623results about "Measurements using NMR spectroscopy" patented technology

This invention pertains to chemometric methods for the analysis of chemical, biochemical, and biological data, for example, spectral data, for example, nuclear magnetic resonance (NMR) spectra, and their applications, including, e.g., classification, diagnosis, prognosis.

A solid-state gyroscope apparatus based on ensembles of negatively charged nitrogen-vacancy (NV⁻) centers in diamond and methods of detection are provided. In one method, rotation of the NV⁻ symmetry axis will induce Berry phase shifts in the NV⁻ electronic ground-state coherences proportional to the solid angle subtended by the symmetry axis. A second method uses a modified Ramsey scheme where Berry phase shifts in the ¹⁴N hyperfine sublevels are employed.

This invention pertains to chemometric methods for the analysis of chemical, biochemical, and biological data, for example, spectral data, for example, nuclear magnetic resonance (NMR) spectra, and their applications, including, e.g., classification, diagnosis, prognosis, etc., especially in the context of bone disorders, e.g., conditions associated with low bone mineral density, e.g., osteoporosis.

A two-dimensional (2D) chemical shift correlated MR spectroscopic (COSY) sequence integrated into a new volume localization technique (90°-180°-90°) for whole body MR Spectroscopy. Using the product operator formalism, a theoretical calculation of the volume localization as well as the coherence transfer efficiencies in 2D MRS is presented. A combination of different MRI transmit/receive rf coils is used. The cross peak intensities excited by the proposed 2D sequence are asymmetric with respect to the diagonal peaks. Localized COSY spectra of cerebral frontal and occipital gray/white matter regions in fifteen healthy controls are presented.

An interpretation method and system for NMR echo-train data in thinly laminated sequences. The invention uses geological information obtained at higher vertical resolution, such as using Electric Micro Imaging, to enhance the vertical resolution of echo-train data, and thus avoids log interpretations in which the hydrocarbon potential of the formation can be misread because low resolution logs tend to provide an average description of the formation. Such averaging is especially problematic in thinly laminated sequences that consist of highly permeable and porous sand layers and less permeable silt or essentially impermeable shale layers. In a preferred embodiment, using the additional high-resolution formation information one can estimate the typical T2-spectra of lithological laminae, and significantly enhance the permeability estimate in the laminated sequences. The method and system are applicable to any temporal data from other logging tools, such as the thermal neutron decay log and others. The system and method enable proper evaluation of the high potential of thinly laminated formations, which may otherwise be overlooked as low permeable formations.

A system and method are presented for use in monitoring brain activity of a subject. The system comprises a control unit which comprises: a data input utility for receiving measured data comprising data corresponding to signals measured during a certain time period and being indicative of a subject's brain activity originated from locations in the subject's brain during said certain time period, and a processor utility which is configured and operable for processing the measured data and generating data indicative thereof in the form of a multi-parameter function presenting a relation between frequency and time data of the measured signals and for analyzing said relation and identifying a subject-related signature corresponding to the subject's brain neural activity.

The disclosed innovation is a method for acquiring spatial frequency spectra from specific locations in a 3D sample using modifications of the current MRI techniques for localized NMR spectroscopy. The innovation in its simplest abstraction is to add the use of a read out gradient to the current NMR spectroscopy pulse sequences and record the resultant echo. These techniques generate spectra from a selected region or generate an image of the results over a region of the sample. These methods can be applied to analyzing the structure of trabecular bone as well as for analyzing or diagnosing disease in cases where there is a difference in the spatial frequency power spectrum due to physiologic or disease processes. Various embodiments are disclosed.

A method for detecting the presence of precipitants in a hydrocarbon stream, the method comprising introducing at least a portion of the hydrocarbon stream into a measurement chamber of an NMR measuring device, assaying the fluids in the chamber with proton nuclear magnetic resonance to obtain NMR signals, and processing the NMR signals to detect the formation of precipitants in the hydrocarbon stream. The method may be carried out at first and second locations, and NMR signals obtained at the two locations compared to detect precipitation of precipitant between the two locations. A method of monitoring the water content of a hydrocarbon stream in a flowline comprising introducing at least a portion of the hydrocarbon stream into an NMR measuring device, measuring a baseline NMR water signal of the hydrocarbon stream and comparing subsequent NMR water signals with the baseline NMR water signal to detect changes in the water content of the hydrocarbon stream.

A system and a method for applying ¹³C or ¹H NMR spectroscopy to a sample of crude oil in order to calculate the cetane number, pour point, cloud point, aniline point and octane number of a gas oil fraction of the crude oil.

The chemical composition of petroleum samples is measured using orbitrap mass spectrometry with electrospray ionization (ESI). The orbitrap measurement is used in a screening to determine if one or more higher resolution (but more expensive) compositional analyses are justified.

The present invention relates to a device capable of producing a high resolution chemical analysis of a sample, such as fluid, based upon nuclear magnetic resonance (NMR) spectroscopy, where the nuclear magnetic polarizations of the sample are generated by sequentially illuminating the sample with a focused beam of light carrying angular orbital angular momentum (OAM) and possibly momentum (spin). Unlike in usual NMR used for magnetic nuclear resonance imaging (MRI) or spectroscopy, the invention does not make use of a strong magnet.

