45 results about "Nuclear imaging" patented technology

Systems and methods for detecting multiple events during nuclear imaging scans, and for reconstructing images based on the detected events, are disclosed. In some embodiments, an image scanning system scans a subject, and generates a signal characterizing a detection event. The system generates sampled data based on sampling the at least one signal. Further, the system applies a trained machine learning process to the sampled data. Based on the application of the trained machine learning process, the system generates pulse data characterizing a plurality of decoupled pulses. For example, the pulse data may characterize pulse energy values of each of the decoupled pulses, and corresponding times for each of the pulses. Further, the method includes transmitting the pulse data to generate time-coincident pairs for image reconstruction.

A system and method includes acquisition of nuclear imaging data, reconstruction of a three-dimensional image based on nuclear imaging data, input of the three-dimensional image to a trained convolutional network to either generate a linear attenuation correction map and a simulated computed tomography image based on the linear attenuation correction map or generate simulated computer tomography images directly, application of a segmentation algorithm to the simulated computed tomography image to generate a segmentation map, and display of the segmentation map.

The present application relates to the technical field of data processing. Disclosed are a multi-nuclear imaging radio frequency power amplifier and a multi-nuclear magnetic resonance imaging hardware system. The multi-nuclear imaging radio frequency power amplifier comprises: a radio frequency signal input end, a radio frequency switch, a pre-compensation circuit, a voltage-controlled attenuator, a voltage-controlled phase shifter, a broadband radio frequency power amplifier, a broadband directional coupler and a radio frequency signal output end; a first output abnormality protection control circuit; a second output abnormality protection control circuit; an amplitude control circuit; and a phase control circuit. By means of the multi-nuclear imaging radio frequency power amplifier in the present invention, nonlinear correction can be performed on the amplitude and phase of a broadband radio frequency power amplifier, such that the broadband radio frequency power amplifier keeps meeting the requirements for high linearity and high power at an operating frequency point of a corresponding nuclide, so as to ensure the linear relationship between input and output signals of a radio frequency power amplifier and adequate signal strength, thereby avoiding the generation of artifacts due to signal distortion, and ensuring the accuracy and clarity of magnetic resonance imaging.

The present disclosure relates to the field of nuclear imaging and therapy, and more specifically to high purity copper radiotracer compositions useful in imaging, such as positron emission tomography (PET) and single-photon emission computerized tomography (SPECT), and therapy. More specifically, the present disclosure relates to novel compositions useful in imaging and treatment of conditions such as prostate cancer, somatostatin receptor-expressing tumors, like neuroendocrine tumor, epithelial tumors, as well as to methods wherein such compositions are prepared.

The present disclosure relates to the field of nuclear imaging and therapy, and more particularly, to high purity copper radiotracer compositions that can be used in imaging (e.g., positron emission tomography (PET) and single photon emission computed tomography (SPECT)) and therapy. More specifically, the present disclosure relates to novel compositions useful for imaging and treating conditions (e.g., prostate cancer, somatostatin receptor expressing tumors, such as neuroendocrine tumors, epithelial tumors), and methods of making such compositions.

Systems and methods for correcting timing information associated with captured nuclear imaging data, and for reconstructing medical images based on the corrected timing information, are disclosed. In some embodiments, an image scanning system scans a subject, detects an event, and generates timing data for the detected event. The timing data includes a first number of bits, and characterizes a time that a crystal of the image scanning system detected the event. The image scanning system shifts the first number of bits by a predetermined amount to generate a second number of bits, where the second number of bits includes at least one bit representing a lower order time value than the least significant bit of the first number of bits of the timing data. Further, the image scanning system generates timing correction data for the event based on the second timing data.

There are provided fructose-based radiopharmaceuticals, pharmaceutical compositions comprising same, methods for preparing same, and methods of using same for biomedical imaging, particularly nuclear imaging using PET or PET / CT. (Compound 7)

Methods and apparatus for machine learning-based medical imaging event detection and image reconstruction. Systems and methods for detecting a plurality of events during a nuclear imaging scan and for reconstructing an image based on the detected events are disclosed. In some embodiments, an image scanning system scans an object and generates a signal characterizing a detection event. The system generates sampled data based on sampling at least one signal. In addition, the system applies a trained machine learning process to the sampled data. Based on the application of the trained machine learning process, the system generates pulse data characterizing a plurality of decoupled pulses. For example, the pulse data may characterize a pulse energy value for each decoupled pulse, and a corresponding time for each pulse. In addition, the method includes transmitting the pulse data to generate a temporal coincidence pair for image reconstruction.

