43 results about "Artificial kidney" patented technology

A peritoneal-based (“bloodless”) artificial kidney processes peritoneal fluid without need for additional fluids (“waterless”). Fluid is separated into a protein-rich stream and a protein-free stream. The protein-rich stream is regenerated using a sorbent assembly, and its protein composition can be modified by removal of selected protein(s) (“dialysate-pheresis”). It is then reconstituted with additives and returned into the peritoneal cavity, thereby reducing protein-loss and providing oncotic-pressure for ultrafiltration. The protein-free stream is used to produce free water, and an alkaline or acid fluid for optimization of the composition of the regenerated stream. The unused protein-free stream can be used to “reverse flush” the separator to maintain its patency and the excess discarded for fluid-balance regulation. Compared to prior art, immobilization of urease allows more protein rich fluid to be regenerated and re-circulated into the peritoneal cavity for toxin removal and allows practicable development of portable and wearable artificial kidneys.

An insertion guide is used for inserting an arterial needle, which takes blood out from the body, and a venous needle, which returns purified blood into the body, into one or two fistulae formed in a vein running beneath the skin of the arm. The insertion guide may include a holder having an arterial guide hole, which guides the arterial needle downwards at an incline from the shoulder side to the wrist side relative to the fistula, and a venous guide hole, which guides the venous needle downwards at an incline from the wrist side to the shoulder side relative to the fistula.

The present invention provides polysulfone-based hollow fiber membranes having high water permeable performance and for use in therapy of chronic renal failures, said hollow fiber membranes having high safety and high stability in performance and being excellent in module-fabricating workability. The present invention also provides a process for manufacturing the same. The present invention relates to a bundle of a plurality of selectively permeable polysulfone-based hollow fiber membranes wherein the amount of a hydrophilic polymer eluting from each hollow fiber membrane is not larger than 10 ppm, and wherein the content of the hydrophilic polymer in the outer surface of the hollow fiber membrane is 25 to 50 mass %, and this bundle is characterized in that any of extracted solutions from ten fractions of said bundle, obtained by dividing the bundle at substantially regular intervals along the lengthwise direction, shows a maximum value of smaller than 0.10 in UV absorbance at a wavelength of 220 to 350 nm, with the proviso that the extracted solutions are obtained by the extraction method for tests regulated in the approval manufacturing standards for dialytic artificial kidney devices; and in that the difference between the maximum and the minimum out of the maximum values of UV absorbance of the extracted solutions from the respective fractions is not larger than 0.05.

The present invention relates to systems, methods and uses for recycling at least a part of water lost during various renal replacement therapy processes, e.g. in the preparation of a fresh dialysate solution or fresh reconstitution fluid for kidney disease dialysis and hemofiltration by utilizing water from the spent fluids. The system of the invention is useful in hemodialysis and in peritoneal dialysis as well as in hemofiltration for reuse of water from filtrates and spent fluids. In addition, the system of the invention is useful in the development of a renal assist device or artificial kidney.

A peritoneal-based artificial kidney processes peritoneal fluid without need for additional fluids. Spent dialysate is separated into a protein-rich stream and a protein-free stream. The protein-rich stream is regenerated using a sorbent assembly, and its protein composition can be modified by removal of selected protein(s). Alternatively, the spent dialysate is first processed in a sorbent assembly and then separated into the protein-rich and protein-free streams. Immobilization of urease allows more protein rich fluid to be regenerated and re-circulated into the peritoneal cavity for toxin removal and allows practicable development of portable and wearable artificial kidneys.