The present invention provides magnetic resonance multidimensional selectivity based on spatiotemporal encoding (SPEN). In particular, multidimensional selectivity is achieved by the concurrent application of frequency-swept irradiation and magnetic field gradients for the sequential manipulation of spins in space in one dimension or more. Simultaneous spatial and spectral selectivity is disclosed.

An embodiment of a method of detecting a J-coupling includes providing a polarized analyte adjacent to a vapor cell of an atomic magnetometer; and measuring one or more J-coupling parameters using the atomic magnetometer. According to an embodiment, measuring the one or more J-coupling parameters includes detecting a magnetic field created by the polarized analyte as the magnetic field evolves under a J-coupling interaction.

An apparatus and method for remote NMR/MRI spectroscopy having an encoding coil with a sample chamber, a supply of signal carriers, preferably hyperpolarized xenon and a detector allowing the spatial and temporal separation of signal preparation and signal detection steps. This separation allows the physical conditions and methods of the encoding and detection steps to be optimized independently. The encoding of the carrier molecules may take place in a high or a low magnetic field and conventional NMR pulse sequences can be split between encoding and detection steps. In one embodiment, the detector is a high magnetic field NMR apparatus. In another embodiment, the detector is a superconducting quantum interference device. A further embodiment uses optical detection of Rb—Xe spin exchange. Another embodiment uses an optical magnetometer using non-linear Faraday rotation. Concentration of the signal carriers in the detector can greatly improve the signal to noise ratio.

An exemplary methodology, procedure, system, method and computer-accessible medium can be provided to determine one or more particular frequencies of cross-relaxation between at least one molecule and at least one particular compound, determine a chemical exchange based on magnetic resonance data using a further frequency which is different from the one or more particular frequencies, and derive particular information about the anatomical region of interest based on the chemical exchange.

Apparatus for performing in-vitro DNP-NMR measurements on a sample comprises magnetic field generating apparatus (1a, 1b) located in a cryostat (2) and surrounding a bore defining respective NMR and DNP working regions (90, 92). A system for performing DNP on a suitably prepared sample in the DNP working region. A system for performing a NMR process on a sample in the NMR working region. A sample positioning mechanism (5) which can be inserted in the bore (3) to bring a sample in turn into each of the working regions. The magnetic field generating apparatus is suitably structured so that the magnetic field in the DNP working region has a homogeneity or profile suitable for performing DNP on the sample and the magnetic field in the NMR working region has a homogeneity or profile suitable for performing a NMR process on the sample.

A nuclear magnetic resonance method and apparatus are disclosed. A sample is provided where the nuclear spin Hamiltonian operator of the component molecules of the sample possess one or more symmetry operations. A quasi equilibrium nuclear spin ensemble state in a sample is created. The quasi equilibrium nuclear spin ensemble state includes at least two manifolds of spin states which transform differently under the symmetry operations of the Hamiltonian and the manifolds having different mean nuclear spin populations. The quasi equilibrium nuclear spin ensemble state is allowed to remain for a time of equal to or substantially greater than 3T₁, where T₁ is the spin lattice relaxation time. The symmetry operation of the Hamiltonian is broken. A sequence of magnetic fields is applied to generate a nuclear magnetic resonance signal from the sample. The nuclear magnetic resonance signal is detected.

The invention provides a method for obtaining a high-resolution three-dimensional NMR spectrum under a non-uniform magnetic field, and relates to nuclear magnetic resonance spectrometers. The method comprises the steps that (1) a one-dimensional spectrum is sampled by using a conventional one-dimensional pulse sequence and used for analyzing the condition of the non-uniformity of the magnetic field to obtain the line width of a spectral line and provide a basis for experimental spectral width parameter settings; (2) a precompiled intermolecular zero-quantum-coherence three-dimensional spectrum pulse sequence is guided into a nuclear magnetic resonance spectrometer; (3) an intermolecular zero-quantum-coherence signal selection module, an indirect dimension evolution period t1 module, an indirect dimension evolution period t2 module, an indirect dimension evolution period t3 module and a signal sampling period t4 module of the intermolecular zero-quantum-coherence three-dimensional spectrum pulse sequence are opened, and experiment parameters of all the modules of the pulse sequence are set; (4) the intermolecular zero-quantum-coherence three-dimensional spectrum pulse sequence in the step (3) after experimental parameter setting is executed, and data sampling is performed; (5) after data sampling is completed, relevant data post-processing is performed, so that the high-resolution three-dimensional NMR spectrum free of influence by the non-uniform magnetic field is obtained.

Systems and methods for testing properties of a test sample with a tri-axial nuclear magnetic resonance include a tri-axial load frame encasing a tri-axial load cell having a tri-axial sample holder and a piston assembly. A radial space surrounds the tri-axial sample holder. The tri-axial load frame further encases at least one end cap operable to contact the tri-axial load cell, and a nuclear magnetic resonance instrument. An axial pressure line is in fluid communication with the piston assembly, a confining pressure line is in fluid communication with the radial space, and a pore pressure line in fluid communication with the test sample. The axial pressure line, the confining pressure line, and the pore pressure line are independent and separate fluid flow paths.