258results about "Reagent containers" patented technology

The present invention relates to a device comprising at least one reaction space with a single pre-dispensed dried reagent composition suitable for performing an assay method for detecting at least one analyte in a sample to be added to the reaction space, wherein the reagent composition comprises at least one set of analyte-specific proximity probes and a drying stabiliser, wherein the proximity probes in the set each comprise a binding domain for binding directly or indirectly to the analyte and a nucleic acid domain. The invention further relates to a method of performing a detection assay with use of the device, as well as a method of preparing the device.

Methods of partition-based analysis. In an exemplary method, a device having a port fluidically connected to a chamber may be selected. A sample-containing fluid may be placed into the port. The sample-containing fluid may be moved from the port to the chamber. Partitions of the sample-containing fluid may be formed. A monolayer of the partitions in the chamber may be created. At least a portion of the monolayer may be imaged.

Described herein are systems, methods, and devices for pathogen identification. A system includes a housing configured to receive a sample comprising pathogen(s), a pipettor system disposed inside the housing, centrifuge(s) disposed inside the housing, a mechanical agitator disposed inside the housing, and a controller. The controller is configured to transfer the sample to a processing tube using the pipettor system, centrifuge the processing tube using the centrifuge(s) to concentrate the pathogen(s) in the sample, remove a fluid from the processing tube using the pipettor system, leaving the concentrated pathogens in the processing tube, add a lysis buffer to the processing tube using the pipettor system, move the processing tube to the mechanical agitator using the pipettor system, and agitate the processing tube using the mechanical agitator to perform lysis of the concentrated pathogens. The system is further configured to perform PCR using a nucleic acid extracted from the sample.

A biochemical analysis device and a biochemical analysis method are provided. A control device detects an error based on the current height (H3) of the nozzle (8) when the liquid level sensor detects that the nozzle (8) contacts the sample and the previous height (H2) when the liquid level sensor last detected that the nozzle (8) contacts the sample, and when an error is detected, performs error notification in a manner different from that when other errors are detected.

The present invention relates broadly to production of a reagent on-board an instrument. The instrument is provided with a probe for dispensing said reagent, a concentrate chamber adapted to contain a concentrate and a diluent chamber adapted to contain a diluent. The probe includes an in-line mixing chamber adapted to receive the concentrate and the diluent to provide the reagent at the required concentration for dispensing by the probe.

A system for compounding precise amounts of fluid from one or more source containers into at least one target container is described. The fluid can be drawn from the one or more source containers via an intermediate measuring container such as a syringe pump actuated by a stepper motor or other electronic motor. A system controller can use a measured back EMF value of the motor to determine a pressure within a syringe pump, and control the operation of the motor based at least in part on the determined pressure. The determined pressures of a plurality of syringe pumps can be used to optimize the speed at which the syringe pumps dispense fluid from the source containers while avoiding an overpressure condition which can compromise a compounding process and damage one-way valves within the system.

The PCR plate according to the present invention includes: a body portion having one or more reaction wells; an insertion portion extending from the body portion, inserted into a nucleic acid extraction cartridge, and having an injection port into which a nucleic acid solution is injected; a flow path portion allowing the nucleic acid solution to flow from the injection port to the reaction wells; and a blocking portion attached to the body portion for blocking backflow of the nucleic acid solution from the reaction wells to the flow path portion side.

Non-contact dispensers and related systems and methods are disclosed. In accordance with an implementation, an apparatus includes a non-contact dispenser includes a body defining an inlet, an outlet, and a flow path fluidly coupling the inlet and the outlet. The non-contact dispenser also includes a first valve to control flow into a portion of the flow path, a second valve to control flow out of the outlet, and a pump positioned between the first valve and the second valve.

