289 results about "Science research" patented technology

The present invention provides a cartridge for analyzing a fluid sample. The cartridge provides for the efficient separation of cells or viruses in the sample from the remaining sample fluid, lysis of the cells or viruses to release the analyte (e.g., nucleic acid) therefrom, and optionally chemical reaction and / or detection of the analyte. The cartridge is useful in a variety of diagnostic, life science research, environmental, or forensic applications for determining the presence or absence of one or more analytes in a sample.

A chemical processing microsystem useful for identifying and optimizing materials (e.g., catalysts) that enhance chemical processes or for characterizing and / or optimizing chemical processes is disclosed. The chemical processing microsystem comprises a plurality of microreactors 600 and, in a preferred embodiment, a plurality of microseparators 900 integral with the chemical processing microsystem 10. The microreactors 600 are preferably diffusion-mixed microreactors formed in a plurality of laminae that include a modular, interchangeable candidate-material array 100. The material array 100 comprises a plurality of different candidate materials (e.g., catalysts), preferably arranged at separate, individually addressable portions of a substrate (e.g., wafer). The microseparators 900 are similarly formed in a plurality of laminae that include a modular, interchangeable adsorbent array 700. The adsorbent array 700 comprises one or more adsorbents, preferably arranged at separate, individually addressable portions of a substrate to spatially correspond to the plurality of different candidate materials. Modular microfluidic distribution systems are also disclosed. The chemical processing microsystem can be integrated into a material evaluation system that enables a comprehensive combinatorial material science research program.

The invention discloses a preparation method of chitosan-polyurethane ionic compound elastomeric material, which comprises the following steps: polyisocyanates reacts with polymer polylol and then reacts with diol or diamine, organic solvent and ionization reagent are added in the reactants to react with water for generating anionic waterborne polyurethane and further performs the ionic recombination reaction with cationic chitosan water solution to obtain the microemulsion or latex of chitosan-polyurethane ion composite, and finally the microemulsion or latex of chitosan-polyurethane ion composite is dried and solidified to obtain the chitosan-polyurethane ionic compoundelastomeric material. The chitosan-polyurethane ionic compoundelastomeric material has the advantages of good mechanical property, easy processing, good oil-water resistance property, good cohesive property with parent metal, controllable performance, good biocompatibility, biodegradable property, high biological activity, good blood contact property, good bacteriostatic property, good antibacterial property, and the like, can be applied in fields of mechanical industry, building industry, sport, medical treatment, and the like, and especially has wider purpose in aspects of life science research, medical materials and medical appliances.

A local inventory control system according to the invention can be remotely regulated by a centralized server architecture. The local inventory control system contains product offered by a business entity, and the same business entity can control unlocking of the local inventory control system using the centralized server architecture. In a practical implementation, the inventory control features are integrated with e-commerce features such that the local inventory control system can be automatically unlocked subsequent to the completion of online purchase transactions initiated at the local site. The inventory control system is well-suited as part of a supply program to manage vendor inventories of life science research products.

The invention relates to a stabilizing agent for protein solutions, in particular to a long-acting protein solution stabilizing agent. The agent comprises 0.1-5g protein, 0.1-10g sugar, 0.1-10g organic matter, 0.01-0.1g preservative, and 10-200mmol buffer solution salt per 100ml water, and a pH (Potential of Hydrogen) value is 7.2-7.4. The agent has simple constituents, protects the stability of the protein, prevents the protein from degeneration, does not interfere with target reaction, and has general applicability to the most protein solutions. The agent has obvious effects, and can keep the effectiveness of the protein solutions for a long time, and the protein solutions are to be used for the fields of reagents for clinical diagnosis, life science research and the like.

A chemical processing microsystem useful for identifying and optimizing materials (e.g., catalysts) that enhance chemical processes or for characterizing and / or optimizing chemical processes is disclosed. The chemical processing microsystem comprises a plurality of microreactors 600 and, in a preferred embodiment, a plurality of microseparators 900 integral with the chemical processing microsystem 10. The microreactors 600 are preferably diffusion-mixed microreactors formed in a plurality of laminae that include a modular, interchangeable candidate-material array 100. The material array 100 comprises a plurality of different candidate materials (e.g., catalysts), preferably arranged at separate, individually addressable portions of a substrate (e.g., wafer). The microseparators 900 are similarly formed in a plurality of laminae that include a modular, interchangeable adsorbent array 700. The adsorbent array 700 comprises one or more adsorbents, preferably arranged at separate, individually addressable portions of a substrate to spatially correspond to the plurality of different candidate materials. Modular microfluidic distribution systems are also disclosed. The chemical processing microsystem can be integrated into a material evaluation system that enables a comprehensive combinatorial material science research program.

