807 results about "Red blood corpuscle" patented technology

The invention discloses a broad-spectrum antibacterial peptide SS-7 and application thereof, and belongs to the field of biological medicine. The amino acid sequence of the broad-spectrum antibacterial peptide SS-7 disclosed by the invention is VRRVRFVVLRRIKKWRRI, and the broad-spectrum antibacterial peptide SS-7 has a remarkable inhibition effect on various gram-positive bacteria and gram-negative bacteria such as drug-resistant strains such as methicillin-resistant staphylococcus aureus (ATCC43300) and shows low toxicity and no hemolytic toxicity on eukaryotic cells and red blood cells of mammals; lPS and lipoteichoic acid on the surfaces of bacteria can be combined to achieve the effect of neutralizing the bacteria, and a very good treatment and protection effect is achieved on animals infected by the bacteria. The antibacterial peptide SS-7 can be used for preparing an antibacterial agent and preparing a medicine for preventing or treating bacterial infection, has the advantages of being wide in antibacterial spectrum, low in drug-resistant mutation frequency, low in toxicity and low in production cost, can effectively solve the current bacterial drug resistance problem, and has wide application prospects and important clinical value.

The invention relates to the technical field of liquid chromatography-mass spectrometry series connection, and particularly discloses a method for detecting folic acid metabolites of red blood cells through the liquid chromatography-mass spectrometry series connection technology. And an image analysis algorithm based on artificial intelligence and deep learning is utilized to extract a chromatographic separation state, so that gradient parameters are dynamically adjusted, the requirement of manual intervention is reduced, and the separation process of a target object in a complex matrix is favorably optimized. Particularly, key features in a chromatogram can be automatically identified and quantified based on a deep learning method, and gradient elution parameters are intelligently and dynamically adjusted according to the information, so that more optimized substance separation and detection can be realized. For example, if separation of a certain component is not ideal, the separation effect of the component can be improved by adjusting the proportion of the mobile phase B, so that the gradient elution process is optimized.

The invention discloses a reticulocyte recognition and grading system based on a blood smear, and particularly relates to the field of medical cell morphology examination, and the system comprises an image acquisition module, a staining normalization module, an instance segmentation module, an erythrocyte classification module, a reticulocyte grading module and a statistics output module. The image acquisition module adopts an automatic microscope platform to continuously scan the blood smear under a 100-time visual field, acquires a high-quality bright field channel image through an automatic focusing technology, and monitors image definition, contrast and illumination uniformity; the statistical output module is used for calculating the proportion and bluish violet intensity statistics of reticulocytes of each level, and generating a visual quality control result and a diagnostic report; according to the invention, full-automatic processing from samples to reports is realized, interpretability and high classification precision are both considered, subjective difference and omission ratio of manual microscopic examination are significantly reduced, and efficiency and consistency of clinical detection are improved.

The invention relates to the technical field of nano-drugs, in particular to low-intensity focused ultrasound response nanoparticles for enhancing thrombus targeting and penetration, a preparation method of the nanoparticles and application of the nanoparticles in anti-thrombus treatment. The low-intensity focused ultrasound response nanoparticle for enhancing thrombus targeting and penetration comprises a platelet membrane shell, and a core is formed by wrapping perfluoropentane and L-arginine with polylactic acid-glycolic acid copolymer-polyethylene glycol. The platelet membrane ensures that the nanoparticles specifically target a thrombus part; under the stimulation of LIFU, the nanobubbles penetrate through the deep layer of thrombus, L-arginine is oxidized into L-citrulline, and nitric oxide is formed. Meanwhile, the LIFU triggers liquid-gas phase change and nitric oxide release, the ultrasonic cavitation effect is enhanced through the synergistic effect, thrombus structures including red blood cells, blood platelets and fibrin are specifically attacked, and efficient thrombolysis treatment is achieved. According to the technical scheme, the technical problem that the thrombolysis effect of ultrasonic nanoparticles is not ideal can be solved, and good clinical application prospects are achieved.

