprises targeted enrichment, and a targeted enrichment system comprises N-methyl-5-fluoroindole-2-formamide, 2, 2 '-disulfide bis (5-nitropyridine) and an acetonitrile aqueous solution; a linear positive ion mode is adopted for mass spectrometry, effective mass spectrum peaks with the signal-to-noise ratio larger than 1.5, the half-peak width larger than 5 and the relative intensity larger than 8% are screened, and the similarity is calculated according to the intensity weighted Euclidean distance; according to the method, the mass spectrum peak resolution can be remarkably improved, the distinction degree of related strains is improved, background noise is reduced, and the identification bottleneck in the prior art is solved.

A method, apparatus, electronic device, and computer-readable storage medium for detecting anomalies in power line inspection images are disclosed. The method includes: acquiring a power line inspection image; identifying and segmenting the power line inspection image based on the type of equipment to be inspected to obtain a target inspection image; performing multi-scale decomposition and extraction on the target inspection image to obtain scale features; mapping the target inspection image based on the scale features to determine a target detection region image; enhancing the target detection region image to obtain an enhanced image; and comparing and analyzing the enhanced image with a normal image at the target detection region image to obtain an anomaly detection result. The method and apparatus provided by this invention enable accurate anomaly detection in power line inspection images.

This application discloses a single-source energy spectrum imaging device, relating to the field of medical technology. The method includes a radiation source, a detector assembly, and a grating assembly. Both the detector assembly and the grating assembly are positioned along the emission direction of the radiation source. The detector assembly is used to simultaneously acquire at least two types of radiation image signals during a single exposure of the radiation source, with the at least two types of radiation image signals corresponding to different energy ranges. The grating assembly is located between the radiation source and the detector assembly. The grating assembly includes an enhanced anti-scattering grating with a micro-aperture array for allowing radiation to pass through. The enhanced anti-scattering grating includes a blocking layer and an absorption layer, with the absorption layer compositely disposed on the surface of the blocking layer, absorbing the characteristic radiation generated by the blocking layer. This application solves the technical problem in existing single-source, single-exposure dual-energy imaging where scattered radiation easily contaminates the detector signal, leading to distortion of the energy spectrum data and severe image artifacts.

The invention relates to the field of chemical analysis, in particular to a digestion method and a detection method for ICP-MS (Inductively Coupled Plasma Mass Spectrometry) detection of cationic guar gum. The invention relates to a digestion method for cationic guar gum ICP-MS detection. The digestion method comprises the following steps: S1, accurately weighing a sample; s2, pre-digestion: enabling the sample to be in full contact with concentrated nitric acid; s3, adding hydrogen peroxide; s4, carrying out digestion in a high-pressure tank; and S5, post-processing: fixing the volume for later use. The ICP-MS determination method using the digestion method comprises the following steps: A1, preparing a standard curve and an internal standard solution; a2, ICP-MS instrument condition determination: using helium as collision gas; and A4, calculating a result. According to the method, a nitric acid-hydrogen peroxide and high-pressure tank assisted digestion technology is adopted to thoroughly decompose organic macromolecules, and then the digested solution is detected by using an ICP-MS method, so that the characteristic elements in the cationic guar gum can be accurately and sensitively measured.

The application belongs to the field of fluorescent probes, and discloses a kind of fluorescent probe for monitoring dynamic change of hydrogen peroxide in different subcellular organelles, preparation method and application thereof, the probe is with flavonol as parent nucleus, and hydrogen peroxide ratio type fluorescent probe PML is targeted to lysosome, and hydrogen peroxide ratio type fluorescent probe PZD is targeted to lipid droplet.The application also provides the preparation method and application of the probe.The probe provided by the application has novel structure, simple synthesis method, good recognition effect on hydrogen peroxide, especially hydrogen peroxide in subcellular organelles, fast response speed, high sensitivity, reliable inspection result, good biocompatibility, subcellular organelle positioning function, so that they can be used for monitoring hydrogen peroxide in intracellular microenvironment, and it has great significance to apply probe technology to practical related pathological model to develop the mechanism of hydrogen peroxide in its pathology, especially in the process of ferroptosis.