65 results about "Dialysis fluid" patented technology

This utility model relates to the field of packaging and sealing technology, and discloses a peritoneal dialysis fluid packaging and sealing machine, including a support plate. A slide rail is fixedly connected to the upper surface of the support plate, and a slider is fixedly connected to the upper surface of the slide rail. A clamping assembly is provided outside the slider, the clamping assembly including a clamping plate. The clamping plate is disposed outside the slider, and a connecting rod two is fixedly connected to the outer wall of the clamping plate. A fixing post one is rotatably connected to one end of the outer wall of the connecting rod two, and a fixing post two is rotatably connected to one end of the connecting rod two. A connecting rod three is rotatably connected to the outer wall of the fixing post one. In this utility model, the clamping plate stably clamps the packaging bag by driving the gears and connecting rods through a motor. Combined with the sliding of the slider on the slide rail, the packaging bag can be accurately transported to the sealing position, improving the stability of clamping and transporting, ensuring accurate positioning of the packaging bag during the sealing process, reducing sealing deviations caused by displacement, and improving sealing quality.

This invention discloses an open, non-contact liquid heating method, comprising: collecting temperature data of multiple points of dialysis fluid and heating unit, and obtaining flow rate deviation and temperature sensor consistency deviation indices during dialysis fluid infusion; preprocessing the temperature data to obtain a stable multi-source temperature data sequence; fusing the multi-source temperature data to obtain the dialysis fluid characterization temperature, and analyzing it in conjunction with temperature change characteristics, flow rate deviation, and temperature sensor consistency deviation indices to construct a system state characterization quantity; identifying the heating stage based on the system state characterization quantity, using the dialysis fluid characterization temperature as the control target, generating heating control quantities according to the heating stage, and introducing compensation corrections when the flow rate changes; performing anomaly detection based on the system state characterization quantity, and jointly judging it in conjunction with the flow rate deviation and temperature sensor consistency deviation indices, generating anomaly scores based on the judgment results, and outputting corresponding hierarchical control strategies.

The application discloses a dialysate temperature measuring system and method, a temperature control system and a hemodialysis machine, and relates to the technical field of dialysis. The system comprises: a first temperature sensor configured to detect a first dialysate temperature in a dialysate pipeline of the hemodialysis machine when the hemodialysis machine is working; a second temperature sensor configured to synchronously detect a dialysate waste temperature in a dialysate waste pipeline of the hemodialysis machine with the first temperature sensor when the hemodialysis machine is working; and a computing device connected to the first temperature sensor and the second temperature sensor, configured to obtain a second dialysate temperature in a dialyzer according to the first dialysate temperature and the dialysate waste temperature. Thus, the dialysate temperature in the dialyzer can be obtained without distortion, and accurate dialysate temperature control can be realized.

The utility model discloses a kind of dialysis tubes of bidirectional laminar flow, including pipe body, inner passage, outer passage and fiber bundle film;Two liquid inlets and two liquid outlets are provided on the side of pipe body;Inner passage is communicated with two liquid inlets;Outer passage is set around inner passage, outer passage lower end is communicated to inner passage lower end, and outer passage is communicated to two liquid outlets;Fiber bundle film is communicated to the two ports of pipe body to transport back blood.The utility model is communicated to inner passage bottom by setting inner passage and outer passage in pipe body, and when dialysate is injected into inner passage through liquid inlet, dialysate can form dialysate laminar flow in inner passage, dialysate can form waste liquid laminar flow in outer passage after flowing into outer passage by dialysis, to form bidirectional laminar flow to improve hemodialysis effect.

The present application relates to the field of medical devices, and discloses a peritoneal dialysis patient peritonitis early warning device based on microfluidic technology, comprising a peritoneal dialysis external catheter and a microfluidic detection module; the peritoneal dialysis external catheter comprises a main passage for dialysis liquid infusion or dialysis waste liquid drainage, and a detection branch selectively communicated with the main passage; a flow path switching structure is arranged on the peritoneal dialysis external catheter, and the flow path switching structure is used for switching between a normal state and a detection state. In the present application, the detection branch selectively communicated with the main passage is arranged on the peritoneal dialysis external catheter, and the flow path switching structure is used for switching between the normal state and the detection state, so that the dialysis waste liquid can enter the microfluidic detection module for detection while maintaining the drainage of the main passage, in-situ detection is realized without changing the basic operation process of peritoneal dialysis, and good clinical process compatibility is achieved.

