11 results about "Sentinel lymph node" patented technology

The invention relates to the technical field of medical instruments, and discloses a breast cancer sentinel lymph node positioning system and method, and the system comprises a data collection subsystem, a space positioning subsystem and a central processing subsystem. The method comprises the following steps: acquiring an anatomical structure image, a radioactivity counting rate and fluorescence intensity after performing primary fluorescence, radioactivity and secondary pulse type fluorescence tracer injection in sequence; establishing a global coordinate system and generating an anatomical region of interest; constructing a weighted directed topological graph based on the initial fluorescence data, and obtaining a baseline flow velocity; extracting radionuclide dynamic characteristics based on the radioactive data; a functional flow rate attenuation coefficient is calculated based on the second pulsed fluorescence data. And a multi-factor scoring model is applied, topological information, dynamic characteristics and functional flow velocity attenuation coefficients are fused, and a comprehensive score is calculated to identify the sentinel lymph node. According to the method, the lymphatic flow topological structure, nuclide dynamics and functional flow velocity information are combined, and the positioning accuracy and reliability are improved.

The application relates to the technical field of medical devices, in particular to a skin ultrasound contrast-based axillary sentinel lymph node puncture guiding method. The core of the method is as follows: after injecting an ultrasound contrast agent with a specific particle size through the skin, a preset low-mechanical-index high-frame-rate double-amplitude contrast imaging mode is adopted to dynamically track lymph drainage and sentinel lymph node development, and the enhancement characteristics are recorded; then, under the guidance of multimodal imaging which is fused with real-time contrast, elastic imaging and color Doppler, the target lymph node is accurately punctured and biopsied, and a tissue sample is obtained for pathological analysis. The application realizes integrated operation from sensitive development of the sentinel lymph node, function evaluation to accurate puncture, and provides a non-radiation high-precision puncture guiding method for accurate evaluation of the axillary lymph node state of breast cancer patients before operation.

The utility model relates to the technical field of tracer injection, and discloses a sentinel lymph node tracer injector which comprises a needle cylinder, a needle head assembly is inserted into the bottom end of the needle cylinder, the needle head assembly comprises a needle head sleeve and an injection needle head, and the injection needle head is fixedly installed at the bottom of the needle head sleeve. According to the sentinel lymph node tracer injector, when a piston is controlled by an auxiliary pull rod to extract a tracer, a fixing ring fixedly connected with the surface of the auxiliary pull rod drives sliding blocks on the two sides of a pointing lever fixedly connected with a linkage arm to slide in two sets of sliding sleeve shells; in the sliding process, the extraction amount can be clearly known through comparison of the pointing lever and the milliliter line, meanwhile, one of the limiting grooves formed in one set of sliding sleeve shells is aligned with the milliliter line needing milliliter extraction, and then a limiting insertion rod is inserted to form limiting; and therefore, the single extraction amount is quantified in the extraction process, and excessive extraction is avoided.

The present invention provides a near-infrared-II (NIR-II, 1000-1700 nm) chemiluminescence resonance energy transfer (CRET) nanosystem, a preparation method therefor, and a use thereof. The NIR-II CRET nanosystem is constructed by means of multi-component synergistic self-assembly of a pH-responsive amphiphilic short peptide, a metal ion, an NIR-II CRET functional unit, and a photosensitizer, and has an NIR-II CRET signal activated by responding to both pH and MPO enzyme in a microenvironment. The NIR-II CRET nanosystem can be used as a diagnostic reagent to achieve accurate tracing and localization of a sentinel lymph node of breast cancer by means of an NIR-II contrast agent. The nature of the sentinel lymph node is determined by means of the NIR-II CRET signal activated by responding to both pH and MPO enzyme, thereby overcoming the technical problem that it is difficult for conventional sentinel lymph node diagnosis methods to avoid false negatives and false positives, and achieving in-vitro localization and qualitative integrated diagnosis and treatment of a metastatic sentinel lymph node of breast cancer.

The provided is a system that provides information with high accuracy by performing voxel-based both cross-sectional and volumetric three-dimensional imaging in cancer tissues, especially in determining the necessary surgical margins of the breast tumor removed from the patient with breast cancer surgery and the presence of the tumor in the sentinel lymph node, which is the first lymph node from which the tumor drained. The provided will not be applied directly to humans and the human body, but to the tumor and / or tumorous tissue removed from the patient's cancerous organ (especially the breast). By changing the software parameters and the applied X-ray range used in breast tumors, a deep technology-based system developed can also be used in human lung, liver, pancreas, thyroid, brain, skin, small intestine, large intestine, stomach, gall bladder, esophagus, bladder, kidney, ovary, uterus, cervix, testis and prostate tumors and tumorous tissue fragments.