Described herein are systems, methods, and devices for pathogen identification. The system includes a housing configured to receive a sample containing a pathogen, a pipetter system disposed within the housing, a centrifuge disposed within the housing, a mechanical agitator disposed within the housing, and a controller. The controller is configured to transfer the sample to a processing tube using the pipetter system, centrifuge the processing tube using the centrifuge to concentrate the pathogens in the sample, remove liquid from the processing tube using the pipetter system to leave the concentrated pathogens in the processing tube, add a lysis buffer to the processing tube using the pipetter system, move the processing tube to a mechanical agitator using the pipetter system, and agitate the processing tube using the mechanical agitator to lyse the concentrated pathogens. The system is further configured to perform PCR using nucleic acids extracted from the sample.

Implementations include systems for sequencing a biological sample. The systems can include a reusable subsystem and a removable subsystem. The reusable subsystem can actuate and operate the removable subsystem to automate sequencing. A base unit of the reusable subsystem can form a fluidic connection between an integrated reagent cartridge and an integrated sensor cartridge of the removable subsystem. The integrated reagent cartridge can be configured to hold reagents and the integrated sensor cartridge can be configured with a biosensor for sequencing the biological sample.

The invention relates to the technical field of scientific research of micropaleontology fossils, in particular to a dripping and dissolving device for radioactive insect fossil treatment. The dripping and dissolving device comprises a comprehensive experiment table, a device box, a rock block placing module and a dripping bottle, the comprehensive experiment table comprises a base, a first vertical rod is arranged on the base, and a liquid dropping bottle support assembly is fixed to the first vertical rod. A second vertical rod is further included, and the second vertical rod is sleeved with a third vertical rod so that the third vertical rod can rotate left and right. The other end of the third vertical rod is connected with a fourth vertical rod and a magnifying lens connected with the fourth vertical rod. A device box is arranged on the base, and a rock block placing module and a hanging lug type screen are arranged in the device box. According to the dripping and dissolving device, the dripping speed and the corrosion position are accurately regulated and controlled, complete extraction and in-situ observation of fossils are guaranteed, surrounding rocks are effectively removed, and the extraction efficiency of important fossils is improved. According to the dripping and dissolving device, technical support is provided for radioactive insect fossil research, and the safety design is greatly enhanced.

The present invention discloses a detection device, including a first cavity for collecting and a second cavity for detecting, a detection element is arranged in the second cavity, an opening that can be connected with the second cavity is arranged on the first cavity, and the opening can be sealed by pressure, after sealing, the connection between the first cavity and the second cavity is cut off; after the pressure changes, the first cavity and the second cavity can be connected, and the sample can enter the second cavity from the first cavity. The detection device of the present invention can collect samples for secondary detection while collecting detection samples, which is simple and fast; the detection device of the present invention can quantitatively collect samples and perform accurate quantitative detection, and the detection results are true and reliable with high accuracy; and the detection device of the present invention is simple to use and easy to operate; the present invention can also adjust the mass of the liquid sample entering the second cavity by controlling the time, so as to perform accurate quantitative detection.

To provide a suitable fluid container management system. [Solution] A system and method for transporting a container (100) includes or employs a container loading interface (200), a container storage module (400), and a container distributor (300) configured to transport a container from the container loading interface to the container storage module. The container loading interface includes a movable support platform (202) that can move between an accessible position and an inaccessible position, and a container loading carrier (214). The container storage module includes a housing (402) and a container storage carrier (418). The container distributor includes a container gripper (320) configured to grasp a container onto the container loading carrier and transport the container to the container storage carrier in the container storage module.

A system for compounding precise amounts of fluid from one or more source containers into at least one target container is described. The fluid can be drawn from the one or more source containers via an intermediate measuring container such as a syringe pump actuated by a stepper motor or other electronic motor. A system controller can use a measured back EMF value of the motor to determine a pressure within a syringe pump, and control the operation of the motor based at least in part on the determined pressure. The determined pressures of a plurality of syringe pumps can be used to optimize the speed at which the syringe pumps dispense fluid from the source containers while avoiding an overpressure condition which can compromise a compounding process and damage one-way valves within the system.