The invention provides a red blood cell test time domain adaptation detection method based on an average teacher model, which belongs to the field of deep learning and comprises the steps of pre-training, data enhancement, random recovery, loss calculation and update of a teacher model and a student model. First, a benchmark detection model is pre-trained on source domain data to obtain initial features. In the test stage, target domain data is input into the teacher model and the student model after being subjected to weak enhancement and strong enhancement respectively. A pseudo label is generated after the teacher model is input, so that the influence of error accumulation in the continuous adaptation process is reduced; the student model is optimized through the cross entropy loss of the prediction result of the teacher model, and the teacher model is updated through an index moving average method. In addition, a random recovery method is adopted, knowledge is explicitly recovered from a source domain pre-training model to a student model, and the problem of disastrous forgetting is effectively relieved. And the final model can keep good performance for target domain data during testing.

The invention belongs to the technical field of biological medicine, and particularly relates to application of chlorbuconazole or salt thereof in preventing, relieving or treating diseases related to HIF-2alpha. In-vitro experiments prove that the chlorbuconazole enhances the transcriptional activity of HIF-2alpha so as to promote the expression of downstream genes regulated and controlled by the HIF-2alpha; it is proved that chlorburazol has the effects of increasing erythropoiesis and relieving renal injury on an aristolochic acid-induced zebra fish chronic kidney disease model, a cisplatin-caused acute kidney injury and renal anemia model and a unilateral ureteral obstruction model. Meanwhile, the traditional Chinese medicine composition belongs to new use of old medicines, so that the medicine research and development cost and the treatment cost are saved, and the traditional Chinese medicine composition has obvious economic benefits and clinical application values.

The invention relates to the technical field of medical quality control products, in particular to a quality control substance for lymphocyte subpopulation analysis and a preparation method thereof, and the quality control substance comprises human monocyte simulation particles, human granulocyte simulation particles, human lymphocyte simulation particles, human erythrocyte simulation particles, human platelet simulation particles and a preserving fluid, adding the human monocyte simulation particles, the human granulocyte simulation particles, the human lymphocyte simulation particles, the human erythrocyte simulation particles and the human platelet simulation particles into a preserving fluid, and uniformly mixing according to the concentration of the human body particles, so as to obtain the quality control substance for lymphocyte subpopulation analysis. Compared with the prior art, the quality control substance for lymphocyte subpopulation analysis and the preparation method thereof have the advantages that the preparation method is simple to operate, small in batch difference and good in stability, and can be applied to quality control in the field of detection of quality control substances for flow cytometry lymphocyte subpopulation analysis.

The invention discloses a construction method, a recognition method and a system for simulating lung cancer metastasis cells in cerebrospinal fluid based on diffraction imaging and a deep learning technology. The construction method comprises the following steps: culturing a plurality of lung cancer cell lines which are easy to cause brain metastasis, collecting whole blood of a healthy person and splitting red blood cells; the method comprises the following steps: respectively acquiring diffraction images of cultured cells through a polarization diffraction imaging flow cytometry with a TDI camera to obtain a pair of diffraction image pairs with S polarization and P polarization; performing image processing on the obtained diffraction cell image pair, and establishing a training image data set and a test image data set; and establishing a convolutional neural network, and training the convolutional neural network according to the training image data set to obtain a model for identifying the lung cancer metastatic cells in the cerebrospinal fluid. When in use, a cerebrospinal fluid sample of a patient is collected, S polarization and P polarization image pairs are obtained, and the trained model is input to respectively extract S polarization and P polarization image features of cells for feature recognition, so that whether the current sample contains lung cancer cells or not is predicted.

The invention discloses a diluent for whole blood lateral immunochromatography detection as well as a preparation method and a detection method thereof, and belongs to the technical field of immunochromatography detection. The diluent solves the technical problems of unsmooth chromatography, background interference, poor stability of detection results and the like caused by red blood cells during direct detection of whole blood samples. The diluent comprises a buffer system, an osmotic pressure regulator glycine, a nonionic surfactant polysorbate, an erythrocyte aggregation inducer polyvinylpyrrolidone, a dynamic viscosity regulator trehalose, a blocking protein, a stabilizer combination L-methionine and L-histidine, and a composite formula of water. Red blood cells are effectively induced to gather and intercept on the sample pad through the synergistic effect of all the components, and meanwhile the stability of the chromatography process and the activity of the detection reagent are maintained. The diluent is mainly used for lateral immunochromatography quantitative detection of markers such as pro-enkephalin, C-reactive protein, cardiac troponin I or N-terminal pro-brain natriuretic peptide in a whole blood sample.

