93 results about "Quantitative imaging" patented technology

Systems and methods for analyzing pathologies utilizing quantitative imaging are presented herein. Advantageously, the systems and methods of the present disclosure utilize a hierarchical analytics framework that identifies and quantify biological properties / analytes from imaging data and then identifies and characterizes one or more pathologies based on the quantified biological properties / analytes. This hierarchical approach of using imaging to examine underlying biology as an intermediary to assessing pathology provides many analytic and processing advantages over systems and methods that are configured to directly determine and characterize pathology from underlying imaging data.

The invention provides a heart MRI quantitative imaging motion correction and parameter graph reconstruction and segmentation method and system. The method comprises the following steps: constructing a multi-task model; and constructing a motion-free simulation signal data set of the selected quantity imaging task, and pre-training the single-pixel parameter estimation network and the single-pixel signal simulation network based on the data set. And constructing a real image data set of the selected amount of imaging tasks, fixing network parameters obtained by pre-training, and training a multi-task model to determine values of residual parameters in the model. And performing motion correction, quantitative parameter graph reconstruction and region-of-interest segmentation on a newly acquired image sequence of the selected amount of imaging task through the trained multi-task model, and outputting a reconstructed quantitative parameter graph and a segmentation mask of the quantitative parameter graph. The method is more accurate and quicker, and can realize full-automatic and one-stop post-processing of heart quantitative imaging.

The invention discloses a living blood vessel and lymph multi-parameter quantitative photoacoustic microscopic imaging system which comprises a high repetition frequency laser source, a photoacoustic scanning probe and a molecular imaging device. Through the cooperation of the multi-wavelength fast switching laser and the high-speed scanning probe, synchronous, dynamic and quantitative imaging of vascular function parameters and lymph concentration in a living tissue microenvironment is realized. The system has a video-level imaging rate and can capture a rapid biological process; through coaxial design of dispersion correction and a photoacoustic focus, high spatial resolution and high signal-to-noise ratio of a multispectral image are guaranteed; and the compact probe design realizes large-range scanning. The technology provides a powerful in-vivo visualization tool for research on life science problems such as tumor evolution and drug metabolism.

The invention relates to a magnetic resonance imaging electromagnetic parameter distribution scanning and calculation method, which comprises the following steps that a fast spin echo sequence I is adopted to scan a target body, parameters are (alpha1, TE0, TR0 and Bw1), alpha is a deflection angle, TE is echo time, TR repetition time and Bw receiving bandwidth; scanning a target body by adopting a fast spin echo sequence II, wherein parameters are (alpha2, TE0, TR0 and Bw1); scanning a target body by adopting a fast spin echo sequence III, wherein parameters are (alpha2, TE0, TR0 and Bw2); and scanning the homogeneous water model by adopting the fast spin echo sequences I, II and III. And under the condition that the magnetic vector precession meets the conditions that the amplitudes are comparable when the phases are the same and the phases are differentiable when the amplitudes are the same, each magnetic field and electric field parameter is calculated based on the homogeneous water model data. According to the invention, decoupling of the proton density and the sensitive field of the signal is realized, so that magnetic resonance weighted quantization imaging becomes possible.

According to the subclinical non-obstructive coronary atherosclerosis metaphase plaque progress risk prediction method based on interpretable machine learning provided by the invention, multi-dimensional images and clinical features are integrated, and individualized risk prediction of subclinical non-obstructive coronary atherosclerosis is realized. Quantitative imaging biomarkers are managed for a long time, a key tool is provided for early screening of high-risk individuals, clinical doctors can be helped to judge whether comprehensive strategies such as enhanced lipid lowering, anti-inflammation and lifestyle intervention need to be adopted in time or not, plaque stabilization or fading is maximized, and the clinical effect is improved. And further, the future cardiovascular event risk is reduced. According to the method, a Shapley additive SAHP interpretation technology is introduced, the relative contribution of each prediction feature is quantified, and the interpretability of a machine learning model is improved. According to the method, a webpage tool for calculating the plaque progress probability on line is deployed, and the contribution degree of each feature to the plaque progress prediction result of a specific patient can be displayed more visually.

