Carbamazepine immunogen, anti-carbamazepine specific antibody, detection reagent and detection kit

A detection kit, carbamazepine technology, applied in biological testing, immunoglobulins, specific peptides, etc., can solve the problems of low antibody sensitivity and difficult to meet clinical needs, and achieve high immunogenicity and strong binding force. , high specificity effect

Active Publication Date: 2011-09-14
HAINAN JINYU MEDICAL TESTING CENT CO LTD
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  • Abstract
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AI Technical Summary

Problems solved by technology

However, the sensitivity of antibodies prepared by this derivation method is low, and it is difficult to meet the clinical needs

Method used

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  • Carbamazepine immunogen, anti-carbamazepine specific antibody, detection reagent and detection kit
  • Carbamazepine immunogen, anti-carbamazepine specific antibody, detection reagent and detection kit
  • Carbamazepine immunogen, anti-carbamazepine specific antibody, detection reagent and detection kit

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Embodiment Construction

[0027] The technical scheme that the present invention takes is:

[0028] The carbamazepine immunogen has a structural formula as shown in formula (I):

[0029]

[0030] In the formula, R is a linking group, and the carrier has immunogenicity. Preferably, the carrier is an immunogenic protein. Proteins are usually the carrier of choice, although other sufficiently large immunogenic substances can also be used as carriers. The most commonly used immunogenic carriers include serum albumin, hemocyanin (KLH) and thyroglobulin. The choice of carrier is the basic common sense of those skilled in the art.

[0031] R is preferably –O-(CH 2 ) n -COO-, n is an integer between 1 and 20, in particular, R is –O-(CH 2 ) 4 -COO-.

[0032] An anti-carbamazepine specific antibody is produced by immunizing animals with the above-mentioned carbamazepine immunogen.

[0033] The "antibody" referred to in the present invention not only refers to the complete antibody molecule, but also ...

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Abstract

The invention discloses a carbamazepine immunogen, an anti-carbamazepine specific antibody, a detection reagent and a detection kit.

Description

technical field [0001] The invention relates to a carbamazepine immunogen, an anti-carbamazepine specific antibody, a detection reagent and a detection kit. Background technique [0002] Carbamazepine (5 H -dibenzo[ b , f ]azepine-5-carboxamide, 5H-dibenzo[b,f]azepine-5-carboxamide), its structural formula is shown in formula (II). [0003] [0004] Carbamazepine is a class of antiepileptic and mood stabilizing drugs, mainly used in the treatment of epilepsy, bipolar disorder and trigeminal neuralgia. Carbamazepine has many side effects, including: anaphylaxis that may be life-threatening; toxicity to the trigeminal nerve that may cause severe damage to the skin and internal organs. It is therefore very important to monitor the patient's blood drug levels during treatment. [0005] The immunoassay method established by using the specific antibody against carbamazepine has been applied to the tracking and monitoring of carbamazepine in the patient's blood. Existing a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K14/765C07K14/795C07K14/435C07K16/44G01N33/53G01N33/543
Inventor 虞留明梁耀铭李洪波
Owner HAINAN JINYU MEDICAL TESTING CENT CO LTD
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