2191results about How to "Shorten the duration" patented technology

The present invention provides methods and systems for patient-specific seizure onset detection. In one embodiment, at least one EEG waveform of the patient is recorded, and at least one epoch (sample) of the waveform is extracted. The waveform sample is decomposed into one or more subband signals via a wavelet decomposition of the waveform sample, and one or more feature vectors are computed based on the subband signals. A seizure onset can then be identified based on classification of the feature vectors to a seizure or a non-seizure class by comparing the feature vectors with a decision measure previously computed for that patient. The decision measure can be derived based on reference seizure and non-seizure EEG waveforms of the patient. In another aspect, similar methodology is employed for automatic detection of alpha waves. In other aspects, the invention provides diagnostic and imaging systems that incorporate the above seizure-onset and alpha-wave detection methodology.

A remote device in accordance with the present invention includes an adaptive power receiver that receives wireless power from the wireless power supply by induction. The adaptive power receiver may be switched among two or more modes of operation, including, for example, a high-Q mode and a low-Q mode. By controlling the switching between modes, the amount of energy received by the adaptive receiver may be controlled. This control is a form of adaptive resonance control or Q control.

The present invention relates to biphenyl-pyrazole compounds and in particular biphenyl-pyrazolecarboxamides. The invention further provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions beneficially treated by antagonism or inverse agonism of the CB1 receptor, such as obesity, smoking cessation, and normalization of blood lipid composition.

The present invention provides methods and system for managing neurological disorders such as epilepsy. In one embodiment, the method comprises measuring one or more signals from a patient and processing the one or more signals to characterize a patient's propensity for a future seizure. The characterized propensity for the seizure is thereafter used to determine an appropriate action for managing or treating the predicted seizure; and a recommendation is communicated to the patient that is indicative of the appropriate action.

A method for providing customized interactive voice response menus can include monitoring user interactions with an interactive voice response system. Data concerning the user interactions can be stored. A request to initiate an interactive voice response session can be received. The interactive voice response system can determine an identity for a user making the request. The interactive voice response system can generate a customized menu for the user. At least a portion of the customized menu can be based upon the usage data. The customized menu can be presented to the user.

A system that automates the clearing and settlement of electronic coupons (E-Coupons) by leveraging existing technologies and enabling E-Coupon redemption at any merchant having electronic funds transfer (EFT) capabilities, such as credit / debit card acceptance. The system reduces opportunities for fraud, reduces or eliminates the need for manual clearinghouse counting and sorting of coupons, and provides an electronic audit trail for coupon redemption, tying a specific purchase to a specific coupon. After registering and selecting coupons, consumers then use an E-Coupon card or account access device at a merchant's point-of-sale (POS) terminal. E-Coupon values are deducted from the consumer's final amount due. Both consumer package goods manufacturers (CPGs) and merchants may be charged a fee. Expired coupons are automatically removed from the account and their value refunded to the CPGs. Reports on redeemed coupons and consumer profiles can be generated and provided to CPGs or merchants.

A method and apparatus for direct interstitial treatment of tissue, while preventing backflow and decreasing drainage of a flowable composition from an injected area, by using a catheter and / or a needle with single or multiple inflatable member(s) that stretches, dilates and compresses target tissue and allows for an improved interstitial deposition, distribution and retention of the flowable composition, drug(s), agent(s), or particle(s), into a body organ, fluid, tissue, or tumor, thereby increasing procedural safety and efficacy of direct interstitial therapies.

A method of operating a liquid crystal cell includes DC-balancing by displaying an inverse image with electric fields of increased magnitude relative to the image producing electric fields. While the inverse image is displayed the image is prevented from being visible by either turning off the light source or re-directing or blocking the light from reaching the viewing area. The image producing electric fields and the inverse image producing electric fields are such that the cumulative time integral of the electric fields that are present in one direction across the liquid crystal material is substantially equal to the cumulative time integral of the electric fields that are present in the opposite direction during the given period of time during the operation of liquid crystal cell. The time duration of the inverse image portion is shorter than the time duration of the image portion by an amount proportional to the increased magnitude of the additional electric fields. Because of the shorter time period when no image is visible, the system brightness is increased.

System and method for making incisions in eye tissue at different depths. The system and method focuses light, possibly in a pattern, at various focal points which are at various depths within the eye tissue. A segmented lens can be used to create multiple focal points simultaneously. Optimal incisions can be achieved by sequentially or simultaneously focusing lights at different depths, creating an expanded column of plasma, and creating a beam with an elongated waist.

Systems, methods, and computer-readable storage media for inter-node data replication while reducing network traffic for remote backup. A system receives a command to duplicate a dataset, located on a source network node, to a remote network node, accesses, on the source network node, signatures of a previous snapshot of the dataset and signatures of a current snapshot of the dataset, performs, at the source network node, a local signature comparison between the previous snapshot and the current snapshot to identify one or more signatures that do not match, sends the signatures that do not match to the remote network node, searches, on the remote network node, for the signatures that do not match, and sends data associated with the signatures that do not match to the remote network node for incorporation within a current remote snapshot if they do not exist on a current remote network node.

