275 results about "Biological property" patented technology

Methods and systems utilizing quantitative imaging are presented herein. Advantageously, the systems and methods of the present disclosure utilize a hierarchical analysis framework that identifies and quantifies biological properties / analytes from imaging data, and then identifies and characterizes one or more pathologies based on the quantified biological properties / analytes. This hierarchical approach using imaging to examine underlying biology as an intermediate for assessing pathology provides numerous analysis and processing advantages over systems and methods configured to directly determine and characterize pathology from underlying imaging data.

Systems and methods for analyzing pathologies utilizing quantitative imaging are presented herein. Advantageously, the systems and methods of the present disclosure utilize a hierarchical analytics framework that identifies and quantify biological properties / analytes from imaging data and then identifies and characterizes one or more pathologies based on the quantified biological properties / analytes. This hierarchical approach of using imaging to examine underlying biology as an intermediary to assessing pathology provides many analytic and processing advantages over systems and methods that are configured to directly determine and characterize pathology from underlying imaging data.

Systems and methods for analyzing pathologies utilizing quantitative imaging are presented herein. Advantageously, the systems and methods of the present disclosure utilize a hierarchical analytics framework that identifies and quantify biological properties / analytes from imaging data and then identifies and characterizes one or more pathologies based on the quantified biological properties / analytes. This hierarchical approach of using imaging to examine underlying biology as an intermediary to assessing pathology provides many analytic and processing advantages over systems and methods that are configured to directly determine and characterize pathology from underlying imaging data.

The invention discloses bacillus subtilis Gxunw-30 and application thereof, and belongs to the technical field of agricultural microorganisms. The bacillus subtilis Gxunw-30 provided by the invention is preserved in Guangdong Microbial Culture Collection Center on October 12, 2024, and the preservation number of the bacillus subtilis Gxunw-30 is GDMCC No: 65245. The bacillus subtilis Gxunw-30 provided by the invention has the capability of inhibiting plant pathogens in a broad spectrum, and can be used for antagonizing a variety of plant pathogens such as helminthosporium triticum, trichosporon pseudoacaceae, hechiense fusarium, fusarium chlamydosporum, cryphonectria parasitica, fusarium pseudograminearum, botryosphaeria dothidea and the like. The strain has the properties of decomposing organophosphorus, producing protease, producing ammonia, producing indole and fixing nitrogen, and has the biological properties of plant growth promotion and the like. The recombinant bacterium also contains a gene for coding an antibacterial substance, and has the capability of synthesizing the antibacterial peptides of iturin, surfactin, fengmycin and bacilysin, and the recombinant bacterium also contains a gene for coding the antibacterial substance and has the capability of synthesizing the antibacterial peptides of iturin, surfactin, fengmycin and bacilysin. The strain has the effects of preventing diseases and promoting growth, provides a good biocontrol resource for prevention and treatment of plant diseases, and has a relatively good application value for research and development of plant growth-promoting preparations and biocontrol microbial agents.

Systems and methods for generating a polymer sequence for a biological molecule having one or more target biological properties are provided. A plurality of target metric values for one or more target biological properties of a biological molecule and a seed for a nucleic acid or amino acid sequence for the biological molecule are inputted into a conditional generator model of a conditional generative adversarial network to obtain as output from the conditional generator model a nucleic acid or amino acid sequence for the biological molecule that is predicted by the conditional generator model to confer on the biological molecule the one or more target biological properties approximating the plurality of target metric values.

The invention provides a Villonella enteritidis strain and an application of the Villonella enteritidis strain. The preservation number of the Villonella enteritidis strain is GDMCC No: 65234. The invention also provides a preparation containing the Wehonor enteritidis, a culture method and application of the Wehonor enteritidis as a labeled microorganism or a target spot in preparation of drugs for screening diseases caused by the Wehonor enteritidis. According to the present invention, the virulence gene and the pathogenicity of the Wehonor enteritidis are analyzed, such that the Wehonor enteritidis has the potential pathogenicity for aggravating the inflammatory bowel disease, and the strain provides specificity in the aspects of biological characteristics, pathogenicity and the like compared with the Wehonor micrococcus, such that the cognition of the Wehonor micrococcus in the intestinal tract is new improved, and the Wehonor micrococcus enteritidis can be used for the treatment of the inflammatory bowel disease. Moreover, a new view angle and a new direction are provided for research on the effect of the Wehonor coccus in the intestinal diseases such as IBD (Infectious Bursal Disease).

