The invention relates to super-hydrophobic and anti-pollution flashover one-component adhesive, and a preparation method and application thereof, and belongs to the technical field of adhesives and coatings. The adhesive comprises the following components in part by mass: 100 parts of hydroxyl-terminated polysiloxane, 50 to 150 parts of fire retardant, 1 to 5 parts of hydrophobic enhancer, 0.2 to 2 parts of structure modifier, 3 to 15 parts of cross-linking agent, and 0.2 to 5 parts of catalyst. The method comprises the steps of performing vacuum drying treatment to the hydroxyl-terminated polysiloxane, reinforcing filler, the fire retardant, the hydrophobic enhancer and the structure modifier which are mixed for 1 to 3 hours at 80 to 150 DEG C, cooling the mixture, feeding the cross-linking agent and the catalyst to the mixture, uniformly mixing, and then obtaining the adhesive. The adhesive can be dissolved in organic solvent and then is served as coating. The adhesive has the advantages that the adhesive can be directly used, the bonding strength is high, the flame retardant rating is high, the pollution prevention effect is good, the technology is simple, the controllability is good, the adhesive can be directly used and can also be dissolved in solvent to perform coating operation, and the like.