20 results about "Carbamazepine" patented technology

The invention relates to a preparation method and application of a composite piezoelectric catalytic material NaNbO3-coated BiFeO3 for rapidly degrading antibiotics, NaNbO3 is flaky crystal grains with [001] crystallographic orientation prepared by a two-step molten salt method, and BiFeO3 is micro-nano particles prepared by a coprecipitation method. Composite micro-nano BiFeO3 powder and [001] oriented NaNbO3 flaky grains form a heterojunction, conversion of mechanical energy and electric energy of the material is achieved under the ultrasonic vibration condition, inductive charges are generated on the surface of the material, and photon-generated carriers move reversely under driving of a built-in electric field. According to the invention, the piezoelectric catalytic degradation capability of the BiFeO3 and NaNbO3 composite piezoelectric catalytic materials with different proportions on four antibiotics, namely oxytetracycline, levofloxacin, carbamazepine and paracetamol in different time periods is researched. When the mass ratio of the BiFeO3 to the NaNbO3 composite material is 1: 3, the oxytetracycline degradation rate within 30 min can reach 78.2%, the oxytetracycline degradation rate within 120 min can reach 91.8%, and the piezoelectric electro-catalysis characteristic is rapid and efficient. The method disclosed by the invention has important significance in developing a high-efficiency piezoelectric catalyst for degrading antibiotics.

The utility model discloses an ethanol purifying and recycling device in a carbamazepine ammonification process, and belongs to the technical field of chemical production equipment. The device comprises a rectification and purification device, a reflux control device connected with the rectification and purification device, and a molecular sieve dryer used for ethanol recycling, and the rectification and purification device comprises a supergravity bed used for rectification and purification, a reboiler and a condenser. The backflow control device comprises a main conveying pipe connected to the condenser, a first branch conveying pipe and a second branch conveying pipe, wherein the first branch conveying pipe and the second branch conveying pipe are arranged at the end of the main conveying pipe. According to the utility model, the rectification recovery of ethanol is realized through the supergravity bed, the reboiler and the condenser, and the reflux ratio is controlled through the reflux control device, so that the purity and the recovery efficiency of the recovered ethanol are improved; ethanol in the collecting tank after rectification is dried through the molecular sieve dryer, absolute ethanol is obtained, and the crude carbamazepine product is subjected to secondary refining, so that the ethanol in the carbamazepine ammoniation process is recycled with the advantages of industrial production, simple process and low energy consumption.

The application discloses application of a eutectic solvent in improving solubility of carbamazepine, wherein the eutectic solvent is prepared by taking castor oil acid or 1,2-propanediol as a hydrogen bond donor, taking menthol or glycerol as a hydrogen bond acceptor, and the molar ratio of the hydrogen bond acceptor to the hydrogen bond donor being 1-7:1-3. The activity coefficient prediction module of the COSMO-RS model is used to screen a suitable hydrogen bond acceptor (HBA) and a hydrogen bond donor (HBD) to construct a eutectic solvent DESs system, so that the problem of low efficiency of a traditional trial-and-error method is solved, and a low-cost and green eutectic solvent DESs is successfully prepared through further systematic optimization. The solubility experiment data show that the prepared DESs can significantly improve the solubility of carbamazepine, and a new way is provided for development of a carbamazepine preparation.

The present application relates to a kind of methods for degrading carbamazepine by sodium periodate catalysis driven by ultraviolet light.To the water to be treated containing carbamazepine,1.0mM sodium periodate is added, and irradiated by ultraviolet light with excitation wavelength of 254nm, so as to degrade carbamazepine.Using sodium periodate oxidation alone, ultraviolet photolysis is almost ineffective for degrading carbamazepine, and the combination of sodium periodate and ultraviolet light can effectively degrade carbamazepine. The present application further studies the intermediate product of degrading carbamazepine by sodium periodate catalysis driven by ultraviolet light, and obtains 7 degradation intermediates, which can be used for detecting or evaluating the degradation degree, degradation speed and residual pollution of carbamazepine. The degradation experiment of carbamazepine in actual water body shows that the method of the present application has good stability and is less affected by environmental factors.

The invention relates to application of an activating agent in promotion of uranium element discharge. Specifically, the activating agent is prepared from rifampicin, erythromycin, progesterone, aldosterone, bilirubin, cholate vinblastine, doxomicin, adriamycin, paclitaxel, bosentan, ambrisentan, digoxin, verapamil, tonavir, amprenavir, indinavir, hypericum perforatum juice, curcumin, atorvastatin beclomethasone, budesonide, divaricasone carbamazepine and caffeine. And phenytoin. The use dosage of the activating agent is 10 to 60 mg / kg. According to the method, the accumulation amount of uranium in important organs such as bones and kidneys can be remarkably reduced, so that the potential toxic influence on the key organs is reduced.