The invention provides a plant lactobacillus YH001 with bacteriostatic activity as well as a screening method and application of the plant lactobacillus YH001. The phytobacterium plantarum YH001 has the taxonomic name of Lactiplantibacillus plantarum, is preserved in the Guangdong Microbial Culture Collection Center, and has the preservation number of GDMCC No: 65693, the preservation number of Lactiplantibacillus plantarum YH001 is CGMCC NO: 65693, and the preservation number is CGMCC NO: 65693. The preservation date is December 30, 2024. The strain has excellent biological characteristics of no hemolysis, acid resistance, cholate resistance and the like, and has wide application potential in the fields of food, medicine and the like. The fermentation supernatant still keeps high bacteriostatic activity after being treated at a high temperature of 121 DEG C, and shows excellent thermal stability. Therefore, the strain has a wide application prospect in research and development of antibacterial agents, food leavening agents and preservative products.

An antibacterial peptide screening framework is constructed on the basis of a protein language model and a biological information method, and particularly, an antibacterial peptide screening model is developed by combining a protein language model screening result with actual biological activity and biological properties of antibacterial peptide through an innovative calculation method; the problems that in the prior art, antibacterial peptide screening is low in efficiency, insufficient in accuracy and the like are effectively solved, the prediction mode of the functional characteristics of the antibacterial peptide is improved, the diversity and novelty of screening results are improved, and an efficient, accurate and flexible new method is provided for screening of the antibacterial peptide.

The invention belongs to the technical field of food fermentation, and provides a lactobacillus plantarum CMRC 1L and application thereof. The lactobacillus plantarum CMRC 1L disclosed by the invention is separated from a sour meat sample in Maojia village region in Lijiang City, Yunnan Province, grows well on an MRS culture medium, is high in acid production speed, has the biological characteristics of salt resistance, frostbite resistance, inhibition of growth and reproduction of spoilage microorganisms and the like, has a good fermentation effect on various plant proteins, and is an excellent strain for preparing a leavening agent for production. The invention also provides a leavening agent containing the strain and application of the leavening agent in vegetable protein meat products. Compared with the vegetable protein jerky without the leavening agent, the vegetable protein jerky product prepared by the preparation method provided by the invention has the advantages of stable quality, fresh and sweet fermentation fragrance, no beany flavor and good flavor and taste. The strain CMRC 1L has great potential when being applied to production of vegetable protein meat products.

The invention relates to plant lactobacillus and application thereof. Wherein the gene of the molecular marker for the plant lactobacillus has a nucleotide sequence selected from one of the following sequences: (1) a nucleotide sequence as shown in SEQ ID NO: 24; (2) a nucleotide sequence having at least 97%, 98%, 99% or higher homology with the nucleotide sequence as shown in SEQ ID NO: 24; and (3) a nucleotide sequence with one or more nucleotide sequences, such as 1, 2, 3, 4, 5 or more nucleotide substitutions, deletion or insertion, in the nucleotide sequence as shown in SEQ ID NO: 24. The plant lactobacillus provided by the invention is non-toxic, has good biological characteristics, has a good curative effect on prevention and / or treatment of vaginal infection and related diseases, and avoids the problems of increased drug resistance, high recurrence rate and the like caused by use of antibiotic and other antibacterial drugs during treatment of vaginal infection and related diseases.

A device, a substrate including a connection port. The substrate includes traces to enable a circuit of the substrate. The circuit is connected to the connection port. A light sensor mechanically and electrically attached respectfully to a first planar surface of the substrate and the circuit. A light source is mechanically and electrically attached respectively to the first planar surface and the circuit. The light source is located lateral to the light sensor at a first distance. A light signal of the light source emanates from the light source at an angle perpendicular to the first planar surface and a reflector mechanically attached to the first planar surface and located between the light sensor and the light source. The light signal is substantially reflected by the reflector away from the light sensor.