Disclosed is a conjugate for gene transfer, which is capable of being used for treatment of incurable diseases, comprising an oligonucleotide intended to be transferred into target cells and a hydrophilic polymer, wherein an end of the oligonucleotide is covalently conjugated to the hydrophilic polymer. Also, the present invention discloses polyelectrolyte complex micelles formed from such a conjugate and a cationic polymer or cationic peptide. Such polyelectrolyte complex micelles can effectively transfer oligonucleotides as therapeutic agents into target cells, making it possible to obtain desired activities of the delivered oligonucleotides in target cells even when the micelles are clinically applied at a relatively low concentration. Therefore, the conjugate and the polyelectrolyte complex micelle are very useful in basic life science research and the medical field.

The invention relates to a moving posture capture system, which comprises a plurality of sensors used for measuring moving posture and a host computer used for processing posture data, wherein, an inertia posture measure sensor module enables bidirectional connection with a master control module through a USART communication cable, the master control module and the host computer enable bidirectional connection in a wireless mode, and the power supply management module is respectively connected to the inertia posture measure sensor module and the master control module. The system integrates a triaxial magnetic field sensor and a six spindle acceleration and angular velocity sensor, the inertia strapdown posture is used for resolving, Kalman digital filtering and data fusion algorithm are combined to accurately measure three-dimensional stereo, the collected data can be automatically corrected without the influence of environmental factors, the moving postures of human, animal and objects can be captured, the data output by the system can be directly used by the users, and high quality animation with vivid effect can be produced. The moving posture capture system can be used for dynamic simulation of role models of cartoon, movie and television and game, as well as scientific research of motion state of human, animal and objects.

A framework for to enable collaborative research includes enabling scientific researchers to dynamically interact with others, collaboratively author, annotate, review, comment on others' data, and discuss their research. The framework allows for providing a dynamic collaboration environment by harnessing collective contributions from a group of researchers and facilitating broader participation of people into research projects. The framework is a Web-based collaborative platform to dynamically integrate information for scientific research. Besides data integration, the system provides essential collaboration capabilities to boost user participation and collaboration. The system will not only enable users as active information contributors to bring significant new values to the data, but also provide an environment for scientific researchers to do collaborative research in a large research community.

The present invention relates to a novel method and a novel device, incorporating dynamic speckle lighting with a conventional wide field fluorescence microscope organically to implement approximately confocal fluorescence microscopy (i.e., quasi-confocal fluorescence microscopy). The present invention employs an argon ion laser as the light source; the exciting light passes through a scattering object, a relay light path system for expanding and shaping, and then is coupled to the fluorescence microscope and focused to the sample. The stepping and revolution of the scattering object is controlled with a computer to produce a dynamic speckle pattern on the sample. The received fluorescent images are processed to obtain high-resolution spatial chromatographic images under no need to scan condition. The method can be used to obtain high-resolution three-dimensional chromatographic and microscopic image information of biological tissue samples in a non-intrusive manner. The device has simple structure, high cost-performance ratio, and is favorable for post data processing, easy to operate and apply; therefore, the device and method have a wide market application prospect and great significance for clinical diagnosis and life science research.