1. Name of the product in this design: Sealing cap (dialysis fluid container). 2. Purpose of this design: For use as a sealing cap for dialysis fluid containers. 3. The key design features of this product are the combination of shape and pattern. 4. The image or photograph that best illustrates the design's key points: a 3D model.

The application discloses an ultrafiltration permeation regulation method and device based on a gradient sponge structure dialysis membrane and relates to the technical field of hemodialysis. An intelligent response membrane assembly containing a nonlinear aperture gradient is constructed; a signal is collected and a concentration polarization critical index is calculated; when the threshold value is exceeded, a multi-frequency coupling pulse control instruction containing a mechanical resonance excitation waveform and a phase reverse matching osmotic pressure oscillation waveform is generated; mechanical resonance excitation is applied to the blood side to induce membrane layer micro-breathing deformation, and an osmotic pressure oscillation waveform is injected into the dialysate side to form a reverse solute diffusion field; microgel deformation feedback signals are monitored in real time, waveform parameters are dynamically adjusted, and the concentration polarization critical index is returned to a safe interval until the ultrafiltration flux is adaptively regulated. The device comprises an intelligent gradient membrane assembly, a fluid power regulation module, an osmotic pressure wave generation module, a sensing feedback array and a central processing unit, can effectively inhibit membrane pollution and concentration polarization, and improves the system operation stability.

A blood purification apparatus (1A) comprises: a dialysate supply unit that prepares a dialysate from at least first and second stock solutions; a first container unit (110) and a first holder unit; and a second container unit (120) and a second holder unit. The first container unit (110) contains a first raw material powder which is a raw material powder of the first stock solution, and the first raw material powder contains at least two of a calcium salt, a magnesium salt, a potassium salt, and a sodium salt as main components. The second container unit (120) contains a second raw material powder which is a raw material powder of the second stock solution, and the second raw material powder contains sodium hydrogen carbonate as a main component. The first holder unit constitutes a first flow path through which a dissolution solution is introduced into the first container unit (110) and through which the first stock solution, which contains the first raw material powder dissolved in the dissolution solution, is delivered to the dialysate supply unit. The second holder unit constitutes a second flow path through which a dissolution solution is introduced into the second container unit (120) and through which the second stock solution, which contains the second raw material powder dissolved in the dissolution solution, is delivered to the dialysate supply unit.

The present application belongs to the technical field of food production and processing, and particularly relates to a method for preparing pineapple fruit powder by boiling granulation, which comprises the following steps: adding γ-cyclodextrin into pineapple juice, stirring and dissolving to obtain an inclusion liquid; subjecting the inclusion liquid to ceramic membrane microfiltration to obtain a dialysate; subjecting the dialysate to vacuum decompression concentration and filtration to obtain a concentrated liquid; weighing auxiliary materials according to the total solid mass of the concentrated liquid, and dividing the auxiliary materials into first auxiliary materials and second auxiliary materials; placing the first auxiliary materials into a boiling granulator, spraying the concentrated liquid to obtain shaped particles; preparing an embedding solution from the second auxiliary materials, and performing spray embedding, drying and sieving on the shaped particles to obtain pineapple fruit powder. The pineapple fruit powder prepared by the method has high solubility, good fluidity, low hygroscopicity, high nutrient retention rate, low processing cost and long product shelf life.

A medical fluid generation system is disclosed. In an example, a peritoneal dialysis fluid generation system includes water purification equipment configured to provide purified water; a presterilized tubing set including a container for storing peritoneal dialysis fluid; at least one glucose or buffer concentrate; and a hemodialysis machine in fluid communication with the water purification equipment. The hemodialysis machine includes at least one mixing pump for mixing the at least one glucose or buffer concentrate with the purified water to form peritoneal dialysis fluid, a dialysis fluid pump for delivering the peritoneal dialysis fluid to the container, and a control unit configured to control the at least one mixing pump to form the peritoneal dialysis fluid and the dialysis fluid pump to deliver the peritoneal dialysis fluid to the container.