The invention provides an anti-CD235a monoclonal antibody and an application of the anti-CD235a monoclonal antibody. The monoclonal antibody provided by the invention can be specifically combined with the CD235a protein. The anti-CD235a monoclonal antibody provided by the invention has high specificity and affinity with the CD235a protein, and can be applied to detection of red blood cells or erythroid cells.

There are provided polypeptides that include an Activin receptor type IIB (ActRIIB) ectodomain (ECD) variant. In some embodiments, a polypeptide of the disclosure includes an ActRIIB-ECD variant fused to an Fc domain moiety. The disclosure also provides pharmaceutical compositions and methods of using the polypeptides to treat diseases and conditions associated with TGFβ superfamily ligand signaling, such as metabolic disorders, diabetes, obesity, cardiometabolic disease, pulmonary hypertension, fibrosis, muscle weakness and atrophy, bone damage, and / or low red blood cell levels (such as anemia).

The invention discloses an anti-idiotype antibody for detecting and neutralizing an anti-D antibody, the anti-idiotype antibody comprises a heavy chain variable region and a light chain variable region, the heavy chain variable region comprises at least one of an HCDR1 sequence, an HCDR2 sequence and an HCDR3 sequence, and the amino acid sequence of the HCDR1 has an amino acid sequence as shown in SEQ ID No.17; the amino acid sequence of the HCDR2 has an amino acid sequence as shown in SEQ ID No. 18; the amino acid sequence of the HCDR3 has an amino acid sequence as shown in SEQ ID No. 19. The anti-idiotype antibody and the anti-D-mediated erythrocyte agglutination effect can be used for developing various diagnostic reagents, and can be used for detecting a mixed sample containing various anti-D blood group accident antibodies.

The invention discloses a concentrated platelet product, a production process, a platelet preserving fluid and a storage method, and belongs to the technical field of biology. The production process comprises the following steps: taking fresh anticoagulant whole blood, shaking and depolymerizing; performing light centrifugation on the fresh anticoagulant whole blood subjected to shaking depolymerization to obtain upper-layer platelet-rich plasma I and lower-layer blood cells I; performing gradient centrifugation on the lower-layer blood cells I to obtain upper-layer and lower-layer red blood cells II containing an albuginea layer, plasma and a small amount of red blood cells; performing gradient centrifugation on the upper layer to obtain platelet-rich plasma II and lower-layer red blood cells III; combining the platelet-rich plasma I and the platelet-rich plasma II to obtain mixed platelet-rich plasma I; centrifuging the mixed platelet-rich plasma I to obtain upper-layer mixed platelet-rich plasma II and lower-layer red blood cells IV; centrifuging the upper-layer mixed platelet-rich plasma II to obtain upper-layer plasma and lower-layer platelets V; and adding a certain amount of plasma or platelet preserving fluid into the platelet V to obtain the concentrated platelet product.

The invention discloses a neutralizing anti-idiotype antibody of an anti-D antibody, the neutralizing anti-idiotype antibody comprises a heavy chain variable region and a light chain variable region, the heavy chain variable region comprises at least one of HCDR1, HCDR2 and HCDR3 sequences, the amino acid sequence of the HCDR1 is as shown in SEQ ID No.1, the amino acid sequence of the light chain variable region is as shown in SEQ ID No.2, the amino acid sequence of the light chain variable region is as shown in SEQ ID No.3, and the amino acid sequence of the light chain variable region is as shown in SEQ ID No.4. The amino acid sequence of the HCDR2 is as shown in SEQ ID No. 2; the amino acid sequence of the HCDR3 is as shown in SEQ ID No. 3. The neutralizing anti-idiotype antibody has the effect of neutralizing anti-D-mediated erythrocyte agglutination, can be used for detecting a mixed sample containing various anti-D blood group accidental antibodies, and can also be used for risk assessment and clinical diagnosis and treatment by using Rh-HDFN.

The invention relates to a multiplex PCR (Polymerase Chain Reaction) primer probe combination, a kit and a detection method for human red blood cell RHCE genetic typing detection, and belongs to the field of biomedicine clinical molecular detection. The invention provides a multiplex PCR (Polymerase Chain Reaction) primer probe combination for human red blood cell RHCE genetic typing detection, and further provides a kit containing the multiplex PCR primer probe combination. The method has the technical advantages that the RHCE gene variation site specific primer and probe are designed through an improved ARMS technology and a homologous sequence specific base method, so that higher specificity and accuracy are realized; only four-hole reaction is needed, detection of RHC, RHc, RHE, RHe, CW- / CW +, CX- / CX +, V-VS- / V + VS + and V + / V-can be completed at a time, and higher flux and efficiency are achieved; according to the method, multiple fluorescent PCR is combined with a Taqman probe technology, qualitative typing detection is carried out on the human red blood cell RHCE gene, and compared with a traditional method, higher sensitivity, higher experiment speed, higher accuracy and a wider application range are shown.

