155 results about "Blood processing" patented technology

The invention provides a GelMA microneedle patch loaded with chromogenic gold nano bipyramids and a preparation method thereof.The method comprises the steps that citric acid, chloroauric acid and a CTAC solution are mixed, then sodium borohydride is added, and a seed solution is obtained through stirring and standing; mixing chloroauric acid, silver nitrate, hydrochloric acid and CTAB (cetyltrimethyl ammonium bromide), and sequentially adding ascorbic acid and the seed solution to obtain a growth solution; carrying out centrifugation, morphology regulation and chemical etching purification to obtain a chromogenic gold nano bipyramid solution; the preparation method comprises the following steps: reacting gelatin with methacrylic anhydride in PBS, dialyzing and freeze-drying to obtain GelMA; dissolving GelMA in the gold nanoparticle bipyramid solution, and adding a photoinitiator LAP to obtain a mixed precursor solution; and the GelMA microneedle patch loaded with the gold nano bipyramid is prepared through mold casting, centrifugation, ultraviolet light crosslinking and drying demolding. The microneedle extraction and gold nano bipyramid color development integrated scheme is initiated, blood sampling is not needed, the dermis interstitial fluid is extracted in a minimally invasive mode through the microneedle, detection pain and trauma are reduced, the cross infection risk of blood treatment is avoided, and the microneedle microneedle microneedle microneedle microneedle microneedle microneedle microneedle microneedle microneedle microneedle microneedle microneedle microneedle microneedle microneedle microneedle microneedle microneedle microneedle microneedle microneedle microneedle microneedle

The invention provides a bulb tube current feedback and synchronous irradiation control system in a blood irradiator, and belongs to the technical field of medical irradiation equipment. Comprising a current acquisition module used for processing target blood by a target blood irradiator and outputting a current signal, a signal conditioning module used for carrying out filtering, level conversion and electromagnetic noise suppression processing on the output current signal, and a current control module. An STM32 microcontroller adopts an incremental proportional control algorithm to dynamically adjust output gain of a high-voltage generator, a synchronous irradiation control module, generation of a synchronous control signal and operation of a management module, a target blood irradiator is controlled to enter a low-power-consumption mode in a non-irradiation stage, and the current of a bulb tube is collected in real time and is processed, so that the current of the high-voltage generator is obtained. High precision and stability of the current signal are ensured, a synchronous control signal is generated according to the current signal after signal conditioning and the irradiation process state, and coordination control of sample rotation and radiation output is realized.

The present application relates to an extracorporeal blood treatment system (50) for treating a subject, the system comprising: an extracorporeal blood circuit (52); a dialysate fluid circuit (54); the extracorporeal blood circuit and the dialysate fluid circuit being separated by a membrane (56) of a filtration unit (58); at least one blood pump (60) for controlling the flow of blood through the blood circuit; at least one dialysate fluid pump (62) for controlling the flow of dialysate fluid through the dialysate fluid circuit (54); a system computing unit (64) operatively connected to the blood pump and to the dialysate fluid pump, the system computing unit having at least one input; wherein the system computing unit is adapted to receive a desired blood concentration of glutamine GLN b , to receive a desired blood concentration of glucose GLUCOSE b , and to receive a desired blood concentration of ketone bodies KETONE b ; the system computing unit being adapted to control the blood pump and the dialysate fluid pump such that an actual concentration value of glutamine GLN a is driven to approach GLN b , and an actual concentration value of glucose GLUCOSE a is driven to approach D b , and an actual concentration value of ketone bodies is driven to approach KETONE a . The present application relates to a treatment device for use in an extracorporeal blood treatment system, a method for treating cancer using the system, a controller for controlling the method and a dialysis liquid suitable for use in the method.