The invention discloses a rock and soil disintegration test device as well as a using method. A base is connected with fulcrum bars; a vertical stretching valve is connected with the fulcrum bars respectively; a fulcrum bar is provided with a horizontal stretching valve, and a second hook is hung on the fulcrum bar; one end of a spring-loaded thrust meter is connected with the second hook; the lower part of the other end of the spring-loaded thrust meter is connected with the hook; copper wires are fastened to four edge corners of a metal grid net, and at the other end, the copper wires are twisted into a strand to be hung on the hook; rock and soil test samples are placed on the metal grid net, and then are immersed into a flask. The using method of the rock and soil disintegration test device comprises the following steps: (1) a no-load test, namely pouring distilled water into the flask, and recording the reading number F0 on the spring-loaded thrust meter; (2) rock and soil test sample manufacture, namely manufacturing a soil test sample and a rock test sample respectively by a cutting ring and a cutter; (3) a disintegration test, namely placing the rock and soil test samples on the metal grid net, and immersing into water, thus completing the test; (4) data processing. The rock and soil disintegration test device is simple in structure, easy to assemble and debug, low in cost, high in precision, good in stability and high in applicability, and can be widely applied to rock and soil engineering science research.

The invention discloses a water sampler which is simple, portable and easy to operate. Users can collect water samples in different locations and at different depths by the bank. Based on environmental science research and the actual situation of work practice, the water sampler not only solves the problem of manual sampling, but also improves the work efficiency and safety factor of outdoor water sampling activity, thus saving labor power and material resources and bringing convenience to science researchers and environment workers. The floating automatic water sampler consists of four parts, namely, a structure system, a power control system, a water sampling system and an automatic control system. The water sampler, adopting the structure, can receive instructions of operators ashore and arrive at an appointed location to collect water samples, and can collect the water samples at different depths in different locations according to a preset sampling depth. The water samples collected at different depths and in different locations can be automatically and separately stored and return to a departure site. The collected water sample amount can meet the general requirements of water quality monitoring.

The invention belongs to the technical field of water circulation of water conservancy projects and particularly relates to a distributed-type river basin water deficit calculating method based on terrain and soil characteristics. The method comprises the following steps: step1, processing basic data of an underlying surface of a river basin; step 2, counting grid terrain indices within basin perimeters; step 3, calculating soil characteristic parameters within the basin perimeters; step 4, quantitatively expressing distribution of river basin water deficit; and step 5, drawing cumulative distribution curves of river basin water deficit to acquire a calculating model of distributed-type river basin water deficit. when being applied to real-time flood forecasting, The distributed-type river basin water deficit calculating method based on the terrain and soil characteristics can substantially improve accuracy of flood forecasting and provide reliable scientific support for river basin flood-prevention early warning and the like. The distributed-type river basin water deficit calculating method based on the terrain and soil characteristics is not only suitable for a lumped-type hydrological model but also suitable for a distributed-type hydrological model and can effectively promote in-depth development of river basin hydrology science research.

Culture substrates, cell arrays, automatic chemical dispensers and assay systems necessary for conveniently assaying multiple chemicals such as drugs and toxic agents are provided. Herein used is a substrate for a high-density cell array characterized in that it has a surface comprising an ordered array of discrete microdomains coated with a cell adhesive polymer and successively surrounded by a domain coated with a cell non-adhesive hydrophilic polymer and then a domain coated with a cell non-adhesive highly hydrophobic material. This substrate for a high-density cell array and an assay system using it can greatly reduce side effects of drugs and dramatically improve the performance of drug therapy for diseases by optimizing the type and concentration of the drug used (e.g., an anticancer agent). The present invention provides a very useful technology that can also be used for drug development, environmental impact assessment and basic life science researches.

The invention discloses a fish behavior and nerve observation and research device and method. A side-face camera is installed on one side of a fish tank, and the other side of the fish tank is provided with an installation support. A top-surface camera, a stimulation controller, a rotating arm angle control stepping motor, a rotating arm and a rotating arm fixing support are installed on the installation support. Stimulation horizontal movement control devices are installed on the rotating arm, stimulation height control stepping motors are installed on the horizontal movement control devices and connected with height control connecting lines, the height control connecting lines are connected with stimulation points, and stimulation assemblies are installed on the stimulation points. A computer is used for controlling the cameras and the stimulation controller. The observation and research method includes the steps that three-dimensional calculation is performed on fish behaviors, calculation and analysis are performed on the fish behaviors, and fish nerve research is performed through sound, light, electricity, drug stimulation and fish behavior analysis. According to the fish behavior and nerve observation and research device and method, wider and deeper cognition to fish behaviors and nerves is performed, and the fish behavior and nerve observation and research device and method have a great effect in the field of human life science research.