According to the carbapenem-resistant klebsiella pneumoniae bacteriophage and the application, biological characteristic research, morphological analysis and other analysis are carried out on the bacteriophage, and it is found that the bacteriophage has a wide application prospect as a novel potential therapeutic agent and bactericide; meanwhile, the invention also provides a new feasible method for infection control and related application of clinical carbapenem-resistant klebsiella pneumoniae by researching the in-vitro synergistic effect of the klebsiella pneumoniae after the klebsiella pneumoniae is combined with carbapenem antibiotic meropenem.

The invention discloses ethanol dehydrogenase, recombinant genetically engineered bacteria and application of the ethanol dehydrogenase in asymmetric reduction of prochiral carbonyl compounds, the ethanol dehydrogenase has good biological performance, heterologous expression in Escherichia coli engineering bacteria is achieved, intracellular coenzyme can be directly utilized when whole cells are adopted as a catalyst, and the catalyst has a good application prospect. Zero addition of the coenzyme is realized, the enzyme has the advantages of high activity, high stereoselectivity, wider substrate spectrum and the like, prochiral ketone compounds can be greenly and efficiently catalyzed to be converted into corresponding chiral alcohols, and the problems of low conversion rate, low yield, low e.e. Value, complex reaction process, more byproducts and the like in a traditional chemical method are solved. The ethanol dehydrogenase has good tolerance to isopropanol, and the isopropanol can be used as a hydrogen source to realize the circulation of coenzyme. And the byproduct acetone generated by the enzyme catalytic reaction and the isopropanol remaining in the reaction can be separated and recovered by a technical means, so that the production cost is greatly reduced.

The invention relates to a strain of Chryseobacterium sp. ZJUHULYY1 and application of the Chryseobacterium sp. ZJUHULYY1 in promotion of corn growth and iron absorption, and provides a strain of Chryseobacterium sp. ZJUHULYY1, which is preserved in China Center for Type Culture Collection on April 27, 2025, and has a preservation number of CCTCC NO: M 2025904. The strain of Chryseobacterium sp. ZJUHULYY1 is obtained by separating and purifying from rhizosphere soil of corn, and the strain of Chryseobacterium sp. ZJUHULYY1 is obtained by separating and purifying from rhizosphere soil of corn. The biological characteristics of the strain are as follows: after being cultured in an LB plate culture medium at 30 DEG C for 24 hours, the bacterial colony is round or oval, golden yellow, smooth and glossy in surface, neat in edge and negative in gram staining; when the strain is inoculated to rhizosphere of corn growing in calcareous soil, compared with a control group, the plant height, chlorophyll content, biomass and active iron content of the corn are all remarkably improved, the growth condition of the corn in the calcareous soil is effectively improved, and the absorption and utilization efficiency of the corn on iron elements is improved.

A method, computer program product, and computer system are provided for evaluating carbon sequestration contributions of nature-based assets located in water environments. The method includes: obtaining meta-descriptors of a nature-based asset and a region of a water environment in which the asset is located; mapping dimensions of the nature-based asset; accessing data of monitored physical characteristics of the nature-based asset in the water environment based on the meta-descriptors of the asset; accessing data of monitored carbon concentration in the region of the water environment based on the meta-descriptors of the region; accessing data on monitored physical, chemical, and biological properties of the water environment based on the meta-descriptors of the region; and applying a model to the accessed data to assign a carbon sequestration contribution per unit measurement of the nature-based asset.

The invention discloses a degradable hypha mulching film and a preparation method thereof, and belongs to the field of agricultural mulching materials, and the degradable hypha mulching film is composed of hypha layers and a hypha cross-linking layer clamped between the hypha layers. The mushroom hypha mulching film is prepared by utilizing the characteristics of adhesion, water resistance and heat preservation of mushroom hyphae, and the method specifically comprises the following steps: culturing mushroom liquid strains, spraying the mushroom liquid strains onto plant fiber paper by taking the plant fiber paper as a bottom film, and degrading lignin and cellulose of the fiber paper by the hyphae to form a hypha cross-linked film, so as to prepare the mushroom hypha mulching film. The film has the basic characteristics of a mulching film, the prepared hypha mulching film has the characteristic of being naturally degraded after the crop growth cycle ends, and no residual matter is left in the soil environment in the degradation process. After the mulching film is degraded, the soil fertility can be effectively improved, the physicochemical properties and biological characteristics of soil can be improved, the problem of environmental pollution caused by the use of a traditional mulching film is further reduced, and powerful support is provided for sustainable development of agricultural production.

