97 results about "Sentinel lymph node" patented technology

Cavity and sentinel lymph node marking 412 devices, marker delivery devices, and methods are disclosed. More particularly, upon insertion into a body, the cavity marking device and method enable one to determine the center, orientation, and periphery of the cavity by radiographic, mammography, echogenic, or other noninvasive imaging techniques. A composition and method are disclosed for locating the sentinel lymph node in a mammalian body to determine if cancerous cells have spread thereto. The composition is preferably a fluid composition consisting of a carrier fluid and some type of contrast agent; alternatively, the contrast agent may itself be a fluid and therefore not need a separate carrier fluid. This composition is capable of (1) deposition in or around a lesion and migration to and accumulation in the associated sentinel node, and (2) remote detection via any number of noninvasive techniques. Also disclosed is a method for remotely detecting the location of a sentinel node by (1) depositing a remotely detectable fluid in or around a lesion for migration to and accumulation in the associated sentinel node and (2) remotely detecting the location of that node with a minimum of trauma and toxicity to the patient. The composition and method may serve to mark a biopsy cavity, as well as mark the sentinel lymph node. The marking methods also may combine any of the features as described with the marking device and delivery device.

The present invention relates to a device for observing a sentinel lymph node (SLN) in a human body. More particularly, the present invention relates to a device for observing an SLN by detecting near-infrared (NIR) fluorescence caused by a fluorescent material such as indocyanine green (ICG) at the SLN and a method for detecting NIR fluorescence at an SLN. Particularly, in the implementation of a composite image obtained by reproducing a fluorescent material such as ICG and NIR fluorescence emitted by excitation light together with a visible light image, it is possible to detect an SLN with high accuracy through a color contrast method and/or a temporal modulation method using an NIR fluorescence image signal and a visible reflection light image signal.

A composition is provided accompanying nonoparticles having diameters in the range of about 100 to 800 nanometers with hollow cores and outer shells with mechanical properties such that they rupture on exposure to predetermined ultrasound energy. The composition is useful for identifying sentinel lymph nodes.

In accordance with the present invention, there are provided methods for identifying the sentinel lymph node in a drainage field for a tissue or organ in a subject. In select embodiments, the invention allows for the identification of the first or sentinel lymph node that drains the tissue or organ, particularly those tissues associated with neoplastic or infectious diseases and disorders, and within the pertinent lymph drainage basin. Once the drainage basin from the tissue or organ, i.e., the sentinel lymph node, is identified, a pre-operative or intraoperative mapping of the affected lymphatic structure can be carried out with a contrast agent. Identification of the first or sentinel lymph node, on the most direct drainage pathway in the drainage field, can be accomplished by a variety of imaging techniques, including ultrasound, MRI, CT, nuclear and others. Moreover, once the lymphatic structure is identified as being associated with neoplastic or infectious diseases and disorders, the affected lymphatic structure can be removed surgically or by a suitable minimally invasive procedure to allow pathological analysis to be performed to determine whether certain diseases or disorders exist, without resort to more radical lymphadenectomy. Further, the agent can be made to carry diagnostic or therapeutic probes to be activated and/or delivered to the injection site or any part of the lymphatic pathway downstream from the injection site.

Apparatus for determining magnetic properties of materials comprises a portable probe (1), an equipment trolley (2) holding cryogenics and electronics and connecting cables (3). The probe (1) comprises a drive coil (4) and a correction coil (5), the drive coil (4) being disposed symmetrically with respect to an inner second-order gradiometer sensor coil (8). Electrical connectors in the form of 2-metre long Belden (1192A) microphone cables (3) are used to connect the apparatus on the equipment trolley (2) to the drive coil (4), the correction coil (5) and the sensor coil (8). The drive coil (4) is driven so as to generate a sinusoidally varying magnetic field. The electronics comprise a flux-locked loop (9), a SQUID controller (10), a data acquisition module (11), which captures and processes the signals and a computer (12). A liquid-nitrogen dewar (13) is supported on the equipment trolley (2) and houses a sensitive SQUID detector (14) and a transfer coil (15) made from copper. Possible applications of the apparatus include an intra-operative tool for sentinel lymph node detection in the treatment of breast cancer, and a non-destructive evaluation tool for detecting voids and defects in aluminium and applications in the aeronautics industry.