The invention relates to an electrochemiluminescence imaging system, which comprises an electrochemical reaction pool, an electrochemiluminescence imaging pool, a stabilized voltage direct current power supply and a CCD (Charge Coupled Device) imaging unit, wherein the electrochemical reaction pool is electrically connected with the electrochemiluminescence imaging pool through at least one bipolar electrode; a pole of the bipolar electrode is arranged in the electrochemical reaction pool, the other pole of the bipolar electrode is arranged in the electrochemiluminescence imaging pool, and the two poles are connected through a wire; a driving electrode is also arranged in the electrochemical reaction pool and the electrochemiluminescence imaging pool respectively; the two driving electrodes are connected with a positive electrode and a negative electrode of the stabilized voltage direct current power supply through a wire respectively; and an electrochemiluminescence phenomenon in the electrochemiluminescence imaging pool is recorded by the CCD imaging unit. The electrochemiluminescence imaging system has the advantages of simple instrument, low cost, high detection sensitivity, quickness and high energy, and has great significance to promotion of development of basic electrochemical science research, high-flux and high-sensitivity analysis detection and a screening technology of electro-catalysts in fuel cells.

The invention discloses a single station earthquake P wave detection warning device and relates to seismological observation technology. The single station earthquake P wave detection warning device comprises a data acquisition module, a data analysis and logging module and a communication and alarm module, wherein the data acquisition module, the data analysis and logging module and the communication and alarm module are connected in sequence. The data acquisition module is composed of three-axial force balance acceleration sensor and an external connection acceleration sensor interface. The data analysis and logging module is composed of a analog-digital (AD) convertor, a digital signal processor (DSP), an advanced RISC machine (ARM) and system thereof, a global position system (GPRS) module, a P wave early warning algorithm, a real-time clock and a secure digital (SD) card storage. The communication and alarm module is composed of a computer, an alarm box and a P wave early warning instrument application software. The single station earthquake P wave detection warning device has the functions of acquisition, storage, analysis and alarm. Earthquake monitoring and earthquake P wave early warning are achieved only a single device is needed. The single station earthquake P wave detection warning device has the advantages of being small in size, light, easy to carry, convenient to install, low in cost and suitable for network layout of an earthquake early warning project and a national earthquake early warning science research project for a key project.

Methods and compositions are provided for modulating, e.g., increasing or decreasing, the expression of telomerase reverse transcriptase (TERT). In the subject methods, the binding interaction of the TERT Site C repressor site with a Site C repressor protein complex made up of one or more proteins is modulated to achieve the desired change in TERT expression. A feature of the subject invention is that the target Site C repressor protein complex includes an LSF protein. The subject methods and compositions find use in a variety of different applications, including the immortalization of cells, the production of reagents for use in life science research, therapeutic applications; therapeutic agent screening applications; and the like.

The invention provides a preserving fluid and a preserving method for maintaining high cell activity of a tissue sample, wherein the preserving fluid comprises the components: ion buffer solution components, carbohydrate components,, components avoiding the generation of ice crystals in and out solutions of tissue cells at a low temperature of 0-6 DEG C, components providing supplement, antioxidant and anti-apoptosis components for anabolism of the tissue cells; the preserving fluid has good biocompatibility, does not contain toxic or harmful components, and also does not contain components such as animal-derived protein, antibiotics and hormones influencing tissue gene expression. Different from traditional ultralow-temperature cryopreservation (-80 DEG C), the cryopreservation method disclosed by the invention can effectively realize low-temperature storage (0-6 DEG C) of fresh tissue samples of human beings and animals, maintains high cell activity of tissues, maintains tissue morphology, and is used for preservation and transportation of the tissue samples. Meanwhile, the nucleic acid integrity of the tissue and the stability of gene expression can be effectively maintained, the original state of the tissue is maintained, and the method can be used for gene detection, scientific research and other related experiments.

