182results about "Measurements using electron paramagnetic resonance" patented technology

By producing the proper wave interference using superimposed angularly separate waves that overlap with the proper time-phase relationship (called “Time-Correlated Standing-wave Interference”), wave energy is amplified (by “Coherent Intensity Amplification”) and teleported to precise locations. For instance, in one application, energy is teleported to one or more areas within a living body for such therapeutic applications as destroying cancer cells or plaques within arteries. A system implementing this technique creates amplified constructive interference at one or more selected disease locations, while producing destructive interference at surrounding locations. In this application example, the technique allows energy to be “teleported” to tumor cells, plaques, or other diseased cells, for instance, to destroy them, while surrounding healthy cells receive virtually no energy, obviating collateral damage from the treatment. The same method can be used to diagnose disease by detecting energy teleported to different locations.

A quantum sensing module, a quantum current transformer, and a current measurement method, the quantum sensing module comprising a quantum probe (1), a laser module (2), a microwave module (3), a photoelectric detection module (4), a lock-in amplifier (5), a frequency locking module (6), and a data processing module (7); the quantum probe (1) comprises a diamond sensing unit (11) and a microwave radiator (12); the laser module (2) is configured to output an excitation laser; the microwave module (3) is configured to output a microwave signal; the photoelectric detection module (4) is configured to receive photoluminescence generated by the diamond sensing unit (11) and convert same into an output voltage signal; the lock-in amplifier (5) comprises a modulating unit and a demodulating unit; the frequency locking module (6) comprises a PID control unit and a frequency acquiring unit. The quantum current transformer comprises a quantum sensing module, which is configured to measure a current in a conductor. The current measurement method is applied to the quantum current transformer to obtain current information within the conductor. This improves magnetic detection efficiency and increases current measurement precision.

By producing the proper wave interference using superimposed angularly separate waves that overlap with the proper time-phase relationship (called “Time-Correlated Standing-wave Interference”), wave energy is amplified (by “Coherent Intensity Amplification”) and teleported to precise locations. For instance, in one application, energy is teleported to one or more areas within a living body for such therapeutic applications as destroying cancer cells or plaques within arteries. A system implementing this technique creates amplified constructive interference at one or more selected disease locations, while producing destructive interference at surrounding locations. In this application example, the technique allows energy to be “teleported” to tumor cells, plaques, or other diseased cells, for instance, to destroy them, while surrounding healthy cells receive virtually no energy, obviating collateral damage from the treatment. The same method can be used to diagnose disease by detecting energy teleported to different locations.

A sensor element for checking the authenticity of a planar data carrier, in particular a banknote, has a spin resonance feature. The sensor element contains a magnetic core having an air gap, into which the planar data carrier can be inserted for authentication and which defines an axial direction extending between the adjoining surfaces of the magnetic core, a polarization device for generating a static magnetic flux in the air gap, a modulation device for generating a time-varying magnetic modulation field in the air gap, and a resonator for exciting the spin resonance feature of the data carrier to be checked. The modulation device is formed by at least one planar coil arranged in the air gap, which planar coil has one or more turns about the axial direction of the air gap in one plane. The disclosure also relates to a checking device having such a sensor element.

A sensor element for testing a flat-surface data carrier has a spin resonance feature. The sensor element includes a magnetic core with an air gap, into which the flat-surface data carrier can be inserted for testing, a polarization device for generating a static magnetic flux in the air gap, and a resonator device for exciting the spin resonance feature of the data carrier to be tested in the air gap. The resonator device contains at least two stripline resonators, which are designed and configured to be operated at different excitation frequencies.

A sensor element is for testing a planar data carrier with a spin resonance feature. The sensor element includes a magnetic core having an air gap into which the planar data carrier can be inserted for testing purposes, a polarization device for generating a static magnetic flux in the air gap, and a resonator device for exciting the spin resonance feature of the data carrier to be tested in the air gap. The resonator device has at least two stripline resonators positioned at different positions in the air gap. The polarization device generates an in-homogeneous magnetic flux in the air gap so that the static magnetic flux has a first field strength at the position of a first stripline resonator and a second, different field strength at the position of a second stripline resonator.

In a general aspect, a magnetic resonance system performs magnetic resonance measurements. In some examples, a magnetic resonance system includes a data processing device and a superheterodyne spectrometer system. The data processing device generates digital intermediate frequency (IF) signal information based on the pulse profile. The digital IF signal information is configured to suppress a mirror sideband in the magnetic resonance control signal. The superheterodyne spectrometer generates a magnetic resonance control signal based on the digital IF signal information.