The invention provides a crocodile source Aeromonas daka argH gene deletion strain, a crocodile source Aeromonas daka argH gene back-filling strain and a construction method and application of the crocodile source Aeromonas daka argH gene deletion strain and the crocodile source Aeromonas daka argH gene back-filling strain, an argH gene recombinant suicide plasmid pRE112-delta argH is constructed by adopting a seamless cloning method, an Aeromonas daka strain is jointed with E.coli WM3064 containing the pRE112-delta argH to obtain the argH gene deletion strain delta argH, and a corresponding gene back-filling strain C delta argH is further constructed. Through biological characteristic analysis, the argH gene deletion reduces synthesis of arginine of Aeromonas dakara and biofilm formation amount, reduces growth rate, proteolytic activity and resistance to crocodile-derived antibacterial peptide, but enhances hemolytic activity, and significantly improves the survival rate of Caenorhabditis elegans, so that the Aeromonas dakara has a good application prospect in treatment of caenorhabditis elegans, and the Aeromonas dakara has a good application prospect in treatment of caenorhabditis elegans. Important reference is provided for further researching the regulation effect of the argH gene in a bacterial pathogenic mechanism and developing related prevention and control strategies.

The invention belongs to the technical field of biology, and particularly relates to bacillus velezensis HALZ676 as well as application and a method of the bacillus velezensis HALZ676 to cowhide fermentative degradation, the bacillus velezensis HALZ676 is separated from preserved pig trotters, and by analyzing biological characteristics, whole genome and metabonomics differences of the bacillus velezensis HALZ676, the cowhide can be efficiently degraded, and the cowhide can be efficiently degraded. It is found that peptide components smaller than 3000 Da in cow leather degradation liquid obtained through fermentation of the strain HALZ676 account for 68% or above, and the cowhide degradation liquid has remarkable antioxidant capacity and antibacterial capacity; the cowhide fermentation liquor is mainly used for promoting conversion and enrichment of antioxidant, anti-inflammatory and anti-cancer metabolites through a linoleic acid metabolic pathway, so that the antioxidant, anti-inflammatory and anti-cancer capacities of the cowhide fermentation liquor are enhanced; the cowhide fermented by the strain HALZ676 can enrich functional active components, and a theoretical basis and a promising strategy are provided for high-valued production of processing byproducts of livestock and poultry skin fermented by probiotic bacillus with high yield of collagenase.

A method for computational drug design includes defining a population of a plurality of compounds. Each compound includes one or more molecular properties. The method includes defining a training set of compounds from the population for which one or more biological properties are known. The method includes selecting, from the population, a subset of one or more compounds that are not in the training set. The method includes determining a subset score of the selected subset based on molecular properties of the one or more compounds in the selected subset, and evaluating the selected subset based on the determined subset score. The subset score is determined based on a frequency of the molecular properties in the population and on a frequency of the molecular properties in a sampled set comprising the training set and the selected subset.

The invention relates to the technical field of agricultural resources and environment, and particularly discloses a rapid fertilization improvement method for newly-reclaimed red soil dry land. The method systematically integrates the core steps of soil diagnosis aluminum toxicity passivation, composite conditioner deacidification, two-stage deep ploughing, organic and inorganic biological synergistic fertilization, soil moisture content regulation and control, earth surface covering, green manure planting and returning to the field and the like. The applied composition comprises a soil composite conditioner, a charcoal-based organic fertilizer and a specific functional microbial agent, wherein the soil composite conditioner comprises modified oyster shell powder, a calcium magnesium phosphate fertilizer, humic acid, polyglutamic acid and the like. The method relates to key processes such as temperature programming calcination modification of raw materials, co-pyrolysis and composite granulation of the materials and the like. The method can synchronously and quickly improve the chemical and biological properties of soil and optimize the physical structure of a plough layer, and has the advantages of high improvement targeting, synergistic interaction of all steps, high fertilizing speed and lasting effect; in addition, the method has the advantages of being coherent in process, high in resource utilization efficiency and easy to implement on a large scale.

