29 results about "Nuclear imaging" patented technology

The present disclosure relates to the field of nuclear imaging and therapy, and more specifically to high purity copper radiotracer compositions useful in imaging, such as positron emission tomography (PET) and single-photon emission computerized tomography (SPECT), and therapy. More specifically, the present disclosure relates to novel compositions useful in imaging and treatment of conditions such as prostate cancer, somatostatin receptor-expressing tumors, like neuroendocrine tumor, epithelial tumors, as well as to methods wherein such compositions are prepared.

Systems and methods for correcting timing information associated with captured nuclear imaging data, and for reconstructing medical images based on the corrected timing information, are disclosed. In some embodiments, an image scanning system scans a subject, detects an event, and generates timing data for the detected event. The timing data includes a first number of bits, and characterizes a time that a crystal of the image scanning system detected the event. The image scanning system shifts the first number of bits by a predetermined amount to generate a second number of bits, where the second number of bits includes at least one bit representing a lower order time value than the least significant bit of the first number of bits of the timing data. Further, the image scanning system generates timing correction data for the event based on the second timing data.

There are provided fructose-based radiopharmaceuticals, pharmaceutical compositions comprising same, methods for preparing same, and methods of using same for biomedical imaging, particularly nuclear imaging using PET or PET / CT. (Compound 7)

Systems and methods for motion estimation and correction in nuclear imaging systems are disclosed. In some examples, a processing device receives measurement data, such as positron emission tomography (PET) measurement data, from an image scanning system. The processing device applies a histo-imaging process to the measurement data and, based on applying the histo-imaging process to the measurement data, generates a histo-image. Further, the processing device applies a trained machine learning process to the histo-image and, based on applying the trained machine learning process to the histo-image, the processing device generates a short-frame image. The processing device also determines a position of a mass in the short-frame image, and generates motion data characterizing a motion of the mass based on the position. In some examples, a reconstructed image is generated based on the motion data.

This invention discloses a neutron-gamma dual-mode synchronous imaging method and system based on single-pixel detection, belonging to the field of nuclear imaging technology. The method includes: irradiating the sample under test with modulated neutron beams of different encoding modes, identifying the neutron event count and gamma-ray energy spectrum for each irradiation; dividing the sample under test into several pixel units, reconstructing a neutron transmission structure image based on the neutron event count for each irradiation; obtaining the detection efficiency of the characteristic gamma rays received by each pixel unit of the sample under test, and constructing a gamma response modulation matrix in combination with the neutron transmission structure image; extracting the net count of the characteristic peaks of the target element from the gamma-ray energy spectrum, reconstructing an element distribution image in combination with the gamma response modulation matrix, and fusing it with the neutron transmission structure image for output. This invention achieves synchronous acquisition of structural and elemental information, automatic spatial registration, and joint high-precision reconstruction, and is particularly suitable for the engineering application of miniaturized neutron sources.

The application relates to a multi-nucleus imaging sequence determination method, device and magnetic resonance system, wherein the multi-nucleus imaging sequence determination method comprises the following steps: acquiring an initial multi-nucleus imaging sequence, wherein the initial multi-nucleus imaging sequence comprises the pulse arrangement of several kinds of nuclei in a single repetition time; and adjusting the pulse arrangement of at least one kind of nucleus to optimize the initial multi-nucleus imaging sequence, thereby obtaining a target multi-nucleus imaging sequence. According to the application, the target multi-nucleus imaging sequence can be obtained, and the target multi-nucleus imaging sequence is a multi-nucleus imaging sequence obtained by combining and optimizing a plurality of single-nucleus imaging sequences. Therefore, the multi-nucleus imaging sequence can complete the scanning and imaging of multiple kinds of nuclei in one scanning and imaging process, and compared with sequentially imaging each kind of nucleus respectively, the scanning time of the sequence is shortened, and the imaging efficiency is improved. The application solves the problem that there is no imaging sequence determination method for multi-nuclear magnetic resonance imaging technology in the related art.

Systems and methods for generating synthetic attenuation correction maps (e.g., µ-maps), and for reconstructing images based on emission data and the synthetically generated attenuation correction maps, are disclosed. In some examples, a nuclear imaging reconstruction system receives emission data, such as positron emission tomography data, from an image scanning system. The nuclear imaging reconstruction system applies a segmentation process to the emission data and, based on the segmentation process, generates segmentation data characterizing a plurality of segments. Further, the nuclear imaging reconstruction system generates attenuation correction data that includes attenuation correction values for each of the plurality of segments. For example, based on the type of a particular segment (e.g., lung, heart, liver segments), the nuclear imaging reconstruction system assigns corresponding attenuation correction values. The nuclear imaging reconstruction system may reconstruct an image based on the emission data and the attenuation correction data.

