47 results about "Chloroquine Phosphate" patented technology

The invention belongs to the technical field of spinning, and particularly relates to a process for dip-coating fiber surface with emulsion polymerization chloroquine diphosphate microcapsules. The process comprises the steps that a fiber main material and hydroxypropyl methyl cellulose are added into a solvent, a stock solution is prepared by heating and dissolving, and then the stock solution isadded into a spinning box; the stock solution in the spinning box is ejected by a spinning jet, and is solidified in a DMAC aqueous solution to obtain a composite fiber; and the surface of the composite fiber is coated with the microcapsules with an antiviral agent containing chloroquine diphosphate as capsule cores and the fiber main material as capsule walls to obtain a finished fiber. According to the process, the antiviral agent containing chloroquine diphosphate is taken as the capsule cores of the microcapsules, then the surface of the composite fiber is coated with the microcapsules toobtain the finished fiber, so that in the use process, the antiviral agent on the surface of the finished fiber has a slow-release property, and the antiviral effective time of the finished fiber isprolonged.

The invention belongs to the field of pharmacy, and particularly relates to a compound reserpine orally disintegrating tablet for treating hypertension and a preparation method of the compound reserpine orally disintegrating tablet. The compound reserpine orally disintegrating tablet is prepared from the following raw and auxiliary materials in parts by weight: 0.03 part of reserpine, 1 part of hydralazine hydrochloride, 0.025 part of cyclopenthiazide, 1.5 parts of hydrochlorothiazide, 2 parts of promethazine hydrochloride, 30 parts of potassium chloride, 5 parts of rutin, 2.5 parts of phosphate chloroquine, 1 part of vitamin B1, 1 part of vitamin B6, 2-10 parts of a stabilizer fumaric acid and other pharmaceutical adjuvants. An experiment result shows that the orally disintegrating tablet is short in onset time, long in medicine duration time, and convenient for treatment of a patient for a long period of time; the medication safety is improved; meanwhile, the prescription is high in process stability, and is free of effects of environmental temperature and humidity; and the difference between batches of the preparations is significantly reduced; and the stability of a sample is improved.

The invention provides an application of a chloroquine compound or a salt thereof in the preparation of a medicament for treating acute leukemia. The chloroquine compound or the salt thereof can be any one of chloroquine, chloroquine phosphate, hydroxychloroquine, chloroquine hydrochloride, nivaquin, chloroquine silicate or aminochloroquine. By using the chloroquine medicament having stabilizing effect on the cell membrane and the intra-cellular membrane structure to treat the leukemia cell strain and the primary cell, the growth of the leukemia cell can be retarded and the apoptosis rate of the leukemia cell can be obviously increased after the treatment, thereby indicating that the chloroquine compound and the salt thereof can be used for treating leukemia.

The invention discloses a preparation process of chloroquine phosphate. The preparation process of the chloroquine phosphate comprises the following steps of: (1) taking 4, 7-dichloroquinoline as an initial raw material, carrying out condensation reaction with 2-amino-5-diethylaminopentane, and carrying out alkalization extraction to obtain chloroquine; and (2) salifying the chloroquine obtained in the step (1) with phosphoric acid to obtain chloroquine phosphate. The invention provides a preparation process of chloroquine phosphate. In the preparation process, the use of organic solvents suchas benzene and other catalysts such as phenol is avoided, and a condensation crystallization impurity removal step is introduced, so that the product purity is high, the individual impurity is less than 0.1%, the green chemical requirements and pharmacopeia standards are met, the operation is simple and convenient, the process is simplified, the production efficiency is improved, and the method is suitable for industrial production.

The invention relates to a compound dibazole and hydrochlorothiazidum capsule and process for preparation, wherein the raw materials include dibazole, promethazine, chloroquine phosphate, guanoxan sulfate, vitamin B6, potassium chloride, crystoserpine, hydrochlorothiazidum, calcium lactate, vitamin B1, magnesium trisilicate and medicinal starch. The end product can effectively lower blood pressure.

The invention provides a novel asymmetric synthesis method of (S) chloroquine. According to the invention, 5-(N-diethylamino)-2-pentanone and (S)-alpha-methyl benzylamine are adopted as raw materials,and in the presence of Lewis acid, an asymmetric reductive amination reaction is carried out to obtain (S,S)-5-(N'-diethylamino)-N-((1-phenyl)ethyl)-2-pentylamine, catalytic hydrogenation is performed to remove benzyl to obtain a side chain (S)-5-(N'-diethylamino)-2-amyl amine for synthesizing chloroquine, the (S)-5-(N'-diethylamino)-2-amyl amine is condensed with 4,7-dichloroquinoline to obtain(S)-chloroquine, salifying is performed with phosphoric acid, and recrystallizing is performed to obtain (S)-chloroquine phosphate with ee value of more than 99%, wherein the the total yield of the four-step reaction exceeds 70%; and the preparation method is stable, reliable, economical, efficient and easy to industrialize.

The invention provides a chloroquine inhalant and a preparation method thereof, and belongs to the field of medicine preparations. The inhalant comprises chloroquine phosphate or hydroxychloroquine sulfate, a stabilizer and a diluent, can improve use efficiency, has a preventive effect, such as a new epidemic situation-COVID-19, and can take effect quickly. The powder inhalation has better stability, has the effects of masking taste, enhancing stability and protecting organism biological membranes on chloroquine phosphate or hydroxychloroquine sulfate after being wrapped by the stabilizer, is absorbed through the lungs, has a high targeting effect, also can effectively avoid the first-pass effect caused by the liver during oral administration, and improves bioavailability.

The invention discloses an organic composite photocatalyst for degrading medicines and pathogenic bacteria and a preparation method thereof, and belongs to the technical field of water pollutant treatment. In the method of the present invention, a simple green method is used to load cercosporin on the macroporous adsorption resin to obtain a supported photocatalyst. It can generate singlet oxygen, superoxide radicals, etc. under the irradiation of fluorescent lamps and even sunlight. These oxygen free radicals can react with drugs and pathogenic bacteria, so as to achieve the purpose of degrading drugs and pathogenic bacteria. The method can completely degrade drugs within 3 hours of reaction under light, these drugs include: antibacterial drugs: quinolones ciprofloxacin, gatifloxacin, moxifloxacin, ofloxacin, enrofloxacin , sparfloxacin, trimethoprim sulfonamides, and antiviral drugs: chloroquine phosphate. In addition, the photocatalyst can also effectively inhibit the pathogenic bacteria Staphylococcus aureus, realizing the simultaneous removal of drugs and pathogenic bacteria in water pollution.