An electron paramagnetic resonant (EPR) instrument able to determine chemical properties of a sample using paramagnetic resonance is provided. In one embodiment, the instrument is able to measure the paramagnetic concentration of a wide variety of practical substances, ranging from food and beverages to biological specimens and solid-state electronic materials. The disclosed device can be portable and perform a measurement faster than commonly used techniques to quantify this parameter, including methods that use vibrating sample magnetometers and currently available electron paramagnetic resonance spectrometers.

A current sensor for detecting an electrical current in a line (LTG) comprises means for optical excitation and fluorescence analysis of non-magnetic centers (NV) or paramagnetic centers (NV) in isotropic sensor elements (SE1, SE2). Pump radiation (LB) with a specific wavelength and intensity is used to generate fluorescent radiation (FL), the intensity and time delay of which are measured relative to the pump radiation. The current sensor generates a magnetic field through the current flow, which floods the non-magnetic centers (NV) with different magnetic flux densities (B1, B2). The current value (ILTG) is determined from the detected fluorescence intensities and delays. A computing module (CTR) enables the evaluation, storage, transmission, or output of the data.

The invention relates to an optical waveguide (LWL) comprising a sensor element (SE), wherein: the sensor element (SE) has a carrier material (TM); a plurality of diamonds (DM) are embedded in the carrier material (TM); one or more or all diamonds (DM) of these diamonds (DM) have NV centres (NVZ) and / or other paramagnetic centres; and the NV centres (NVZ) of the sensor element (SE) and / or the other paramagnetic centres of the sensor element (SE) emit at least fluorescent radiation (FL) when irradiated with pump radiation (LB). The invention is characterised in that the carrier material (TM) is a radiation-cured carrier material (TM). This allows for a series production process that can self-adjust and has a high Cpk value. In order to ensure the functionality of the devices constructed therewith, it is necessary that: the carrier material (TM) is substantially transparent to radiation with a pump radiation wavelength (λpmp) of the pump radiation (LB) with which the NV centres (NVZ) and / or the other paramagnetic centres are pumped; and the carrier material (TM) is substantially transparent to radiation with a fluorescence wavelength (λn) of the fluorescent radiation (LB) of the NV centres (NVZ) and / or the other paramagnetic centres.

An inductive assembly is provided that can be used to achieve a large effective volume for excitation and detection and high concentration sensitivity, preferably with low power consumption. [Solution] The present invention relates to an inductive array particularly for use in an oscillator arrangement for generating and / or detecting magnetization of a sample, having a plurality of inductive segments, each of which has an inductive element and a connection circuit electrically connected to the inductive element for electrically connecting to adjacent inductive segments.

In a general aspect, a magnetic resonance system performs a magnetic resonance measurement. In some examples, a magnetic resonance system includes data processing apparatus and a superheterodyne spectrometer system. The data processing apparatus generates digital intermediate frequency (IF) signal information based on a pulse profile. The digital IF signal information is configured to suppress an image sideband in a magnetic resonance control signal. The superheterodyne spectrometer generates the magnetic resonance control signal based on the digital IF signal information.

The invention relates to a compound of formula (I) wherein n = 1 or 2, A and A'are independently selected from the group consisting of the following substituents (II-a) and (II-b), R and R 'are independently selected from H and a linear or branched C1-C3 alkyl group, Z is selected from a linear or branched C1-C4 alkyl group and an aryl group optionally substituted by a linear or branched C1-C3 alkyl group and / or by a hydroxyl group, and the structural unit of formula (N) is selected from the following structural units (III-a), (III-b), (III-c), (III-d) and (III-e) wherein for each structural unit (III-a), (III-b), (III-c), (III-d) and (III-e), Ra, Rb, Rc and Rd are independently selected from a linear or branched C1-C4 alkyl group. .

A method for relaxation time determination includes delivering a series of radio frequency (RF) pulses in a sequence to a specimen having a magnetic resonance spin system. The pulses are separated by equal time intervals and the sequence has a duration comparable or greater than a spin-lattice relaxation time for the spin system. The method includes receiving a response after each RF pulse in the series. The response includes a free induction decay and spin echoes. The method includes generating a series of single point imaging (SPI) images from each response. Each SPI image of the series corresponds to an RF pulse in the series. The method includes converting SPI images to a spin-spin relaxation map and a spin-lattice relaxation map.

The invention provides a method for characterising the state of health of at least one electrochemical element (24) of a battery (20), the battery (20) being a battery having a paramagnetic element with a solid or gel electrolyte, the method comprising a step of: - acquiring data relating to the at least one electrochemical element (24), the data comprising a spectrum obtained via the use of an electron paramagnetic resonance technique or an image obtained via the use of an electron paramagnetic resonance technique; and - analysing the acquired data to detect the presence or absence of an abnormal structure of the paramagnetic element in the at least one electrochemical element (24).

