310 results about "Mouth mucosa" patented technology

The present invention includes compositions and methods for the treatment and prevention of oral mucosal disorders and for promotion of bone health. In particular, the present invention describes new therapeutic and preventative uses for 3,3′-diindolylmethane (DIM), or a DIM-related indole, alone or in combination with anti-inflammatory agents and/or antibacterial agents, to treat oral mucosal disorders and promote bone health. The compositions of the invention are used to prevent and reverse oral mucosal disorders and bone loss (osteopenia and osteoporosis) associated with aging and chronic inflammation. Oral mucosal disorders include Periodontitis, gingivitis and related oral mucosal inflammation. Formulations of the compositions of the invention include capsules, tablets, toothpastes, oral gels, mouthwashes, mouth rinses, lozenges, chewing gum, dental floss, and dental topical formulations, and fortified foods.

The invention provides a buccal smokeless tobacco product with cigar flavor. The product is characterized by being prepared from a tobacco material serving as a main raw material and combined with seasoning auxiliary materials, wherein the product comprises the following ingredients in percentage by weight: 50 to 70 percent of tobacco material, 10 to 30 percent of water, 1 to 5 percent of Rum, 1 to 5 percent of flavoring agent, 1 to 5 percent of sodium bicarbonate, 1 to 5 percent of sweetening agent, and 1 to 10 percent of flavoring agent. The smokeless tobacco product material prepared by adopting the prescription is reddish brown or brownish black, oily and slightly shining, has mellow and rich cigar flavor with a little flue-cured tobacco flavor or light tobacco flavor. When being used, the product is put between the side part of the upper lip of oral cavity and the gum, and the components are dissolved by virtue of saliva and absorbed through mouth mucosa without chewing. The product prepared according to the technology provided by the invention has rich cigar flavor, smooth and comfortable taste and proper sensory stimulation, is suitable for consumer psychology and taste characteristics of national consumers, and can provide satisfaction similar to traditional tobacco and foreign existing buccal tobacco.

The invention discloses a chlorhydric acid naloxone hypoglossal spraying drug delivery system or compound and the preparing method, belonging to pharmacology field. It is characterized in that: it is hypoglossal spraying agent, and the comprised components and their weight proportion are as follows: (1) chlorhydric acid naloxone or naloxone free alkali or naloxone medical salt: 0. 1-30%, (2) absorption promoter: 0. 5-10%; (3) osmotic pressure regulator: 0. 1 -5%; (4) bodying agent: 0. 5-30%; (5) corrigent: 0. 01-20%; (6) conservative 0. 01-0. 5%, (7) water: 45-95%. The invention is characterized by good adjustment, especially suitable for patient in comatose state; high biological utilization rate, convenient utilization. The product is characterized by stable performance, controllable quality and no stimulation to mouth mucosa.

The invention discloses an application of a centella extract in Chinese medicinal toothpaste and relates to the technical field of toothpaste, namely in a preparation technique of the toothpaste, the centella extract is added into the toothpaste as an ancillary drug raw material for resisting inflammation and dental ulcer. In preparation of the toothpaste provided by the invention, centella is added as a raw material of a natural plant active component, and the centella not only is safe to use and has remarkable effects for resisting inflammation and dental ulcer, but also can prevent periodontitis, gingivitis and dental ulcer and restore oral mucosa, moreover, the toothpaste adopts single drug, so the production technique is simple, the source of the traditional Chinese medicine raw materials is wider, and the cost is lower.

Pro-toothpaste compositions formulated to receive a volume of allergen solution to provide toothpastes that exhibit efficacy for oral mucosal immunotherapy (OMIT) and acceptable consumer and product stability properties, along with kits of pro-toothpaste, allergen/extracts of allergens, and optionally compounding means and/or specialized toothbrushes are provided. Toothpastes suitable and effective for OMIT and methods for managing allergic symptoms and for reducing risk of allergy in people without symptoms employing the pro-toothpastes, toothpastes and kits of the invention are also disclosed.

The invention discloses a compound preparation for treating mouth mucosa lichen planus. The compound preparation is prepared from the following raw materials in part by weight: 16 to 28 parts of common lophatherum herb, 16 to 28 parts of largetrifoliolious bugbane rhizome, 16 to 28 parts of toad coat, 16 to 28 parts of golden thread, 16 to 28 parts of multiflora rose root, 16 to 28 parts of caudate sweetleaf, 12 to 25 parts of villous amomum fruit, 12 to 25 parts of trogopterus dung, 12 to 25 parts of costustoot, 12 to 25 parts of Christina loosestrife herb, 12 to 25 parts of hedgehog fungus, 12 to 25 parts of blister beetle, 6 to 18 parts of notoginseng root, 6 to 18 parts of lotus stamen, 6 to 18 parts of eggplant root, 6 to 18 parts of edible bayberry bark, 6 to 18 parts of calculus bovis factitius, 6 to 18 parts of vitamin C, 1 to 12 parts of axillary choerospondias fruit, 1 to 12 parts of saffron, 1 to 12 parts of ginseng flower, 1 to 12 parts of gleditsia seed, 1 to 12 parts of loquat leaf and 1 to 12 parts of water chestnut. According to the compound preparation, the raw materials are compatible with each other to condition viscera, so the compound preparation has the effects of removing necrotic tissue, promoting tissue regeneration and repairing deformed mucosae quickly.

