17 results about "Chloroquine Phosphate" patented technology

The application discloses a BN-g-C3N4 / Cs3Bi2Br9 composite photocatalyst for degrading chloroquine phosphate and a synthesis method thereof. The BN-g-C3N4 / Cs3Bi2Br9 composite photocatalyst is characterized by the fact that, as shown by a scanning electron microscope, Cs3Bi2Br9 is in-situ grown on the surface of BN-g-C3N4, and the two monomers form a composite material, and the size and morphology of the two are not obviously changed. The synthesis method of the composite photocatalyst is simple, the photocatalytic activity is high, the method is easy to enlarge, and the composite photocatalyst has good stability and reusability, and has a good engineering application prospect.

The invention provides a method for treating ribavirin and chloroquine phosphate in water through ultraviolet light catalysis, aiming at the problem of low removal efficiency of two common antiviral drugs, namely ribavirin and chloroquine phosphate, of a traditional sewage treatment method. According to the method, a certain amount of TiO2 and KMnO4 are added into water, ribavirin and chloroquine phosphate are removed under ultraviolet irradiation, the result shows that ribavirin and chloroquine phosphate can be efficiently removed through the UV / KMnO4 / TiO2 technology, the treatment effect is far better than that of methods such as independent UV, UV / KMnO4 and UV / TiO2, and the UV / KMnO4 / TiO2 technology has an obvious synergistic effect. Besides, TiO2 is the most common photocatalytic material at present, and potassium permanganate KMnO4 is a common oxidant, so that the UV / KMnO4 / TiO2 method has the characteristics of simplicity, easiness in obtaining and easiness in implementation, and can be widely applied to engineering practice.

The application discloses a preparation method and application of an r-MIL-88A / OV-BiOBr photo-Fenton catalyst rich in oxygen vacancies. The photo-Fenton catalyst rich in oxygen vacancies is characterized in that, as shown by transmission electron microscopy and scanning electron microscopy, the morphology of an optimal ratio catalyst OV-BM-25 is that a certain amount of OV-BiOBr flower balls are attached to the surface of the r-MIL-88A rod-shaped structure. Under the irradiation of a low-power white light-emitting diode (LED), the optimal ratio catalyst OV-BM-25 prepared exhibits good photo-Fenton degradation activity, and can degrade and convert organic pollutants in pharmaceutical wastewater containing chloroquine phosphate and the like into non-toxic or low-toxic substances. The photo-Fenton catalyst preparation method provided by the application is simple, has high photo-catalytic efficiency, good mineralization effect, good stability, reusability and the like, has a good application prospect, and is easy to prepare on a large scale.

The present invention discloses a preparation method and application of an Mn@(TiC-TiN)-NH2 ozone catalyst for degrading chloroquine phosphate in water. The preparation method includes the following steps: S1. Prepare a carrier Zn-Ti organic framework material; S2. Prepare TiC / TiN-CNTs; S3. Etch with ammonia water to obtain TiC / TiN-NH2; S4. Chelate and load manganese and perform ultrasonic cavitation treatment to obtain an ozone catalyst for degrading chloroquine phosphate in water, namely Mn@(TiC-TiN)-NH2. The Mn@(TiC-TiN)-NH2 catalyst prepared by the present invention has a large specific surface area and high catalytic ability for ozone, and can achieve a decomposition efficiency of more than 94% for chloroquine phosphate pollutants at the mg / L level within 40 minutes, and can effectively purify pharmaceutical wastewater such as chloroquine phosphate.

The invention discloses an oxygen-vacancy-rich cobalt aluminate Fenton-like catalyst and a preparation method and application thereof, the oxygen-vacancy-rich cobalt aluminate Fenton-like catalyst is spinel type cobalt aluminum oxide, and the content of Co element in the spinel type cobalt aluminum oxide is 20-27 at.%, the content of Al element in the spinel type cobalt aluminum oxide is 10-15 at.%, and the content of O element in the spinel type cobalt aluminum oxide is 60-70 at. The oxygen vacancy-rich cobalt aluminate Fenton-like catalyst disclosed by the invention is used for activating PMS to generate sulfate free radicals and high-valence metals, 94.3% of carbamazepine can be degraded within 7 minutes, and the degradation rate within 10 minutes reaches 99.5%. In addition to carbamazepine, the cobalt aluminate Fenton-like catalyst rich in oxygen vacancy disclosed by the invention has a relatively good degradation rate on various pollutants such as o-nitrophenol, rhodamine B, ciprofloxacin, chloroquine phosphate, tetracycline and the like.