Semi-crystalline polymer blended gas or chemical separation membranes are obtained by melting and processing 50-99 wt % of a thermoplastic resin, 1-50 wt % of a semicrystalline polymer and 0.1-10 wt % of a compatibilixer. A method for fabricating semi-crystalline polymer blended gas or chemical separation membrane includes the steps of: mixing 50-99 wt % of thermoplastic resin, 1-50 wt % of semi crystalline polymer and 0.1-10 wt % of compatibilizer; and axially drawing the resulting blend melt coming from an extrusion die. The separation membrane exhibits high selectivity when applied in a gas separation process exceeding the limit value which has been seldom overcome by the existing separation membranes as well as high permeability enough to be applied in real gas separation processes. This enhanced selectivity is ascnbed to the morphology of the ternary blends and different interaction between the compatibilizer and diffusing molecules. The membrane prepared by this method can be used for chemical separation processes (such as reverse osmosis, artificial kidney, artificial lung, drug delivery, drug release, to name a few) as well as liquids and gas separation processes.

A wet spinning process for forming a tubular fiber membrane is provided. The tubular fiber membrane has a nanoporous skin layer and a microporous lumen layer. The skin layer defines an outer surface of the fiber membrane and the lumen layer defines a lumen surface of the fiber membrane. The pores in the skin layer may have an average pore size of less than about 7 nm, and pores in the lumen layer may have an average pore size of from about 0.5 to about 3 μm. The fiber membranes may be used in artificial renal proximal tubules, artificial kidneys, bioreactors, or fiber cartridges.

Methods, systems, and kits are provided for performing hemodialysis, hemodiafiltration, and peritoneal dialysis on a portable machine suitable for both clinical and home use. Peritoneal dialysate can be flowed into and out of the peritoneal cavity, and can also be regenerated within the system, without the need for introducing fresh dialysate. Common hardware and software can be utilized for both peritoneal dialysis and other forms of dialysis such as hemodialysis, hemofiltration, and hemodiafiltration, allowing for facile transition between different dialysis modes using the same dialysis machine.

The invention discloses a wearable artificial kidney. The wearable artificial kidney comprises a hemodialysis assembly, and also comprises a wearable device, and the hemodialysis assembly is installed on the wearable device; the hemodialysis assembly comprises a blood pump, a dialyzer, a dialysis fluid pump and a dialysis fluid container; the blood pump is connected with the dialyzer through a pipe and used for providing power for blood flowing through the dialyzer; the dialysis fluid pump is connected in the pipe between the dialysis fluid container and the dialyzer in series, and the dialysis fluid pump is used for providing power for dialysis fluid flowing through the dialyzer. The wearable artificial kidney can be carried by a dialysis person so that it can be achieved that hemodialysis of a hemodialysis patient is completed in the daily work and life.

The invention relates to nano molybdenum sulfide and application of the nano molybdenum sulfide as an efficient adsorbent for uremia toxin. The technical problems that in the prior art, an adsorption material in a dialysate purification device capable of wearing an artificial kidney is difficult to store, the adsorption efficiency is low, and the biocompatibility is poor are solved. The nano molybdenum sulfide has a two-dimensional ultrathin nanosheet structure, a large number of defects exist on a basal plane due to the interlayer spacing, and the molybdenum disulfide with wide interlayer spacing and rich lattice defects can be used as an efficient adsorbent for uremia toxins. The invention reports that molybdenum disulfide with wide interlayer spacing and rich lattice defects is used for adsorbing uremia toxins urea, creatinine and uric acid for the first time. Compared with commercial MoS2, activated carbon, narrow-interlayer-spacing MoS2 with lattice defects and narrow-interlayer-spacing MoS2 without lattice defects, the dialysate purification material with high adsorbability, high selectivity and high stability is obtained by analyzing and researching the adsorption performance of the material under different conditions (adsorbent dosage, adsorption time, temperature and the like).

Various types of a medical device are described which is used as an implantable renal replacement therapy (an implantable artificial kidney). This device removes toxins and excess water from blood of patients with kidney failure or end stage renal disease. Additionally, other configurations of the device can be used as an external (extracorporeal) device.