The invention provides a magnetic resonance multi-core imaging coil assembly, a magnetic resonance imaging device and a method, the magnetic resonance multi-core imaging coil assembly comprises a multi-core transmit-receive surface coil and a hydrogen core induction surface coil, the multi-core transmit-receive surface coil is configured to transmit and receive radio frequency signals of at least one non-hydrogen nuclide, and the hydrogen core induction surface coil is configured to receive the radio frequency signals of at least one non-hydrogen nuclide. The hydrogen nuclear induction surface coil is a passive coil, and the hydrogen nuclear induction surface coil is configured to transmit a received hydrogen nuclear magnetic resonance signal to a receiving port of a hydrogen nuclear volume radio frequency coil of magnetic resonance equipment in a magnetic induction coupling mode. According to the magnetic resonance multi-core imaging coil assembly and the magnetic resonance imaging equipment, the hydrogen core induction surface coil is arranged and can receive magnetic resonance signals of the hydrogen core of the measured object, the distance between the hydrogen core induction surface coil and the measured object is small, mutual interference between the hydrogen core induction surface coil and the multi-core receiving and transmitting surface coil is controllable, and the magnetic resonance imaging efficiency is improved. Therefore, the transmission efficiency can be ensured, and the signal-to-noise ratio is improved.

The invention provides a method for normalizing nuclear imaging data by processing it through a deep learning algorithm, specifically a neural network comprising at least one convolutional layer, to reduce inter-center, intra-center, and patient weight biases. The method accepts data from diverse sources, including different imaging centers, scanner models, and patient populations, and applies bias reduction techniques, such as normalizing image intensity, to produce normalized data. This normalized data is then utilized in various downstream tasks, such as computer-aided diagnosis and clinical trials, yielding improved accuracy compared to non-normalized data. The neural network is designed to adapt to new data sources without retraining, enhancing the method's flexibility.

A cooling fan assembly for a nuclear imaging system is provided, wherein the fan assembly may include: a fan; an air inlet opening; an air outlet opening; and a honeycomb structured sheet mounted across the air inlet opening whereby when the fan is in operation and air flows through the air inlet opening, the honeycomb structured sheet promotes laminar flow of air at the air inlet opening and attenuates acoustic noise generated by the fan.

A low-noise amplifier and a multi-nuclear magnetic resonance imaging radio frequency coil. The low-noise amplifier matches a low-noise impedance with a source impedance by means of a multi-frequency noise matching circuit (131), and transforms input impedances of a plurality of frequency bands to a low pure resistance, so as to suppress a coupling current of a coil array, and then nuclear magnetic resonance signals of the plurality of frequency bands undergo primary amplification and secondary amplification by means of a first-stage amplification circuit (12) and a second-stage amplification circuit (14). After each amplification, impedance matching between a preceding-stage circuit and a subsequent-stage circuit is performed by means of an impedance matching circuit, so as to achieve the purposes of improving the transmission gain of the received nuclear magnetic resonance signals of the plurality of frequency bands and reducing the noise coefficient of the nuclear magnetic resonance signals, thereby solving the technical problem in the prior art where decoupling coil arrays that receive a plurality of frequency bands requires a separate channel for each frequency, resulting in increased size and cost.

For dosimetry, a miniaturized nuclear imaging system with a solid-state detector is used to determine the activity and / or injected dose of radiopharmaceuticals. By being sized to scan a syringe or vial, the solid-state detector can be used to determine the injected dose with higher accuracy than current dose calibrators and with less frequent use of calibration or normalization sources. The miniaturized nuclear imaging system reconstructs activity in the same way as a nuclear imaging system that scans patients, and therefore can be used to calibrate a dose model. A tissue mimicking phantom with a solid-state dosimeter measures the dose from a radiopharmaceutical that is used to calibrate the dose model.

The invention provides a computer software and hardware security monitoring device for nuclide imaging, and relates to the technical field of software and hardware monitoring. The computer software and hardware security monitoring device for nuclide imaging comprises a host, a plurality of heat dissipation mechanisms are fixedly arranged on one side of the host, a fan tester is fixedly arranged at the upper end of the host, and cables are fixedly connected between the heat dissipation mechanisms and the fan tester. When host hardware is monitored, the rotating speed of the fan of the heat dissipation mechanism can be monitored in real time through the fan tester, and meanwhile, the temperature of the host hardware can be monitored in real time through the infrared temperature measurement sensor; a written virus detection program and a permission key detection program accessed by a user are transmitted into detection hardware, and connected user equipment is directly detected through the detection hardware, so that malicious viruses in peripheral physical access downloading equipment are greatly prevented from entering a host.