A method and a system for generating a multimodal diagnostic output related to a pathological condition of a patient includes at least one processor and a memory storing instructions executable by the processor to receive medical image data and narrative data of the patient. The medical image data is preprocessed through normalization, while the narrative data is standardized to ensure consistency. The preprocessed image data is input into a trained deep residual network (ResNet) to extract quantitative imaging features indicative of the pathological condition. In parallel, the preprocessed narrative data is input into a thematic analysis module to derive thematic codes reflecting emotional, cognitive, or social factors of the patient. The extracted imaging features and thematic codes are fused into a combined feature vector, which is processed by an integrated diagnostic model to generate a multimodal diagnostic output that enhances clinical precision and contextual interpretation.

The invention discloses a multi-element quantitative analysis method for laser ablation inductively coupled plasma mass spectrometry, and aims to solve the problems that the quantitative process of the existing LA-ICP-MS technology depends on a standard sample, the automation degree is low, and the existing LA-ICP-MS technology cannot adapt to complex multi-element signals. According to the method, full-automatic and multi-element (such as 9 main quantities and 30 trace elements) quantitative analysis is realized in the LA-ICP-MS field without an internal standard and an external standard, the analysis efficiency, the accuracy and the data comparability among different platforms are remarkably improved, and a breakthrough solution is particularly provided for application of element quantitative imaging and the like.

The present invention provides an imaging method for the singular mode vibration mode of FBAR based on the semi - analytical finite element theory, including the following steps: Step S1, constructing a semi - analytical finite element formulation of a FBAR with a complex electrode configuration; Step S2, using triangular elements to mesh the upper surface of the FBAR to obtain the coordinates of three nodes in each mesh element; Step S3, determining the interpolation shape function, stiffness matrix and mass matrix of each mesh element according to the node coordinates; Based on the semi - analytical finite element theory, the present invention characterizes the vibration mode of a three - dimensional FBAR at ultra - high frequencies, reduces the three - dimensional modal vibration imaging of a three - dimensional FBAR device to two - dimensional planar imaging. The simplification of the element type and the substantial reduction in the number of elements make the imaging technology provided by the present invention have a lower time cost. At the same time, it does not require various parameter settings and post - processing in commercial finite element software, realizing fast and quantitative imaging of the FBAR vibration mode.

The application relates to a kind of quantitative imaging methods of living cells based on digital holographic microscopic sequential displacement aberration correction, and belongs to the field of optical measurement, comprising: collecting three holograms by sequentially displacing living cells; obtaining three original phase maps by phase demodulation; obtaining total mask map; sequentially displacing phase map in reverse direction; performing difference calculation to obtain global phase system aberration difference data; obtaining local system aberration difference data by using total mask map; performing difference processing on Chebyshev polynomial to obtain local polynomial difference data by using total mask map; fitting global system aberration by calculating corresponding coefficients from difference data; subtracting global system aberration from three original phase maps to obtain phase map of living cells after aberration correction. The application realizes high-precision quantitative phase imaging of living cells while retaining high-frequency information, has excellent displacement distance robustness, does not need to be equipped with high-precision displacement mechanism, and greatly reduces the hardware cost of measurement system.

The present invention is a high-resolution magnetic resonance fingerprinting method based on radio frequency encoding, a device and storage medium, where radio frequency encoding is introduced into MRF, n time evolution signals can be collected by designing and respectively scanning a set of n radio frequency pulse signals, separate time evolution signals representing n sub-slices can be obtained after decoding and calculating according to a encoding process, and then separate quantitative images of the n sub-slices can be obtained through dictionary matching. Compared with conventional MRF, a slice resolution of the quantitative images obtained in the imaging method of the present invention is increased by n times and a signal-to-noise ratio is not reduced. Through a phantom experiment and a human experiment, accuracy of quantitative effect and an effective improvement of the resolution of the present invention are proved, and the present invention can provide higher-resolution quantitative imaging results.