The application provides a method and application for improving DNA yield in vitro amplification, and belongs to the technical field of biology. The application provides a method for improving DNA yield in vitro amplification, which comprises the following steps: (1) reacting a reaction system at 27-38 DEG C for 40-60 min; (2) adding the reaction liquid into a dialysis bag, adding dialysis liquid into an outer tube, and dialyzing at 30-38 DEG C; (3) supplementing tRNA into the reaction liquid for sealing after dialyzing for 1-3 h; the reaction system in step (1) comprises 5x synthesis enzyme mix, 5x synthesis reaction buffer, NTP, dNTP, a template and water; and the concentration of the dNTP is 0.1-0.5 mM. The method can significantly improve the DNA yield in vitro amplification, the concentration of the amplification product is increased by more than about 134 %, and the core problem of insufficient yield in the in vitro DNA amplification is effectively solved.

The application discloses dialysis concentrate preparation equipment, one-way centralized liquid supply system and a working method thereof, to solve the problems of complex structure, large floor area and low working efficiency of the existing liquid preparation equipment. The application comprises a box body and a main machine, the box body is internally provided with a water tank, a powder bin, a mixer, a liquid supply balancer and a mixer stirring pump, reverse osmosis water and dialysis powder are injected into the mixer, and stirring is performed through the mixer stirring pump; the main machine is used for controlling the working of the water tank, the mixer and the liquid supply balancer; the application has the advantages of simple structure, convenient use, full intelligent preparation of dialysis concentrate, improved working efficiency, reduced artificial burden, exquisite and compact complete equipment, saved floor space, small floor area, liquid preparation mode of immediate use, inhibited bicarbonate ion volatilization, improved dialysis liquid purity, separated supply of concentrate to dialysis machines in negative area and positive area, realized one-way branch liquid supply, and avoided hospital infection risk.

A renal failure therapy system includes a fresh dialysis fluid tube having a connector for connecting to a dialyzer, a spent dialysis fluid tube having a connector for connecting to the dialyzer, a dialysis fluid circuit including a fresh dialysis fluid line, a spent dialysis fluid line, at least one of (i) a first disinfection device positioned between the fresh dialysis fluid line and the fresh dialysis fluid tube, or (ii) a second disinfection device positioned between the spent dialysis fluid line and the spent dialysis fluid tube, and recirculation circuitry extending to a first machine connector for mating with the connector of the fresh dialysis fluid tube during disinfection and a second machine connector for mating with the connector of the spent dialysis fluid tube during disinfection. The system also includes a control unit configured to cause the first and second disinfection devices to be energized during the local disinfection.

The application discloses a silk fibroin solution purification device and a purification method thereof, which comprises a dialysate storage tank, a dialysis water tank, a finished product storage tank and a PLC control cabinet; a liquid pumping pump, a self-priming pump and a dialysis cavity are installed in the dialysis water tank, a dialysis bag is hung in the dialysis cavity, and the liquid inlet and the liquid outlet of the dialysis bag are connected to the liquid pumping pump and the self-priming pump through liquid inlet electromagnetic valves and liquid outlet electromagnetic valves respectively; the liquid pumping pump is connected to the liquid pumping electromagnetic valve of the dialysate storage tank, and the self-priming pump is connected to the liquid inlet of the finished product storage tank; water inlet electromagnetic valves and water outlet electromagnetic valves are further installed on the dialysis cavity; and the PLC control cabinet is connected to all electromagnetic valves, the liquid pumping pump and the self-priming pump. The application adopts the PLC to monitor information of each module and control a dialysis process, liberates manual work, reduces cost, improves dialysis precision at the same time, ensures purification quality, improves product purity, automatically monitors a dialysis end point, improves consistency of purification, sets a dialysis circulating flow system and improves dialysis efficiency.

The utility model provides a straight head tweezers with a stopper, including elastic sheet, the elastic sheet is set up in U shape, both ends of elastic sheet all are fixedly connected with adjusting mechanism, the outside fixed mounting of adjusting mechanism has clamping arm, the outside fixed mounting of clamping arm has tweezers chuck, the outside fixed connection of clamping arm has limit mechanism, the end of limit mechanism is covered in the outside of tweezers chuck, during the application of this tweezers, the limit mechanism of its tweezers controls the depth of chuck through guide rail, slide and concave protection stopper, when adjusting, loosens the limit screw slide and adjusts the protection stopper position, in the operation, the protection stopper first contacts dialysis liquid mouth and forms physical limit, the depth error is controlled in 0.2mm, the risk of membrane bundle injury reduces more than 90%, the concave protection stopper covers the outside of chuck, provides lateral protection and does not shield the inside clamping area, the convex letter slide and guide rail ensure that the adjustment is convenient and stable, and safety and clamping effect are considered.