The invention discloses a medicament for treating canker. The medicament is prepared from the following raw materials in part by weight: 3 to 17 parts of calcined keel, 3 to 17 parts of calcined oyster, 2 to 16 parts of Chinese gall, 1 to 9 parts of borneol, 0.5 to 7 parts of dried alum and 7 to 24 parts of natural indigo. A preparation method for preparing the medicament for treating the canker comprises the following steps of: crushing the calcined keel, the calcined oyster, the Chinese gall, the borneol, the dried alum and the natural indigo to be 80 and 120 meshes, and preparing the crushed raw materials into powder or suppository. The medicament has the effects of inducing astringency, diminishing inflammation, stopping bleeding, eliminating putridity and engendering the new, dispersing swelling, detoxifying and promoting flesh engendering and wound closing, and has extremely good curative effect on various chronic cankers such as mouth mucosa ulcer, bedsore burst ulcer, trauma non-healing ulcer, ulcer of skin and external diseases, cervical erosion and colpitis and skin surface cankers caused by burn, scald and the like.

The invention provides an oral mucosa epithelium model and an in-vitro construction method thereof and belongs to the technical field of tissue engineering biological materials. The in-vitro oral mucosa epithelium model is formed through stratification of one or two of oral mucosa squamous cancer cell lines TR146, Tca8113, SCC-4, SCC-9, SCC-25,HN-6 and CAL-27 with an air-liquid interface culture method adopting different culture systems at different stages after in-vitro amplification according to cytobiology and engineering principles.

An electronic cigarette device comprises a cigarette holder, a cigarette holder base, a smoke passage located at the rear of the cigarette holder base, an atomizing core located in the smoke passage, and a buffer module disposed between the cigarette holder base and the smoke passage. A cavity is formed between the buffer module and the cigarette holder base. A buffer smoke passage is further arranged in the cavity. The buffer smoke passage is located between the cigarette holder and the smoke passage. The cigarette holder is not linearly communicated with the smoke passage in the straight direction by the buffer smoke passage. The electronic cigarette device has the advantages that the smoke passage is prevented from being directly communicated with the cigarette holder, tobacco tar is prevented from entering the oral cavity, the effective length of the smoke passage is increased relatively, the contact area of smoke and the smoke passage is increased, smoke temperature is lowered favorably, the mouth mucosa and respiratory tract are prevented from being burnt by the smoke, explosion sound is reduced, and user experience is enhanced.

The present invention discloses a suspension composition for treating oral mucositis caused by chemoradiotherapy, and relates to a new drug for treating oral mucositis. The suspension composition comprises: 1, local anesthetics; 2, histamine 1 receptor antagonists; 3, a mucosal repairing agent and a drug dispersing agent; 4, an anti-foaming agent; 5, microcrystalline cellulose; 6, unreactive assistant materials; 7, pure water. The preparation method comprises: 1, preparing a solution I; 2, preparing a solution II; 3, adding the solution I to the solution II at a stirring state, completely stirring, adjusting the pH value of the mixed solution to 6-9 to obtain the suspension composition. According to the present invention, the suspension composition provided by the present invention has characteristics of good uniformity and strong stability, is not easy to agglomerate when the suspension composition is placed for a long time; the preparation method has characteristics of simple process and low production cost; the suspension composition can be applicable for treating the oral mucositis caused by the chemoradiotherapy, and severe mouth ulcers caused by anaerobic bacteria; the suspension composition provides effects of analgesia, inflammation eliminating and mucosa repairing; the clinical efficacy of the suspension composition is obvious; the use of the suspension composition is convenient and safe.

The invention discloses anti-moth children toothpaste. The anti-moth children toothpaste is prepared form the following components in parts by weight: 3-7 parts of propolis tincture, 7-9 parts of screwtree root extractive, 10-15 parts of calcium carbonate, 4-6 parts of newtol, 9-12 parts of glycerol, 5-7 parts of citric acid, 2.5-4.5 parts of vitamin, 7-12 parts of degerming rhzomorph, 0.5-1 part of sodium laurinol, 8-10 parts of sodium benzoate, 3-6 parts of a surfactant, and 80 parts of deionized water. The anti-moth children toothpaste is capable of clearing away heat and toxic materials due to addition of screwtree root extractive, can achieve effects of preventing and treating tooth decay, diminishing inflammation and relieving pain, and cleaning oral cavity, can remove ozostomia and prevent oral diseases after long-term use, has no irritation to mouth mucosa, and enables a user to have fresh breath, and medicinal materials are easily available and low in cost.