The present invention discloses an automatic calibration device and method for the excitation light intensity in quantitative FRET imaging. The device includes a FRET multi-wavelength combined light source, a beam splitting device, a light intensity detector, a lower computer and an upper computer. The FRET multi-wavelength combined light source is used to generate the excitation light for the donor channel and the acceptor channel during the FRET microscopic imaging process. The beam splitting device is used to split the excitation light. The light intensity detector is used to detect the partial light intensity of the excitation light for the donor and acceptor in the split light path. The lower computer completes channel selection and light intensity control by receiving instructions from the upper computer. The upper computer is used to collect and process the excitation light intensity information of the channels sent by the light intensity detector, and send a compensation instruction to the lower computer. The present invention is designed with independent modules, which can be conveniently placed in the output light path of any multi-wavelength combined light source and is flexibly applicable to different experimental environments. It can control the output intensity of the excitation light for the donor and acceptor and the intensity ratio of the donor and acceptor according to the requirements of the FRET experiment, and is suitable for quantitative FRET detection.

A high-resolution, multi-parameter quantitative magnetic resonance imaging method and system based on multi-scan overlapping echoes relates to magnetic resonance imaging methods. The method comprises: designing a high-resolution, multi-parameter, simultaneous quantitative imaging sequence based on multi-scan overlapping echoes and determining its sampling parameters; using the designed sequence and sampling parameters in a magnetic resonance instrument that meets the sequence and sampling parameters to acquire data from the imaging object and obtain magnetic resonance signals; processing the magnetic resonance signals to obtain images acquired by the sequence; designing a high-fidelity quantitative reconstruction method; and using the method to quantitatively reconstruct the acquired magnetic resonance images to obtain high-resolution, multi-parameter quantitative magnetic resonance images. This method enables high-resolution, multi-parameter simultaneous quantitative magnetic resonance imaging and overcomes the problem of loss of reconstructed details under low signal-to-noise ratio conditions. Experimental results demonstrate that the reconstructed magnetic resonance quantitative parameter images are highly consistent with those obtained by reference methods, exhibit high imaging accuracy, and have broad application prospects.

This invention discloses a single-snapshot spatial frequency domain imaging and morphology correction method, system, and device, comprising: acquiring a set of monochromatic fringe images with different center wavelengths based on the same projected image; simultaneously inputting each monochromatic fringe image in the set into two parallel and independent deep learning networks, wherein the first deep learning network is used to extract the DC and AC components of the image; the second deep learning network is used to extract the wrapping phase component and fringe hierarchy information of the image, and perform absolute phase calculation to obtain the three-dimensional morphology before correction; performing height correction on the three-dimensional morphology and calculating the corrected diffuse reflectance image; performing background segmentation on the corrected diffuse reflectance image and spatially aligning it to the same coordinate system; and retrieving the optical characteristic parameters and physiological parameters of the tissue based on the spatially registered multi-wavelength diffuse reflectance data. This invention ultimately achieves real-time, wide-field, high-precision, and highly robust quantitative imaging of tissue physiological parameters.

The present invention relates to the hyperspectral detection of luminescence, in particular to the luminescence detection of solid phase samples excited using a radiation source.

The application discloses a B0 robust cardiac T1 quantitative imaging method, and belongs to the field of magnetic resonance quantitative imaging, and comprises the following steps: designing a dual-phase increment cardiac T1 quantitative imaging acquisition sequence, collecting original data based on the dual-phase increment cardiac T1 quantitative imaging acquisition sequence, constructing a simulation signal dictionary based on a magnetic resonance physical model, matching the original data with the simulation signal dictionary to obtain the best dictionary entry corresponding to the original data, and obtaining a T1 quantitative image and a B0 quantitative image based on the best dictionary entry. The application encodes B0 information by using a dual-phase increment sequence design, realizes B0 robust T1 quantitative imaging, reduces the influence of B0 field inhomogeneity under high field strength, and reduces bSSFP black band artifact interference. In combination with the dictionary matching technology, T1 and B0 are jointly estimated, more accurate T1 estimation and B0 quantitative images are provided, the method is easy to deploy and apply on an existing MRI platform, and has high implementation and migration feasibility.

The application provides a one-stop multi-delay arterial spin labeling kidney perfusion measurement method and system, and belongs to the field of magnetic resonance imaging. The method comprises the following steps: acquiring a time-encoding-based kidney arterial spin labeling sequence image of a subject; acquiring a kidney M0 image of the subject, wherein the M0 image is consistent with the number of layers, resolution and image acquisition mode of the kidney arterial spin labeling sequence image; and performing registration on the kidney arterial spin labeling sequence image and the M0 image to obtain a kidney perfusion measurement result of the subject. The application can realize one-stop multi-delay blood perfusion quantitative imaging of the kidney, greatly improves the imaging efficiency of traditional kidney multi-delay arterial spin labeling imaging, and fills the blank of one-stop multi-delay blood perfusion imaging of the kidney.

