285 results about "Functional imaging" patented technology

A body scanning system includes a CT transmitter and a PET configured to radiate along a significant portion of the body and a plurality of sensors (202, 204) configured to detect photons along the same portion of the body. In order to facilitate the efficient collection of photons and to process the data on a real time basis, the body scanning system includes a new data processing pipeline that includes a sequentially implemented parallel processor (212) that is operable to create images in real time not withstanding the significant amounts of data generated by the CT and PET radiating devices.

A method of generating images of a portion of a body includes introducing a contrast agent into the body, generating a first set of image data using radiation at a first energy level after the contrast agent is introduced into the body, generating a second set of image data using radiation at a second energy level after the contrast agent is introduced into the body, and creating a volumetric composite image using the first and the second sets of image data.

An apparatus for wide-field functional imaging (WIFI) of tissue includes a spatially modulated reflectance / fluorescence imaging (SI) device capable of quantitative subsurface imaging across spatial scales, and a laser speckle imaging (LSI) device capable of quantitative subsurface imaging across spatial scales using integrated with the (SI) device. The SI device and LSI device are capable of independently providing quantitative measurement of tissue functional status.

A method and system for localization of fluorescence in a scattering medium such as a biological tissue are provided. In comparison to other optical imaging techniques, this disclosure provides for improved spatial resolution, decreased computational time for reconstructions, and allows anatomical and functional imaging simultaneously. The method including the steps of illuminating the scattering medium with an excitation light to excite the fluorescence; modulating a portion of the emitted light from the fluorescence within the scattering medium using an ultrasonically induced variation of material properties of the scattering medium such as the refractive index; detecting the modulated optical signal at a surface of the scattering medium; and reconstructing a spatial distribution of the fluorescence in the scattering medium from the detected signal.

Various embodiments of the present invention include systems and methods for multimodal functional imaging based upon photoacoustic and laser optical scanning microscopy. In particular, at least one embodiment of the present invention utilizes a contact lens in combination with an ultrasound transducer for purposes of acquiring photoacoustic microscopy data. Traditionally divergent imaging modalities such as confocal scanning laser opthalmoscopy and photoacoustic microscopy are combined within a single laser system. Functional imaging of biological samples can be utilized for various medical and biological purposes.

A cardiac functional analysis system reconstructs a 3D anatomical image volume using image frames acquired at predetermined cardiac phases over multiple cardiac cycles in response to a trigger derived from hemodynamic signals. A medical imaging system generates 3D anatomical imaging volume datasets from acquired 2D anatomical images. The system includes an image acquisition device for acquiring 2D anatomical images of a portion of patient anatomy in selectable angularly variable imaging planes in response to a synchronization signal derived from a patient blood flow related parameter. A synchronization processor provides the synchronization signal derived from the patient blood flow related parameter. An image processor processes 2D images acquired by the image acquisition device of the portion of patient anatomy in multiple different imaging planes having relative angular separation, to provide a 3D image reconstruction of the portion of patient anatomy.

The present invention provides an apparatus for functional imaging of an object that is compact, sensitive, and provides real-time three-dimensional images. The apparatus includes a source of non-ultrasonic energy, where the source induces generation of ultrasonic waves within the object. The source can provide any type of non-ultrasonic energy, including but not limited to light, heat, microwaves, and other electromagnetic fields. Preferably, the source is a laser. The apparatus also includes a single capacitive micromachined ultrasonic transducer (CMUT) device or an array of CMUTs. In the case of a single CMUT element, it can be mechanically scanned to simulate an array of any geometry. Among the advantages of CMUTs are tremendous fabrication flexibility and a typically wider bandwidth. Transducer arrays with high operating frequencies and with nearly arbitrary geometries can be fabricated. A method of functional imaging using the apparatus is also provided.

Novel methods and imaging agents for functional imaging of lymph structures are disclosed herein. Embodiments of the methods utilize highly sensitive optical imaging and fluorescent spectroscopy techniques to track or monitor packets of organic dye flowing in one or more lymphatic structures. The packets of organic dye may be tracked to provide quantitative information regarding lymph propulsion and function. In particular, lymph flow velocity and pulse frequency may be determined using the disclosed methods.