Provided is an analysis device with which it is possible to improve the throughput of sample analysis and the measurement accuracy of red blood cells. An analysis device is provided with: WDF reaction chambers (C21, C22) for preparing a WDF measurement sample from a subject; an RBC / PLT reaction chamber (C11) for preparing an RBC / PLT measurement sample from a subject; an optical measurement unit (381) for measuring the WDF measurement sample and acquiring an optical signal corresponding to white blood cells; and an electric measurement unit (382) for measuring the RBC / PLT measurement sample and acquiring an electric signal corresponding to red blood cells. At least a portion of a measurement period including a WDF measurement sample prepared in the WDF reaction chamber C21 and the WDF measurement sample prepared in the WDF reaction chamber C21 and at least a portion of a measurement period including a WDF measurement sample prepared in the WDF reaction chamber C22 and the WDF measurement sample prepared in the WDF reaction chamber C22 overlap.

The invention discloses an intelligent pulmonary tuberculosis detection method and system based on images and clinical data, and belongs to the field of medicines.The method comprises the steps that S1, high-resolution chest X-ray images and clinical data such as serum C-reactive protein concentration, erythrocyte sedimentation value, erythrocyte distribution width and body temperature are collected; s2, performing non-linear contrast enhancement on the image, and extracting lung gate texture, lung field transparency and cavity edge features; s3, fusing the image and the clinical features through a graph attention mechanism, and generating a high-dimensional fusion vector; s4, risk grade discrimination is carried out through a multi-scale residual mapping network, and five-grade labels are output; and S5, optimizing the model by utilizing the pathology definite diagnosis sample in combination with the cross entropy and the center loss. The method has the beneficial effects that accurate grading evaluation of the pulmonary tuberculosis risk is realized, and the accuracy of early screening and the clinical interpretability of the model are improved.

The invention relates to the technical field of biological detection, and provides a kit and a method for rapidly detecting a platelet antibody by utilizing a phytolectin solid-phase adsorption method. The detection kit provided by the invention comprises a reaction plate which is coated with phytolectin and adsorbs platelets. According to the method, the platelet of multiple persons is adsorbed by utilizing the non-specific adsorption capacity of the phytolectin, and the adsorbed platelet is directly freeze-dried to the bottom of a microwell plate. During use, a detection result can be obtained only by adding detected plasma / serum into the reaction plate for incubation and then adding an anti-human globule reagent and indicating red blood cells, so that intermediate links of detection are reduced, and standardization and automation of detection are facilitated.

The invention relates to the technical field of platelet-rich plasma preparation, and discloses a platelet-rich plasma preparation device and a preparation method thereof.The platelet-rich plasma preparation device comprises a split type cabin, a red blood cell cabin cover and a PRP cabin cover, and the red blood cell cabin cover and the PRP cabin cover are connected to the two ends of the split type cabin in a threaded mode; compared with a traditional mode that the locking rods are fixedly connected into the cabin, according to the preparation device, the locking rods are movably connected into the cabin, when the cabin needs to be locked, the corresponding driving blocks are pressed, the driving blocks push the locking rods, and the locking rods can be locked through the driving blocks. The locking rod is inserted into the hole of the communicated cabin for blocking and locking, the traditional mode that the length of the cabin is shortened by screwing the cabin and the locking rod is inserted into the hole of the communicated cabin for blocking and locking is changed, screwing is not needed, and the accident that plasma leaks out due to the fact that connection of the cabins falls off due to the fact that the screwing direction is wrong is avoided.

The invention discloses application of capsaicin to resistance of grass carp to hypoxia stress, and belongs to the technical field of agricultural cultivation. Aiming at the problems of red blood cell function damage, liver and gill tissue damage and the like of grass carps under hypoxia stress, a trace amount of capsaicin is added into the grass carp feed, so that the feed formula is optimized, the reduction of red blood cell quantity and brittleness increase of grass carps in the later growth period caused by hypoxia stress are relieved, liver damage is relieved, and the growth period of grass carps is prolonged. The death rate of the grass carp in a low-oxygen environment is reduced, the culture risk is reduced, and the method has the characteristics of being green, safe, low in cost and remarkable in economic benefit and is suitable for large-scale grass carp culture industry.