The invention discloses a contrast agent filtering device for coronary surgery and a using method thereof, the device is integrally in a plastic bag shape and comprises a filtering bag body, the bottom of the filtering bag body is provided with a transfusion connector and a blood transfusion connector which are provided with sealing covers, and an inner opening is sleeved with a filter screen support with a filter screen; the filter bag body is divided into a filter area and an adsorption particle storage area through a middle seal, a flushing connector and a hanging hole are arranged at the top, and the filter bag body can be matched with a vibration disc for use. The use method comprises the steps that blood containing a contrast agent is extracted and input into the filtering area, the middle seal is opened through pressing, the blood makes full contact with the adsorption particles through vibration or manual extrusion so as to adsorb the contrast agent, then the filtered blood is infused back, and residual plasma can be infused back after being diluted with normal saline. The device is simple in structure, low in cost and easy and convenient to operate, the filtering effect is improved by 30% compared with the prior art, the adsorption rate reaches 75%-85%, contrast agents in blood can be effectively removed, damage to the kidney of a patient is reduced, and the device is particularly suitable for blood treatment of the patient after coronary angiography.

The invention discloses blood component single sampling equipment capable of monitoring in real time in the field of blood treatment equipment. The equipment comprises a blood sampling module, a centrifugal separation module, a component collection module and an anticoagulant conveying module, and further integrates a multi-dimensional real-time monitoring system and a closed-loop self-adaptive regulation and control module. The multi-dimensional real-time monitoring system comprises an online micro-fluidic component detection unit, a physiological parameter monitoring unit and an equipment operation monitoring unit, can realize real-time online detection of blood component purity, cell activity and pollutant residue in the separation process, and synchronously monitors circulation physiological parameters of a blood donor and an equipment operation state at the same time; the closed-loop self-adaptive regulation and control module can dynamically adjust parameters such as the centrifugal rotating speed, the fluid pump speed and the anticoagulant ratio according to real-time monitoring data, and precise closed-loop control over the separation process is achieved. The quality stability of blood single-sampling components can be remarkably improved, meanwhile, the operation risk is greatly reduced, and the method is suitable for clinical blood component single-sampling and preparation scenes.

A valve for an extracorporeal blood treatment system includes a first body portion having a first passageway and a second passageway. The valve further includes a second body portion that is movable relative to the first body portion from a first valve position to a second valve position. The second body portion includes a third passageway and a fourth passageway. In the first valve position the first passageway and the third passageway are in fluid communication and define a first substantially linear flow path and the second passageway and the fourth passageway are in fluid communication and define a second substantially linear flow path. In the second valve position the first passageway and the fourth passageway are in fluid communication and define a third substantially linear flow path and the second passageway and the third passageway are in fluid communication and define a fourth substantially linear flow path.

A blood treatment apparatus (1) defines first and second flow circuits (C1, C2) separated by a dialyzer (20). The second flow circuit (C2) comprises return and withdrawal lines (24′, 24″) for connection to a vascular system of a subject during a treatment session. After the treatment session, a control system causes an operator to connect the second flow circuit (C2) to a first port (32) of a container (30), the apparatus (1) to perform a rinseback procedure, the operator to disconnect the return line (24′) from the vascular system and re-arrange the second flow circuit (C2) to define a closed loop, and the apparatus (1) to draw residual liquid from the closed loop into the first flow circuit (C1) through a dialyzer membrane (21). To facilitate drainage of the residual fluid with a conventional line set, the second flow circuit (C2) is connected to a second port (33) of the container (30) to include the container (30) in the closed loop, or the return and withdrawal lines (24′, 24″) are connected in fluid communication with the first port of the container (30) through a three-way manifold coupling unit.

Extracorporeal blood treatment device comprising a hydraulic system (B) with several lines (7, 9) for supplying dialysate for dialysis treatment and a control system (15) comprising at least one electrical component (17A, 17B, 17C), wherein the hydraulic system (B) has at least one port (11) for the inflow of a fluid into the extracorporeal blood treatment device, and the extracorporeal blood treatment device has a cooling device (19) for cooling the at least one electrical component (17A, 17B, 17C) of the control system (15), which has at least one liquid-coolable cooling element (21) which is in thermal contact with the at least one electrical component (17A, 17B, 17C) of the control system (15), wherein the cooling device (19) has at least one inlet (22A) which is in fluid communication with the port (11) for the inflow of a fluid.and has at least one outlet (22B) which is in fluid communication with a drain (10, 31), and wherein the cooling element is designed such that the liquid flows through the cooling element (21) and the thermal contact between the at least one electrical component (17A, 17B, 17C) of the control system (15) and the cooling element (21) is a contact contact, characterized in that the permeate supplied centrally to the device for extracorporeal blood treatment is used as the cooling liquid for the cooling element (21).