Systems, methods, and probes are provided for functional imaging by radioactive-emission-measurements, specific to body structures, such as the prostate, the esophagus, the cervix, the uterus, the ovaries, the heart, the breast, the brain, and the whole body, and other body structures. The nuclear imaging may be performed alone, or together with structural imaging, for example, by x-rays, ultrasound, or MRI. Preferably, the radioactive-emission-measuring probes include detectors, which are adapted for individual motions with respect to the probe housings, to generate views from different orientations and to change their view orientations. These motions are optimized with respect to functional information gained about the body structure, by identifying preferred sets of views for measurements, based on models of the body structures and information theoretic measures. A second iteration, for identifying preferred sets of views for measurements of a portion of a body structure, based on models of a location of a pathology that has been identified, makes it possible, in effect, to zoom in on a suspected pathology. The systems are preprogrammed to provide these motions automatically.

Compounds and methods related to NIR molecular imaging, in-vitro and in-vivo functional imaging, therapy / efficacy monitoring, and cancer and metastatic activity imaging. Compounds and methods demonstrated pertain to the field of peripheral benzodiazepine receptor imaging, metabolic imaging, cellular respiration imaging, cellular proliferation imaging as targeted agents that incorporate signaling agents.

Various embodiments of the present invention include systems and methods for multimodal functional imaging based upon photoacoustic and laser optical scanning microscopy. In particular, at least one embodiment of the present invention utilizes a contact lens in combination with an ultrasound transducer for purposes of acquiring photoacoustic microscopy data. Traditionally divergent imaging modalities such as confocal scanning laser ophthalmoscopy and photoacoustic microscopy are combined within a single laser system. Functional imaging of biological samples can be utilized for various medical and biological purposes.

A medical accelerator system consisting of coplanar and non-coplanar beams, on line magnetic resonance anatomic and functional imaging and cone beam computed tomographic imaging for single session image guided all field simultaneous radiation therapy and radiosurgery is provided. This system enables single session simulation, field-shaping block making, treatment planning, dose calculations and treatment of tumors. The radiation exposure time to the tumor and the normal tissue is reduced to a few seconds to less than a minute. In filed intensity modulated radiation is rendered by combined divergent and pencil beam, multiple smaller fields within a larger field, selectively varying beam's energy, dose rate and beam weight. Since all the treatment fields are treated simultaneously the dose rate at the tumor site is the sum of each of the converging beam's dose rate at depth. This super-high biological dose rate impairs the lethal and sublethal damage repair.

Various embodiments of the present invention include systems and methods for multimodal functional imaging based upon photoacoustic and laser optical scanning microscopy. In particular, at least one embodiment of the present invention utilizes a contact lens in combination with an ultrasound transducer for purposes of acquiring photoacoustic microscopy data. Traditionally divergent imaging modalities such as confocal scanning laser ophthalmoscopy and photoacoustic microscopy are combined within a single laser system. Functional imaging of biological samples can be utilized for various medical and biological purposes.

An apparatus for wide-field functional imaging (WiFI) of tissue includes a spatially modulated reflectance / fluorescence imaging (SI) device capable of quantitative subsurface imaging across spatial scales, and a laser speckle imaging (LSI) device capable of quantitative subsurface imaging across spatial scales using integrated with the (SI) device. The SI device and LSI device are capable of independently providing quantitative measurement of tissue functional status.

A universal ophthalmic examination device and an ophthalmic examination method have the object of combining in an inexpensive apparatus in a simple manner the device-related requirements for image generation, measurement and functional imaging for carrying out visual stimulation and highly time-resolved and highly spatially resolved image documentation using continuous illumination and flash mode and the requirements for measurements in the infrared spectral region and visible spectral region with a time regime that can be freely selected to a great extent. The light of at least one light source is modified in a program-oriented manner with respect to its intensity curve and / or time curve with a temporally defined relationship to the adjustments of the at least one light source, of the image recording and of the evaluation for purposes of adaptive matching to an examination task in the illumination beam path by an individual, shared light manipulator and is used as modified light for illumination and for selective stimulation.