The invention relates to the field of medical/cosmetic apparatuses, and in particular relates to mouth mucosa repairing liquid containing human-like collagen, wherein the rapid transdermal absorption of the human-like collagen can be promoted. The mouth mucosa repairing liquid containing human-like collagen can be used for repairing the mouth mucosa in the medical/cosmetic field. The mouth mucosa repairing liquid contains the human-like collagen, Carbomer, glycerol, polysorbate-80 and water.

The invention relates to false tooth nursing liquid, in particular to false tooth nursing liquid containing marine biological sterilization components and used for daily sterilization and nursing of false teeth. The false tooth nursing liquid has the following advantages: (1) the detection proves that the nursing liquid has a remarkable sterilization effect, and has an effect of killing common bacteria in the using process of the false teeth; (2) according to the toxicological detection, the nursing liquid does not have irritation on the skin, the vagina mucosa and the eyes of a tested animal, and does not have a teratogenic, carcinogenic or mutagenic effect; (3) the nursing liquid is colorless, odorless, residue-free and pollution-free; the corrosion rate on each of four metal sheets is less than 0.01 mm/a, namely the nursing liquid nearly does not have corrosion; (4) due to multiple marine biological components, the nursing liquid has health-care and moisturizing effects on the oral mucosa and the skin; (5) after the nursing liquid is used, the false teeth can be directly worn, and re-flushing is not required; and (6) the production process is simple. The selected formula comprises the following components in percentage by weight: 4.0 to 6.0 percent of carboxymethyl chitosan, 2.0 to 4.0 percent of algal polysaccharide, 6.0 to 8.0 percent of marine biological lysozyme, 8.0 to 10.0 percent of salt, and the balance of purified water.

The invention discloses cationic bacteriostatic agent containing toothpaste. The cationic bacteriostatic agent containing toothpaste comprises the following components in parts by weight: 14-30 partsof silicon dioxide, 40-70 parts of sorbitol, 3-10 parts of glycerol, 1-5 parts of polyethylene glycol-8, 0.3-2 parts of cellulose gum, 0.1-2 parts of carrageenan, 0.1-5 parts of sodium lauroyl sarcosine, 0.01-0.2 part of cetylpyridinium chloride, 0.01-5 parts of trimethyl glycine, 0.1-0.3 part of sucralose, 0.01-1.0 part of dipotassium glycyrrhizinate, 0.01-0.5 part of a buffering agent, 0.01-2.0parts of essence, 0-0.5 parts of sodium benzoate and 7-25 parts of water. Through compounding, the problem of oral mucosa exfoliation caused by irritation of cations of the sodium lauroyl sarcosine tooral mucosa can be improved; in addition, toothpaste which has bacteriostatic, mothproof and periodontitis and gingivitis preventing properties, has a good mouth feel and is applicable to various people is prepared, and the toothpaste is suitable for popularization and application.

The invention discloses novel effective antimoth toothpaste. The toothpaste is prepared from the following components in parts by weight: 13-16 parts of calcium carbonate, 3.5-5.5 parts of xylitol, 0.4-0.8 part of essence, 8-10 parts of glycerinum, 4.5-5.5 parts of citric acid, 4-7 parts of clove oil, 2.5-3.5 parts of sodium carboxymethylcellulose, 12-15 parts of silicon dioxide gel, 3-5 parts of vitamin, 6.5-9.5 parts of Avomec, 0.5-1 part of sodium lauryl sulfonate, 8-10 parts of sodium benzoate and 80 parts of deionized water. The novel effective antimoth toothpaste has the effects of preventing tooth decay and gum bleeding, diminishing inflammation, treating gum swelling and intermittent pain and protecting teeth, can be used for effectively killing bacteria in the oral cavity, does not irritate mouth mucosa to refresh breath, and has the advantages of wide medicinal material source and low cost.

The invention provides gargle for preventing and treating mouth mucositis caused by chemoradiotherapy. The gargle is prepared from hydrochloric acid doxepin, glycerol, dimethyl sulfoxide and purified water. Every 100 ml of the gargle is prepared from 0.1-10 g of hydrochloric acid doxepin, 5-20 g of glycerol, 2-20 g of dimethyl sulfoxide and the balance water. Hydrochloric acid doxepin serves as a main active ingredient, and glycerol and dimethyl sulfoxide serve as auxiliary materials. Hydrochloric acid doxepin has the effects of restraining nerve functional pain and mouth mucosa reactions, so that euphagiaof a patient is promoted, and normal treatment on the patient is guaranteed. The prepared gargle can effectively treat pain and abnormal food uptake symptoms shown due to mouth mucositis caused by chemoradiotherapy, and the gargle is different from medicine which is used for treating mouth mucositis caused by chemoradiotherapy and has definite clinical effects on the existing market. The gargle is simple in preparation process, controllable in quality and suitable for industrial production.