The invention provides systems, methods and a node accessing and anchoring device, comprising an elongated shaft, a tissue cutting member, at least one anchoring element extending from a position at or near the distal end of the shaft; and a radiation detector. The radiation detector is effective to locate and identify sentinel lymph nodes following injection of radioactive material into a primary lesion site within a patient. The tissue cutting member, which may be activated with radio frequency energy, is effective to allow access of the elongated shaft to a sentinel lymph node. The anchoring elements are effective to anchor the device to or adjacent a sentinel lymph node accessed by the device. Anchoring elements may assume radially, longitudinally, or mixed radially and longitudinally curved or coiled configurations when deployed.

The invention provides methods for pre- and intra-operatively localizing penile sentinel lymph nodes by injection of fluorescent dyes into penile tumors.

Embodiments of methods and apparatus use electron paramagnetic resonance spectroscopy to provide a signal from melanin to image a melanoma. Embodiments of methods and apparatus use electron paramagnetic resonance spectroscopy to provide a signal from melanin to detect metastatic melanoma in a sentinel lymph node. Embodiments of methods and apparatus use electron paramagnetic resonance spectroscopy to provide a signal from melanin to measure light penetration in melanocytes in skin.

The present invention relates generally to the field of fluorescent dyes as a system useful for surgery imaging. More particularly, the present invention relates to systems, methods and kits for exciting fluorescent, phosphorescent or luminescent molecules with light from a light source and detecting the relative fluorescent, phosphorescent, or luminescent light intensity emitted from the fluorescent, phosphorescent, or luminescent molecule. Such systems may be applied as mapping agents for various surgical techniques, such as for cancer surgeries and biopsies.

The present invention is characterized by easy and rapid detection of a sentinel lymph node by performing sentinel lymph node biopsy with fluorescent particles having a predetermined particle diameter.

Methods for treating a patient suffering from a neoplastic disease are disclosed and described. A number of diseases can be treated under the present methods, including without limitation gall bladder cancer, hepato cellular cancer, ovarian cancer, small intestine cancer, lung cancer, mesothelioma, breast cancer, kidney cancer, pancreas cancer, prostate cancer, carcinoid cancer, leiomyosarcoma, or metastasis thereof. A general method for providing such treatment may include: 1) identifying in a patient one or more sentinel and/or metinel lymph nodes draining the neoplasm; 2) resecting the one or more nodes and, optionally all or part of the tumour or metastasis; 3) isolating tumour-reactive T-lymphocytes from said lymph nodes; 4) in vitro expanding said tumour-reactive T-lymphocytes; and 5) administering the thus obtained tumour-reactive T-lymphocytes to the patient.

The present invention relates to the field of diagnostic imaging and provides compositions of ultrasound contrast agents, particularly gas-filled microvesicles suspensions, in combination with vital dyes. The compositions of the invention are advantageously used in the visualization of the lymphatic system, particularly for the detection of the sentinel lymph node or nodes of a tumor.

The invention relates to preparation and application of a nano-micelle imaging agent for a cervical cancer sentinel node. A nanometer imaging agent high polymer PEG-PLGA is used as a carrier, micelleparticles are formed through polymerization, indocyanine green is loaded inside, TMTP1 targeting peptide is modified on the surface of a micelle, and maleic amide connected with a surface hydrophilicgroup PEG end of the micelle is connected with a sulfhydryl group of TMTP1 with ring formation by amido bonds at the head and the tail. The near infrared fluorescence nano-micelle diagnosis reagent provided by the invention can image the cervical cancer sentinel node in real time, can distinguish whether tumor cell metastasis occurs or not, and offers the assistance for the imaging diagnosis of intraoperative lymph nodes of cervical cancer in clinic in the future and the guidance of individualized treatment of tumor patients.

The invention provides a specific sentinel lymph node developer drug and a preparation method thereof. A Rituximab antibody is modified and subject to 99mTc marking, so that 99mTc-Rituximab can be obtained, which can combine with a CD20 antigen in the sentinel lymph node to accurately position the sentinel lymph node, thus the sentinel lymph node development of the breast cancer and a biopsy analysis can be performed on breast cancer patients, thereby laying a foundation for establishing a complete set of safe, convenient and effective sentinel lymph node development technology of breast cancer and providing a method and basis for widely clinical application in the coming days.