The present invention provides a porous material which has continuous pores and comprises a polymethyl methacrylate as a main component, wherein the continuous pores have a diameter of 0.001 μm to 500 μm and at least one surface of the porous material has a porosity of 10% to 80%; a separation membrane composed of the same; an adsorbent composed of the same; and a method production of the same. A porous material whose surface porosity and pore diameter are each controlled in a specific range can be obtained. The porous material has a fine and uniform porous structure in which the pore diameter can be controlled in the order of nanometers to micrometers; therefore, it can be advantageously used as a separation membrane such as a blood component separation membrane of an artificial kidney or the like or as an adsorbent.

The invention discloses an autologous blood recovery and concentration temperature variable filtration system. The filtration system comprises a blood recycling machine and a disposable supporting component. The blood recycling machine is formed by an artificial heart-lung machine and a heat exchange water tank, wherein the artificial heart-lung machine is provided with at least two rolling pump heads. The disposable supporting component comprises a suction tube, a suction channel, an anticoagulant drug bag, a blood storage device, an artificial kidney, a thermode, a blood filter and a transfusion cannula. The filtration system can be used for recovering lost blood in a surgery field in a surgical operation and recovering exudation at incisions after the operation and can also be used for recovering the lost blood of a non-infectious traumatic bleeder. Reclaimed blood is subjected to concentration, temperature change and filtration and is transfused back into a patient, blood components are not lost, and blood platelets in the blood and components containing blood coagulation factors in blood plasma are preserved; input of blood products containing various allogeneic components is reduced, input of allogeneic blood is decreased, and the occurrence rate of haematogenous infectious diseases is reduced.

The invention discloses a method for determining the content of beta2-microglobulin. The method comprises the following steps: 1, preparing a test solution; the method comprises the following steps: taking 1ml of a sample, putting the sample into a 100ml measuring flask, adding a 6mol/L urea solution to a scale, standing at room temperature for 1 hour, and filtering by using a 0.45 mu m filter membrane, thereby obtaining the target product. 2, preparing a reference substance solution; the method comprises the following steps: taking a proper amount of a beta 2-microglobulin reference substance, putting the reference substance into a 100ml measuring flask, adding a 6mol/L urea solution to a scale, and standing at room temperature for 1 hour, so that each 1ml of the prepared solution contains 10mu g of beta 2-microglobulin; step 3, determining according to a high performance liquid chromatography; according to the present invention, the high performance liquid chromatography is adopted to perform determination, such that the beta 2-microglobulin result in the urine and the peritoneal effusion of the patient can be rapidly and conveniently determined, the important significance is provided for the monitoring of the beta 2-microglobulin in the patient body, and the important significance is provided for the artificial kidney research and development.

The invention relates to a preparation method of a bone bioremediation preparation with induced gene expression. The prepared biomaterial can be used for manufacturing biological bone repair toothpaste, tissue engineering regeneration, injury repair medical material and the like; and in particular, the biomaterial has important scientific value and significance on the aspects of tissue engineering bone, peripheral nerve, blood vessel, tendon, in vitro artificial liver artificial kidney device, tissue engineering mouth mucosa, bone repair material, dental caries prevention, gomphiasis, bleeding gums, oral rehabilitation and injury repair, and makes important contribution to the human tissue generation engineering.

The invention discloses a method for realizing an artificial lung/artificial kidney. According to the method, a bundled hollow fiber module A and a bundled hollow fiber module B are mutually replacedand combined with a main exchange container, and are matched with a multi-parameter monitoring and control unit for use, and the artificial lung or the artificial kidney can be realized as required. The invention further discloses a device for an artificial lung/artificial kidney. The device comprises a bundled hollow fiber module A, a bundled hollow fiber module B, a main exchange container, a blood pump, a debubbler, a blood guide tube, a container, a pipeline, a check valve, a stop valve, a component integration box and a multi-parameter monitoring and control unit. The invention provides abrand-new technical means, and can realize the two functions of artificial lung/artificial kidney through one machine. The device has simple structure, convenient replacement, greatly reduces use cost, and has important application value in clinical treatment and scientific research.