This application relates to the field of analytical detection technology, specifically to sample pretreatment methods, kits, and detection methods for the detection of antiepileptic drugs. The sample pretreatment method for the detection of antiepileptic drugs in this application includes one or more of the following antiepileptic drugs: valproic acid, carbamazepine, phenytoin, levetiracetam, lamotrigine, and phenobarbital. The sample pretreatment method includes the following steps: mixing magnetic beads with an activation solution to prepare a magnetic bead suspension; mixing the sample to be tested, the magnetic bead suspension, and an internal standard solution, and separating the supernatant and the magnetic bead complex after magnetic adsorption treatment; adding an eluent to the magnetic bead complex, and collecting the magnetic bead-target complex after elution treatment; adding an elution buffer to the magnetic bead-target complex, and collecting the supernatant after elution treatment for detection. The above sample pretreatment method is simple to operate, time-saving, and low-cost, providing key technical support for the efficient quantitative detection of antiepileptic drugs.

The application provides a carbamazepine supramolecular hydrogel and a preparation method, a characterization method and an application thereof. The carbamazepine supramolecular hydrogel is prepared by using Fmoc group modified phenylalanine dipeptide molecules and carbamazepine molecules as raw materials, organic solvents and water as solvents, and has the advantages of simple preparation method, good biocompatibility, crystal form conversion of carbamazepine into amorphous, and slow release of carbamazepine. The infrared spectrum analysis method is used to monitor the change process in situ and in real time, to explore the structure change of the carbamazepine crystal, and to explore the intermolecular interaction mechanism of the peptide-based supramolecular gel on the crystal form conversion, so as to provide a theoretical basis for the structure-activity relationship of the drug.

The application discloses a new process for continuously preparing carbamazepine, and comprises the following steps: (1) dissolving indole in an organic solvent as raw material liquid I, filling a copper catalyst and the like in a tubular reactor, and reacting the raw material liquid I through the tubular reactor to obtain a reaction liquid, and distilling the reaction liquid to obtain 1-phenylindole; (2) dissolving 1-phenylindole and an acid catalyst in organic solvents respectively as raw material liquids II and III, mixing and reacting the raw material liquids II and III through a tubular reactor to obtain a reaction liquid, and recrystallizing the reaction liquid to obtain imino stilbene; (3) dissolving imino stilbene and triphosgene in organic solvents as raw material liquids IV and V, mixing and reacting the raw material liquids IV and V through a tubular reactor, mixing and reacting the reaction liquid with ammonia water again, and finally recrystallizing the reaction liquid to obtain carbamazepine; the process has three steps of reaction in total, the yield of each step is above 85%, the reaction speed is fast, the side reaction is less, the mass transfer and heat transfer efficiency is high, the safety is high, the waste is less, the cost is low, and the post-treatment is convenient.

The invention relates to the technical field of biological medicines, in particular to application of a CCR1 / 5 inhibitor Met-RANTES in inhibition of pathological pain of trigeminal nerves. According to the invention, CCR1 / 5 is taken as a therapeutic target of chronic pain, and a medicine which is remarkable in analgesic effect, small in side effect and capable of relieving chronic pain and improving pain mood is developed by combining the pharmacological function of an inhibitor Met-RANTES of CCR1 / 5. The Met-RANTES inhibits a central nervous system chemokine receptor CCRR1 / 5 in a targeted manner in a regular nasal administration manner, so that pathological mechanical pain-sensitive response and accompanying negative emotion caused by chronic compression of trigeminal nerves can be remarkably relieved, and pain feeling is relieved. In addition, the analgesic effect of the drug combination of the Met-RANTES and the carbamazepine is more obvious than that of the drug combination of the Met-RANTES and the carbamazepine which are independently used. The nasal delivery mode enables the medicine to directly reach the central nervous system, and reduces side effects of the whole body.

The invention relates to the technical field of analysis and detection, in particular to a sample pretreatment method for anti-epileptic drug detection, a kit and a detection method. According to the sample pretreatment method for anti-epileptic drug detection, an anti-epileptic drug comprises one or more of valproic acid, carbamazepine, phenytoin, levetiracetam, lamotrigine and phenobarbital; the sample pretreatment method comprises the following steps: mixing magnetic beads with an activating solution to prepare a magnetic bead suspension; mixing a to-be-detected sample, the magnetic bead suspension and the internal standard solution, performing magnetic attraction treatment, and separating supernate and a magnetic bead compound; leacheate is added into the magnetic bead compound, and after leaching treatment, a magnetic bead-target compound is collected; and adding an eluent into the magnetic bead-target compound, carrying out elution treatment, and collecting a supernatant for detection. The sample pretreatment method is simple to operate, short in time consumption and low in cost, and can provide key technical support for efficient quantitative detection of the anti-epileptic drugs.