The invention belongs to the technical field of aquatic culturing engineering, and particularly relates to a trachidermus fasciatus breeding and culturing workshop system for simulating the natural ecological environment. A workshop system for simulating the field habitat is built according to the ecological habit of trachidermus fasciatus, and comprises a hard ecological environment system and a soft ecological environment system. The ecological environment built by the system can completely meet the requirements of trachidermus fasciatus in each period, such as breeding, migration and growth, so the scale production of full-manual breeding and culturing of trachidermus fasciatus is realized. The system can continuously build and expand the manual species of trachidermus fasciatus, and meet the requirement of trachidermus fasciatus fries, fingerlings and adult fishes required by science research, enhancement and releasing, and development and utilization. Compared with the conventional intensive culturing mode, the system has the advantages that the construction cost and running cost are greatly reduced, the culturing benefit is greatly improved, and the application prospect is wide.

The invention discloses a volume tense data modeling method based on a determined learning theory. The method aims at volume tense data with noise, wherein the volume tense data are ubiquitous in science researches and engineering practices and generated a dispersed nonlinear system normally. A modeling process comprises that the volume tense data are defined and preprocessed through filtering; a neural network identifier is structured by adopting a dynamic radial basis function (RBF) neural network, and a reasonable adjusting rule of RBF neural network weight is designed; and a model is built for the neural network of the volume tense data. The volume tense data modeling method has the advantages of simplifying modeling of the volume tense data and performance analysis, being applied to rapid similarity judgment of the volume tense data and the like.

The invention relates to an aerial photogrammetry simulation system. The aerial photogrammetry simulation system not only can make an aerial photogrammetry track device of itself adjust the positions of air strips at any time according to requirements, but also can be combined with a ground total-factor terrain and ground feature model and an aerial photogrammetry data processing center. Therefore, the aerial photogrammetry simulation system not only can meet requirements of teaching of the cartology and the photogrammetry, and further can meet requirements of teaching of the digital photogrammetry, the principle and method of remote sensing and a plurality of courses belonging to the surveying and mapping technology subject, but also can provide experimental facilities for the photogrammetry scientific research performed by teachers.

The present invention makes non-grating surface plasmon resonance (SPR) optical coupler with plastic to replace optical glass, and belongs to the field of waveguide optics and biological sensing technology. The disposable low cost optical coupler made with low refractive index plastic has low cost, less noise, raised SPR biosensor S / N ratio, convenient instrument operation, and convenient integration with other parts. The SPR biosensor of the present invention may be used in clinical detection, sanitary environment monitoring, industrial production and basic life science research relative to mutual action of macro biomolecules.

The invention belongs to the technical field of biosensors and specifically relates to a full-automatic high-flux optical biosensing device. The device comprises an oblique incidence-light reflection differential imaging unit, a sample and liquid processing unit, and a system control and data acquisition processing unit. The oblique incidence-light reflection differential imaging unit comprises a monochromatic light generator, a beam expander, a polarizer, a polarization modulator, a phase shifter, a lens, a mechanical translation table, an imaging lens, a polarization analyzer and a photoelectric detector; the sample and liquid processing unit comprises a biochip, a fluid cavity, a buffer solution pump, a sample solution pump, a selector valve and a switching valve; the system control and data acquisition processing unit comprises an amplifying circuit, an AC weak signal detector and an electronic computer. The full-automatic high-flux optical biosensing device is capable of performing high-flux, in-situ, real-time and rapid detection on the biochip, and is full automatic in operation, high in detection efficiency, and has wide application prospect in the fields of life science research, high-flux medicine screening, clinical diagnosis, food and environment safety detection and the like.

The invention belongs to the field of molecular biology, and discloses application of a segment of isolated nucleotide sequence in construction of zebra fish with reduced intramuscular spines. The nucleotide sequence is shown as SEQ ID NO.1, by using a conventional method in the field, the SEQ ID NO.1 is taken as a target gene to perform gene mutation operation, F0 with mutation is screened out, F1 generated by hybridization of F0 and a wild type is subjected to genotyping, and mutant F1 is screened out and selfed, so that the zebra fish strain with few intramuscular spines which is remarkablyreduced by more than 70% in the number of intramuscular spines and is stably inherited can be obtained. According to the application of the segment of isolated nucleotide sequence in construction ofzebra fish with reduced intramuscular spines, the segment of isolated nucleotide sequence is used to obtain a fish strain with reduced intramuscular spines for the first time, and the application of the segment of isolated nucleotide sequence in construction of zebra fish with reduced intramuscular spines has the advantages of remarkable character improvement effect, short breeding time, stable heredity, low cost and the like, has the basic value and the application value of scientific research, can be used for researching the development mechanism of the intramuscular spines of the fish, andprovides a method for obtaining a stable genetic strain with few intramuscular spines of various fish.