An aspect of the disclosure provides an apparatus comprising: an electromagnetic resonator configured to support an oscillating electromagnetic field in a sample; a cold load having a noise temperature lower than the noise temperature of the electromagnetic resonator; a coupler controllable to provide: a first coupling between the electromagnetic resonator and the cold load to reduce the noise temperature of the electromagnetic resonator; a second coupling, different from the first coupling, to the electromagnetic resonator for sensing an electromagnetic field associated with the sample.

A method for time-resolved pump-probe resonance spectroscopy, comprising the steps of:-exposing a sample (4) to a radio frequency pump pulse (20), where the radio frequency pump pulse (20) drives a resonance, where the resonance is electron spin resonance and / or nuclear magnetic resonance, where the sample (4) is located within a magnetic bias field (22); -detecting the sample (4) with an electron detection beam (7) from the electron source (6); detecting a detection beam characteristic of the electron detection beam (7) by means of a detector unit (8), the detection beam characteristic being dependent on a magnetic moment (25) of the sample (4), the magnetic moment (25) being dependent on the driven resonance, the detector unit (8) being configured to detect the detection beam characteristic of the electron detection beam (7) at a temporal resolution for time-resolved detection of the driven resonance; and determining a property of the resonance, in particular a state of the resonance, preferably a change in the state of the resonance, on the basis of the detected probe beam property.

Disclosed is a method for characterising a sample (E), said method comprising magnetically coupling the sample to a microwave resonator (RHS) such that the coupling dominates the relaxation dynamics of an electron spin (SEL) of a paramagnetic centre of the sample, and determining, by nuclear-magnetic-resonance spectroscopy, coefficients Cij of coupling between a nuclear spin of the sample, called the probe nuclear spin (SNi), and other nuclear spins (SNj, SNk) of the sample, said method employing indirect detection of a state of said probe nuclear spin (SNi), through counting of microwave photons, of respective noise signals (SBS) produced by the return to equilibrium of said electron spin (SEL). An apparatus for implementing such a method is also disclosed.

An electromedical system (1) for the non-invasive diagnosis of neoplastic diseases comprising an electromagnetic source unit (2), a receiving unit (3), a multi-band and multi-channel antenna (4) and a processing unit (5) provided with a data processing software. The electromagnetic source unit (2) is configured to generate and radiate an electromagnetic pump signal, an electromagnetic probe signal and a test and reference signal. The receiving unit (3) is configured to receive and measure in amplitude and phase the signals generated by the electromagnetic source unit (2) and captured, in use, by the multi-band and multi-channel antenna (4).

The invention discloses a mirror image tuning method based on an electron paramagnetic resonance spectrometer and a storage medium, and the method comprises the steps: obtaining a sample path signal generated by a microwave link and a noise reference signal generated by a noise mirror image link, and generating a main path tuning curve according to the sample path signal, generating a mirror image main path tuning curve according to the noise reference signal; according to the main path tuning curve, controlling a microwave source to generate a microwave signal of which the frequency is the same as the sample resonant frequency of a to-be-detected sample in a sample resonant cavity on the main path; and adjusting the frequency and the reference path of the sample resonant cavity according to the main path tuning curve, adjusting the frequency of the mirror image resonant cavity on the mirror image main path according to the frequency of the sample resonant cavity, and adjusting the mirror image reference path according to the mirror image main path tuning curve. According to the method, the correlation between the sample path signal and the noise reference signal is improved, the effect of carrying out noise suppression on the sample path signal according to the noise reference signal is further improved, and the signal-to-noise ratio of the EPR is effectively improved.

A high-frequency magnetic field generating device includes a plate coil and a high-frequency power supply that generates microwave current that flows in the plate coil, wherein one edge line part in a top end side and one edge line part in a bottom end side among four edge line parts of the plate coil act as two coils arranged with a predetermined gap in parallel with each other, wherein between the two coils an electron spin resonance material is arranged or the coils are arranged at one side from an electron spin resonance material. The high-frequency magnetic field generating device further includes a circuit board, wherein the two coils are arranged on one surface of the circuit board so as to be substantially perpendicular to the one surface.

The use of a cell-permeant molecular probe to assay the presence, and monitor the production, of the reactive oxygen species, superoxide, in red blood cells (RBCs) is described. The assay is performed using electron paramagnetic resonance (EPR) spectroscopy and a cell-permeant hydroxylamine spin trap. The cell-permeant molecular probe is not detected or quantifiable by EPR in its reduced form. However, upon entering the RBCs, the probe is oxidized by reacting with superoxide to yield a stable nitroxide radical that is detected and quantified using EPR. Our studies indicate that superoxide production is consistent with RBC metabolism that predicts lipid oxidation, membrane injury and poor post-transfusion performance. Therefore, measurement of reactive oxygen species can be used as an indicator of RBC quality at the time of donation and after storage.