The application discloses a kind of time sequence in situ zymogram soil enzyme activity quantitative imaging methods based on multi-parameter screening, it is related to soil enzyme activity detection technical field, the method collects time sequence fluorescence image of enzymatic reaction, constructs pixel-level time sequence gray matrix;Multi-stage screening is carried out to pixel, including initial screening based on gray value and standard deviation, slope and goodness of fit screening of sliding window fitting, and reaction time window final screening;Extract maximum local linear growth rate as uncorrected enzyme activity, introduce diffusion correction model correction, obtain corrected enzyme activity;Quantitative conversion and visual output are realized in combination with fluorescence standard curve.This application changes static measurement into dynamic process analysis, effectively suppresses background noise, significantly improves the sensitivity, spatial resolution and quantitative accuracy of enzyme activity detection.

The application discloses a kind of superficial tissue viscoelasticity imaging system and imaging method, belong to biomedical ultrasonic imaging technical field;Among them, superficial tissue viscoelasticity imaging system includes ultrasonic robot, synchronous control module and data processing module;Ultrasonic robot is carried with the flexible patch ultrasonic probe of multiple source pressure sensing module setting, and ultrasonic robot, flexible patch ultrasonic probe and synchronous control module cooperate to realize the synchronization of creep mechanics excitation application, ultrasonic data acquisition and mechanics data acquisition;Data processing module is used to based on KVFD fractional viscoelasticity model inversion elastic modulus, flow parameter and viscous time constant, generates viscoelasticity multi-parameter quantitative imaging graph.The present application realizes automatic precision force loading and standardization imaging, solves the technical problems of poor repeatability of manual pressurization, unstable curved surface fitting, large physiological interference and insufficient viscoelasticity quantitative precision in the prior art.

The present application discloses a magnetic resonance quantitative imaging method, apparatus, device and storage medium thereof based on image structure and physical relaxation priors. The method comprises: extracting image blocks with structural similarity based on a block matching method, and constructing a low-rank structure tensor based on the image blocks; constructing a low-rank parameter tensor for a weighted image using a signal physical relaxation prior; and establishing an image reconstruction model and solution method based on a low-rank tensor using the low-rank structure tensor and the low-rank parameter tensor. The above-mentioned scheme provided by the present application greatly accelerates the data scanning speed and reduces the quantitative imaging time. During image reconstruction, the reconstruction method proposed by the present invention can still accurately reconstruct a parameter-weighted image from highly undersampled data at a high acceleration factor.

The invention provides a quantitative detection method for extracellular vesicles based on self-interference spectrum reconstruction, and relates to the crossing field of biomedical detection and optical engineering. The method comprises the following steps: adding a clinical sample into a digital micro-fluidic chip, and separating sample liquid drops and liquid drops with functional modified magnetic beads through an electrode; mixing the two liquid drops, adding a vesicle binding solution, mixing, and incubating; fixing the magnetic beads through magnetic control, removing the solution, and adding deionized water to clean the magnetic beads; after removing the magnetic bead cleaning solution, adding a vesicle eluent and the magnetic beads for incubation; liquid drops containing extracellular vesicles are separated out; transferring the liquid drops containing the extracellular vesicles to the upper part of a gold-plated slide, incubating and then removing the liquid drops; washing the hybridized gold-plated glass slide with deionized water; and detecting the number and particle size distribution of the vesicles by using a self-interference spectral imaging system. According to the invention, quantitative counting, particle size measurement and surface protein marker detection of extracellular vesicles can be realized at the same time, and quantitative imaging precision and detection efficiency of single vesicles are improved.