Provided herein are red blood cell control compositions comprising one or more populations of lysable hydrogel particles having an impedance that is substantially similar to the impedance of a human red blood cell of average diameter; and a population of hemoglobin molecules or a population of dye molecules that have substantially similar absorbance as hemoglobin; wherein (i) and / or (ii) are present in an amount that corresponds to a normal blood sample or disease state, or (i) and (ii) are present at a ratio that corresponds to a normal blood sample or disease state.

The invention relates to the technical field of bioengineering, in particular to an SOD (superoxide dismutase) impurity removal and purification process which comprises the following steps: extracting SOD enzyme from fresh animal blood, separating high-purity red blood cells through gradient centrifugation, preparing a crude extract by combining hypotonic lysis and freeze thawing strengthening, then selectively precipitating hemoglobin and other heat-sensitive impurity proteins by adopting a gradient temperature rise thermal denaturation method, and purifying to obtain the SOD impurity removal and purification process. The method comprises the following steps: extracting SOD, removing pigments and lipid impurities by using a mixed adsorbent, further enriching SOD by using ammonium sulfate salting-out, and finally obtaining high-purity SOD powder through vacuum freeze drying by combining ion exchange chromatography and ultrafiltration concentration technologies. The method has the advantages of high efficiency, rapidness and low cost, impurities can be effectively removed through a combined process of hypotonic / freeze-thaw cracking, hemoglobin removal through thermal denaturation, ammonium sulfate salting-out, ion exchange chromatography and ultrafiltration concentration, the purity and the recovery rate of the SOD enzyme are remarkably improved, the whole purification process is carried out at 4 DEG C, and the method is suitable for industrial production. The influence of high temperature on the activity of the SOD enzyme is avoided.

Mean corpuscular parameter values for a sample, such as a mean corpuscular hemoglobin or mean corpuscular volume for the red blood cells in a sample, can be calculated based on individual cell corpuscular parameter values for the red blood cells in the sample. These values may be obtained using a machine learning algorithm. Such a machine learning algorithm may be trained using sets of training images annotated with transducer derived mean corpuscular parameter values, thereby allowing a flow imaging based analyzer to provide parameter values which may otherwise not be available with that type of analysis tool.

The invention belongs to the technical field of tumor organoid culture, and particularly relates to a myeloblastoma organoid as well as a culture medium, a culture method and application thereof. The culture medium is prepared from DMEM (Dulbecco Modified Eagle Medium): F12, Neurobase, KOSR (Kovary Orthogonal Sequence Repeat), GlutaMax, A-A, CDLC (Clinical Dissolved Liquid Chromatography), N2, B27, Heparin, T3 and BDNF. The culture method comprises the following steps: taking a medulloblastoma tumor tissue, directly cutting into blocks, and then carrying out red blood cell lysis to obtain small tumor blocks; the myeloblastoma tumor tissue does not need to be subjected to enzyme digestion treatment; the small tumor blocks are cultured with the culture medium, and myeloblastoma organoid is generated; and carrying out subculture on the obtained myeloblastoma organoid by adopting the culture medium to obtain the myeloblastoma organoid. The myeloblastoma organoid obtained through culture highly retains the tissue structure and the cell type of a parent tumor, can simulate in-vivo growth and development of the tumor in vitro, and can be used for personalized medicine screening.

Provided are a promoter of a gene specifically expressed in fetal trophoblast cells and a gene specifically expressed in fetal nucleated red blood cell-specific expression gene, as well as a recombinant herpes simplex virus type I obtained by replacing the wild type promoter of the genomic ICP of the recombinant herpes simplex virus type I with the aforesaid promoter and preparation and use thereof. Also provided are a diagnostic kit for prenatal screening and use thereof, as well as a method for isolating fetal cells from a maternal blood sample in pregnancy.

