54 results about "Sentinel node" patented technology

The present invention relates to a device for observing a sentinel lymph node (SLN) in a human body. More particularly, the present invention relates to a device for observing an SLN by detecting near-infrared (NIR) fluorescence caused by a fluorescent material such as indocyanine green (ICG) at the SLN and a method for detecting NIR fluorescence at an SLN. Particularly, in the implementation of a composite image obtained by reproducing a fluorescent material such as ICG and NIR fluorescence emitted by excitation light together with a visible light image, it is possible to detect an SLN with high accuracy through a color contrast method and / or a temporal modulation method using an NIR fluorescence image signal and a visible reflection light image signal.

Cavity and sentinel lymph node marking devices, marker delivery devices, and methods are disclosed. More particularly, upon insertion into a body, the cavity marking device and method enable one to determine the center, orientation, and periphery of the cavity by radiographic, mammography, echogenic, or other noninvasive imaging techniques. A composition and method are disclosed for locating the sentinel lymph node in a mammalian body to determine if cancerous cells have spread thereto. The composition is preferably a fluid composition consisting of a carrier fluid and some type of contrast agent; alternatively, the contrast agent may itself be a fluid and therefore not need a separate carrier fluid. This composition is capable of (1) deposition in or around a lesion and migration to and accumulation in the associated sentinel node, and (2) remote detection via any number of noninvasive techniques. Also disclosed is a method for remotely detecting the location of a sentinel node by (1) depositing a remotely detectable fluid in or around a lesion for migration to and accumulation in the associated sentinel node and (2) remotely detecting the location of that node with a minimum of trauma and toxicity to the patient. The composition and method may serve to mark a biopsy cavity, as well as mark the sentinel lymph node. The marking methods also may combine any of the features as described with the marking device and delivery device.

The invention provides methods for pre- and intra-operatively localizing penile sentinel lymph nodes by injection of fluorescent dyes into penile tumors.

The invention discloses a system and a method for opto-acoustic and ultrasonic synchronous imaging used for superficial position imaging, and relates to the technical field of medical examination imaging equipment. The system comprises a laser and an opto-acoustic-ultrasonic dual-mode imaging system. The opto-acoustic-ultrasonic dual-mode imaging system comprises a signal control and processing module, an opto-acoustic-ultrasonic dual-mode imaging module, an image display, and a handheld opto-acoustic probe. The handheld opto-acoustic probe is also internally provided with an ultrasonic transducer. The laser is used to output laser signals. The signal control and processing module is used to output ultrasonic signals. The handheld opto-acoustic probe is used to transmit laser signals and ultrasonic signals to a to-be-detected superficial position. The opto-acoustic-ultrasonic dual-mode imaging module is used to rebuild an ultrasonic image and an opto-acoustic image, and send the images to the image display to display. The system is high in sensitivity and large in imaging depth, and can be flexibly applied in human body superficial position imaging of breasts, sentinel node, thyroid, prostate, etc.

A method of treating inflammatory bowel disease (IBD) comprises collecting regulatory T cells in an activated or non-activated state from a patient's sentinel lymph nodes draining bowel segments with or without IBD, optionally activating the cells by contacting them with a cytokine and an antigen extract obtained from an inflamed bowel segment, expanding the T cells in vitro, and re-infusing the expanded T cell to the patient. Also disclosed are methods for obtaining sentinel nodes, for expanding T cells, for re-establishing the TH1 / TH2 balance in the patient suffering from Crohn's disease, and corresponding uses of the expanded T cells, the cytokine and of antigen extract, as well as of correspondingly activated and expanded T cells.