Systems and methods for motion estimation and correction in nuclear imaging systems are disclosed. In some examples, a processing device receives measurement data, such as positron emission tomography (PET) measurement data, from an image scanning system. The processing device applies a histo-imaging process to the measurement data and, based on applying the histo-imaging process to the measurement data, generates a histo-image. Further, the processing device applies a trained machine learning process to the histo-image and, based on applying the trained machine learning process to the histo-image, the processing device generates a short-frame image. The processing device also determines a position of a mass in the short-frame image, and generates motion data characterizing a motion of the mass based on the position. In some examples, a reconstructed image is generated based on the motion data.

This invention discloses a neutron-gamma dual-mode synchronous imaging method and system based on single-pixel detection, belonging to the field of nuclear imaging technology. The method includes: irradiating the sample under test with modulated neutron beams of different encoding modes, identifying the neutron event count and gamma-ray energy spectrum for each irradiation; dividing the sample under test into several pixel units, reconstructing a neutron transmission structure image based on the neutron event count for each irradiation; obtaining the detection efficiency of the characteristic gamma rays received by each pixel unit of the sample under test, and constructing a gamma response modulation matrix in combination with the neutron transmission structure image; extracting the net count of the characteristic peaks of the target element from the gamma-ray energy spectrum, reconstructing an element distribution image in combination with the gamma response modulation matrix, and fusing it with the neutron transmission structure image for output. This invention achieves synchronous acquisition of structural and elemental information, automatic spatial registration, and joint high-precision reconstruction, and is particularly suitable for the engineering application of miniaturized neutron sources.

The application relates to a multi-nucleus imaging sequence determination method, device and magnetic resonance system, wherein the multi-nucleus imaging sequence determination method comprises the following steps: acquiring an initial multi-nucleus imaging sequence, wherein the initial multi-nucleus imaging sequence comprises the pulse arrangement of several kinds of nuclei in a single repetition time; and adjusting the pulse arrangement of at least one kind of nucleus to optimize the initial multi-nucleus imaging sequence, thereby obtaining a target multi-nucleus imaging sequence. According to the application, the target multi-nucleus imaging sequence can be obtained, and the target multi-nucleus imaging sequence is a multi-nucleus imaging sequence obtained by combining and optimizing a plurality of single-nucleus imaging sequences. Therefore, the multi-nucleus imaging sequence can complete the scanning and imaging of multiple kinds of nuclei in one scanning and imaging process, and compared with sequentially imaging each kind of nucleus respectively, the scanning time of the sequence is shortened, and the imaging efficiency is improved. The application solves the problem that there is no imaging sequence determination method for multi-nuclear magnetic resonance imaging technology in the related art.

Systems and methods for generating synthetic attenuation correction maps (e.g., µ-maps), and for reconstructing images based on emission data and the synthetically generated attenuation correction maps, are disclosed. In some examples, a nuclear imaging reconstruction system receives emission data, such as positron emission tomography data, from an image scanning system. The nuclear imaging reconstruction system applies a segmentation process to the emission data and, based on the segmentation process, generates segmentation data characterizing a plurality of segments. Further, the nuclear imaging reconstruction system generates attenuation correction data that includes attenuation correction values for each of the plurality of segments. For example, based on the type of a particular segment (e.g., lung, heart, liver segments), the nuclear imaging reconstruction system assigns corresponding attenuation correction values. The nuclear imaging reconstruction system may reconstruct an image based on the emission data and the attenuation correction data.

A novel method of measuring endocochlear potential and cochlear function in a patient is presented. The method uses nuclear imaging, such as PET or SPECT, with a radiotracer such as 201Tl to visualize any potassium ion loss in the cochlea of the patient which can contribute to auditory disorders such as hearing loss. This non-invasive technique represents a new method for auditory diagnoses by measurement of cochlear properties which can aid in the development of new therapeutics for auditory disorders.