The invention relates to the technical field of thrombus mining robots, in particular to a micron robot with an asymmetric cilia structure, a preparation method and application. The micro-robot is of an asymmetric composite structure and is composed of a smooth hemisphere and a cilia-shaped structure, sandwich type layered arrangement of a PLGE cilia-shaped nano structure, an MNPs interlayer and a PS sphere core is formed on the surface and the interior of the micro-robot from outside to inside, and cooperative regulation and control of morphology and functions are achieved by regulating and controlling the material proportion of PS and PLGE. The thrombus mining robot shows an efficient thrombolysis effect in a plurality of in-vitro and in-vivo models, and rapid fibrinolysis, deep thrombus penetration and efficient mining of single red blood cells are realized, so that the limitation of a traditional thrombolysis agent is overcome. In addition, the thrombus digging robot has excellent biocompatibility and biological safety, has no obvious cytotoxicity or damage to main organs, and supports the safety of the thrombus digging robot in clinical application.

Separation of the cellular components of whole blood, or other biological fluid, from plasma or serum can be achieved for assay analysis. A device for facilitating separation can include, for example, a capillary tube that accurately draws target blood volume, a pad that chemically interacts with red-blood cells, such that the red blood cells become chemically and / or physically trapped within pad material, a mechanism for plasma recovery from the pad upon diffusion or active mixing, and a dropper tip that facilitates dispensing the mixture onto a test device. The treatment of the cellular components can be performed prior to contact with a buffer solution, so release of the cellular components into the buffer solution is reduced or prevented. Additional filtration can be provided to filter any remaining cellular components in the mixture.

The embodiment of the invention provides a hemolysis risk assessment method and system based on erythrocyte morphology, and belongs to the technical field of biomedical treatment. The method comprises the following steps: carrying out image segmentation on a blood sample smear image to obtain a corresponding target segmentation result; performing target classification on the target segmentation result according to the first reference image and the second reference image to obtain a first classification result corresponding to the first reference image and a second classification result corresponding to the second reference image; calculating the difference degree between the first classification result and the second classification result to obtain a difference value; determining a target classification result of the target segmentation result by using the first classification result and the second classification result according to the difference value; determining a first number corresponding to normal erythrocytes and a second number corresponding to abnormal erythrocytes in the target object according to the target classification result; and performing hemolysis risk assessment on the target object according to the first quantity, the second quantity, the blood sample smear image and the blood item test parameters to obtain a target assessment result corresponding to the target object.

The invention provides a multi-channel viscoelastic micro-fluidic chip, a manufacturing method and a method for separating MCF-7 cells. The multi-channel viscoelastic micro-fluidic chip comprises a first multi-stage shunting module, a pipette, a second multi-stage shunting module, a single-stage viscoelastic micro-fluidic sub-module and a third multi-stage shunting module, the first multi-stage shunting module is connected with one inlet of the single-stage viscoelastic micro-fluidic sub-module through a pipette; the second multi-stage shunting module is connected with the other inlet of the single-stage viscoelastic micro-fluidic sub-module; and the outlet of the single-stage viscoelastic micro-fluidic sub-module is connected with the third multi-stage shunting module. According to the method, the PEO solution is used as sheath fluid, and the action of elastic force is introduced to cells, so that CTC can be directly separated from undiluted human blood in an ultrahigh-flux manner, and the limitation that erythrocytes need to be split and a blood sample needs to be diluted by dozens of times before cell separation in traditional inertial microfluidics is broken through; and the complexity of operation and the risk of sample pollution are reduced.

The invention discloses a non-contrast super-resolution ultrasonic imaging method and system based on a diffusion model, and the method comprises the steps: transmitting a multi-angle composite plane wave to a target object, collecting an echo signal, and carrying out the beam synthesis to obtain an erythrocyte B-type ultrasonic image sequence; a space-time filtering algorithm based on singular value decomposition is applied to the erythrocyte B-type ultrasonic image sequence, erythrocyte signals are separated from tissue signals and noise signals, and an ultrasonic image sequence with the high signal-to-noise ratio is obtained for erythrocyte PD image reconstruction; and carrying out super-resolution mapping on the red blood cell PD image based on the trained diffusion model so as to reconstruct a super-resolution ultrasonic image in a non-contrast mode. According to the method, the dependence on an ultrasonic contrast agent is avoided, super-resolution mapping is carried out on the low-resolution erythrocyte PD image based on the deep learning diffusion model completed through training, ultrasonic imaging with ultrahigh resolution is achieved, the application flexibility of the SR-US imaging technology is improved, and the application range of the SR-US imaging technology is expanded.