The present invention relates to the field of wastewater treatment, and more specifically to a nitrogen-boron co-doped waste tea biochar adsorbent, and its preparation method and application. Dihydrogen diamine and boric acid are first dissolved in deionized water to form a precursor, and then waste tea particles are added to the mixed solution. The mixed solution is freeze-dried to obtain an adsorbent powder, and then the adsorbent powder is carbonized in an inert atmosphere at high temperature to obtain a nitrogen-boron co-doped waste tea biochar adsorption material. The material has simple components, a high specific surface area and high adsorption performance, a significant adsorption effect on chloroquine phosphate and hydroxychloroquine sulfate, and an excellent adsorption effect on drugs in water bodies. The adsorbent can be reused multiple times, is low in cost, and has good application prospects.

The application relates to a preparation method and application of a sponge-loaded MOF-derived Co-doped carbon nitride nanotube catalyst, wherein the preparation method takes supramolecular self-assembly as a basic process, takes ZIF-67 as a Co source, realizes in-situ fixation of Butvar B-76 (PVB) on melamine sponge, and realizes in-situ fixation of the Co-doped carbon nitride nanotube catalyst in a melamine acid etching action and a carbonization process, so that efficient activation of PMS can remove chloroquine phosphate in water.

The invention belongs to the field of sewage treatment and advanced oxidation, and adopts a two-step hydrothermal synthesis technology to prepare a composite material molybdenum disulfide intercalation cobalt-manganese layered double hydroxide, and the molybdenum disulfide intercalation cobalt-manganese layered double hydroxide is applied to activated calcium sulfite to degrade chloroquine phosphate in water. The morphology of the LDH is not changed in ion exchange and vulcanization processes, and the growth of MoS2 is restrained in the LDH middle layer, so that the original aggregation structure is changed. Meanwhile, the layered agglomeration structure of LDH is also improved, the compound MoS2-coated LDH is relatively loose, and the specific surface area of the catalyst is effectively increased, so that the catalytic efficiency is improved. The method is simple to operate, and the prepared material has excellent reusability and stability and has certain application value in wastewater treatment.

The invention relates to the technical field of nano materials, and discloses a self-driven low-oxygen responsive Z-DNA targeted Janus nano motor and a preparation method thereof.The preparation method comprises the steps that firstly, an ammonia water solution and absolute ethyl alcohol are mixed and react with tetraethoxysilane to obtain a first solution, and the first solution is freeze-dried to obtain spherical MSN nano particles; preparing a chitosan solution; a second solution is obtained from the spherical MSN nano particles and gamma-glycidyl ether oxypropyl trimethoxy silane; adding a chitosan solution, chloroquine phosphate, anhydrous copper chloride and a hydrogen peroxide solution to obtain a third solution; adding an azo compound, freeze-drying, dispersing the obtained particles in absolute ethyl alcohol, dropwise adding on the surface of a silicon wafer to form a uniform film layer, and forming a platinum thin layer by using an ion sputtering instrument to obtain a nano motor CP-Chl (at) MPt; the problems that in the prior art, a targeting mechanism is lacked, a biological membrane cannot be actively penetrated, targeted intervention Z-DNA structure is lacked, the synergistic effect of ROS on cell membrane permeability and drug internalization is neglected, and the sterilization efficiency of an infected part is not high are solved.

To address the low removal efficiency of ribavirin and chloroquine phosphate, two common antiviral drugs, in traditional wastewater treatment methods, this invention provides a method for treating ribavirin and chloroquine phosphate in water using ultraviolet photocatalysis. This invention removes ribavirin and chloroquine phosphate by adding a certain amount of TiO2 and KMnO4 to the water under ultraviolet irradiation. Results show that the UV / KMnO4 / TiO2 process can efficiently remove ribavirin and chloroquine phosphate, with a treatment effect far exceeding that of UV alone, UV / KMnO4, or UV / TiO2 methods, indicating a significant synergistic effect. Furthermore, since TiO2 is currently the most common photocatalytic material, and potassium permanganate (KMnO4) is a common oxidant, the UV / KMnO4 / TiO2 method is simple, readily available, and easy to implement, making it widely applicable in engineering practice.