The application provides an ultrasonic craniocerebral tomography method based on a physically embedded neural network, and steps are as follows: firstly, according to the distribution characteristics of a craniocerebral biological tissue, a real physical CT brain model is converted into a craniocerebral acoustic velocity distribution map; secondly, according to the craniocerebral velocity distribution map and the physical characteristics of craniocerebral ultrasonic signal propagation, a sound field time domain signal is acquired; thirdly, the sound field time domain signal is subjected to data preprocessing to acquire a frequency domain data matrix, and a numerical simulation database is established; then, a neural network structure based on a full waveform inversion algorithm and embedding physics is built, and the network is trained by using the craniocerebral acoustic velocity distribution map and the frequency domain data matrix to obtain a combination of optimal network hyperparameters; finally, the frequency domain data matrix to be predicted is input into the network to realize high-precision and real-time ultrasonic craniocerebral tomography. The application realizes quantitative imaging and evaluation of brain structure, and has the advantages of fast imaging speed and high imaging precision.

The invention discloses a multi-parameter magnetic resonance quantitative imaging method and system, and relates to the technical field of MRI (magnetic resonance imaging), and the method comprises the steps: employing a multi-overlap echo sequence XMOLED, carrying out the simulation of magnetic resonance simulation software, and generating a simulation XMOLED image, constructing a simulation data set composed of a large number of paired simulation XMOLED images, simulation T2, T2 * and an apparent diffusion coefficient (ADC) quantitative graph, and training a deep learning neural network used for reconstruction of the magnetic resonance parameter quantitative graph; sequence parameters are configured on a magnetic resonance imaging instrument, an XMOLED signal of an actual imaging object is collected, and an XMOLED image of the actual imaging object is obtained through signal processing; and inputting the XMOLED image of the actual imaging object into the trained magnetic resonance parameter quantitative graph reconstruction network for reconstruction to obtain T2, T2 * and ADC quantitative graphs of the actual imaging object. According to the method, T2, T2 * and ADC quantitative diagrams can be obtained at the same time only through single-sequence XMOLED collection, the problem that scanning time is prolonged due to multi-sequence combined imaging is solved, and rapid and accurate multi-parameter quantitative magnetic resonance imaging is achieved.

This invention provides a method and system for motion correction in quantitative magnetic resonance imaging (MRI) based on dictionary matching, comprising: Step S1: generating a dictionary by simulating the evolution of the MRI signal and constructing an optimization problem to be solved; Step S2: performing dictionary matching on the acquired quantitative imaging image sequence to obtain a parameter map and a simulated image sequence; Step S3: registering the acquired image sequence to the simulated image sequence to correct motion; alternately executing steps S2 and S3 to solve the optimization problem until convergence, obtaining the motion-corrected image sequence and parameter map. This invention models the contrast changes of the quantitative imaging image sequence based on MRI physics, thus being more accurate and robust than methods based on image characteristics.

The method of operating an image device comprises receiving an input of virtual tissues modeled with an arbitrary shape and a quantitative feature, simulating a TOF change or a signal strength change of ultrasound data having penetrated the virtual tissues modeled with a speed-of-sound distribution or an attenuation coefficient distribution in a first and in a second direction, and creating an image pair representing the TOF change or the signal strength change, creating a speed-of-sound distribution image or an attenuation coefficient distribution image of each of the virtual tissues as a ground truth of an image pair created in the corresponding virtual tissue, and training a first neural network that reconstruct the speed-of-sound distribution image from an input image pair or training a second neural network that reconstructs the attenuation coefficient distribution image from the input image pair.

The present invention discloses a brain function quantitative imaging device, comprising: a main structure for detecting brain function, and an electric telescopic cable structure arranged at the upper end of the main structure for detecting brain function; a hanging strap structure arranged at the lower end of the main structure for detecting brain function, wherein an adjusting structure is arranged on one side of the hanging strap structure, and the adjusting structure is fixedly connected to one side of the hanging strap structure; an installation limiting structure arranged above the adjusting structure, and a surrounding detection structure is arranged above the installation limiting structure; a distribution area control board arranged on one side of the surrounding detection structure, and detection dots are arranged on the surface of the distribution area control board; a connecting line arranged at one end of the detection dots, and the connecting line is integrally formed with one end of the detection dots. It realizes multi-faceted scanning and detection during the use of the brain function quantitative imaging device, thereby effectively avoiding the problem of affecting the judgment and treatment of medical staff.

