Chloroquine spray and preparation method thereof

A technology of chloroquine and spray, which is applied in the direction of pharmaceutical formulations, antiviral agents, local antibacterial agents, etc., can solve the problems affecting the quality and curative effect of drugs, the low bioavailability of tablets, and the difficulty of dividing doses or coatings, etc., to achieve Achieve long-term protection, promote absorption and residence time, and have less toxic and side effects
CN111419787APending Publication Date: 2020-07-17广州康健医学科技有限公司 +2
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
广州康健医学科技有限公司
Publication Date
2020-07-17

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Abstract

The invention discloses a chloroquine spray and a preparation method thereof. The spray consists of a powder and a solution, wherein the powder contains chloroquine or a chloroquine derivative, a carrier macromolecular material and a sweetening agent, and the solution is a salt solution containing borneol and / or menthol. The spray containing a chloroquine medicament is developed for the first time, has small toxic and side effects, can be directly used for antibacterial and antiviral protection of the oral and nasopharynx, can be used for clearing the nose and cleaning the pharynx and throat,and has the original clinical treatment application. Meanwhile, the method utilizes the carrier macromolecular material to wrap the chloroquine, prolongs the retention time of the chloroquine spray in the oral mucosa or the nasal mucosa to achieve the effect of slow release and long-acting, and can obviously improve the bacteriostatic disinfection effect of the chloroquine by being supplemented with menthol, borneol and ethanol. The chloroquine spray is mild and non-irritating, has good taste and convenient use, and can provide normal care for healthy people and more effective prevention andtreatment measures for infected or latent people in the aspects of virus protection such as novel coronavirus and the like.
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Description

Technical field

[0001] The invention belongs to the field of medical and health technology. More specifically, it relates to a chloroquine spray and a preparation method thereof. Background technique

[0002] In the study of SARS-related coronaviruses, it was found that chloroquine can effectively prevent the spread of SARS-related coronaviruses during cell culture. The mechanism of action is to inhibit the terminal glycosylation of ACE2. In addition, existing clinical studies have found that chloroquine phosphate has initially shown a good clinical effect on the new coronavirus, and it has been written into the "New Coronavirus Pneumonia Diagnosis and Treatment Plan (Trial Sixth Edition)". On the afternoon of February 17, 2020, Sun Yanrong, deputy director of the Biological Center of the Ministry of Science and Technology, also introduced chloroquine at a press conference. Chloroquine phosphate is an antimalarial drug that has been used clinically for more than 70 years. Past r...

Claims

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