A graphical user interface of an extracorporeal blood treatment system may include one or more bar-shaped parameter adjustment elements. The bar-shaped parameter adjustment element may be used to determine and adjust one or more parameters associated with one or more processes performed by the extracorporeal blood treatment system. The bar parameter adjustment element may be scaled such that a midpoint of the bar parameter adjustment element represents a reference value.

A blood collection tube comprising: a test tube comprising a vacuum facilitating an extraction of blood from a patient; the test tube further comprising a test tube septum comprising a mechanism having a space-occupying element enabling decreasing a slosh of the blood within the test tube; and wherein the test tube is compatible with conventional blood processing equipment.

Method for monitoring the condition of a gear pump (1) of a device (100) for extracorporeal blood treatment comprising the steps: - Determining a normalization characteristic map, wherein the normalization characteristic map for a new reference gear pump (1) relates a volume flow rate (Q) of a fluid (2) generated by the reference gear pump (1), a pressure (Δp) of the fluid (2) applied to the reference gear pump, a torque (M) generated by the reference gear pump (1) and a rotational speed (n) of the reference gear pump (1) to each other, - during the operation of the gear pump (1), determining an operating characteristic map, wherein the operating characteristic map for a gear pump (1) used during a certain operating period relates a volume flow rate (Q) of the fluid (2) generated by the gear pump (1), a pressure (Δp) of the fluid (2) applied to the gear pump (1), a torque (M) generated by the gear pump (1) and a rotational speed (n) of the gear pump (1) to each other, and - Determining the condition of the gear pump (1) as a function of the normalization map and the operating map.

An extracorporeal blood treatment apparatus (100) comprises: a treatment unit (200); an extracorporeal blood circuit (300) comprising a blood withdrawal line (301) connected to the treatment unit (200) and connectable to a first access port (A) or a second access port (B) of a patient and a blood return line (302) connected to an outlet (202) of the treatment unit (200) and connectable to the second access port (B) or the first access port (A) of the patient; a switching valve (1) in fluid communication with the blood withdrawal line (301) and the blood return line (302) and with the first access port (A) and the second access port (B), which is switchable between: (i) a first switching condition, wherein the first access port (A) and the second access port (B) are respectively fluidly connected to the blood withdrawal line (301) and the blood return line (302) to trigger a normal mode of operation; (ii) a second switching condition, wherein the first access port (A) and the second access port (B) are respectively fluidly connected to the blood return line (302) and the blood withdrawal line (301) to trigger a reversing mode of operation wherein blood coming from the patient is circulated through the treatment unit (200) according to an opposite / reverse direction and returned to the patient; (iii) a third switching condition, wherein the first access port (A) and the second access port (B) are fluidly connected to each other and the blood withdrawal line (301) and the blood return line (302) are fluidly connected to each other to trigger a recirculation mode, wherein the extracorporeal blood circuit (300) is not in fluid communication with the first (A) and the second access port (B).

A disposable circuit for extracorporeal blood treatment comprising a filtration unit (2) and a blood circuit (6, 7) having a blood withdrawal line (6) and a blood return line (7) designed to be connected to the cardiovascular system of a patient, wherein the blood withdrawal line (6) and the blood return line (7) are provided with an arterial connector (40) and a venous connector (41) which are detachably connected to a vascular access device of the patient; at least one fluid line (15, 21, 25, 42; 42a) is connected to the blood circuit (6, 7) and the disposable circuit further comprises a first auxiliary connector (51, 53, 55, 57, 59) and a second auxiliary connector (50, 52, 54, 56, 58) which are arranged on the blood circuit (6, 7) or on the fluid line (15, 21, 25, 42; 42a) and are configured to be removably connected with the arterial connector (40) and the venous connector (41) in a recirculation configuration so as to define a closed circuit which allows fluid recirculation.

