154results about "Reagent containers" patented technology

Described herein are systems, methods, and devices for pathogen identification. A system includes a housing configured to receive a sample comprising pathogen(s), a pipettor system disposed inside the housing, centrifuge(s) disposed inside the housing, a mechanical agitator disposed inside the housing, and a controller. The controller is configured to transfer the sample to a processing tube using the pipettor system, centrifuge the processing tube using the centrifuge(s) to concentrate the pathogen(s) in the sample, remove a fluid from the processing tube using the pipettor system, leaving the concentrated pathogens in the processing tube, add a lysis buffer to the processing tube using the pipettor system, move the processing tube to the mechanical agitator using the pipettor system, and agitate the processing tube using the mechanical agitator to perform lysis of the concentrated pathogens. The system is further configured to perform PCR using a nucleic acid extracted from the sample.

The present invention relates broadly to production of a reagent on-board an instrument. The instrument is provided with a probe for dispensing said reagent, a concentrate chamber adapted to contain a concentrate and a diluent chamber adapted to contain a diluent. The probe includes an in-line mixing chamber adapted to receive the concentrate and the diluent to provide the reagent at the required concentration for dispensing by the probe.

A system for compounding precise amounts of fluid from one or more source containers into at least one target container is described. The fluid can be drawn from the one or more source containers via an intermediate measuring container such as a syringe pump actuated by a stepper motor or other electronic motor. A system controller can use a measured back EMF value of the motor to determine a pressure within a syringe pump, and control the operation of the motor based at least in part on the determined pressure. The determined pressures of a plurality of syringe pumps can be used to optimize the speed at which the syringe pumps dispense fluid from the source containers while avoiding an overpressure condition which can compromise a compounding process and damage one-way valves within the system.

The PCR plate according to the present invention includes: a body portion having one or more reaction wells; an insertion portion extending from the body portion, inserted into a nucleic acid extraction cartridge, and having an injection port into which a nucleic acid solution is injected; a flow path portion allowing the nucleic acid solution to flow from the injection port to the reaction wells; and a blocking portion attached to the body portion for blocking backflow of the nucleic acid solution from the reaction wells to the flow path portion side.

Described herein are systems, methods, and devices for pathogen identification. The system includes a housing configured to receive a sample containing a pathogen, a pipetter system disposed within the housing, a centrifuge disposed within the housing, a mechanical agitator disposed within the housing, and a controller. The controller is configured to transfer the sample to a processing tube using the pipetter system, centrifuge the processing tube using the centrifuge to concentrate the pathogens in the sample, remove liquid from the processing tube using the pipetter system to leave the concentrated pathogens in the processing tube, add a lysis buffer to the processing tube using the pipetter system, move the processing tube to a mechanical agitator using the pipetter system, and agitate the processing tube using the mechanical agitator to lyse the concentrated pathogens. The system is further configured to perform PCR using nucleic acids extracted from the sample.

Implementations include systems for sequencing a biological sample. The systems can include a reusable subsystem and a removable subsystem. The reusable subsystem can actuate and operate the removable subsystem to automate sequencing. A base unit of the reusable subsystem can form a fluidic connection between an integrated reagent cartridge and an integrated sensor cartridge of the removable subsystem. The integrated reagent cartridge can be configured to hold reagents and the integrated sensor cartridge can be configured with a biosensor for sequencing the biological sample.

To provide a suitable fluid container management system. [Solution] A system and method for transporting a container (100) includes or employs a container loading interface (200), a container storage module (400), and a container distributor (300) configured to transport a container from the container loading interface to the container storage module. The container loading interface includes a movable support platform (202) that can move between an accessible position and an inaccessible position, and a container loading carrier (214). The container storage module includes a housing (402) and a container storage carrier (418). The container distributor includes a container gripper (320) configured to grasp a container onto the container loading carrier and transport the container to the container storage carrier in the container storage module.

