The invention relates to a
copper phthalocyanine covalent organic framework material with photodynamic / chemical dynamic sterilization and a preparation method and application thereof, and belongs to the technical field of advanced functional materials and biological medicines. A
covalent organic framework is synthesized by taking 4, 4 ', 4', 4 ''-
tetra-(4-amino)
copper phthalocyanine (CuTAPc) as a main
structural unit, and the distance between photosensitizers can be limited, so that the self-aggregation
quenching of the photosensitizers is reduced, and a good photodynamic effect is realized. Meanwhile, the
copper ions consume
glutathione overexpressed in the bacterial microenvironment, consumption of
active oxygen is avoided, Fenton-like reaction is further triggered, toxic
active oxygen is generated, chemical power synergistic treatment is achieved, the defect that the depth of light penetrating through the tissue is limited is effectively overcome, and a good
treatment effect on
deep tissue is achieved. A composite antibacterial film is further constructed based on the material. The multifunctional material has good stability and
active oxygen generation capability, has good
biological safety, and has huge potential in the fields of bacterial infection treatment, fruit and vegetable preservation and the like.