The invention relates to a recombinant mussel-like mucoprotein as well as a coding gene and application thereof, and belongs to the technical field of gene engineering and protein engineering. According to the invention, partial functional sequences of different types of mussel mucin are screened, assembled and spliced to obtain a section of brand new mussel mucin-like sequence, and the sequence is optimized by escherichia coli codon preference to construct a high-expression recombinant strain. According to the recombinant strain, the soluble expression quantity of the target protein is remarkably improved by optimizing culture conditions. The recombinant protein does not carry any exogenous tag, and the provided purification method is low in cost, high in yield and suitable for large-scale production. The prepared recombinant mussel-like protein has good adhesiveness and oxidation resistance, and the modified recombinant mussel-like protein is further provided, and the biological performance of the modified recombinant mussel-like protein is better than that of unmodified recombinant mussel-like protein.

The invention discloses a disease-resistant nursery stock planting method based on nursery stock root protection, and relates to the technical field of nursery stock cultivation and planting. The problem that in the prior art, seedling root systems are not pertinently protected, and consequently the disease resistance of the seedling root systems is insufficient is solved. The survival rate and disease resistance of the seedlings are remarkably improved through whole-process refined treatment, the seedling selection link is accurately screened according to biological characteristics, and the seedling root system quality is guaranteed from the source; soil treatment is combined with deep ploughing, composite disinfection and improvement technologies, soil air permeability is improved by 40% or above, pathogenic bacteria are eliminated, root system protection measures and differentiated pruning and soaking schemes are customized according to different nursery stock characteristics, intertillage and soil loosening are matched with ventilation pipeline laying, and the root system growth physical environment is optimized; the multi-parameter sensor network is linked with the root system monitoring device, real-time dynamic regulation and control of the soil environment and the root system growth state are achieved, the disease resistance of the seedlings is enhanced, and the survival rate and the growth quality of the seedlings are improved.

The invention provides a saline-alkali soil improver with a high-activity surface and application, and belongs to the technical field of saline-alkali soil improvement. Under the ultrasonic condition, a sulfur source is pre-loaded into biomass, under the action of sulfate free radicals, the surface of hydrothermal carbon is etched in the hydrothermal reaction process, the specific surface area and porosity are increased, and meanwhile, part of fractured C-C bonds provide active sites for sulfur doping; meanwhile, alginate and Fe < 3 + > are cross-linked to form a hydrogel network, hydrothermal carbon is wrapped, sulfur stability is enhanced, direct contact between the material and soil is reduced, functional groups of the material are protected, efficient ion exchange in the membrane is achieved, and meanwhile the action duration of the material is prolonged. Through a triple mechanism of'exchange desalination-soil agglomeration-nutrient synergism ', physical, chemical and biological characteristics of the saline-alkali soil can be improved, crop growth is promoted, the content of heavy metals in the soil is reduced, carbon immobilization is enhanced, the bioavailability and toxicity of pollutants are reduced, and the structure and function of an ecological system are restored.

The invention relates to III-type collagen, in particular to application of III-type recombinant collagen peptide in a medical beauty filling material. Compared with aerogel obtained by photo-crosslinking only by the III type collagen peptide, the aerogel obtained by photo-crosslinking the III type collagen peptide and the catechol conjugated chitosan has the advantages that the mechanical property and the biological property of the aerogel obtained by photo-crosslinking only by the III type collagen peptide are improved. The III-type collagen peptide is used as a raw material to prepare the aerogel, and the aerogel can be applied to self-filling, has a natural and lasting filling effect and strong stability, and is not easy to deform or shift. The aerogel preparation process provided by the invention is environment-friendly, does not need the steps of high-temperature heating, chemical corrosion, organic solvent elution and the like, and is relatively environment-friendly.

The invention relates to the technical field of sewage treatment, and discloses a multi-index comprehensive evaluation method for performance comparison and selection of a sewage treatment filler, a scoring system including physical properties, chemical properties, biological properties and economic indexes is established, the physical properties include particle size, porosity and mechanical strength, and the chemical properties include adsorbability and ion exchange capacity; the biological properties comprise microbial adhesiveness and biological membrane activity, and the economical efficiency comprises filler cost and operation and maintenance cost. According to the method, multi-dimensional index fusion is adopted, physical, porosity, mechanical strength and chemical Langmuir adsorption models are integrated, biological electron microscope observation biological membrane coverage rate and economical efficiency LCCA analysis indexes are achieved, and full life cycle evaluation is achieved.