A system for compounding precise amounts of fluid from one or more source containers into at least one target container is described. The fluid can be drawn from the one or more source containers via an intermediate measuring container such as a syringe pump actuated by a stepper motor or other electronic motor. A system controller can use a measured back EMF value of the motor to determine a pressure within a syringe pump, and control the operation of the motor based at least in part on the determined pressure. The determined pressures of a plurality of syringe pumps can be used to optimize the speed at which the syringe pumps dispense fluid from the source containers while avoiding an overpressure condition which can compromise a compounding process and damage one-way valves within the system.

The present invention provides a collection bottle for collecting liquid samples, comprising a bottle body with an open end, the bottle body comprising an inner wall and an outer wall, the inner wall comprising a cylindrical portion. The bottle body is characterized in that the cylindrical portion of the inner wall of the bottle body is provided with a guide groove extending downward from the opening, the guide groove comprising a portion that slopes downward and spirals downward. Compared to existing technologies, the present invention has a higher liquid sample extrusion rate, making it easier to meet the minimum amount of liquid sample required for testing, thereby improving the success rate of testing and the accuracy of test results.

The present invention relates to the field of biological sample testing technology, and in particular, to a testing system. The testing system includes a reagent reaction vessel and a test device. A reagent storage portion and a push rod movable relative to the reagent storage portion are packaged in the reagent reaction vessel, the reagent storage portion comprises at least one reagent containing cavity, and the reagent containing cavity is sealed by a sealing element; and the push rod is connected to the sealing element, and the push rod is used for cooperation with the test device to separate the sealing element from the reagent storage portion. The test device includes a test cassette, wherein an ejection rod is arranged in the test cassette, and the ejection rod cooperates with the push rod to separate the sealing element from the reagent storage portion. According to the present invention, when the reagent storage portion is inserted, the ejection rod can be quickly pushed to operate, and one operation completes multiple functions such as releasing the reagent, fixing the reagent reaction vessel, and focusing on a test area at the same time, thereby simplifying the reaction steps.

The present invention is directed to a cartridge device for a measuring system for measuring viscoelastic characteristics of a sample liquid, in particular a blood sample, comprising a cartridge body having at least one measurement cavity formed therein and having at least one probe element arranged in said at least one measurement cavity for performing a test on said sample liquid; and a cover being attachable on said cartridge body; wherein said cover covers at least partially said at least one measurement cavity and forms a retaining element for retaining said probe element in a predetermined position within said at least one measurement cavity. The invention is directed to a measurement system and a method for measuring viscoelastic characteristics of a sample liquid.

There is described an assembly for handling biological material, including a first biological handling element, with a first volume having a first port, and a second biological handling element, with a second volume having a second port. The assembly also includes an aseptic connecting element, for aseptically fluidly connecting the first port and the second port, and an aseptic disconnecting element, for aseptically fluidly disconnecting the first port and the second port. Further, one or more of the first biological handling element and the second biological handling element are movable to bring their respective ports into registration with one another to allow, in use, aseptic fluid connection and aseptic fluid disconnection.

Provided herein are devices and methods for the rapid processing and analysis of samples. In particular, a small-volume sample (e.g., nucleic acid sample) is exposed to (e.g., contacted with) different temperature zones within a device to process (e.g., amplify) and / or analyze (e.g., quantitate) the sample in an assay.

A system and method are provided that include the steps of hydrating a lyophilized reagent and homogenizing the hydrated reagent under the control of a control circuit that implements a hydration and homogenization protocol. A lyophilized reagent nozzle sipper that includes a distal tip extends into a lyophilized reagent well such that the distal tip does not contact the associated lyophilized reagent, and a specified amount of hydration fluid is automatically aspirated from a corresponding hydration reservoir by a corresponding sipper and dispensed into the lyophilized reagent well based on a hydration and homogenization protocol implemented by the control circuit. The method may also include extending the lyophilized reagent nozzle sipper into the lyophilized reagent well such that the distal tip contacts the hydrated reagent and automatically aspirating and discharging the hydrated reagent based on a hydration and homogenization protocol implemented by the control circuit.