The invention provides a magnetic resonance multi-core imaging coil assembly, a magnetic resonance imaging device and a method, the magnetic resonance multi-core imaging coil assembly comprises a multi-core transmit-receive surface coil and a hydrogen core induction surface coil, the multi-core transmit-receive surface coil is configured to transmit and receive radio frequency signals of at least one non-hydrogen nuclide, and the hydrogen core induction surface coil is configured to receive the radio frequency signals of at least one non-hydrogen nuclide. The hydrogen nuclear induction surface coil is a passive coil, and the hydrogen nuclear induction surface coil is configured to transmit a received hydrogen nuclear magnetic resonance signal to a receiving port of a hydrogen nuclear volume radio frequency coil of magnetic resonance equipment in a magnetic induction coupling mode. According to the magnetic resonance multi-core imaging coil assembly and the magnetic resonance imaging equipment, the hydrogen core induction surface coil is arranged and can receive magnetic resonance signals of the hydrogen core of the measured object, the distance between the hydrogen core induction surface coil and the measured object is small, mutual interference between the hydrogen core induction surface coil and the multi-core receiving and transmitting surface coil is controllable, and the magnetic resonance imaging efficiency is improved. Therefore, the transmission efficiency can be ensured, and the signal-to-noise ratio is improved.

The invention provides a method for normalizing nuclear imaging data by processing it through a deep learning algorithm, specifically a neural network comprising at least one convolutional layer, to reduce inter-center, intra-center, and patient weight biases. The method accepts data from diverse sources, including different imaging centers, scanner models, and patient populations, and applies bias reduction techniques, such as normalizing image intensity, to produce normalized data. This normalized data is then utilized in various downstream tasks, such as computer-aided diagnosis and clinical trials, yielding improved accuracy compared to non-normalized data. The neural network is designed to adapt to new data sources without retraining, enhancing the method's flexibility.

A method and apparatus for deep learning based motion detection in nuclear imaging systems. Systems and methods for detecting object movement within a medical image based on a trained deep learning process are disclosed. In some examples, an image processing system receives positron emission tomography (PET) measurement data and common modal measurement data from an image scanner. The image processing system generates a PET image and a common-mode image based on the PET measurement data and the common-mode measurement data, respectively. Further, the image processing system inputs the PET image and the common modal image to a first trained neural network and generates a first feature of the PET measurement data and a second feature of the common modal measurement data. The image processing system inputs the first feature and the second feature to a second trained neural network and generates displacement data characterizing a displacement between the first feature and the second feature. Based on the displacement data, the image processing system generates display data for display.

A cooling fan assembly for a nuclear imaging system is provided, wherein the fan assembly may include: a fan; an air inlet opening; an air outlet opening; and a honeycomb structured sheet mounted across the air inlet opening whereby when the fan is in operation and air flows through the air inlet opening, the honeycomb structured sheet promotes laminar flow of air at the air inlet opening and attenuates acoustic noise generated by the fan.

A low-noise amplifier and a multi-nuclear magnetic resonance imaging radio frequency coil. The low-noise amplifier matches a low-noise impedance with a source impedance by means of a multi-frequency noise matching circuit (131), and transforms input impedances of a plurality of frequency bands to a low pure resistance, so as to suppress a coupling current of a coil array, and then nuclear magnetic resonance signals of the plurality of frequency bands undergo primary amplification and secondary amplification by means of a first-stage amplification circuit (12) and a second-stage amplification circuit (14). After each amplification, impedance matching between a preceding-stage circuit and a subsequent-stage circuit is performed by means of an impedance matching circuit, so as to achieve the purposes of improving the transmission gain of the received nuclear magnetic resonance signals of the plurality of frequency bands and reducing the noise coefficient of the nuclear magnetic resonance signals, thereby solving the technical problem in the prior art where decoupling coil arrays that receive a plurality of frequency bands requires a separate channel for each frequency, resulting in increased size and cost.

The invention provides a synthesis method and application of a carbon 11 labeled molecular imaging probe, and belongs to the technical field of nuclear imaging, the synthesis method of the carbon 11 labeled molecular imaging probe provided by the invention comprises the following steps: taking cesium carbonate as a catalyst, mixing a molecular imaging probe precursor and excessive 11C-CH3I, and reacting to generate the carbon 11 labeled molecular imaging probe. According to the invention, cesium carbonate is used as a catalyst for the first time to synthesize the C11 labeled molecular imaging probe, and the synthesized molecular imaging probe can complete imaging in various tissues and has the advantages of high radiochemical purity and high biological safety.

