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Laser scanning imaging device

A laser scanning imaging and laser scanning technology, which is applied in the directions of fluorescence/phosphorescence, material excitation analysis, scattering characteristic measurement, etc., can solve the problems of inability to image biological samples and obtain comprehensive detection information, and achieve good image display effect, Great practical value and the effect of improving the spatial resolution of imaging

Active Publication Date: 2010-12-15
HUAWEI TEHCHNOLOGIES CO LTD
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Problems solved by technology

[0005] However, neither two-photon excitation fluorescence microscopy nor second harmonic imaging can obtain all-round detection information, and cannot perform multi-directional imaging of biological samples.

Method used

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Embodiment Construction

[0021] By adding a near-infrared scattering imaging detection channel, the distribution image of the optical characteristic parameters (such as absorption and scattering coefficients, etc.) inside the living biological tissue can be reconstructed, which can provide more detection information, so that two-photon excitation fluorescence microscopy imaging and secondary Harmonic imaging techniques are complemented.

[0022] The following mainly describes the structure of the laser scanning imaging device with reference to the accompanying drawings.

[0023] Such as figure 1 Shown is a structural diagram of a laser scanning imaging device in a preferred embodiment. The laser scanning imaging device includes a laser 10, an electro-optic modulator 11, a laser scanning mirror 12, a lens pair 13, a first filter 14, a microscope objective lens 15, a second filter 16, a near-infrared scattered light detection channel 17, Two-photon excitation fluorescence detection channel 18 , second...

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Abstract

The invention relates to a laser scanning imaging device, comprising a laser, a laser scanning mirror, a micro objective, a near-infrared scattered light detection channel, a two-photon excited fluorescence detection channel, a second harmonic detection channel and a data acquisition imaging system. The laser scanning imaging device can simultaneously realize microscopic two-photon excited fluorescence imaging, second harmonic imaging and near-infrared scattering imaging, can be widely applicable to the fields such as quick high resolution structure and function imaging of living biological samples and has great practical value.

Description

【Technical field】 [0001] The invention relates to the technical field of optical detection and imaging, in particular to a laser scanning imaging device. 【Background technique】 [0002] Rapid high-resolution structural and functional imaging of living biological samples is an important topic in modern life science research. The observation of living biological samples needs to meet the following conditions at the same time: 1. It has high spatial and temporal resolution, such as subcellular spatial resolution (molecular level) and sub-millisecond time resolution; 2. It has little damage to the sample and can Realize long-term observation; 3. High sensitivity and good specificity. [0003] Two-photon excited fluorescence microscopy is a new type of high-resolution optical microscopy imaging technology developed in the 1990s. Compared with single-photon fluorescence microscopy imaging techniques (such as wide-field fluorescence imaging, confocal fluorescence microscopy imagi...

Claims

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Application Information

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IPC IPC(8): G01N21/63G01N21/64G01N21/49
Inventor 张春阳李德荣陈超雄
Owner HUAWEI TEHCHNOLOGIES CO LTD
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