The present invention provides a collection bottle for collecting liquid samples, comprising a bottle body with an open end, the bottle body comprising an inner wall and an outer wall, the inner wall comprising a cylindrical portion. The bottle body is characterized in that the cylindrical portion of the inner wall of the bottle body is provided with a guide groove extending downward from the opening, the guide groove comprising a portion that slopes downward and spirals downward. Compared to existing technologies, the present invention has a higher liquid sample extrusion rate, making it easier to meet the minimum amount of liquid sample required for testing, thereby improving the success rate of testing and the accuracy of test results.

To provide a suitable fluid container management system.SOLUTION: Systems and methods for transferring containers (100) include or employ a container loading interface (200), a container storage module (400), and a container distributor (300) configured to transfer containers from the container loading interface to the container storage module. The container loading interface includes a movable support platform (202) that is movable between an accessible position and a non-accessible position, and a container loading transporter (214). The container storage module includes a housing (402) and a container storage transporter (418). The container distributor includes a container gripper (320) configured to grasp a container on the container loading transporter and to transfer the container to the container storage transporter in the container storage module.SELECTED DRAWING: Figure 1

A biological sample processing apparatus includes a holder. The holder detachably holds a liquid supplier. The liquid supplier includes a storage and an ejector. The storage stores a liquid used for processing a biological sample. The ejector pushes the liquid out from inside the storage to eject the liquid directly to an ejection destination.

The invention relates to a holder for a sample tube. An apparatus for holding a sample tube for sample preparation is provided. The apparatus includes a sample tube holder having an opening to receive a sample tube. The apparatus includes a hinge assembly having a hinge plate and a hinge support, where the hinge plate is movable relative to the hinge support. In one example, the hinge plate pivots in two rotational directions and slides in two translational directions relative to the hinge support. The hinge plate limits vertical movement of the sample tube within the sample tube holder. In one aspect, a method includes inserting a sample tube into an opening of a sample tube holder, and pivoting and sliding a hinge plate relative to a hinge support, where the hinge plate limits vertical movement of the sample tube within the sample tube holder.

The present invention relates to the field of biological sample testing technology, and in particular, to a testing system. The testing system includes a reagent reaction vessel and a test device. A reagent storage portion and a push rod movable relative to the reagent storage portion are packaged in the reagent reaction vessel, the reagent storage portion comprises at least one reagent containing cavity, and the reagent containing cavity is sealed by a sealing element; and the push rod is connected to the sealing element, and the push rod is used for cooperation with the test device to separate the sealing element from the reagent storage portion. The test device includes a test cassette, wherein an ejection rod is arranged in the test cassette, and the ejection rod cooperates with the push rod to separate the sealing element from the reagent storage portion. According to the present invention, when the reagent storage portion is inserted, the ejection rod can be quickly pushed to operate, and one operation completes multiple functions such as releasing the reagent, fixing the reagent reaction vessel, and focusing on a test area at the same time, thereby simplifying the reaction steps.

The automatic analyzer includes a control unit 130 provided with a determination unit 117 which determines requirement or non-requirement of the calibration executed to the loaded reagent when the reagent ID reader identifies the reagent, a request generation unit 119 which makes a notice of a standard solution necessary for the calibration when the determination unit 117 determines requirement of the calibration, and generates a calibration request when loading of the standard solution is detected, and a planning unit 120 which makes a plan of the carry-in and the calibration to execute the calibration as required immediately after the carry-in of the reagent into the reagent disc 110. This makes it possible to lessen the process to be performed by the user until the reagent is made available for measurement of the patient specimen.

The present invention is directed to a cartridge device for a measuring system for measuring viscoelastic characteristics of a sample liquid, in particular a blood sample, comprising a cartridge body having at least one measurement cavity formed therein and having at least one probe element arranged in said at least one measurement cavity for performing a test on said sample liquid; and a cover being attachable on said cartridge body; wherein said cover covers at least partially said at least one measurement cavity and forms a retaining element for retaining said probe element in a predetermined position within said at least one measurement cavity. The invention is directed to a measurement system and a method for measuring viscoelastic characteristics of a sample liquid.