Various embodiments of the present invention include systems and methods for multimodal functional imaging based upon photoacoustic and laser optical scanning microscopy. In particular, at least one embodiment of the present invention utilizes a contact lens in combination with an ultrasound transducer for purposes of acquiring photoacoustic microscopy data. Traditionally divergent imaging modalities such as confocal scanning laser opthalmoscopy and photoacoustic microscopy are combined within a single laser system. Functional imaging of biological samples can be utilized for various medical and biological purposes.

Various embodiments of the present invention include systems and methods for multimodal functional imaging based upon photoacoustic and laser optical scanning microscopy. In particular, at least one embodiment of the present invention utilizes a contact lens in combination with an ultrasound transducer for purposes of acquiring photoacoustic microscopy data. Traditionally divergent imaging modalities such as confocal scanning laser opthalmoscopy and photoacoustic microscopy are combined within a single laser system. Functional imaging of biological samples can be utilized for various medical and biological purposes.

The invention discloses an emotional stability evaluation system based on magnetic resonance imaging and an evaluation method thereof. The emotional stability evaluation system comprises an emotional stability characteristic sample database, a magnetic resonance imaging unit, a characteristic extraction unit, a pattern classifier and an emotional stability evaluation unit, wherein a magnetic resonance structure of emotional levels and emotional components with different emotional stabilities and resting state functional imaging attributes are stored in the emotional stability characteristic sample database; the magnetic resonance imaging unit acquires imaging data of a magnetic resonance structure phase and a resting state functional phase of the brain of a detected individual, and transmits the imaging data to the characteristic extraction unit; the characteristic extraction unit extracts the magnetic resonance structure and the resting state functional imaging attribute of the brainof the detected individual from the imaging data; the pattern classifier carries out classifier training on the magnetic resonance structure and the resting state functional imaging attribute; and the emotional stability evaluation unit evaluates the emotional stability level and / or emotional cause of the detected individual according to the classifier training result, the magnetic resonance structure and the resting state functional imaging attribute. Therefore, the system realizes accurate, objective and stable evaluation on the emotional level and cause of the detected individual.

The present invention is directed to a system, method and software program product for implementing 3-D Complete-Body-Screening medical imaging which combines the benefits of the functional imaging capability of PET with those of the anatomical imaging capability of CT. The present invention enables execution of more complex algorithms measuring more accurately the information obtained from the collision of a photon with a detector. The present invention overcomes input and coincidence bottlenecks inherent in the prior art by implementing a massively parallel, layered architecture with separate processor stacks for handling each channel. The prior art coincidence bottleneck is overcome by limiting coincidence comparisons to those with a time stamp occurring within a predefined time window. The increased efficiency provides the bandwidth necessary for increasing the throughput even more by extending the FOV to over one meter in length and the execution of even more complex algorithms.

Provided is a multi-purpose imaging apparatus (10) comprising a body (14) and imaging means (36) housed within the body (14). The body (14) is adapted to releasably engage an adaptor (12). The adaptor (12) has an aperture (108) extending therethrough that aligns with the optical axis (X) of the imaging means (36) when so engaged, such that at least a portion of the optical axis (X) is not obscured. The adaptor (12) also has optics for illuminating a subject within the optical axis (X) for diagnostic purposes.

This invention relates to one method to acquire biology spectrum information and life information and to realize three-dimensional imaging. The invention is characterized by the following: getting multi-photon or single photon triggering of five-dimensional fluorescent microscope imaging information, that is three-dimensional space, one dimensional time and spectrum. This multi-parameter compound measurement and technique, which can satisfy the needs of different layers in study and can realize the flexible made three-dimensional spectrum for measurement.

Various embodiments of the present invention include systems and methods for multimodal functional imaging based upon photoacoustic and laser optical scanning microscopy. In particular, at least one embodiment of the present invention utilizes a contact lens in combination with an ultrasound transducer for purposes of acquiring photoacoustic microscopy data. Traditionally divergent imaging modalities such as confocal scanning laser opthalmoscopy and photoacoustic microscopy are combined within a single laser system. Functional imaging of biological samples can be utilized for various medical and biological purposes.

A system, method, and apparatus includes a computer readable storage medium with a computer program stored thereon having instructions that cause a computer to access a first anatomical image data set of an imaging subject acquired via a morphological imaging modality, access a functional image data set of the imaging subject acquired via a functional imaging modality, register the first anatomical image data set to the functional image data set, segment the functional image data set based on the functional image data set, define a binary mask based on the segmented functional image data set, and apply the binary mask to the first anatomical image data set to construct a second anatomical image data set and an image based thereon. The second anatomical image data set is substantially free of image data of the first anatomical image data set correlating to an area outside the region of physiological activity.