A magnetic sensor (10) includes a diamond substrate (11) and a waveguide body (14) in contact with the diamond substrate (11). The diamond substrate (11) includes, on a surface (11a) not in contact with the waveguide body (14), a first layer (11La) including a diamond crystal on which an NV center (12) is disposed and, on a surface (11b) in contact with the waveguide body (14), a second layer (11Lb) on which a conductive pattern (13) is disposed. The waveguide body (14) includes a line (15) configured to transmit a microwave that generates electron spin resonance to the conductive pattern (13) and an optical waveguide (16) configured to transmit exciting light and fluorescence, the exciting light irradiating the diamond substrate (11) and emitting the fluorescence in the first layer (11La) of the diamond substrate (11).

The invention relates to a sensor element (30) for testing a flat data carrier (10), in particular a banknote, that has a spin resonance feature (12). The sensor element contains a magnetic core (34) having an air gap, into which the flat data carrier (10) can be inserted for testing, an element for generating a static magnetic flux in the air gap, and a resonator (32) for exciting the spin resonance feature of the data carrier to be tested. According to the invention, it is provided that the resonator is formed by a stripline resonator (40) which is arranged in the air gap of the magnetic core and comprises a flat carrier (42) having an upper side (44-O) and a conducting structure (46) which is arranged on the upper side (44-O) of the carrier with a characteristic length l.

The present invention relates to a method for determining the coupling between magnetometers in an array of N magnetometers (e.g., by means of an optically pumped magnetometer), wherein each magnetometer includes a field cancellation system that can be enabled to operate the magnetometer in a zero field. The method includes a first phase (P1), in which the N magnetometers are divided into N - 1 magnetometers with the field cancellation system deactivated and one measuring magnetometer with the field cancellation system activated. The first phase includes: - generating (GENj) by these magnetometers a plurality of reference magnetic fields with known amplitudes and different directions, - measuring (MESi) by the measuring magnetometer the ambient magnetic field on a plurality of measurement axes, - determining (CALCij) the coupling coefficient between the measuring magnetometer and each of the N magnetometers based on the measured values and these known amplitudes.

In a general embodiment, a magnetic resonance system performs magnetic resonance measurements. In some examples, the magnetic resonance system includes a data processing unit and a superheterodyne spectrometer system. The data processing unit generates digital intermediate frequency (IF) signal information based on the pulse profile. The digital IF signal information is configured to suppress image sidebands in the magnetic resonance control signal. The superheterodyne spectrometer generates the magnetic resonance control signal based on the digital IF signal information.

This invention provides a spectroscopic apparatus capable of achieving particularly high measurement accuracy using pulse excitation signals generated by a voltage-controlled oscillator. [Solution] The present invention provides a method for supplying a second magnetic field to a sample position by exciting an induction assembly with an excitation signal, wherein the excitation signal is periodically switched between an excitation period in which the operating frequency has a sample-specific resonant frequency and an idle period in which the operating frequency has an idle frequency different from the resonant frequency, and the operating phase of the excitation signal is matched to the excitation reference phase of an excitation reference signal separately from the excitation signal when the operating frequency is switched from the idle frequency to the resonant frequency, the excitation signal is generated by a primary voltage-controlled oscillator, the excitation reference signal is generated by a first secondary voltage-controlled oscillator, and the matching of the operating phase to the excitation reference phase is performed by injection-synchronizing the primary voltage-controlled oscillator with the first secondary voltage-controlled oscillator.

The present invention relates to a compound of formula (I), wherein n = 1 or 2, and A and A' are independently chosen from among the group consisting of the following substituents (ll-a) and (ll-b), R and R' being independently chosen from among H and C1-C3 linear or branched alkyls, Z being chosen from among a C1-C4 linear or branched alkyl group and an aryl group optionally substituted with a C1-C3 linear or branched alkyl group or / and with a hydroxyl group, and the unit of formula (N) is chosen from among the following units (III-a), (III-b), (III-c), (III-d) and (III-e), Ra, Rb, Rc and Rd being, for each unit (lll-a), (lll-b), (lll-c), (lll-d) and (lll-e), independently chosen from among C1-C4 linear or branched alkyls.

In a general aspect, an electron magnetic resonance apparatus includes a resonator that resides in a cryogenic environment in a primary magnetic field. A sample holder in the cryogenic environment is maintained in a spaced relationship with the resonator. The sample holder includes a sample container. A sample heating device is positioned so that the sample container is thermally coupled to the sample heating device, and the sample heating device controls a temperature of the sample to be in a temperature range that is above an operating temperature of the resonator.