A pressure cell holder for attachment to a housing of an extracorporeal blood treatment machine, such as a dialysis machine. The pressure cell holder includes a gripping device for holding a pressure cell inserted into the pressure cell holder by enclosing or engaging the pressure cell, and an ejector mechanism for ejecting the pressure cell when the gripping device is released.

Hemodialysis and similar dialysis systems including a variety of systems and methods that make hemodialysis more efficient, easier, and / or more affordable, and include new fluid circuits for fluid flow in hemodialysis systems and a reciprocating diaphragm pump for pumping fluids. The reciprocating diaphragm pump includes a flexible diaphragm, a first rigid body having a curved pumping chamber wall, a second rigid body having an opposing curved control chamber wall. The diaphragm is interposed between the pumping chamber wall and the control chamber wall to define a pumping chamber and a control chamber. The diaphragm of the pump has a peripheral bead arranged to locate the diaphragm between the first rigid body and the second rigid body and a diaphragm body having a curved, semi-spheroid or domed shape. The diaphragm is pre-formed or molded so that during a delivery stroke of the pump, the elastic force of the diaphragm resisting its deployment into the pumping chamber prevents a peripheral portion of the diaphragm body from fully contacting the pumping chamber wall.

The application belongs to the technical field of medical equipment, and provides a blood treatment system including a blood treatment assembly, an optical detection assembly and a control module. The blood treatment assembly uses a treatment liquid to treat blood of a target object to obtain waste liquid and treated blood, and the treated blood is transfused back to the target object. The optical detection assembly generates irradiation light of at least three wavelengths, wherein the irradiation light of the first wavelength is used for detecting bilirubin or free hemoglobin, the irradiation light of the second wavelength is used for detecting intracellular hemoglobin, and the irradiation light of the third wavelength is used for detecting the waste liquid. The optical detection assembly collects light information of emergent light of the at least three wavelengths. The control module obtains light change information corresponding to the at least three wavelengths according to the light information of the emergent light of the at least three wavelengths and the light information of the irradiation light of the at least three wavelengths. Whether the light change information corresponding to the at least three wavelengths satisfies a preset alarm condition is judged to determine whether to perform a hemolysis alarm or a blood leakage alarm, so that detection is distinguished.

A pump and pressure measurement device for a blood treatment apparatus, comprising a pump, in particular a roller pump for pumping a liquid, a pump bed configured to receive a pump tube, a first pressure measurement unit arranged to measure a pressure of the liquid. Furthermore, the pump and the pressure measuring device are provided with a receiving space for at least partially positioning a line connector connected to the pump line wherein the line connector further comprises a pressure measuring chamber adapted to measure the pressure by means of the pressure measuring unit. Furthermore, a blood treatment device has the pump and the pressure measuring device, and a line connector and a line assembly, which are adapted to the pump and the pressure measuring device.

This disclosure relates to medical fluid pumping systems and related devices and methods. In some aspects, a blood treatment system includes a user interface; a processor in communication with the user interface and configured to perform operations including: presenting instructions on the user interface, the instructions pertaining to at least one modality of a set of modalities, wherein the set of modalities include hemodialysis (HD), hemofiltration (HF), and hemodiafiltration (HDF), wherein the instructions pertain to a component of a blood treatment machine of the blood treatment system; receiving information associated with the component of the blood treatment machine; and eliminating modalities from the set of modalities to determine a modality of the blood treatment machine based on the received information.

The invention relates to an extracorporeal blood treatment apparatus comprising a blood treatment unit 1 that is divided by a semipermeable membrane 2 into a first compartment 3, which is part of a fluid system II, and a second compartment 4, which is part of an extracorporeal blood circuit I. The invention also relates to a method for operating a blood treatment apparatus of this kind. The blood treatment apparatus according to the invention has a pressure-based checking device 32 which interacts with the control unit 31 for a valve device 21 and is designed such that a fluid connection between an upstream portion 20A and a downstream portion 20B of a flow path 20 for a special operating mode can only be established if the pressure-based checking device 32 detects an operating state in which it is ensured that fluid in the flow path 20 for a special operating mode flows towards a flow path 10 leading to a drain 11. This ensures that the fluid in question can only flow into the flow path 10 that leads to the drain 11, and cannot get into another flow path 8 in which fresh treatment fluid is located.