The application discloses a high-field animal magnetic resonance multi-nuclear radio frequency volume coil, a system and a control method, which comprises coaxially arranged outer and inner birdcage coils. A plurality of diodes are arranged on the end ring of the inner birdcage coil, and a direct current feeding node is arranged on the birdcage leg structure; the direct current feeding node and the diodes form a direct current control loop through the birdcage leg and the end ring, and are used for controlling the on-off of the diodes. When the outer coil works, a reverse bias voltage is applied to make all the diodes of the inner coil cut off, and when the inner coil works, a forward bias voltage is applied to make all the diodes conduct. The application utilizes the structure of the birdcage to construct a direct current control loop, does not need to additionally introduce a complex feeding network, realizes the complete on-off of the inner coil without increasing radio frequency loss, effectively eliminates the electromagnetic coupling between the double-layer coils, is compact in structure, and is particularly suitable for a small-aperture high-field animal magnetic resonance multi-nuclear imaging system.

Systems and methods for detecting multiple events during nuclear imaging scans, and for reconstructing images based on the detected events, are disclosed. In some embodiments, an image scanning system scans a subject, and generates a signal characterizing a detection event. The system applies a peak detection process to the signal and, based on the application of the peak detection process, detects a position of each of a plurality of peaks of the signal. Further, the system determines an amplitude of each of the peaks of the signal. The system also determines an energy value for each of the peaks based on applying a curve fitting process to the position and the amplitude of each of the peaks. The system may also determine a time-offset value for a peak based on its position in relation to a previous peak, and may transmit the energy values and corresponding times to generate time-coincident pairs for image reconstruction.

The present disclosure relates to the field of nuclear imaging and therapy, and more specifically to high purity copper radiotracer compositions useful in imaging, such as positron emission tomography (PET) and single-photon emission computerized tomography (SPECT), and therapy. More specifically, the present disclosure relates to novel compositions useful in imaging and treatment of conditions such as prostate cancer, somatostatin receptor-expressing tumors, like neuroendocrine tumor, epithelial tumors, as well as to methods wherein such compositions are prepared.

The invention relates to the technical field of biochemical sensing and fluorescence imaging, in particular to a chromazole near-infrared viscosity-sensitive probe, a preparation method thereof and application of the probe in living cell imaging. The preparation method of the probe comprises the following steps: dissolving tryptazole tetrafluoroborate and benzaldehyde or a derivative thereof in acetonitrile, stirring at room temperature to react, evaporating to remove a solvent after the reaction is finished, and separating and purifying through column chromatography to obtain the tryptazole near-infrared viscosity sensitive probe. The application of the probe in living cell nucleus imaging is to mark chromosomes in a cell mitosis process, so that chromosome migration behaviors are visualized. The probe is high in utilization rate, mild in preparation reaction condition, simple and convenient to operate, green and efficient. The cell nucleus of the living cell can be quickly dyed at low concentration, the cytoplasm, the nuclear membrane and the nucleolus of the living cell can be distinguished through the fluorescence brightness, and the mitosis process of the cell can be traced. A feasible strategy is provided for developing a near-infrared probe with a rapid cell nucleus staining function.

Electrical circuits and corresponding methods within nuclear imaging systems that generate timing signals for detected image scanning events, and the reconstruction of images based on the timing signals, are disclosed. In some examples, an image scanner circuit includes derivative logic and peak-hold logic electrically coupled to the derivative logic. The derivative logic is configured to receive an event signal for a detected event from an event detector of an image scanner and, based on the event signal, output a derivative signal of the event signal. The peak-hold logic is configured to receive the derivative signal and, based on a voltage level of the derivative signal, output a peak-hold signal. The peak-hold signal is output at a first voltage level when the voltage level of the derivative signal is increasing, and is output at a second voltage level when the voltage level of the derivative signal is decreasing.

An apparatus, system and methods are provided for performing nuclear imaging with a modified Compton camera. The modified Compton camera features multiple gamma detectors for detecting gamma rays emanating from a subject (e.g., a human patient injected with a radiopharmaceutical), and a collimator for collimating incident gamma rays. Instead of the cone-shaped volume of space that a traditional Compton camera identifies as the origination of a given detected gamma ray, collimation of incoming rays allows the modified Compton camera to reduce the volume of uncertainty or probability to a planar volume. The resulting images of the subject benefit from higher signal-to-noise ratios compared to a traditional Compton camera.

The current invention relates to a method of nuclear imaging, wherein said method uses an isotope-labeled radiotracer, wherein said isotope has a half-life of at least (750) minutes, said method comprises acquiring a first image by means of a nuclear imaging method of a target area, and obtaining a second image from said first image, wherein said second image is obtained by improving said first image quality by means of a deep learning model.

