The invention relates to the technical field of pharmaceutical
chemistry, in particular to a preparation method of high-purity
carbamazepine (CBZ)-valaciclovir, which comprises the steps of: suspending acyclovir into N,N-
dimethylformamide, adding CBZ-L-
valine and 4-dimethylamino
pyridine to obtain a turbid liquid, cooling the turbid liquid to 0-10 DEG C, adding dicyclohexylcarbodiimide, preserving the temperature for 1-5h, raising the temperature to 18-30 DEG C, controlling the temperature raising time to be 1-2h, filtering
solid in a
reaction system after carrying out heat preservation reaction for 10-20h at a temperature of 18-30 DEG C, decompressing and concentrating filtrate to obtain an oily matter, dissolving concentrate by heating through using
alcohol, cooling
crystal after being dissolved and filtering, recrystallizing and filtering the obtained
solid by using
alcohol, dissolving the obtained
solid by heating through using the N,N-
dimethylformamide with matched quantity to obtain a crude solution of the CBZ-valaciclovir, adding the solution into water with a temperature of 50-80 DEG C to make the solid to separate out, filtering, washing with water with a temperature of 50-80 DEG C to obtain a
filter cake, and
drying to obtain the high-purity CBZ-valaciclovir.