For dosimetry, a miniaturized nuclear imaging system with a solid-state detector is used to determine the activity and / or injected dose of radiopharmaceuticals. By being sized to scan a syringe or vial, the solid-state detector can be used to determine the injected dose with higher accuracy than current dose calibrators and with less frequent use of calibration or normalization sources. The miniaturized nuclear imaging system reconstructs activity in the same way as a nuclear imaging system that scans patients, and therefore can be used to calibrate a dose model. A tissue mimicking phantom with a solid-state dosimeter measures the dose from a radiopharmaceutical that is used to calibrate the dose model.

Methods and apparatus for medical imaging event detection and image reconstruction. Systems and methods for detecting a plurality of events during a nuclear imaging scan and for reconstructing an image based on the detected events are disclosed. In some embodiments, an image scanning system scans an object and generates a signal characterizing a detection event. The system applies a peak detection process to the signal and detects a location of each of a plurality of peaks of the signal based on the application of the peak detection process. In addition, the system determines the amplitude of each peak of the signal. The system also determines an energy value for each peak based on applying a curve fitting process to the localization and amplitude of each peak. The system may also determine a time offset value for a peak based on a location of the peak relative to a previous peak, and may transmit an energy value and a corresponding time to generate a time coincidence pair for image reconstruction.

The invention provides a computer software and hardware security monitoring device for nuclide imaging, and relates to the technical field of software and hardware monitoring. The computer software and hardware security monitoring device for nuclide imaging comprises a host, a plurality of heat dissipation mechanisms are fixedly arranged on one side of the host, a fan tester is fixedly arranged at the upper end of the host, and cables are fixedly connected between the heat dissipation mechanisms and the fan tester. When host hardware is monitored, the rotating speed of the fan of the heat dissipation mechanism can be monitored in real time through the fan tester, and meanwhile, the temperature of the host hardware can be monitored in real time through the infrared temperature measurement sensor; a written virus detection program and a permission key detection program accessed by a user are transmitted into detection hardware, and connected user equipment is directly detected through the detection hardware, so that malicious viruses in peripheral physical access downloading equipment are greatly prevented from entering a host.

The application discloses a high-field animal magnetic resonance multi-nuclear radio frequency volume coil, a system and a control method, which comprises coaxially arranged outer and inner birdcage coils. A plurality of diodes are arranged on the end ring of the inner birdcage coil, and a direct current feeding node is arranged on the birdcage leg structure; the direct current feeding node and the diodes form a direct current control loop through the birdcage leg and the end ring, and are used for controlling the on-off of the diodes. When the outer coil works, a reverse bias voltage is applied to make all the diodes of the inner coil cut off, and when the inner coil works, a forward bias voltage is applied to make all the diodes conduct. The application utilizes the structure of the birdcage to construct a direct current control loop, does not need to additionally introduce a complex feeding network, realizes the complete on-off of the inner coil without increasing radio frequency loss, effectively eliminates the electromagnetic coupling between the double-layer coils, is compact in structure, and is particularly suitable for a small-aperture high-field animal magnetic resonance multi-nuclear imaging system.

Systems and methods for detecting multiple events during nuclear imaging scans, and for reconstructing images based on the detected events, are disclosed. In some embodiments, an image scanning system scans a subject, and generates a signal characterizing a detection event. The system applies a peak detection process to the signal and, based on the application of the peak detection process, detects a position of each of a plurality of peaks of the signal. Further, the system determines an amplitude of each of the peaks of the signal. The system also determines an energy value for each of the peaks based on applying a curve fitting process to the position and the amplitude of each of the peaks. The system may also determine a time-offset value for a peak based on its position in relation to a previous peak, and may transmit the energy values and corresponding times to generate time-coincident pairs for image reconstruction.