The present invention relates to a self-powered photoelectrochemical sensor, a preparation method thereof and an application thereof. Using FTO conductive glass as a substrate, a WO3 and TiO2 heterojunction is prepared as a photoanode, and a layered carbon intercalated ultrathin molybdenum disulfide microsphere modified with electrodeposited gold nanoparticles is used as a photocathode, and a self-powered photoelectrochemical sensing system based on water / oxygen self-circulation is constructed. This system does not require an external driving force and electron donors and acceptors, and both realizes self-power supply and reduces the background interference of the system based on the water / oxygen cycle. A molecularly imprinted membrane specifically recognizing chloroquine phosphate is synthesized on the photocathode by an electrochemical technique to initiate the polymerization reaction of o-phenylenediamine. Using simulated sunlight as an excitation light source, the concentration of chloroquine phosphate is detected by i-t technology on a CHI-660e workstation. The sensor of the present invention has sensitive photoelectrochemical response, a wide detection range and strong anti-interference ability; moreover, the preparation method is simple, rapid and low-cost, and can be applied to the rapid on-line detection of clinical serum and water bodies.

The present application provides a kind of chloroquine phosphate remover and preparation method and application, belong to the technical field of chloroquine phosphate removal. The preparation method provided by the present application includes the following steps: polyphenols, formaldehyde and iron source are placed in water, catalyst is added to stir and dissolve, the obtained solution is transferred to a microwave reaction tube for reaction, the solution after reaction is cooled and filtered to obtain filter residue, and the filter residue is washed with ethanol to obtain iron-doped polyphenol-formaldehyde resin microspheres; ammonium molybdate, thiourea and iron source are placed in water and stirred, and the obtained solution is transferred to an autoclave for reaction, and the solution after reaction is cooled and filtered to obtain filter residue, i.e. iron-doped molybdenum disulfide nanoflowers; iron-doped polyphenol-formaldehyde resin microspheres and iron-doped molybdenum disulfide nanoflowers are ball-milled and mixed according to a certain ratio to obtain chloroquine phosphate remover. The present application can improve the removal rate of chloroquine phosphate, and does not produce by-products such as nitroaromatic compounds, avoiding secondary pollution of water bodies.

The application discloses a kind of phosphorus-containing chloroquine wastewater treatment device, belong to wastewater treatment equipment technical field, two first connecting plate between through lifting rod and upper cover fixed connection, two first fixed plate are equipped with reaction cylinder, upper cover is equipped with stirring mechanism, reaction cylinder is equipped with sealing mechanism respectively on two sides, two first fixed plate are equipped with heating mechanism respectively on two sides, control mechanism is equipped on reaction cylinder, support frame is movably installed with wastewater cylinder, the outlet end of reaction cylinder and the inlet end of wastewater cylinder are interconnected, reset mechanism is equipped on wastewater cylinder.The application is closed by upper cover and reaction cylinder Space, control mechanism can quantitatively add catalyst, catalyst can accelerate the reaction of chloroquine phosphate in wastewater and treating agent, heating plate is close to reaction cylinder, heating plate can accelerate the reaction of treating agent and chloroquine phosphate in wastewater, stirring rod stirring can accelerate the reaction of treating agent and chloroquine phosphate in wastewater, to reach the purpose of effectively degrading chloroquine phosphate in wastewater.

The invention relates to the technical field of pharmaceutical wastewater treatment, in particular to a method for treating chloroquine phosphate wastewater by activating PMS with a platinum nano-catalyst, which comprises the following steps: S1, preparing the platinum nano-catalyst: dropwise adding an ethylene glycol solution of H2PtCl6 into an ethylene glycol solution of NaOH heated in an oil bath, stirring and cooling to room temperature to obtain the brownish black platinum nano-catalyst, the average particle size of platinum nanoparticles in the platinum nano-catalyst is less than or equal to 3 nm; and S2, activating PMS by the platinum nano-catalyst to carry out chloroquine phosphate degradation reaction, namely adding the platinum nano-catalyst and potassium peroxymonosulfate composite salt into chloroquine phosphate wastewater, and carrying out degradation reaction under irradiation of 222 nm ultraviolet light. In order to improve the reaction activity of peroxymonosulfate and further improve the degradation efficiency of chloroquine phosphate in a water body, a UV / PMS system is optimized by adopting a platinum nano-catalyst, and help can be provided for treating wastewater containing chloroquine phosphate.