Imaging optical systems having good transmission and that are well corrected over the full 315 nm-1100 nm ultraviolet-visible-infrared (UV-VIS-IR) wavelength band are disclosed. A wide variety of apochromatic and superachromatic design examples are presented. The imaging optical systems have a broad range of applications in fields where large-bandwidth imaging is called for, including but not limited to forensics, crime scene documentation, art conservation, forgery detection, medicine, scientific research, remote sensing, and fine art photography.

The invention discloses a railway monitoring system simulator, comprising a keyboard and mouse (1), a CPU (2), a memory (3), a display (6), a communication control module (7) and an external interface module (8); wherein, the CPU (2) is electrically connected with the keyboard and mouse (1), the memory (3), a signal output module (4), a signal detection module (5), the display (6) and the communication control module (7); the signal output module (4) and the signal detection module (5) are electrically connected with the external interface (8) by the communication control module (7). The railway monitoring system simulator has the advantages of simple and reasonable circuit, high integration degree, reliable operation and stable performance, and is suitable for being used by railway locomotive vehicle production and transport enterprises and science research units.

The invention belongs to the field of molecular biology DNA marker technique and application. The invention discloses a method for analyzing genetic diversity of Amomum tsao-ko by using inter simple sequence repeat (ISSR) reaction system. The ISSR reaction system comprises (per 25 muL) Mg<2+>-free 10*PCR buffer 3.0 muL, Taq DNA polymerase 1.5 U, Mg<2+> 1.5 mmol / L, dNTP 0.25 mmol / L, primers 0.3 mumol / , and template DNA 50 ng. The reaction mixture is amplified by the following procedures: pre-degeneration at 95 DEG C for 5 min, degeneration at 95 DEG for 1 min, annealing at 50-58 DEG C for 1 min, extension at 72 DEG C for 1 min, after 35 cycles, extension at 72 DEG C for 10 min, and storage at 4 DEG C. The method of the invention provides technical guide and theoretical support for Amomum tsao-ko resource identification, genetic diversity analysis and other scientific researches.

The invention discloses a winding force-adjustable test transformer. The winding force-adjustable test transformer comprises a transformer body, a compaction device, a piezoelectric sensor set, a vibration sensor and a processor, wherein the piezoelectric sensor set comprises a first piezoelectric sensor and a second piezoelectric sensor, integral and partial compaction force of a transformer winding can be adjusted through the compaction device, the first piezoelectric sensor is used for monitoring a compaction force of a coil and axial electric power borne by the winding during a test, the second piezoelectric sensor is used for monitoring radial contraction force of the coil in real time, and the vibration sensor is used for monitoring vibration of the transformer in actual operation. The winding force-adjustable test transformer is advantaged in that the structure is simple, force of the winding can be flexibly adjusted, the structure is safe and reliable, winding loosing, fault short circuit and force of the transformer winding during vibration in actual operation can be actually simulated, and the winding force-adjustable test transformer can be applied to transformer design check, fault simulation, test monitoring and science research fields.

The invention relates to a protein enzyme-hydrolysis reactor which can change microcurrent control chip and the preparing method in the microcurrent control chip field. The reactor comprises a microcurrent control chip with two-tip single channel and a glass fiber(enzyme centre)fixed proteinase, wherein the enzyme centre penetrates the microcurrent channel of the chip and goes out from two tips, the enzyme centre modifies chitose film on the surface with dip-coating method by the glass fiber and is made by fixing the proteinase to the surface of the glass fiber with adsorption, embedding or covalence bond technique, the protein enzyme-hydrolysis reactor which can change microcurrent control chip is acquired by inserting the glass fiber enzyme centre in the micro channel of microcurrent control chip before using. The glass fiber enzyme centre has the inexpensive price, which can change according to the requirements, improves the using efficient of the chip and the enzyme, and reduces the measuring cost of enzyme method. The reactor has the good application prospect in the clinical diagnosis, the environmental monitoring, the life science research and the food analysis field.