The invention relates to a microwave-induced thermoacoustic transcranial quantitative imaging method based on a REAGU-Net network, and the method achieves the simultaneous quantitative reconstruction of dielectric constant, conductivity and sound velocity in brain tissue through the MITAT technology, and provides a new methodology for the characteristic analysis of the brain tissue. A REAGU-Net novel network is developed, an attention guiding block and a residual error inducing block are combined to process the influence of acoustic non-uniformity on reconstruction quality, and effective application of deep learning in quantitative reconstruction is shown; the technology not only shows a good result in cerebral hemorrhage detection, but also can be potentially applied to detection and diagnosis of various diseases including breast cancer, liver diseases and thyroid diseases, and a new quantitative analysis tool is provided for clinic; the DL-MITAT method provided by the invention can provide quantized physical characteristic data, and the data not only is helpful for imaging, but also can provide support for physiological information prediction and the like in subsequent electromagnetic treatment; compared with a traditional TCD or ultrasonic imaging method, the transcranial MITAT has the remarkable advantages that due to the fact that ultrasonic waves of the transcranial MITAT only need to be transmitted with the skull for one time, the possibility of image attenuation and degeneration is reduced, and the imaging quality is improved.

The present application discloses a phase contrast microscope, a phase shift quantitative imaging method, a system and a storage medium. The microscope includes a dot matrix target ring light source, a pupil aperture, a sample stage, a zone plate objective lens, a dot matrix phase shift ring and a detector arranged in sequence. In the present application, the dot matrix target ring light source is imaged on the dot matrix phase shift ring by the zone plate objective lens, and each point source image has a uniquely corresponding phase filtering point on the dot matrix phase shift ring. Since the point source image and the phase filtering point are relatively small, after the sample is placed, most of the low-order diffracted light can pass unobstructed beside the phase filtering point, thereby maximizing the elimination of the cause of halo artifacts. Combining with a simple phase shift imaging method, the purpose of phase shift quantitative imaging is achieved.

The invention discloses a multi-parameter quantitative imaging method and device, nuclear magnetic resonance equipment and a storage medium, the multi-parameter quantitative imaging method is applied to the nuclear magnetic resonance equipment, and the nuclear magnetic resonance equipment comprises a T2 preparation sequence module and a variable flip angle multi-echo gradient echo sequence module connected with the T2 preparation sequence module. Comprising the steps that equivalent echo time is controlled through a T2 preparation sequence module, a flip angle is controlled through a variable flip angle multi-echo gradient echo sequence module, a target object is scanned, and a multi-parameter echo signal is obtained; and performing imaging processing on the multi-parameter echo signal based on the image demand configuration information to obtain a required multi-parameter quantitative image. According to the invention, T2 preparation and a variable flip angle technology are combined, and a multi-parameter echo signal can be obtained through one-time scanning, so that a multi-parameter quantitative image is obtained, and the parameter imaging efficiency is improved.

The invention discloses a multi-parameter quantitative method and system based on multi-overlap echo steady-state free procession and a multi-task learning network, and relates to magnetic resonance imaging. The method comprises the following steps: designing and debugging a multi-overlap echo steady-state free precession sequence to obtain a magnetic resonance image with multiple contrast (T1, T2, T2 *) weighting; generating a training sample of the deep neural network; designing a multi-task deep learning network fusing interlayer information; training a network weight by adopting the training sample; and the trained multi-task deep learning network is adopted to map the actually acquired magnetic resonance image, and quantitative images of a plurality of parameters are obtained at the same time. Rich multi-contrast multi-echo information is provided based on multi-overlap echo steady-state free precession, a multi-task deep learning network fuses characteristics of different tasks in different levels, multiple times of scanning are not needed, and rapid and accurate multi-parameter simultaneous quantitative imaging can be achieved in one time of scanning.

The method of operating an image device comprises receiving an input of virtual tissues modeled with an arbitrary shape and a quantitative feature, simulating a TOF change or a signal strength change of ultrasound data having penetrated the virtual tissues modeled with a speed-of-sound distribution or an attenuation coefficient distribution in a first and in a second direction, and creating an image pair representing the TOF change or the signal strength change, creating a speed-of-sound distribution image or an attenuation coefficient distribution image of each of the virtual tissues as a ground truth of an image pair created in the corresponding virtual tissue, and training a first neural network that reconstruct the speed-of-sound distribution image from an input image pair or training a second neural network that reconstructs the attenuation coefficient distribution image from the input image pair.