A plurality of pins attach to bone, such as a vertebra (not shown). Spacers interpose between pins. A cable extends through pins and spacers between a cap and an expansion sleeve. The expansion sleeve increases cable tension to restrict movement among pins and spacers.

A pulsed laser comprises an oscillator and amplifier. An attenuator and / or pre-compressor may be disposed between the oscillator and amplifier to improve performance and possibly the quality of pulses output from the laser. Such pre-compression may be implemented with spectral filters and / or dispersive elements between the oscillator and amplifier. The pulsed laser may have a modular design comprising modular devices that may have Telcordia-graded quality and reliability. Fiber pigtails extending from the device modules can be spliced together to form laser system. In one embodiment, a laser system operating at approximately 1050 nm comprises an oscillator having a spectral bandwidth of approximately 19 nm. This oscillator signal can be manipulated to generate a pulse having a width below approximately 90 fs.

Described herein are therapeutic targets expressed in cancer stem cells and methods for treating and diagnosing cancer by targeting such cells with antibodies, compounds, nucleic acid, or other therapeutic agent. In one embodiment described herein, therapeutic agents for the treatment of cancer are provided based on the identification of cancer stem cell targets. The present invention also includes therapeutic targets for cancer therapy and cancer stem cell-targeted therapy. The invention includes the treatment of cancer by the administration of compounds or agents that target cancer stem cells.

A method for cross-platform porting of applications includes extracting one or more platform independent models from an existing one or more composite applications running on a given source platform. These platform independent models are then transformed into implementation artifacts on another, target platform, thereby effectively porting the composite application from one platform to another. The generated implementation artifacts on the target platform leverage existing assets in the target environment, which makes these generated artifacts “contextually-aware”.

Methods of identifying subjects at increased risk of cancer, based upon detection of biofilms and / or biofilm-associated microbes within a subject, are disclosed. Therapies designed to prevent formation and / or reduce the size of biofilms in a subject identified to be at increased risk of cancer based upon detection of biofilms and / or biofilm-associated microbes are disclosed. In particular embodiments, the invention provides for identification of a subject at elevated risk of developing or having colorectal cancer and / or a colorectal adenoma, based upon detection of a biofilm and / or biofilm-associated bacteria within the gastrointestinal tract of the subject (optionally, within a biopsy specimen and / or stool sample of such subject). Therapies involving administration of an antibiotic agent and / or a probiotic agent to a subject, to prevent or reduce biofilm formation within the gastrointestinal tract of the subject, optionally provided in combination with additional cancer therapy, are also disclosed.

A circuit and method for programming phase-change memory devices, such as chalcogenide memory (PRAM), are described. The invention is directed to an approach to programming PRAM elements from a reset state to a set state or from a set state to the set state. The invention provides a novel and nonobvious PRAM device and method in which a set pulse duration time is controlled by monitoring the state of the memory element during programming such as by comparing the voltage of a bit line with a reference voltage or comparing the cell resistance with a set state cell resistance. The duration of the set pulse is controlled in response to the detected state of the memory element. The result of the approach of the invention is the significant reduction in PRAM programming errors, such as those caused by a constant-duration set pulse, as well as reduction in programming time duration and power consumption.

The present invention provides methods of therapy of cognitive deficits associated with a central nervous system disorder or condition, methods of enhancing cognitive performance and methods for repeated stimulation of neuronal activity or a pattern of neuronal activity, such as that underlying a specific neuronal circuit(s). The methods comprise combining cognitive training protocols and a general administration of CREB pathway-enhancing agents.

The present invention provides methods for inhibiting interleukin-3 receptor-expressing cells, and, in particular, inhibiting the growth of such cells by using a diphtheria toxin-human interleukin-3 conjugate (DT-IL3) that is toxic to cells expressing the interleukin-3 receptor. In preferred embodiments, the DT-IL3 conjugate is a fusion protein comprising amino acids 1-388 of diphtheria toxin fused via a peptide linker to full-length, human interleukin-3. In certain embodiments, the methods of the present invention relate to the administration of a DT-IL3 conjugate to inhibit the growth of cancer cells and / or cancer stem cells in humans, which cells express one or more subunits of the interleukin-3 receptor. Exemplary cells include myeloid leukemia cancer stem cells. In other embodiments, the methods of the present invention relate to ex vivo purging of bone marrow or peripheral blood to remove cells that express one or more subunits of the interleukin-3 receptor such that the purged bone marrow or peripheral blood is suitable, e.g., for autologous stem cell transplantation to restore hematopoietic function.

