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The present invention provides methods of treating cognitive deficits associated with mental retardation. The methods comprise combining cognitive training protocols and a general administration of phosphodiesterase 4 inhibitors.

The invention discloses a heat accumulating temperature regulating fiber and a method for preparing the same. The fiber takes a polymer phase-change material as component A and a fiber-forming polymer as component B, wherein the mass fraction of the component A in the fiber counts 20-60%, while the mass fraction of the component B in the fiber counts 80-40%; the fiber is produced by using a method comprising the steps of melting composite spinning, solution composite spinning or electrostatic solution composite spinning; the fiber has a composite structure and the cross section of the fiber is shaped as an island or concentric circles, wherein the polymer phase-change material is polypropylene glycol-n-alkyl ether; the number m of glycol repetition units is 1-100; the number n of carbon atoms in alkyl is 11-30; and the heat absorption / dissipation temperature of the fiber is 11.9-53.8 DEG C, while the heat accumulation quantity is 18-55 J / g and 5% thermal gravimetric temperature is above 203 DEG C. The method for preparing the fiber employs the constitution and the structure of the heat accumulating temperature regulating fiber provided by the invention and prepares the fiber by using the method of the melting composite spinning, the solution composite spinning or the electrostatic solution composite spinning.