The invention discloses a cabinet body temperature and humidity regulation and control device, a using method thereof and a cabinet body applying the same, and belongs to the technical field of heat exchange devices. The cabinet body is provided with a cabinet body wall and a cabinet body cavity located in the cabinet body wall. The cabinet body wall is provided with a communication port. The cabinet body cavity is connected with the outside of the cabinet body through the communication port. An electric refrigeration element is further included; the electric refrigeration element is arrangedat the communication port and is in sealed connection with the edge of the communication port; the electric refrigeration element is provided with a first end and a second end; the first end faces thecabinet cavity, and the second end faces the outside of the cabinet body. When the first end is a refrigeration end, the second end is a heat dissipation end; and when the first end is the heat dissipation end, the second end is the refrigeration end. According to the device, external electric energy can be converted into cold energy through the electric refrigeration element, and the cold energyis transmitted to cool the interior of the cabinet body through the cold dissipation aluminum profile, so that high temperature is prevented; meanwhile, heat generated after the electric refrigeration element is electrified can be discharged out of the cabinet body by utilizing the heat dissipation aluminum profile, so that heat exchange between the inside and the outside of the cabinet body is realized.