The invention discloses a chloroquine spray and a preparation method thereof. The spray consists of a powder and a solution, wherein the powder contains chloroquine or a chloroquine derivative, a carrier macromolecular material and a sweetening agent, and the solution is a salt solution containing borneol and/ or menthol. The spray containing a chloroquine medicament is developed for the first time, has small toxic and side effects, can be directly used for antibacterial and antiviral protection of the oral and nasopharynx, can be used for clearing the nose and cleaning the pharynx and throat,and has the original clinical treatment application. Meanwhile, the method utilizes the carrier macromolecular material to wrap the chloroquine, prolongs the retention time of the chloroquine spray in the oral mucosa or the nasal mucosa to achieve the effect of slow release and long-acting, and can obviously improve the bacteriostatic disinfection effect of the chloroquine by being supplemented with menthol, borneol and ethanol. The chloroquine spray is mild and non-irritating, has good taste and convenient use, and can provide normal care for healthy people and more effective prevention andtreatment measures for infected or latent people in the aspects of virus protection such as novel coronavirus and the like.

The invention provides a double-drug-loaded polymer microneedle used for oral mucosa administration. The polymer microneedle is composed of a substrate and drug-loaded microneedles distributed on one side of the substrate in an array, each drug-loaded microneedle is composed of a tip part, a middle part and a bottom part, and the tip part and the middle part are loaded with drugs; the base material of the tip part is a degradable biocompatible high polymer material with a three-dimensional network structure, and the base materials of the middle part and the bottom part are water-soluble biocompatible high polymer materials; and after the polymer microneedle is administrated through the oral mucosa, the substrate and the middle part of the drug-loaded microneedle are dissolved firstly to release the drug loaded on the middle part, the tip part of the drug-loaded microneedle is separated from the middle part and is retained in the oral mucosa, and the drug loaded on the tip part is gradually released along with swelling and degradation of the base material of the tip part. The polymer microneedle can realize gradient order drug release, and can better realize drug combined treatment of oral mucosa diseases.

The invention provides a kit for detecting mitochondria DNA A4263G related to hypertension. The kit consists of a primer sequence, a reagent for extracting a sample genome DNA, a polymer chain reaction (PCR) amplified reaction reagent, a positive sample contrast, a negative sample contrast and an operating manual. According to the kit, the genome DNA is extracted from a small amount of samples (such as a venous blood drop from blood capillary, hair with hair follicle, mouth mucosa blade scraping or spit) by a proteinase K digestion lysis method; segmental nested PCR amplification is performed by the design of primers; and the mitochondria mutation sites related to the hypertension are detected by specific restriction enzyme styI enzyme cutting identification. The kit implements non-invasive detection, is more fast, economic, simple and convenient than the separate detection for the mitochondria DNA A4263G mutation, has low requirement on the equipment and environment, and is favorable for popularization and application and suitable for the extensive screening and preventive inspection for the related population of hypertension.

The invention relates to a water-containing liquid bacterin preparation and the purpose thereof for treating and preventing allergic reaction. The preparation contains an allergen extract which exists in water-containing liquid or suspension containing a protein stabilizer and derives from one or more kinds of artemisia plant pollen.

The invention discloses a flos lonicerae and flos chrysanthemi indici antiviral oral spray and a preparation method thereof. The flos lonicerae and flos chrysanthemi indici antiviral oral spray comprises the following components: 160 to 200 parts of flos lonicerae, 160 to 200 parts of radix scutellariae, 160 to 200 parts of fructus forsythiae, 140 to 180 parts of folium isatidis, 60 to 100 parts of radix glycyrrhizae, 40 to 80 parts of radix bupleuri and 40 to 80 parts of flos chrysanthemi indici. The antiviral oral spray further comprises sucralose, menthol, benzalkonium bromide, ethanol andpurified water, wherein the sucralose accounts for 0.10%-0.15% of the total mass, the menthol accounts for 0.02%-0.05% of the total mass, and the ethanol accounts for 5%-50% of the total mass. 0.45 mgto 0.55 mg of the benzalkonium bromide and 1,000 ml of purified water are added in every 160 g to 200 g of the flos lonicerae. The application range of the flos lonicerae and flos chrysanthemi indiciantiviral oral spray is extended, the antiviral oral spray can be applied to oral mucosa, the number of benefited people is increased, and the healthy development of the traditional Chinese medicineindustry is promoted.