The present invention provides Lactiplantibacillus plantarum and a use thereof. A molecular marker gene for Lactiplantibacillus plantarum has a nucleotide sequence selected from one of the following: (1) a nucleotide sequence as shown in SEQ ID NO: 24; (2) a nucleotide sequence having at least 97%, 98%, 99% or higher homology with the nucleotide sequence as shown in SEQ ID NO: 24; and (3) a nucleotide sequence having one or more, e.g., 1, 2, 3, 4, 5, or more, nucleotide substitutions, deletions, or insertions in the nucleotide sequence as shown in SEQ ID NO: 24. The Lactiplantibacillus plantarum provided by the present invention has non-toxicity and good biological characteristics and has a good curative effect on the prevention and / or treatment of vaginal infection and related diseases thereof.

The invention discloses lactobacillus crispatus CML521 and application thereof, and relates to the technical field of microorganisms, and the lactobacillus crispatus CML521 is technically characterized in that the lactobacillus crispatus CML521 is obtained through separation and culture from poultry craw contents, and the lactobacillus crispatus CML521 has remarkable biological characteristics and can be effectively used for preparing medicines for treating poultry candidiasis; the discovery of the lactobacillus crispatus CML521 provides a brand new treatment thought and method for poultry to treat candidiasis, and the newly discovered microbial strain not only can help poultry to resist the infringement of candidiasis, but also is expected to play an important role in the veterinary medicine field, and provides guarantee for poultry health.

The invention discloses a recombinant plasmid of porcine circovirus type 3 and its application. The recombinant plasmid is a recombinant plasmid obtained by cloning a gene sequence of SEQ ID No. 1 into a pBluescript SK vector through EcoRI and SpeI restriction sites. The recombinant plasmid of the invention can be successfully rescued in PK-15 cells and can be continuously passaged. At the same time, the recombinant PCV3 virus and the PCV3 wild virus in positive PCV3 disease materials have the same biological characteristics, and cannot proliferate in PK-15 cells after inoculation. The successful construction of the recombinant virus provides an indispensable biological material for conducting pig infection experiments and subsequent vaccine development, breaking through the bottleneck of pig infection experiments and the development of immune preparations such as vaccines.

The invention provides a composition with vaginal bacteriostasis, the composition comprises chlorhexidine acetate, a Chinese herbal medicine preparation, lactic acid and a lactobacillus fermentation product, the Chinese herbal medicine preparation comprises cortex phellodendri, fructus cnidii, radix sophorae flavescentis and radix stemonae, and the pH value of the composition is 3.8-4.5. The invention also provides a lotion containing the composition and having a vaginal bacteriostasis effect and a preparation method of the lotion, besides the traditional bacteriostasis component chlorhexidine acetate, the traditional Chinese medicine bacteriostasis component, lactic acid and a lactobacillus fermentation product are also added, and all the components have a synergistic effect on vaginal bacteriostasis after being combined, so that the composition has a good effect on vaginal bacteriostasis. The pH value of the lotion is adjusted to 3.8-4.5 by the added lactic acid, so that the normal acidity of the vaginal cavity is not damaged, the growth of vaginal bacillus is facilitated, the lotion does not contain sugar substances such as chitosan and glucose, the growth and reproduction of pathogenic bacteria and trichomonas vaginalis are not facilitated, and the lotion has a special antibacterial function while the biological characteristics of the vaginal cavity are maintained.

Novel compositions of recombinant human CC10 protein have been generated by chemically modifying the pure protein in vitro. Several new synthetic preparations containing isoforms of chemically modified rhCC10 have been generated by processes that utilize reactive oxygen species and reactive nitrogen species. These preparations contain novel isoforms of rhCC10 which have been characterized with enhanced or altered biological properties compared to the unmodified protein. Preparations containing novel isoforms may be used as standards to identify and characterize naturally occurring isoforms of native CC10 protein from blood or urine and ultimately to measure new CC10-based biomarkers to assess patient disease status. These preparations may also be used to treat respiratory, autoimmune, inflammatory, and other medical conditions that are not effectively treated with the unmodified protein.