Fluidic systems and reagent carriers suitable for storing reagents in a desired manner are generally provided. In some embodiments, the reagent carrier stores a liquid film containing a solid reagent and / or stores different reagents at different locations. In some embodiments, the fluidic system includes a reagent carrier constrained such that the reagent carrier includes a longitudinal axis positioned within 30° of a vertical axis of the fluid reservoir.

A system for compounding precise amounts of fluid from one or more source containers into at least one target container is described. The fluid can be drawn from the one or more source containers via an intermediate measuring container such as a syringe pump actuated by a stepper motor or other electronic motor. A system controller can use a measured back EMF value of the motor to determine a pressure within a syringe pump, and control the operation of the motor based at least in part on the determined pressure. The determined pressures of a plurality of syringe pumps can be used to optimize the speed at which the syringe pumps dispense fluid from the source containers while avoiding an overpressure condition which can compromise a compounding process and damage one-way valves within the system.

Contamination detection systems, kits, and techniques are described for testing surfaces for the presence of analytes of interest, including hazardous contaminants, while minimizing user exposure to these contaminants. Even trace amounts of contaminants can be detected. A collection device provides a swab that is simple to use, easy to hold and grip, allows the user to swab large areas of a surface, and keeps the user's hands away from the surface being tested. The collection device also includes a test strip, and provides a closed fluid transfer mechanism to transfer the collected fluid from the swab to the test strip while minimizing user exposure to hazardous contaminants in the collected fluid. Contamination detection kits can rapidly collect and detect hazardous drugs, including trace amounts of antineoplastic agents, in healthcare settings at the site of contamination.

The application provides a sample adding device, which comprises a container adapted to contain reagents and comprising a container mouth; a sample adding mechanism arranged at least partially in the container and in communication with the interior and exterior of the container to deliver the reagents in the container to the exterior of the container; an interface mechanism adapted to connect the container mouth and the sample adding mechanism; the interface mechanism comprises an interface penetrating along the axial direction of the container mouth, and a support and a bearing member successively sleeved in the interface; the interface is detachably sleeved on the outer periphery of the container mouth, and there is a gap between the interface and the support to adapt to receiving the side wall of the container mouth; the bearing member is sleeved on the outside of the sample adding mechanism; first and second sealing rings are arranged between the support and the bearing member and between the support and the side wall of the container mouth respectively to seal the connection of the interface mechanism with the sample adding mechanism and the container mouth respectively. By using the application, simple assembly between the container and the sample adding mechanism can be realized, and sealing between the container and the sample adding mechanism can be realized.

Systems and methods for monitoring water of a swimming pool or spa include containers or cartridges with one or more liquid reagents for automatic chemistry analysis of recreational water. The cartridges provide a store or supply of one or more reagents and may be quickly and easily replaced and replenished by a user. The cartridges may be self-sealing when the cartridge is not engaged with the monitoring device.

Provided is a cover member (33, 36, 50) for covering an opening of a sample container in which a liquid sample is to be contained. To accurately collect the liquid sample contained in the sample container while preventing a carryover, the cover member is made of an elastic sheet material and has a slit (331, 361, 511) in an area different from a predetermined area through which a sample-collecting tool for collecting the liquid sample is to be inserted. This cover member can be suitably used as a septum configured to cover an opening of a vial, or as a sheet configured to cover openings of a plurality of wells provided on a microplate.