The utility model discloses a carbamazepine quantitative determination kit, and particularly relates to the technical field of kits, the carbamazepine quantitative determination kit comprises a box body, a plurality of assembly seats and a sealing cover, the bottoms of the assembly seats are in bolted connection with the bottom of the box body, a pipe body and a control assembly used for stabilizing the pipe body are arranged in a top storage groove, the pipe body slides down along an inclined plane and contacts and extrudes a positioning plate, and the positioning plate is fixed on the box body. After the rotating roller overcomes the torque force of the coil spring to rotate, the moving seat slides along the wall of the mounting groove, the coil spring is stretched to store energy and the pipe body is placed in place, the coil spring releases elastic potential energy, so that the rotating roller rotates reversely to drive the moving seat and the positioning plate to move towards the center of the storage groove, and the positioning plate and the rubber strip are tightly attached to the pipe body; the pipe body is fixed, the stability is good, shaking, collision and damage of the pipe body and reagent leakage in the transportation and use process can be avoided, safety and accuracy are guaranteed, the structure is flexible, stress is uniform, the pipe body can be conveniently placed in and taken out only by overcoming certain external force, and maintenance and replacement are facilitated through the split type design.

The utility model discloses a carbamazepine bromination process ethanol recovery device based on a rectifying still, and belongs to the technical field of chemical medicine recovery. The device comprises a preheating device, a rectification device, a steam temporary storage device and a heat exchange device, wherein the preheating device is arranged on a guide pipe on one side of the rectification device; the steam temporary storage device is arranged at the tail end of a steam pipe at the top end of the rectification device; the heat exchange device is connected to the lower portion of the steam temporary storage device through a guide pipe. On the basis that ethanol is obtained through rectification and purification of traditional equipment, heat brought by ethanol steam is guided into the preheating device again through the heat exchange device, ethanol mixed waste liquid is heated preliminarily, efficient recycling of the heat is achieved, and the operation cost of the whole equipment is reduced to a great extent.

The present application relates to a kind of drug raw materials and its preparation method and characterization method, specifically related to a kind of carbamazepine-succinic acid co-crystal (CBZ-SA) and its preparation method and terahertz spectroscopy characterization test method.The purpose of the present application is to solve the problem that the position and number of hydrogen bond in the existing carbamazepine-succinic acid co-crystal are uncertain, and the precision of X-ray diffraction method for characterizing carbamazepine-succinic acid co-crystal is not enough, and the steps are complex.The present application provides a preparation method for carbamazepine-succinic acid co-crystal, which is wet grinding method using ethanol, then the terahertz spectroscopy experimental system is used to characterize carbamazepine-succinic acid co-crystal, the terahertz absorption spectrum of CBZ-SA co-crystal is obtained, and the spectrum result obtained can not only prove the result difference of different preparation methods, but also be used as subsequent CBZ-SA prediction structure simulation absorption spectrum for contrast verification, to verify the correctness of CBZ-SA co-crystal prediction structure.

The invention discloses a synthesis method of carbamazepine and analogues thereof, which comprises the following steps of: dispersing a dibenzo [b, f] azepine analogue shown in a formula (I), a photocatalyst and a metal cobalt complex in an organic solvent under an illumination condition, and carrying out dehydrogenation reaction under illumination with a certain wavelength. And after the reaction is finished, carrying out post-treatment on the reaction liquid to obtain carbamazepine and the analogue thereof as shown in the formula (II). The reaction formula is as follows. The synthesis of carbamazepine and the analogue thereof is realized by taking a light source as a reaction energy source, so that the reaction is safer and more environment-friendly, and the cost is lower.

The invention relates to the technical field of analysis and detection, in particular to a method for detecting drugs and personal care products in soil. According to the extraction, separation and enrichment steps of the traditional Chinese medicines and the personal care products, accelerated solvent extraction and solid-phase extraction are combined, so that the extraction rate of the various medicines and the personal care products in the soil can be remarkably increased, the sample loss rate is reduced, and the extraction time is shortened. According to the method, accelerated solvent extraction and solid-phase extraction are combined with a high-performance liquid chromatography coupling technique, isocratic elution is performed for 15-20 minutes, so that various trace drugs and personal care products with different structures and different polarities, such as ibuprofen, carbamazepine, bisphenol A and triclosan, which are remained in soil can be simply, quickly, accurately and universally detected, and the sensitivity is high. Moreover, the detection method provided by the invention is high in accuracy and good in reproducibility, and a rapid, accurate, visual, qualitative and quantitative determination method for the soil traditional Chinese medicines and the personal care products is provided for environmental detection departments, governments and enterprises.