The invention relates to a laser scanning imaging device, comprising a laser, a laser scanning mirror, a micro objective, a near-infrared scattered light detection channel, a two-photon excited fluorescence detection channel, a second harmonic detection channel and a data acquisition imaging system. The laser scanning imaging device can simultaneously realize microscopic two-photon excited fluorescence imaging, second harmonic imaging and near-infrared scattering imaging, can be widely applicable to the fields such as quick high resolution structure and function imaging of living biological samples and has great practical value.

The invention belongs to the field of optical parameter measurement in tissue optical research, and relates to a multichannel near-infrared brain functional imaging parallel detection system, which comprises a light source part, a brain detection part, a detector part, a multifunctional number phase locking detection circuit and a computer. The light source part comprises a plurality of light source units, each group of unit comprises two steady state semiconductor lasers with different wave lengths, digital-to-analogue conversion and filter circuits and current controllers of the two steady state semiconductor lasers, a wavelength division multiplexer and light optical fibers, wherein the light which is produced by the two lasers driven by the current controllers thereof passes by the wavelength division multiplexer, and then passes by the light optical fibers to be fed to the brain detection part; the brain detection part comprises a plurality of optical seats, and the optical seats are connected with one another through link belts to form a netty passage; and all the light optical fibers are connected onto different optical seats. The invention combines the single photon counting technology with the phase locking detection technology, not only the quick imaging requirement is benefited, but also the wide dynamic range requirement is satisfied.

Compounds and methods related to NIR molecular imaging, in-vitro and in-vivo functional imaging, therapy / efficacy monitoring, and cancer and metastatic activity imaging. Compounds and methods demonstrated pertain to the field of peripheral benzodiazepine receptor imaging, metabolic imaging, cellular respiration imaging, cellular proliferation imaging as targeted agents that incorporate signaling agents.

A method for 3D imaging of a biologic object (1) in an optical tomography system where a subcellular structure of a biological object (1) is labeled by introducing at least one nanoparticle-biomarker. The labeled biological object (1) is moved relatively to a microscope objective (62) to present varying angles of view and the labeled biological object (1) is illuminated with radiation having wavelengths between 150 nm and 900 nm. Radiation transmitted through the labeled biological object (1) and the microscope objective (62) within at least one wavelength bands is sensed with a color camera, or with a set of at least four monochrome cameras. A plurality of cross-sectional images of the biological object (1) from the sensed radiation is formed and reconstructed to make a 3D image of the labeled biological object (1).

Compounds and methods related to NIR molecular imaging, in-vitro and in-vivo functional imaging, therapy / efficacy monitoring, and cancer and metastatic activity imaging. Compounds and methods demonstrated pertain to the field of peripheral benzodiazepine receptor imaging, metabolic imaging, cellular respiration imaging, cellular proliferation imaging as targeted agents that incorporate signaling agents.

A method of generating images of a portion of a body includes introducing a contrast agent into the body, generating a first set of image data using radiation at a first energy level after the contrast agent is introduced into the body, generating a second set of image data using radiation at a second energy level after the contrast agent is introduced into the body, and creating a volumetric composite image using the first and the second sets of image data.

The invention discloses a method for acquiring the imaging data of a neuro navigation system, which comprises the following steps of: acquiring scanned images in a functional magnetic resonance imaging mode, wherein the functional magnetic resonance imaging mode comprises BOLD scan cortex functional imaging and DTI scan alba functional imaging; transmitting the scanned images according to DICOM and classifying and converting the scanned images; and according to category, and carrying out the registration and fusion of the neuro navigation structural images and the converted scanned images, wherein the registration and fusion comprises the registration mapping of BOLD activation maps and the fusion of DTI maps. Therefore, the neuro functional images are registered and fused in neuro navigation, cerebral white matter fiber tracks is carried out and used as image data of the neuro navigation system so as to provide a powerful tool for making surgical plan before a surgery and protecting normal brain functions in the surgery and to provide a platform for brain function research.