The disclosure provides gene signatures of classifying an individual afflicted with cutaneous melanoma. The “SLN gene signatures” provided herein classify an individual based on prognosis and / or classify an individual as having a metastasis-positive or -negative sentinel lymph node (SLN). The “N-SLN gene signatures” provided herein classify an individual as having a metastasis-positive or -negative non-sentinel lymph node (N-SLN).

This invention discloses an activated near-infrared II afterglow luminescence composite nanosystem, its preparation method, and its applications. The activated near-infrared II afterglow luminescence composite nanosystem is assembled from visible afterglow nanoparticles, near-infrared II quantum dots, amphiphilic molecules, matrix metalloproteinase-responsive peptides, and fluorescence quenchers. This invention integrates visible afterglow nanoparticles and near-infrared II quantum dots to construct a radiation energy transfer system, achieving long afterglow luminescence in the near-infrared II region. This afterglow signal can be specifically activated by matrix metalloproteinases (MMPs) highly expressed in the breast cancer microenvironment, achieving a state transition from "off" to "on," enabling precise detection of metastatic sentinel lymph nodes in breast cancer.

The invention discloses a novel application of indigo carmine in preparation of a medicine for draining lymph nodes in a tracing area during a malignant tumor treatment operation, and belongs to the technical field of medicines. Aiming at the technical problems of pigmentation, tissue corrosivity and other side injuries of an existing lymph node tracer, animal experiments prove for the first time that indigo carmine with a specific dosage is adopted to trace a tumor area to drain lymph nodes, so that the side effects of the existing tracer can be remarkably reduced, and the curative effect of the tracer is improved. Meanwhile, the detection effect on target lymph nodes is similar to that of the existing common tracer agent methylene blue. The invention provides clear experimental evidence, the known safe drug indigo carmine injection is repositioned to be used for accurately tracing the regional lymph node in the malignant tumor operation, the sentinel lymph node biopsy is guided, the side injury caused by blind enlargement of the operation cleaning range is avoided, and the method has the advantages of short development period, definite tracing effect, low cost and the like. The invention provides a drug choice with clinical application potential for precise and minimally invasive surgery of various malignant tumors.

The present application belongs to the technical field of image processing, and particularly relates to a breast cancer lymph node benignity and malignancy classification system and method based on preoperative and intraoperative images, and aims to solve the problem of breast cancer lymph node error cleaning in the prior art. The present application comprises: a preoperative multi-modal image preprocessing and coding module, which extracts lymph node related high-dimensional pre-defined features of a patient's preoperative multi-modal image; an intraoperative fluorescent image sequence preprocessing and coding module and an intraoperative fluorescent intensity time-varying sequence preprocessing and coding module, which respectively extract global features and local features of intraoperative lymph nodes in fluorescent images; an intraoperative sentinel / non-sentinel lymph node benignity and malignancy classification module, which fuses the high-dimensional pre-defined features, global features and local features, and performs modeling and model training, and classifies breast cancer lymph nodes according to benignity and malignancy through the trained model. The present application has high accuracy and precision of analysis results, and can provide a better auxiliary diagnosis and treatment scheme.

The invention relates to the field of medical instruments, in particular to an automatic breast massage device for sentinel lymph node biopsy, which comprises a device main body, the device main body comprises an arc-shaped support cup, a fixing module and a control module, the arc-shaped support cup is fixedly connected with the fixing module, and a massage module is mounted on the arc-shaped support cup; the massage module comprises a mounting seat, a plurality of massage assemblies and a driving assembly, and the massage assemblies are fixedly connected with the mounting seat; an elastic adaptation assembly and a tracer diffusion auxiliary assembly are further installed in the arc-shaped supporting cup, the driving assembly, the elastic adaptation assembly and the tracer diffusion auxiliary assembly are in signal connection with the control module, and the control module controls the driving assembly according to a preset massage program and real-time data fed back by the elastic adaptation assembly and the tracer diffusion auxiliary assembly. And then the massage assembly is driven to massage the patient. The lymph node dyeing definition and dyeing efficiency are improved, traditional manual massage is replaced, and meanwhile individual differences of different patients are adapted.

Methods of predicting the development of a metastasis in a subject suffering from cancer wherein a sentinel lymph node with respect to the cancer does not comprise cancer cells are provided. Method of predicting the absence of development of a metastasis in a subject suffering from cancer which a sentinel lymph node with respect to the cancer does comprise cancer cells are also provided.