The present invention provides antibodies that bind to the IL-3 receptor alpha subunit alpha (Il3Rα) chain, and compositions comprising such antibodies. The present invention provides methods for inhibiting or reducing an IL3Rα-expressing cell population, the methods comprising contacting a population of IL3Rα-expressing cells (e.g., cancer cells and / or cancer stem cells) with an antibody that binds to IL3Rα. The present invention also provides antibody conjugates comprising an antibody that binds to an IL3Rα chain linked to a cytotoxic agent or anticellular agent and compositions comprising such conjugates. The present invention also provides methods for preventing, treating and / or managing a disorder associated with IL3Rα-expressing cells (e.g., a hematological cancer), the methods comprising administering to a subject in need thereof an antibody that binds to IL3Rα.

The present invention relates to a transmitting apparatus, a receiving apparatus, a system, a signal, and a method of multi-user transmission, wherein transmission settings are divided into common signal information, containing settings / information relevant for multiple receivers and user stream specific information, containing settings / information relevant only to a related user stream. Furthermore, the common signal information may comprise at least one of a duration of the longest user stream field and multi-user resource allocation field, so that the receivers know the mapping of user streams to receivers.

Distortion artifacts preceding a signal transient in an audio signal stream processed by a transform-based low-bit-rate audio coding system employing coding blocks are reduced by detecting a transient in the audio signal stream and shifting the temporal relationship of the transient with respect to the coding blocks such that the time duration of the distortion artifacts is reduced. The audio data is time scaled in such a way that the transients are temporally repositioned prior to quantization in a transform-based low-bit-rate audio encoder so as to reduce the amount of pre-noise in the decoded audio signal. Alternatively, or in addition, in a transform-based low-bit-rate audio coding system, a transient in the audio signal stream is detected and a portion of the distortion artifacts are time compressed such that the time duration of the distortion artifacts is reduced.

A computer-implemented method for managing operating-room resources in a hospital includes the steps of receiving at least one surgery request, identifying the resources required for surgery associated with the surgery request, capturing initial data on availability of the resources, capturing initial patient data, and establishing a pre-scheduled operating-room plan based on an initial optimization, and the further steps of capturing current data on availability of the resources, capturing current patient data and establishing a current operating-room plan based on a current optimization. A computer-based system for managing operating-room resources in a hospital and a modular computer-based system for managing operating-room related processes in a hospital are also disclosed.

An appliance having at least one component, a receiver, and a controller. The component is configured to operate in a normal operation mode and a resource savings mode; wherein an instantaneous resource demand of the at least one component is greater during the normal operation mode than during the resource savings mode. The receiver is adapted to receive a curtailment signal. The controller is connected to the receiver and the component, and determines if a curtailment signal has been received by the receiver. If the curtailment signal was received, the controller determines whether the component should be operated in the resource savings mode, and if so, the controller operates the component in the resource savings mode, and if not, the controller operates the component operated in the normal operation mode.

There is provided a water level sensing apparatus including: a body disposed to be exposed within a liquid tank and having an accommodating space therein; and a capacitance detecting unit accommodated in the accommodating space of the body, wherein the capacitance detecting unit compares an upper side capacitance value and a lower side capacitance value and turns on or off an output signal. Because a changeable reference that the capacitance values of a reference surface and a detected surface of the body are simultaneously changed is used, even if the body comes in contact with moisture or debris, the reference surface and the detected surface are equally affected by the moisture or debris, thus reducing the occurrence of malfunction.

The present invention provides methods of improving cognitive and motor deficits associated with central nervous system (CNS) disorder or condition in an animal. The methods comprise a general administration of phosphodiesterase 4 inhibitors and optionally training the animal under conditions sufficient to produce an improvement in performance.

The roaming of a wireless device 115 extends the effective range of a wireless network 100 by passing a device 115 between access points as the device leaves the coverage area of one and enters another. Roaming can be slow and problematic if an old link is disconnected prior to establishing a new link, especially if authentication and security is required. The present invention speeds up roaming by using existing mechanisms to initiate a new link with a new access point 120 prior to disconnecting the old link with an old access point 110.

The present invention relates to a system and methods for noninvasively providing therapy for movement disorder symptoms. The present invention provides such a therapy system which provides trans-cranial direct current stimulation (tDCS) in order to treat those symptoms and the disorders. The present invention further provides such tDCS therapy while the subject sleeps in order to minimize the time required and impact of the therapy on the subject's waking life. The system, methods, and devices of the present invention are intended to provide a low-dose electrical current, trans-cranially, to a specific area of the subject's brain while he or she sleeps in order to decrease the occurrence, severity, and duration of the symptoms of movement disorders. The present invention aims to reduce the amount of medication necessary, counteract the effects of medication wearing off during sleep, and to overall improve the quality of life of subjects suffering from movement disorders.