A peritoneal dialysis fluid generation system including water purification equipment configured to provide purified water; a presterilized tubing set including a container for storing peritoneal dialysis fluid; at least one glucose or buffer concentrate; and a hemodialysis machine in fluid communication with the water purification equipment. The hemodialysis machine includes at least one mixing pump for mixing the at least one glucose or buffer concentrate with the purified water to form peritoneal dialysis fluid, a dialysis fluid pump for delivering the peritoneal dialysis fluid to the container, and a control unit configured to control the at least one mixing pump to form the peritoneal dialysis fluid and the dialysis fluid pump to deliver the peritoneal dialysis fluid to the container.

The present invention relates to a device for producing a medical solution, preferably a concentrated dialysis solution, comprising a fluid system with a main circuit and a branched section connected thereto. The main circuit contains a pump and a product container, and the liquid circulates within it via the pump. A raw material container can be attached to the branched section. This branched section includes a suction line extending from the attachable raw material container to a suction unit in the main circuit. The suction unit is designed to draw the liquid, along with the undissolved raw material, from the suction line and introduce it into the liquid flowing through the main circuit.In addition, the main circuit includes a fine mixing chamber located between the suction unit and the product container. This fine mixing chamber has two connectors and a retention element, positioned between the connectors, for the undissolved raw material.

The utility model discloses a portable peritoneal dialysis equipment, including equipment casing, heating tray and foldable support device, heating tray sets up at the top of equipment casing, the built -in heating element of heating tray is used for heating the liquid in the dialysate bag, and foldable support device includes rotatably connected in equipment casing one side's support plate and is used for controlling the folding subassembly of support plate unfolding or folding action, when support plate is in the unfolding state with heating tray forms continuous support plane, and fits in equipment casing side when folding. The utility model discloses a portable peritoneal dialysis equipment, through folding subassembly realizes the quick unfolding and folding of support plate, significantly reduces the overall volume of peritoneal dialysis equipment, improves the convenience of home and mobile peritoneal dialysis treatment.

The utility model provides a kind of hemodialysis concentrate present preparation present use dissolver, belong to stirring equipment technical field. Including dissolving tank, the top of dissolving tank is connected with inlet pipe, bottom is connected with outlet pipe, stirring subassembly is provided in dissolving tank, the top of dissolving tank is provided with batching component, batching component includes the weighing hopper and dispersion hopper sequentially arranged from top to bottom, the bottom of weighing hopper is provided with first valve, dispersion hopper is provided with dispersion subassembly for dispersing raw material input into dissolving tank. When configuring dialysate, the weight of each input raw material is weighed by weighing hopper, then the raw material is dispersed and input into dissolving tank body after being dispersed by dispersion hopper, and the raw material is stirred and dissolved into reverse osmosis water by stirring subassembly. It has the effect of high dialysate stirring and dissolving efficiency and good dissolving effect.

This invention belongs to the field of organic probe molecular analysis and detection technology, and discloses a fluorescence / electrochemical dual-mode probe for detecting copper ions (Cu2+), its preparation method, and its application. The probe's molecular structure is as follows: Under argon protection and an ice-salt bath, halogenated hydroxyl chloride and pyridinecarboxyl chloride hydrochloride undergo an esterification reaction in anhydrous dichloromethane solvent catalyzed by triethylamine. The target product is obtained after extraction, drying, vacuum concentration, and column chromatography purification. This probe combines "on-screen" fluorescence detection with ratiometric electrochemical detection, enabling highly sensitive and selective quantitative analysis of free Cu2+ in complex biological samples such as dialysis fluid from Alzheimer's disease (AD) model mice. Compared to existing detection technologies, this probe has advantages such as high selectivity, low detection limit, good stability, and accurate dual-signal cross-validation results, providing a reliable tool for the accurate detection of Cu2+ in biological samples.

The application discloses a peritoneal dialysis catheter assembly capable of preventing fibrin clot blockage, which comprises a drainage tube and a cleaning rod. The drainage tube is internally provided with an axially extending drainage cavity, and the drainage tube comprises an insertion section and a guide section, and the insertion section is provided with a plurality of drainage holes; the cleaning rod is arranged in the drainage cavity, the cleaning rod is coaxially arranged with the drainage tube, and the cleaning rod is provided with a plurality of blades. By means of the energy of the dialysate flow, the blades guide the local deflection and acceleration of the flow direction, induce continuous turbulence and vortex near the inner wall of the drainage cavity, the shear force in the turbulence area can effectively strip the fibrin clot adhered to the cavity wall, and the stirring action of the vortex prevents the deposition of new clots on the surface of the cavity wall. The arrangement of the plurality of blades can generate vortexes with alternating directions at different axial positions, avoid the single stable mode of the flow field and reduce the scouring efficiency, so that the unobstructed state of the drainage cavity can be maintained for a long time without relying on external power.