The utility model provides a fast neutron imaging detector and a detection system, and belongs to the technical field of nuclear imaging detectors. The fast neutron imaging detector comprises a substrate, a scintillator assembly and a photomultiplier. Wherein the substrate is provided with a plurality of through holes, and the plurality of through holes form an array. The scintillator assemblies are arranged in the through holes in a one-to-one correspondence mode, and each scintillator assembly comprises a scintillator and a light guide piece which are arranged in a stacked mode. And the photomultiplier is electrically connected with the light guide sheet in the scintillator assembly. The detector is flexible in design of the area and the spatial resolution, resistant to mechanical impact, high in reliability, stable in performance, low in cost and convenient to debug and overhaul, and the maintenance cost of equipment is reduced.

This application relates to a method, apparatus, and magnetic resonance imaging system for optimizing multinucleus imaging sequences. The optimization method includes: acquiring the multinucleus imaging sequence to be optimized and determining a target coding axis and non-target coding axes; on the target coding axis, for each nuclide, determining the secondary coding scheme of the nuclide's basic coding sequence, and determining candidate coding sequences for the nuclide based on the basic coding sequence and secondary coding scheme; determining the maximum gradient duration sum for a single scan based on the candidate coding sequences of each nuclide on the target coding axis and the fixed coding sequences of each nuclide on the non-target coding axes; and optimizing the candidate coding sequences of each nuclide on the target coding axis with minimizing the maximum gradient duration sum as the optimization objective to obtain the target coding sequence. This application solves the problems of low signal-to-noise ratio and slow multinucleus imaging speed associated with existing multinucleus imaging sequences.

The present disclosure relates to the field of nuclear imaging and therapy, and more specifically to high purity copper radiotracer compositions useful in imaging, such as positron emission tomography (PET) and single-photon emission computerized tomography (SPECT), and therapy. More specifically, the present disclosure relates to novel compositions useful in imaging and treatment of conditions such as prostate cancer, somatostatin receptor-expressing tumors, like neuroendocrine tumor, epithelial tumors, as well as to methods wherein such compositions are prepared.

A computer-implemented method for determining scan parameters includes receiving a set of input parameters. An average per piece of a nuclear imaging scanner having a predetermined field of view (FOV) is determined based on the input parameters, and at least one scan parameter is determined based on the average per piece of the nuclear imaging scanner.

The utility model discloses a 256-channel nuclear pulse waveform acquisition electronics system. The system comprises a 256-path nuclear pulse signal input interface module, a 256-path nuclear pulse signal input buffer module, a 256-path single-ended to differential module, an ADC module, an FPGA processing module, a high-precision system programmable clock module, a high-precision system programmable clock module, an FPGA-JESD synchronization signal fan-out module, a GTX data clock fan-out module and an ADC-JESD synchronization signal fan-out module. And the ADC data clock fan-out module realizes an ultra-high density nuclear imaging electronics system with 256 channels, a 40MHz sampling rate and 12bit sampling precision.

The present disclosure relates to the field of nuclear imaging and therapy, and more specifically to high purity copper radiotracer compositions useful in imaging, such as positron emission tomography (PET) and single-photon emission computerized tomography (SPECT), and therapy. More specifically, the present disclosure relates to novel compositions useful in imaging and treatment of conditions such as prostate cancer, somatostatin receptor-expressing tumors, like neuroendocrine tumor, epithelial tumors, as well as to methods wherein such compositions are prepared.

Data processing systems (DPS) and related methods for nuclear medicine imaging. At an input interface (IN), first projection data (λ), or a first image (V) reconstructable from the first projection data, is received. The first projection data is associated with a first waiting period (ΔT*). The first waiting period indicates the time period from administration of a tracer agent to a start of acquisition by a nuclear medicine imaging apparatus (IA) of the projection date. A trained machine learning module (MLM) estimates, based on the first projection data (λ) or on the first image (V), a second projection data (λ′) or a second image (V′) associable with a second waiting period (ΔT), longer than the first waiting period (ΔT*). Nuclear imaging can thus be conducted quicker. Similar machine learning based data processing systems and related methods are also envisaged to reduce acquisition time periods or the time it takes to reconstruct imagery.

Provided is a cooling fan assembly for a nuclear imaging system where the fan assembly can include a fan, an air inlet opening, an air outlet opening, and a honeycomb structured sheet mounted across the air inlet opening, whereby when the fan is in operation and air is flowing through the air inlet opening, the honeycomb structured sheet facilitates laminar flow of the air at the air inlet opening and attenuates acoustic noise generated by the fan.

Provided are vitamers of vitamin B3 and their derivatives and analogues as radiopharmaceutical compounds, more specifically either as radiotracers for nuclear imaging techniques or as radiotherapeutic agents. Imaging methods, including diagnostic imaging methods, which utilize the radiotracers are also provided.