The present invention generally relates to the field of fluorescent probes comprising a cyanine dye with near-infrared (NIR) emission labelled with a PSMA-targeting moiety and their use in the targeting and imaging of cancer, in particular PSMA-expressing cancers, such as prostate cancer and metastases thereof. The fluorescent probes of the invention also include a different targeting ligand or a prosthetic group that can be radiolabeled, such as a radioligand, forming hybrid tracers that can be respectively used as heterobivalent agents or as bimodal agents in nuclear imaging and Fluorescence Guided Surgery. The invention also relates to methods for preparing these compounds, to pharmaceutical compositions and kits incorporating them and to methods of use them as diagnostic agents in imaging or therapy of diseases, particularly those associated with PSMA-overexpression.

Systems and methods for detecting multiple events during nuclear imaging scans, and for reconstructing images based on the detected events, are disclosed. In some embodiments, an image scanning system scans a subject, and generates a signal characterizing a detection event. The system applies a peak detection process to the signal and, based on the application of the peak detection process, detects a position of each of a plurality of peaks of the signal. Further, the system determines an amplitude of each of the peaks of the signal. The system also determines an energy value for each of the peaks based on applying a curve fitting process to the position and the amplitude of each of the peaks. The system may also determine a time-offset value for a peak based on its position in relation to a previous peak, and may transmit the energy values and corresponding times to generate time-coincident pairs for image reconstruction.

The present disclosure relates to the field of nuclear imaging and therapy, and more specifically to high purity copper radiotracer compositions useful in imaging, such as positron emission tomography (PET) and single-photon emission computerized tomography (SPECT), and therapy. More specifically, the present disclosure relates to novel compositions useful in imaging and treatment of conditions such as prostate cancer, somatostatin receptor-expressing tumors, like neuroendocrine tumor, epithelial tumors, as well as to methods wherein such compositions are prepared.

The present invention discloses a k-space trajectory correction system and method applied to heteronuclear imaging, belonging to the field of imaging technology. The trajectory correction system includes a sampling sequence and signal processing system, a spectrometer control system, and a magnet and radio frequency system. The sampling sequence and signal processing system are connected to the spectrometer control system, and the spectrometer control system is connected to the magnet and radio frequency system through an amplifier and an auxiliary control part. The k-space trajectory correction method applied to heteronuclear imaging proposed by the present invention is used to correct the target k-space trajectory deviation caused by the insufficiency of gradient hardware or the uncompletely eliminated eddy current effect, so as to reduce or eliminate the influence of image artifacts. This method does not require a separate sequence for measuring the k-space trajectory, hardly increases the scanning time, and the measured gradient waveform is the imaging gradient actually used in imaging, which can avoid the influence of insufficient gradient system stability.

The invention relates to the technical field of biochemical sensing and fluorescence imaging, in particular to a chromazole near-infrared viscosity-sensitive probe, a preparation method thereof and application of the probe in living cell imaging. The preparation method of the probe comprises the following steps: dissolving tryptazole tetrafluoroborate and benzaldehyde or a derivative thereof in acetonitrile, stirring at room temperature to react, evaporating to remove a solvent after the reaction is finished, and separating and purifying through column chromatography to obtain the tryptazole near-infrared viscosity sensitive probe. The application of the probe in living cell nucleus imaging is to mark chromosomes in a cell mitosis process, so that chromosome migration behaviors are visualized. The probe is high in utilization rate, mild in preparation reaction condition, simple and convenient to operate, green and efficient. The cell nucleus of the living cell can be quickly dyed at low concentration, the cytoplasm, the nuclear membrane and the nucleolus of the living cell can be distinguished through the fluorescence brightness, and the mitosis process of the cell can be traced. A feasible strategy is provided for developing a near-infrared probe with a rapid cell nucleus staining function.

Electrical circuits and corresponding methods within nuclear imaging systems that generate timing signals for detected image scanning events, and the reconstruction of images based on the timing signals, are disclosed. In some examples, an image scanner circuit includes derivative logic and peak-hold logic electrically coupled to the derivative logic. The derivative logic is configured to receive an event signal for a detected event from an event detector of an image scanner and, based on the event signal, output a derivative signal of the event signal. The peak-hold logic is configured to receive the derivative signal and, based on a voltage level of the derivative signal, output a peak-hold signal. The peak-hold signal is output at a first voltage level when the voltage level of the derivative signal is increasing, and is output at a second voltage level when the voltage level of the derivative signal is decreasing.