A container (100) having a first end (102), a second end (104), and a deformable middle portion (106) and a method for manufacturing the container are disclosed. The container has a folded configuration and an unfolded configuration. The first end and the second end are rigid. The container is configured to store cell culture medium powder. Methods and systems (e.g., dispensers) for producing culture medium using the container are also disclosed. TIFF2023549285000002.tif200152

The invention relates to the technical field of liquid dropping devices, and discloses an endocrine sample classified liquid dropping device which comprises a shell, a plurality of storage grooves are formed in the lower end of the outer wall of the shell, weight sensors are embedded into the bottoms of the storage grooves, a storage cavity is formed in the shell, and a mounting disc is fixedly connected to the lower portion of the inner wall of the storage cavity. When the endocrine sample classified liquid dropping device is used, a servo motor is started to drive a screw rod to rotate and drive a piston rod to move at the same time, a sliding rod is matched to slide in a sliding groove, so that the piston rod is limited to drive a piston disc to move downwards, and it is ensured that the piston disc stably moves downwards; a liquid sample in the storage tank can flow out through the liquid distribution pipe, the capacity of the collected sample can be conveniently detected in real time through cooperation with the weight sensor, a doctor can make more accurate diagnosis, and a more reasonable treatment scheme is formulated for a patient.

Described herein are methods of transferring liquid from a reagent reservoir using a mechanical liquid handler, the reagent reservoir having a sloped bottom along a width of the reagent reservoir, the sloped bottom defining a shallow end and a deep end of the reagent reservoir, wherein the shallow end is proximate to a first sidewall of the reagent reservoir, wherein the deep end is proximate to a second sidewall of the reagent reservoir opposite the first sidewall.

A system for delivering a plurality of reagents into a closed flow cell includes one or more reservoirs comprising reagents, a pump configured to cause a flow of the plurality of reagents, an aspiration device coupled to a first fluid channel, a closed flow cell having an inlet and an outlet, where the inlet is coupled to an end of the first fluid channel, and a de-bubbler coupled to the first fluid channel upstream of the closed flow cell. The de-bubbler is configured to divert one or more bubbles from the first fluid channel.

Provided herein is a spatial sampling system that encodes samples with spatial barcodes that identify original spatial position of a microsample within a biological specimen or from different voxels from a biological sample. The method provides cell / nuclei-level resolution of cells and nuclei within microsamples. The method can comprise tagging cells and or nuclei in each microsample or voxel with a first barcode that encodes the original spatial position of the microsample in the biological specimen or the different voxel in the biological sample; pooling tagged microsamples; dividing the pooled sample into a plurality of subsamples, such that a plurality of subsamples comprise cells and / or nuclei from different original microsamples or voxels.

Disclosed in the present invention are a chip and an encapsulation method therefor. The chip comprises a first sheet material, a second sheet material, a first encapsulant and a second encapsulant, the second sheet material being disposed opposite the first sheet material, the first encapsulant being disposed between the first sheet material and the second sheet material, a lane being formed in the first encapsulant, and the second encapsulant being disposed around an edge of the lane. In this way, the first encapsulant can form a stable lane for a reagent to perform a biochemical reaction, and the second encapsulant can isolate the first encapsulant from the lane, reducing or preventing the influence of special molecules released by the first encapsulant on the biochemical reaction in the lanes, thereby improving sequencing quality.

The present disclosure relates to a container for in vitro drug testing. The container includes a reservoir having a wall made of a gel composition. The reservoir has an opening and is configured to receive a pharmaceutical formulation through the opening. The gel composition is selected to mimic one or more properties of tissue.

Instructions for handling biological material, including: a first biological handling element comprising a first volume having a first connection; a second biological handling element comprising a second volume having a second connection; an aseptic connecting element configured to aseptically fluidically connect the first port and the second port to provide aseptic fluid communication between the first volume and the second volume; an aseptic separation element configured to aseptically separate the first and second ports fluidically in order to prevent aseptic fluid communication between the first and second volumes; and one or more robot arms; wherein one or more robot arms are arranged to move the first biological handling element and / or the second biological handling element to align the first port and the second port with each other to enable the aseptic connecting element, when used, to aseptically fluidically connect the first port and the second port, and to enable the aseptic separating element, when used, to aseptically fluidically separate the first port and the second port.