The present disclosure relates to new types of fluid packaging devices and methods of making and using such fluid packaging devices. In various embodiments, the present disclosure provides devices, systems, and methods for packaging fluids. In various embodiments, the present disclosure provides a device including a storage compartment; a fluid stored in the storage compartment; a first aperture on the storage compartment; and a second aperture on the storage compartment. The first aperture is initially sealed or closed before the use of the device and configured to be opened to receive a pneumatic pressure. The second aperture is initially sealed or closed before the use of the device and configured to be opened to allow the fluid to exit or enter the storage compartment via the opened second aperture.

There is described an assembly for handling biological material, including a first biological handling element, with a first volume having a first port, and a second biological handling element, with a second volume having a second port. The assembly also includes an aseptic connecting element, for aseptically fluidly connecting the first port and the second port, and an aseptic disconnecting element, for aseptically fluidly disconnecting the first port and the second port. Further, one or more of the first biological handling element and the second biological handling element are movable to bring their respective ports into registration with one another to allow, in use, aseptic fluid connection and aseptic fluid disconnection.

Provided herein are devices and methods for the rapid processing and analysis of samples. In particular, a small-volume sample (e.g., nucleic acid sample) is exposed to (e.g., contacted with) different temperature zones within a device to process (e.g., amplify) and / or analyze (e.g., quantitate) the sample in an assay.

A system and method are provided that include the steps of hydrating a lyophilized reagent and homogenizing the hydrated reagent under the control of a control circuit that implements a hydration and homogenization protocol. A lyophilized reagent nozzle sipper that includes a distal tip extends into a lyophilized reagent well such that the distal tip does not contact the associated lyophilized reagent, and a specified amount of hydration fluid is automatically aspirated from a corresponding hydration reservoir by a corresponding sipper and dispensed into the lyophilized reagent well based on a hydration and homogenization protocol implemented by the control circuit. The method may also include extending the lyophilized reagent nozzle sipper into the lyophilized reagent well such that the distal tip contacts the hydrated reagent and automatically aspirating and discharging the hydrated reagent based on a hydration and homogenization protocol implemented by the control circuit.

Fluidic systems and reagent carriers suitable for storing reagents in a desired manner are generally provided. In some embodiments, the reagent carrier stores a liquid film containing a solid reagent and / or stores different reagents at different locations. In some embodiments, the fluidic system includes a reagent carrier constrained such that the reagent carrier includes a longitudinal axis positioned within 30° of a vertical axis of the fluid reservoir.

A system for compounding precise amounts of fluid from one or more source containers into at least one target container is described. The fluid can be drawn from the one or more source containers via an intermediate measuring container such as a syringe pump actuated by a stepper motor or other electronic motor. A system controller can use a measured back EMF value of the motor to determine a pressure within a syringe pump, and control the operation of the motor based at least in part on the determined pressure. The determined pressures of a plurality of syringe pumps can be used to optimize the speed at which the syringe pumps dispense fluid from the source containers while avoiding an overpressure condition which can compromise a compounding process and damage one-way valves within the system.

Contamination detection systems, kits, and techniques are described for testing surfaces for the presence of analytes of interest, including hazardous contaminants, while minimizing user exposure to these contaminants. Even trace amounts of contaminants can be detected. A collection device provides a swab that is simple to use, easy to hold and grip, allows the user to swab large areas of a surface, and keeps the user's hands away from the surface being tested. The collection device also includes a test strip, and provides a closed fluid transfer mechanism to transfer the collected fluid from the swab to the test strip while minimizing user exposure to hazardous contaminants in the collected fluid. Contamination detection kits can rapidly collect and detect hazardous drugs, including trace amounts of antineoplastic agents, in healthcare settings at the site of contamination.