The application discloses a hemodialysis device and a storage medium. The device comprises a memory and a processor. The memory stores a computer program, and the processor executes the computer program to realize a method. In a blood purification treatment stage, the heater is controlled to heat dialysis fluid in a dialysis fluid input pipeline. When the heating temperature of the heater is in a stable state, a first detection temperature obtained by the first temperature sensor for measuring the temperature of the dialysis fluid in a dialysis fluid bag and a second detection temperature obtained by the second temperature sensor for measuring the temperature of the heated dialysis fluid in the dialysis fluid input pipeline are acquired. The heating power of the heater is adjusted according to the temperature difference between the second detection temperature and the first detection temperature. In this way, the application can improve the feedback control accuracy of the heating power of the heating device and ensure the safety and comfort of the blood purification treatment of the patient.

Provided are a method for adjusting a dialysate flow rate and a hemodialyzer capable of quickly completing adjustment of the dialysate flow rate to a desired flow rate. A method for adjusting a dialysate flow rate (100) includes: a pump control value determination step of determining a pump control value corresponding to a desired dialysate flow rate, on the basis of a calibration value indicating a correlation between the desired dialysate flow rate and a pump control value of a circulation pump (92); a pump operation step of operating the circulation pump with the pump control value determined in the pump control value determination step; a difference calculation step of obtaining a difference between a current dialysate flow rate and the desired dialysate flow rate; and a calibration value correction step of correcting the calibration value on the basis of the difference calculated in the difference calculation step.

This invention discloses a method and apparatus for solute removal in hemodialysis with precise membrane pore size control, belonging to the field of blood purification technology. The method involves introducing blood and dialysate into both sides of a dynamically controlled bilayer heterostructure dialysis membrane, collecting characteristic signals of metabolic solutes and plasma functional proteins in the blood, inputting these signals into an adaptive pore size decision model, and outputting target pore size and electric field strength parameters. A low-frequency alternating electric field drives reversible conformational changes in stimulus-responsive polymer chains within the membrane, achieving precise control of the membrane channel's effective sieving pore size, locking the pore size within a threshold range where small molecule solutes permeate while plasma functional proteins are completely retained. Combining axial gradient channels and radial charge sieving mechanisms within the membrane achieves graded and targeted solute removal. A piezoelectrically driven periodic micro-pulsating flow field removes the fouling layer from the membrane surface, improving mass transfer stability. This invention automates and precisely controls the dialysis process, improving solute removal efficiency and plasma protein protection.

Provide herein are a control arrangement and method for evaluating the integrity of a forward osmosis (FO-) membrane of a FO device in a dialysis solution generation apparatus. The FO-membrane separates a feed side and a draw side of the FO device. The FO-device comprises a feed inlet port and a feed outlet port in fluid communication with the feed side, and a draw inlet port and a draw outlet port in fluid communication with the draw side. The method comprises providing a flow of feed solution at the feed side via the feed inlet port and providing a flow of draw solution at the draw side via the draw inlet port, with an osmotic pressure at the draw side that is higher than an osmotic pressure at the feed side. Water is extracted from the feed side to the draw side to dilute the draw solution.

Embodiments pertain to a peritoneal dialysate production and delivery (PD) system configured to produce fresh dialysate for use in peritoneal dialysis of a patient, the system comprising: a water inlet, a water treatment device that is fluidly connectable or connected via the water inlet to a water source and configured to treat water received from the water source to generate treated water; a concentrate supply device that is in fluid communication with the at least one water treatment device to add concentrate comprised in the concentrate supply device to the treated water to generate fresh dialysate fluid; tubing having a lumen for supplying the fresh dialysate fluid to a patient body via a flow path; and a tubing disinfectant supply device that contains and / or that is operable to receive disinfectant agents, wherein the tubing disinfectant supply device is in fluid connection with the tubing for disinfecting at least a portion of the tubing.

Provided is a composition capable of inhibiting peritoneal deterioration. The peritoneal deterioration inhibiting composition of the present invention includes carbon monoxide.