The invention discloses a bridged bisquinoline compound and a preparation method and application thereof. The compound exhibits a certain killing effect on colon cancer, lung cancer, liver cancer, gastric cancer, cervical cancer and breast cancer cells, wherein the killing effect on colon cancer cells is particularly obvious, and is significantly better than positive control drugs chloroquine and cisplatin. In addition, the bridged bisquinoline compound has small toxic and side effects, solves the problem of large toxic and side effects of traditional platinum anti-tumor drugs such as cisplatin, and can be prepared into anti-tumor drugs for application. The preparation method of the bridged bisquinoline compound of the invention is simple and efficient, can realize industrialized production, and has great application value in anti-tumor.

In alternative embodiments, provided are pharmaceutical compositions comprising combinations of drugs, including products of manufacture and kits, and methods for using them, for treating, preventing, ameliorating, slowing the progress of, decreasing the severity of or preventing a coronavirus infection, or a COVID-19 infection, or an infection caused by a virus in the subfamily Orthocoronavirinae, or a virus in the family Coronaviridae, or a virus in the order Nidovirales. In alternative embodiments, combinations, or cocktails, of a drug or drugs as provided herein are administered either enterally, parenterally and / or by inhalation. In alternative embodiments, combinations, or cocktails, of drugs as provided herein are used to block intracellular metabolic pathways and prevent progression of the infection to clinical illness and death. In alternative embodiments, novel aerosol, spray or mist or powder formulations for inhalation are provided. In alternative embodiments, provided are therapeutic combinations of drugs or a drug, a pharmaceutical dosage form, a drug delivery device, or a product of manufacture, comprising: opaganib or YELIVA™, or opaganib or YELIVA™ and oral and / or inhaled chloroquine (or ARALEN™), chloroquine phosphate, chloroquine diphosphate and / or hydroxychloroquine (optionally, PLAQUENIL™), with or without azithromycin, wherein optionally each or all of the opaganib, the chloroquine (or ARALEN™), chloroquine phosphate, chloroquine diphosphate and / or hydroxychloroquine (optionally, PLAQUENIL™), and / or azithromycin, and others, are in or formulated as a formulation for inhalation, for example, formulated as an aerosol, spray, mist, liquid or powder.

The invention discloses a pharmaceutical composition containing a photosensitizer and an autophagy inhibitor, each unit dose of the pharmaceutical composition contains 1-100mg of a photosensitive drug DTP and 6-600mg of an autophagy inhibitor chloroquine phosphate, and the unit dose is the total amount of a pharmaceutical preparation used every day. The pharmaceutical composition containing the photosensitizer and the autophagy inhibitor is prepared by mixing 1-100mg of a photosensitive drug DTP and 6-600mg of an autophagy inhibitor chloroquine phosphate to prepare a liquid preparation for injection administration, such as freeze-dried powder injection, injection, large and small infusion or intravenous drip. The invention also provides an application of a pharmaceutical composition taking the photosensitive drug DTP and the autophagy inhibitor chloroquine phosphate as active ingredients in preparation of antitumor drugs. The pharmaceutical composition taking the photosensitive drug DTP and the autophagy inhibitor chloroquine phosphate as the active ingredients has a remarkable treatment effect in the anti-tumor aspect, not only has a good treatment effect on local tumors of prostatic cancer, but also shows synergistic anti-tumor activity. Combined application of the photodynamic therapy and the autophagy inhibitor is a research hot spot in the field of tumor treatment, and the research trend focuses on improvement of the treatment effect and deep understanding of an interaction mechanism between the photodynamic therapy and cell autophagy, so that the photodynamic therapy and the autophagy inhibitor can be more effectively applied to clinical treatment.