The invention belongs to the technical field of carbamazepine medication guidance, and particularly relates to a gene detection kit and detection system for carbamazepine medication guidance, and the kit comprises a primer and a probe for detecting HLA-A * 31: 01 and HLA-B * 15: 02 genes, a primer and a probe for monitoring internal control genes, a PCR reaction liquid, a positive quality control product and a negative quality control product. The use method of the kit comprises the following steps: taking a blood sample containing the EDTA anticoagulant, and carrying out nucleic acid extraction; pre-mixing and packaging the gene detection reagent to respectively obtain a PCR reaction solution 1 and a PCR reaction solution 2 to jointly form a PCR reaction system; adding the obtained DNA into a PCR reaction system, uniformly mixing, and then carrying out PCR amplification; according to the present invention, the gene detection system comprises the kit, the PCR amplification reaction system and the gene typing interpretation system, and the kit and the system have characteristics of high sensitivity, low cost, simple operation, short detection period, intuitive interpretation and the like, and can rapidly and accurately detect the carbamazepine individualized medication gene polymorphism.

The invention provides a concentration determination kit for five anti-epileptic drugs, the kit is used for detecting the anti-epileptic drugs in a serum sample by liquid chromatography-tandem mass spectrometry, the kit comprises a diluent, an internal standard solution IS, a plurality of calibration products and a plurality of quality control products, and the calibration products and the quality control products are freeze-dried preparations. The kit provided by the invention can be used for detecting that the linearity range of clonazepam is 4-200ng / mL, the linearity range of valproic acid is 3-150mu g / mL, the linearity range of 10, 11-dihydro-10-hydroxycarbamazepine is 0.8-40mu g / mL, the linearity range of levetiracetam is 1.0-50mu g / mL, the linearity range of topiramate is 0.5-25mu g / mL, the correlation coefficient r is not less than 0.9900, and the detection result is accurate and reliable. The in-batch variation coefficient CV is not greater than 15.0%, the inter-batch variation coefficient CV is not greater than 15.0%, and the kit is good in consistency and high in stability. The accurate recovery rate is in a range of 85.0%-115.0%, and the detection result is accurate. The quantitative limit CV is smaller than or equal to 20%, the relative deviation is within the range of + / -15%, and the kit is high in sensitivity and has high repeatability and reliability. The product can be stably stored for 12 months at 2-8 DEG C, and the shelf life is long.

Safe and effective methods for treating a subject suffering from cortisol excess of and in need of concomitant administration of mifepristone along with a CYP3A4 inducer are disclosed herein. The CYP3A4 inducer may be, for example, mitotane, rifampin (also known as rifampicin), rifabutin, rifapentin, phenobarbital, phenytoin, carbamazepine, or St. John's wort. In embodiments, the CYP3A4 inducer is a strong CYP3A4 inducer. In embodiments, the CYP3A4 inducer is a moderate CYP3A4 inducer. In embodiments, the CYP3A4 inducer may be any CYP3A4 inducer. Mifepristone may be orally administered. Mifepristone may be administered with food.

This invention discloses a carbamazepine chemiluminescent immunoassay reagent and its preparation and detection method. The advantages of this invention are: the chemiluminescent immunoassay reagent containing anti-carbamazepine specific antibodies can conveniently, rapidly, and accurately determine the carbamazepine content in a sample, and can simultaneously measure multiple samples on a fully automated chemiluminescent immunoassay analyzer, achieving high-throughput and rapid determination of carbamazepine. It offers high accuracy, strong specificity, and significantly improved precision and detection efficiency compared to previous methods. Furthermore, it achieves full automation of the detection process, requiring less skill from testing personnel, and is easy to implement and widely adopt.

The application belongs to the field of chemical engineering crystallization, and particularly relates to a self-assembled membrane induced carbamazepine crystal form control method and an online monitoring method of a crystallization process. The method comprises the following steps: S1: self-assembled membrane preparation: immersing a treated gold film substrate into a mercapto self-assembled membrane solution to form a film; the mercapto self-assembled membrane solution is an SH-R-R' solution, wherein R is an aromatic group or an alkyl group, and R' is COOH, OH or H; S2: solution cooling crystallization; the method provides a functionalized interface to induce the carbamazepine solution crystallization process, utilizes the interaction between the groups modified on the substrate surface and the drug molecules to induce the crystal nucleus formation process of the system, and through a program temperature control device to obtain different drug crystal forms. The self-assembled membrane modification on the surface of a quartz crystal microbalance crystal microvibration piece can further provide the function of accurately monitoring the crystal nucleus induction point change occurring in the induced carbamazepine process online.