The invention relates to a device for separating gas bubbles from a medical fluid, in particular blood, comprising a venous chamber with a reduced volume and comprising an optionally removable filling body. The invention also relates to a tubing set for use in a device for extracorporeal blood treatment.

The disclosure relates to an extracorporeal blood treatment machine comprising a dialyzer (19) having hollow fibers (2) and a blood side (4) and a dialyzing fluid side (6), an extracorporeal blood circuit, and a dialyzing fluid circuit. The extracorporeal blood treatment machine has a control unit (48) which is configured and prepared to perform automatic priming of the blood treatment machine such that it sets a transmembrane pressure (10) with a pressure gradient from the dialyzing fluid side (6) to the blood side (4) and / or from the blood side (4) to the dialyzing fluid side (6) in order to remove air from the semipermeable membrane (8) during priming. The disclosure further relates to a method for priming a dialyzer (19) having hollow fibers (2) and to a computer program.

An apparatus for extracorporeal blood treatment for chronic therapy, comprising a nutrition bag (33) containing a nutrition liquid, a weighing device (36) configured to determine a weight (W) of the nutrition bag (33), and a nutrition line (34) for infusing the nutrition liquid into a blood return line (7) or into a patient's blood vessel system. An ultrafiltration device (30) is configured to remove fluid from the patient through a semipermeable membrane (5) of a filtration unit (2), sensors (31, 32) are configured for determining an ultrafiltration rate (UFR). A control unit (100) connected with the ultrafiltration device (30), the weighing device (33) and the sensors (31, 32) is programmed to receive a patient prescription and to control the ultrafiltration device (30) to achieve the patient prescription based on the weight (W) and the ultrafiltration rate (UFR).

A line connector has an inlet and an outlet for a liquid, and a first line connector element and a second line connector element. The connector comprises at least one first pressure measurement chamber for measuring a pressure of a liquid present in the first pressure measurement chamber. The first pressure measurement chamber is fluidly arranged between the inlet and the first line connector element or between the outlet and the second line connector element. The measuring surface is arranged at an angle relative to the pumping plane. In addition, the blood treatment device is adapted to receive the tubing connector.

The invention belongs to the technical field of medical instrument processing and blood treatment, and particularly relates to a treatment method capable of effectively heat-sealing water drops and water mist on the surface of a catheter, which comprises the following steps: S1, heat-sealing head positive and negative electrode pretreatment: selecting a heat-sealing head positive and negative electrode metal base material matched with an existing sealing machine, the metal base material needs to meet the requirements for heat conductivity and structural strength in the heat sealing process, appearance processing is conducted on the metal base material through a conventional processing technology, a positive electrode and negative electrode structure conforming to the heat sealing size of the catheter is formed, heat is transmitted to the catheter through the insulating layer, the catheter is thermally fused and sealed, and the blood bag dividing operation is completed. By covering the insulating material on the surfaces of the positive and negative electrodes of the heat sealing head to form a reliable insulating layer, even if the surfaces of the positive and negative electrodes are in contact due to water drops or water mist of a conduit, a current path can be effectively blocked, the short circuit phenomenon is avoided, normal heat sealing operation is ensured, and the problem that the conduit contains water drops and cannot be subjected to heat sealing in the prior art is thoroughly solved.

Systems and methods are provided for separating blood components from whole blood. A blood processing device, as part of a blood processing system, has a controller configured to operate the blood processing device based on a plurality of collection protocols. The blood processing device is wirelessly connected to a remote computing device configured to maintain a plurality of collection protocols. At least one additional computing device is configured to update one or more of the plurality of collection protocols on said remote computing device by communicating changes to a protocol maintained on the remote computing device which updates the plurality of collection protocols at the controller of the blood processing device.

The present invention relates to a system for collecting, separating, concentrating, and reinfusing blood components from whole blood. The system further includes cell modification. The system includes a blood processing device and a fluid flow circuit.

Systems for collecting, separating, concentrating and modifying blood components from whole blood for reinfusion are provided. A system includes a blood treatment device and a fluid flow circuit.